{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:34:40Z","timestamp":1794000880860,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003943"],"award-info":[{"award-number":["82003943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118475","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T16:15:25Z","timestamp":1718900125000},"page":"118475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Scorch processing of rhubarb (Rheum tanguticum Maxim. ex Balf.) pyrolyzed anthraquinone glucosides into aglycones and improved the therapeutic effects on thromboinflammation via regulating the complement and coagulation cascades pathway"],"prefix":"10.1016","volume":"333","author":[{"given":"Linying","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-0187","authenticated-orcid":false,"given":"Jianbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118475_bib1","first-page":"107","article-title":"Platelet aggregation and blood rheology in severe sepsis\/septic shock: relation to the sepsis-related organ failure assessment (SOFA) score","volume":"30","author":"Alt","year":"2004","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.jep.2024.118475_bib2","series-title":"Pharmacopoeia of the People's Republic of China","year":"2020"},{"key":"10.1016\/j.jep.2024.118475_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ijbiomac.2019.05.018","article-title":"Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development","volume":"134","author":"de Andrade","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2024.118475_bib4","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/sj.cdd.4400581","article-title":"Nitric oxide-an endothelial cell survival factor","volume":"6","author":"Dimmeler","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.118475_bib5","series-title":"The Research on the 980 Cases of 'blood Stasis and Heat' from Famous Doctors Based on Theme Dictionary Model","author":"Gu","year":"2014"},{"key":"10.1016\/j.jep.2024.118475_bib6","series-title":"Isolation and Qualitative and Quantitative Study on the Anticomplement Active Constituents of the Uyghur Medicine Italian Agave","author":"He","year":"2017"},{"key":"10.1016\/j.jep.2024.118475_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2023.152707","article-title":"Complement and coagulation crosstalk - factor H in the spotlight","volume":"228","author":"Heurich","year":"2023","journal-title":"Immunobiology"},{"key":"10.1016\/j.jep.2024.118475_bib8","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3389\/fimmu.2018.01057","article-title":"Complement in the initiation and evolution of rheumatoid arthritis","volume":"9","author":"Holers","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118475_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1142\/S0192415X13500341","article-title":"Rhein inhibits the expression of vascular cell adhesion molecule 1 in human umbilical vein endothelial cells with or without lipopolysaccharide stimulation","volume":"41","author":"Hu","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2024.118475_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114027","article-title":"Assessment of the anti-inflammatory effects of three rhubarb anthraquinones in LPS-stimulated RAW264.7 macrophages using a pharmacodynamic model and evaluation of the structure-activity relationships","volume":"273","author":"Hu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118475_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10753-022-01715-z","article-title":"PCSK9 promotes endothelial dysfunction during sepsis via the TLR4\/MyD88\/NF-\u03baB and NLRP3 pathways","volume":"46","author":"Huang","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2024.118475_bib12","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1182\/blood-2018-11-882993","article-title":"Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms","volume":"133","author":"Jackson","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.jep.2024.118475_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-3-319-18603-0_2","article-title":"Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions","volume":"865","author":"Karpman","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jep.2024.118475_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184411","article-title":"Vascular endothelial cell biology: an update","volume":"20","author":"Kr\u00fcger-Genge","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118475_bib15","article-title":"Comparison of three species of rhubarb in inhibiting vascular endothelial injury via regulation of PI3K\/AKT\/NF-\u03baB signaling pathway","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.118475_bib16","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/CM9.0000000000000201","article-title":"Effects of rhubarb on the expression of glucocorticoids receptor and regulation of cellular immunity in burn-induced septic rats","volume":"132","author":"Liu","year":"2019","journal-title":"China Med. J."},{"key":"10.1016\/j.jep.2024.118475_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1144229","article-title":"Endothelial dysfunction and immunothrombosis in sepsis","volume":"14","author":"Maneta","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118475_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1272\/jnms.79.4","article-title":"Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses","volume":"79","author":"Matsuda","year":"2012","journal-title":"J. Nippon Med. Sch."},{"key":"10.1016\/j.jep.2024.118475_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104188","article-title":"Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19)","volume":"137","author":"Norooznezhad","year":"2021","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.jep.2024.118475_bib20","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1111\/bph.15476","article-title":"Complement, inflammation and thrombosis","volume":"178","author":"Rawish","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.118475_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2516.2008.01848.x","article-title":"Function of von Willebrand factor in haemostasis and thrombosis","volume":"14","author":"Reininger","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.jep.2024.118475_bib22","article-title":"Elucidation of the mechanisms and effective substances of Paeoniae Radix Rubra against toxic heat and blood stasis syndrome with a stage-oriented strategy","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118475_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130730","article-title":"Color-reflected chemical regulations of the scorched rhubarb (Rhei Radix et Rhizoma) revealed by the integration analysis of visible spectrophotometry, Fourier transform infrared spectroscopy and high performance liquid chromatography","volume":"367","author":"Yang","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2024.118475_bib24","first-page":"72","article-title":"Establishment and evaluation of animal models of combined stasis and toxin syndrome","volume":"29","author":"Yue","year":"2023","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2024.118475_bib25","first-page":"436","article-title":"Activating blood biological potency assay and chemical fingerprint chromatogram applied to quality evaluation of rhubarb","volume":"52","author":"Zhang","year":"2017","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.jep.2024.118475_bib26","first-page":"413","article-title":"Effect of raw\/stewed rhubarb in Xiayuxue Decoction on vascular endothelial function and microcirculation of rats with heat accumulation of blood stasis","volume":"37","author":"Zhao","year":"2014","journal-title":"Drug Evaluation Research"},{"key":"10.1016\/j.jep.2024.118475_bib27","first-page":"973","article-title":"Comparison of four herb injections promoting blood circulation for removing blood stasis on cold and heat properties","volume":"38","author":"Zhao","year":"2016","journal-title":"Chin. Tradit. Pat. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T03:49:13Z","timestamp":1720756153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124007748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":27,"alternative-id":["S0378874124007748"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118475","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scorch processing of rhubarb (Rheum tanguticum Maxim. ex Balf.) pyrolyzed anthraquinone glucosides into aglycones and improved the therapeutic effects on thromboinflammation via regulating the complement and coagulation cascades pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118475"}}