{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:33:02Z","timestamp":1772832782107,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360795"],"award-info":[{"award-number":["82360795"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2022D01D14"],"award-info":[{"award-number":["2022D01D14"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2021D01D11"],"award-info":[{"award-number":["2021D01D11"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jep.2024.118487","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:47:36Z","timestamp":1719247656000},"page":"118487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Efficacy and mechanism of action of Yanxiao Di'naer formula for non-alcoholic steatohepatitis treatment based on metabolomics and RNA sequencing"],"prefix":"10.1016","volume":"333","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5101-1164","authenticated-orcid":false,"given":"Dong-xuan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao-tao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruo-yu","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-mei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2206-255X","authenticated-orcid":false,"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-long","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1 Suppl. l","key":"10.1016\/j.jep.2024.118487_bib1","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13020-021-00559-3","article-title":"Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages","volume":"17","author":"Cao","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2024.118487_bib3","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.2147\/DDDT.S409691","article-title":"Integrated metabolomics and network pharmacology to reveal the mechanisms of Gandouling tablets against copper-overload-induced neuronal injury in rats with Wilson's disease","volume":"17","author":"Chen","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"10.1016\/j.jep.2024.118487_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3727\/105221619X15536120524171","article-title":"Current and emerging approaches for nonalcoholic steatohepatitis treatment","volume":"19","author":"Chen","year":"2019","journal-title":"Gene Expr."},{"issue":"6037","key":"10.1016\/j.jep.2024.118487_bib5","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.jep.2024.118487_bib6","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1080\/00365521.2023.2225667","article-title":"Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease","volume":"58","author":"Demirel","year":"2023","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jep.2024.118487_bib7","series-title":"Progress in the Study of the Prevention and Treatment Mechanism of Non-alcoholic Steatohepatitis by Traditional Chinese Medicine and its Complementary Therapies","first-page":"1","author":"Du","year":"2024"},{"issue":"2","key":"10.1016\/j.jep.2024.118487_bib8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2017.09.003","article-title":"Genetics and epigenetics of NAFLD and NASH: clinical impact","volume":"68","author":"Eslam","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2024.118487_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.970292","article-title":"The AMPK pathway in fatty liver disease","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Physiol."},{"issue":"7","key":"10.1016\/j.jep.2024.118487_bib10","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.3390\/cells9071638","article-title":"Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease","volume":"9","author":"Fougerat","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41575-020-00366-5","article-title":"Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors","volume":"18","author":"Francque","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2024.118487_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6665893","article-title":"Handgrip strength and Vitamin D as predictors of liver fibrosis and malnutrition in chronic Hepatitis C patients","volume":"2021","author":"Gabr","year":"2021","journal-title":"Dis. Markers"},{"issue":"18","key":"10.1016\/j.jep.2024.118487_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810062","article-title":"Methyl brevifolincarboxylate attenuates free fatty acid-induced lipid metabolism and inflammation in hepatocytes through AMPK\/NF-\u03baB signaling pathway","volume":"22","author":"Geethangili","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118487_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116257","article-title":"Yi-Shen-Hua-Shi granule ameliorates diabetic kidney disease by the \"gut-kidney axis\"","volume":"307","author":"Han","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118487_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41591-023-02242-6","article-title":"Challenges and opportunities in NASH drug development","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2024.118487_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molmet.2018.05.015","article-title":"Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease","volume":"14","author":"Jia","year":"2018","journal-title":"Mol. Metabol."},{"issue":"3","key":"10.1016\/j.jep.2024.118487_bib17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/nu15030586","article-title":"Endogenous n-3 PUFAs improve non-alcoholic fatty liver disease through FFAR4-mediated gut-liver crosstalk","volume":"15","author":"Jiang","year":"2023","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2024.118487_bib18","first-page":"48","article-title":"Determination of rutin in Yanxiao Di'naer syrup by ultraviolet spectrophotometry","volume":"26","author":"Jiang","year":"2020","journal-title":"J. Medi. Pharmacy Chinese Minorities"},{"issue":"2","key":"10.1016\/j.jep.2024.118487_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2017.10.015","article-title":"Pharmacotherapy for NASH: Current and emerging","volume":"68","author":"Konerman","year":"2018","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.jep.2024.118487_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11336","article-title":"The involvement of peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in anti-inflammatory activity of N-stearoylethanolamine","volume":"8","author":"Kosiakova","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2024.118487_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.967623","article-title":"Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: a network pharmacology study and in vivo experimental validation","volume":"13","author":"Lei","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib22","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/s41467-021-24656-x","article-title":"Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40360-020-00438-x","article-title":"Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease","volume":"21","author":"Lin","year":"2020","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.jep.2024.118487_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108593","article-title":"Berberine prevents NAFLD and HCC by modulating metabolic disorders","volume":"254","author":"Lin","year":"2024","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib25","first-page":"54","article-title":"Progress of research on the treatment of non-alcoholic fatty liver disease by external therapeutic methods of Chinese medicine","volume":"16","author":"Liu","year":"2024","journal-title":"Research of Integrated Traditional Chinese and Western Medicine"},{"key":"10.1016\/j.jep.2024.118487_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174304","article-title":"Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK\/mTOR pathway","volume":"907","author":"Luo","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.118487_bib27","article-title":"Exploring Ganweikang tablet as a candidate drug for NAFLD through network pharmacology analysis and experimental validation","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib28","first-page":"7","article-title":"Progress in clinical research on non-alcoholic fatty liver disease and liver transplantation","volume":"44","author":"Mai","year":"2024","journal-title":"Chinese J. Practical Internal Med."},{"key":"10.1016\/j.jep.2024.118487_bib29","first-page":"329","article-title":"Clinical observation report on the treatment of cholecystitis with Uygur medicine Yanxiao Di'naer syrup","author":"Maihefureti","year":"2002","journal-title":"Chin. J. Ethnomed. Ethnopharmacy"},{"key":"10.1016\/j.jep.2024.118487_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120647","article-title":"The potential role of febrile condition in reversing the hepatoprotective effects of quercetin in the livers of LPS-presensitized mice","volume":"302","author":"Mashaly","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.118487_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cellimm.2018.08.006","article-title":"Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release","volume":"332","author":"Pan","year":"2018","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2024.118487_bib32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s12020-014-0384-x","article-title":"Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients","volume":"48","author":"Pan","year":"2015","journal-title":"Endocrine"},{"issue":"23","key":"10.1016\/j.jep.2024.118487_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239044","article-title":"Hepatoprotective potency of chrysophanol 8-o-glucoside from Rheum palmatum L. against hepatic fibrosis via regulation of the STAT3 signaling pathway","volume":"21","author":"Park","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118487_bib34","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221145549","article-title":"MAFLD: a multisystem disease","volume":"14","author":"Pipitone","year":"2023","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s40001-023-01114-6","article-title":"Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of chronic kidney disease (CKD)","volume":"28","author":"Roderburg","year":"2023","journal-title":"Eur. J. Med. Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118487_bib36","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/gutjnl-2022-328105","article-title":"Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease","volume":"72","author":"Simon","year":"2023","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.jep.2024.118487_bib37","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1021\/acsomega.0c05826","article-title":"Feprazone prevents free fatty acid (FFA)-induced endothelial inflammation by mitigating the activation of the TLR4\/MyD88\/NF-\u03baB pathway","volume":"6","author":"Song","year":"2021","journal-title":"ACS Omega"},{"issue":"6","key":"10.1016\/j.jep.2024.118487_bib38","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1053\/j.gastro.2020.01.043","article-title":"Association between fibrosis stage and outcomes of patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis","volume":"158","author":"Taylor","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2024.118487_bib39","article-title":"SIRT1: harnessing multiple pathways to hinder NAFLD","volume":"3","author":"Tian","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118487_bib40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/hep.26751","article-title":"Interferon regulatory factor 3 constrains IKK\u03b2\/NF-\u03baB signaling to alleviate hepatic steatosis and insulin resistance","volume":"59","author":"Wang","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2024.118487_bib41","first-page":"28","article-title":"Effects of Er Chen Tang on rats with type 2 diabetes mellitus combined with non-alcoholic fatty liver disease observed based on SIRT1\/UCP2 signalling pathway","volume":"38","author":"Wang","year":"2021","journal-title":"Chinese Journal of Modern Applied Pharmacy"},{"issue":"5","key":"10.1016\/j.jep.2024.118487_bib42","first-page":"1352","article-title":"Mechanism of Didang Decoction in prevention of anti-atherosclerosis and hyperlipidemia by HPLC-Q-TOF-MS\/MS and network pharmacology based on theory of \"nutrients return to heart and fat accumulates in channels\"","volume":"48","author":"Wu","year":"2023","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2024.118487_bib43","article-title":"Vitamin D alleviates non-alcoholic fatty liver disease via restoring gut microbiota and metabolism","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Microbiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124007864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T03:50:19Z","timestamp":1720756219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124007864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":43,"alternative-id":["S0378874124007864"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118487","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and mechanism of action of Yanxiao Di'naer formula for non-alcoholic steatohepatitis treatment based on metabolomics and RNA sequencing","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118487"}}