{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:30:56Z","timestamp":1790875856599,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022NSFSC0719"],"award-info":[{"award-number":["2022NSFSC0719"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of TCM","doi-asserted-by":"publisher","award":["242022007"],"award-info":[{"award-number":["242022007"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171440"],"award-info":[{"award-number":["32171440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374012"],"award-info":[{"award-number":["22374012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of The Peoples Republic of China","doi-asserted-by":"publisher","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jep.2024.118577","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T20:17:54Z","timestamp":1721074674000},"page":"118577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Metabolomics and molecular docking-directed anti-obesity study of the ethanol extract from Gynostemma pentaphyllum (Thunb.) Makino"],"prefix":"10.1016","volume":"334","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-562X","authenticated-orcid":false,"given":"Suyun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youfan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3094-282X","authenticated-orcid":false,"given":"Baojun","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidore","family":"Mosongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5420-4059","authenticated-orcid":false,"given":"Jiaming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-8880","authenticated-orcid":false,"given":"Jiahui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-2012","authenticated-orcid":false,"given":"Kaifeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 Countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jep.2024.118577_bib2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut microbiota regulation of tryptophan metabolism in health and disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"10","key":"10.1016\/j.jep.2024.118577_bib3","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2337\/dc20-0460","article-title":"Impaired Succinate Response to a mixed meal in obesity and type 2 diabetes is normalized after metabolic surgery","volume":"43","author":"Astiarraga","year":"2020","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.jep.2024.118577_bib4","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1142\/S0192415X18500696","article-title":"Gypenoside UL4-Rich Gynostemma pentaphyllum extract exerts a Hepatoprotective effect on diet-induced nonalcoholic fatty liver disease","volume":"46","author":"Bae","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2024.118577_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463086","article-title":"A 'shape-orientated' algorithm employing an adapted Marr wavelet and shape matching index improves the performance of continuous wavelet transform for chromatographic peak detection and quantification","volume":"1673","author":"Bai","year":"2022","journal-title":"Journal of chromatography. A"},{"issue":"4","key":"10.1016\/j.jep.2024.118577_bib6","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"Journal of hepatology"},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The Expanded Biology of serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"issue":"35","key":"10.1016\/j.jep.2024.118577_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb2878","article-title":"Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice","volume":"6","author":"Christoffersson","year":"2020","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.jep.2024.118577_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nm.3766","article-title":"Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis","volume":"21","author":"Crane","year":"2014","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.jep.2024.118577_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006062","article-title":"Weight reduction for primary prevention of stroke in adults with overweight or obesity","volume":"2006","author":"Curioni","year":"2006","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2024.118577_bib11","series-title":"the National Administration of Traditional Chinese Medicine of the People\u2019s Republic of China","first-page":"5537","article-title":"[Chinese Materia Medica (Vol. 5)] Shanghai Science and Technology Publications","year":"1999"},{"issue":"6628","key":"10.1016\/j.jep.2024.118577_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/387090a0","article-title":"Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese","volume":"387","author":"Enerb\u00e4ck","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.118577_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118966","article-title":"Beinaglutide shows significantly beneficial effects in diabetes\/obesity-induced nonalcoholic steatohepatitis in ob\/ob mouse model","volume":"270","author":"Fang","year":"2021","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.jep.2024.118577_bib14","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1021\/pr300291d","article-title":"Prediction of neuroprotective treatment efficiency using a HRMAS NMR-based statistical model of refractory status epilepticus on mouse: a metabolomic approach supported by histology","volume":"11","author":"Fauvelle","year":"2012","journal-title":"J. Proteome Res."},{"issue":"10","key":"10.1016\/j.jep.2024.118577_bib15","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/oby.21199","article-title":"The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation","volume":"23","author":"Favennec","year":"2015","journal-title":"Obesity"},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2337\/diacare.25.1.148","article-title":"Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications","volume":"25","author":"Franz","year":"2002","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.jep.2024.118577_bib17","article-title":"Serotonin, food intake, and obesity","volume":"22","author":"Galen","year":"2021","journal-title":"Obes. Rev."},{"issue":"3","key":"10.1016\/j.jep.2024.118577_bib18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/advances\/nmz127","article-title":"Tryptophan metabolism: a link between the gut microbiota and brain","volume":"11","author":"Gao","year":"2020","journal-title":"Adv. Nutr."},{"issue":"9","key":"10.1016\/j.jep.2024.118577_bib19","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s10529-012-0944-1","article-title":"Heat-processed Gynostemma pentaphyllum extract improves obesity in ob\/ob mice by activating AMP-activated protein kinase","volume":"34","author":"Gauhar","year":"2012","journal-title":"Biotechnol. Lett."},{"issue":"9","key":"10.1016\/j.jep.2024.118577_bib20","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/s12272-016-0793-x","article-title":"Flavonol glycosides from the aerial parts of Gynostemma pentaphyllum and their antioxidant activity","volume":"39","author":"Jang","year":"2016","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"9","key":"10.1016\/j.jep.2024.118577_bib21","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3390\/nu11092024","article-title":"Mice lacking the intestinal and Renal neutral amino acid transporter SLC6A19 demonstrate the relationship between dietary protein intake and amino acid Malabsorption","volume":"11","author":"Javed","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2024.118577_bib22","article-title":"Microbiota-derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo","volume":"30","author":"Jennis","year":"2018","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"5","key":"10.1016\/j.jep.2024.118577_bib23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molmet.2015.02.003","article-title":"Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control","volume":"4","author":"Jiang","year":"2015","journal-title":"Mol. Metab."},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2337\/diacare.27.1.33","article-title":"Effects of moderate weight loss and orlistat on insulin resistance, regional adiposity, and fatty acids in type 2 diabetes","volume":"27","author":"Kelley","year":"2004","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1124\/pharmrev.123.000886","article-title":"The SLC6A15-SLC6A20 neutral amino acid transporter Subfamily: functions, diseases, and their therapeutic relevance","volume":"76","author":"Kuku\u0142owicz","year":"2023","journal-title":"Pharmacol. Rev."},{"issue":"10","key":"10.1016\/j.jep.2024.118577_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102475","article-title":"Gynostemma pentaphyllum extract Ameliorates high-fat diet-induced obesity in C57BL\/6N mice by upregulating SIRT1","volume":"11","author":"Lee","year":"2019","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2024.118577_bib27","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1142\/S0192415X23500441","article-title":"The role of Gynostemma pentaphyllum in regulating hyperlipidemia","volume":"51","author":"Li","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2024.118577_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109199","article-title":"High fat diet-triggered non-alcoholic fatty liver disease: a review of proposed mechanisms","volume":"330","author":"Lian","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2024.118577_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113744","article-title":"Dammarane-type saponins from Gynostemma pentaphyllum and their anti-aging activities via up-regulating mitochondria related proteins","volume":"213","author":"Liang","year":"2023","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1124\/jpet.107.132670","article-title":"Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract","volume":"325","author":"Liu","year":"2008","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"10","key":"10.1016\/j.jep.2024.118577_bib31","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/2647","article-title":"Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene","volume":"4","author":"Nonogaki","year":"1998","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib32","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1038\/ncomms7794","article-title":"Regulation of systemic energy homeostasis by serotonin in adipose tissues","volume":"6","author":"Oh","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12916-020-01792-7","article-title":"LDL-C: lower is better for longer-even at low risk","volume":"18","author":"Penson","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.jep.2024.118577_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153986","article-title":"Uncovering the mechanisms of dandelion against triple-negative breast cancer using a combined network pharmacology, molecular pharmacology and metabolomics approach","volume":"99","author":"Qu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118577_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010665.pub2","article-title":"Interventions for treating overweight or obesity in adults: an overview of systematic reviews","author":"Roqu\u00e9 i Figuls","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"10.1016\/j.jep.2024.118577_bib36","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.3390\/ijms22062973","article-title":"Tryptophan metabolism and gut-brain homeostasis","volume":"22","author":"Roth","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2024.118577_bib37","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/ijo.2017.261","article-title":"Serotonin prevents differentiation into brown adipocytes and induces transdifferentiation into white adipocytes","volume":"42","author":"Rozenblit-Susan","year":"2017","journal-title":"Int. J. Obes."},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/nrendo.2017.122","article-title":"Current pharmacotherapy for obesity","volume":"14","author":"Srivastava","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/C4MB00414K","article-title":"PLS\/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters","volume":"11","author":"Triba","year":"2015","journal-title":"Mol. Biosyst."},{"issue":"15","key":"10.1016\/j.jep.2024.118577_bib40","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-Activated Brown adipose tissue in Healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.jep.2024.118577_bib41","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrm.2016.96","article-title":"Control of brown and beige fat development","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2024.118577_bib42","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijbiomac.2019.12.213","article-title":"Antioxidant and anti-inflammatory activities of an anti-diabetic polysaccharide extracted from Gynostemma pentaphyllum herb","volume":"145","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 1","key":"10.1016\/j.jep.2024.118577_bib44","article-title":"Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: a review","volume":"319","author":"Xie","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118577_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154834","article-title":"Liver lipidomics analysis reveals the anti-obesity and lipid-lowering effects of gypnosides from heat-processed Gynostemma pentaphyllum in high-fat diet fed mice","volume":"115","author":"Xie","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118577_bib46","series-title":"[Data Mining of Ancient Literature and Retrospective Analysis of the Treatment of PCOS with Fat-Reducing Tea]","author":"Xu","year":"2019"},{"key":"10.1016\/j.jep.2024.118577_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342103","article-title":"Comparing univariate filtration preceding and succeeding PLS-DA analysis on the differential variables\/metabolites identified from untargeted LC-MS metabolomics data","volume":"1287","author":"Xu","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"8","key":"10.1016\/j.jep.2024.118577_bib48","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","article-title":"Tryptophan metabolism in health and disease","volume":"35","author":"Xue","year":"2023","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.jep.2024.118577_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-14080-7","article-title":"Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance","volume":"11","author":"Yabut","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.jep.2024.118577_bib50","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.carbpol.2012.11.074","article-title":"Characterization of a heteropolysaccharide isolated from diploid Gynostemma pentaphyllum Makino","volume":"92","author":"Yan","year":"2013","journal-title":"Carbohydrate polymers"},{"key":"10.1016\/j.jep.2024.118577_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155143","article-title":"Study on the underlying mechanism of Poria in intervention of arrhythmia zebrafish by integrating metabolomics and network pharmacology","volume":"122","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.jep.2024.118577_bib52","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/s41366-018-0047-8","article-title":"Augmented capacity for peripheral serotonin release in human obesity","volume":"42","author":"Young","year":"2018","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.jep.2024.118577_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.885039","article-title":"Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2\/NLRP3 pathway","volume":"13","author":"Yue","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.jep.2024.118577_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103382","article-title":"Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice","volume":"24","author":"Zhang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.jep.2024.118577_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153683","article-title":"A UPLC-MS\/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis","volume":"91","author":"Zhang","year":"2021","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2024.118577_bib56","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/osp4.342","article-title":"Beinaglutide showed significant weight-loss benefit and effective glycaemic control for the treatment of type 2 diabetes in a real-world setting: a 3-month, multicentre, observational, retrospective, open-label study","volume":"5","author":"Zhang","year":"2019","journal-title":"Obesity science & practice"},{"key":"10.1016\/j.jep.2024.118577_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114017","article-title":"Gypenoside LI arrests the cell cycle of breast cancer in G0\/G1 phase by down-regulating E2F1","volume":"273","author":"Zu","year":"2021","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124008766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124008766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:33:38Z","timestamp":1783737218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124008766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":56,"alternative-id":["S0378874124008766"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118577","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics and molecular docking-directed anti-obesity study of the ethanol extract from Gynostemma pentaphyllum (Thunb.) Makino","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118577"}}