{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:48:10Z","timestamp":1793137690218,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073996"],"award-info":[{"award-number":["82073996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020593","name":"Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology","doi-asserted-by":"publisher","award":["2023-JYB-900202-054"],"award-info":[{"award-number":["2023-JYB-900202-054"]}],"id":[{"id":"10.13039\/100020593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jep.2024.118592","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T18:33:29Z","timestamp":1721154809000},"page":"118592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Mechanism analysis of essential oil from Radix Bupleuri for the treatment of asthma through regulation of ectopic olfactory receptor"],"prefix":"10.1016","volume":"334","author":[{"given":"Beiyan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anlei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liansheng","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-8804","authenticated-orcid":false,"given":"Yanling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118592_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/srep38231","article-title":"Defining an olfactory receptor function in airway smooth muscle cells","volume":"6","author":"Aisenberg","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jep.2024.118592_bib2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.2042-7158.2010.01170.x","article-title":"Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action","volume":"63","author":"Ashour","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118592_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12868-023-00822-3","article-title":"Effects of isoflurane and urethane anesthetics on glutamate neurotransmission in rat brain using in vivo amperometry","volume":"24","author":"Beitchman","year":"2023","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.jep.2024.118592_bib4","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.biopha.2017.04.133","article-title":"Bupleurum chinense extract ameliorates an OVA-induced murine allergic asthma through the reduction of the Th2 and Th17 cytokines production by inactivation of NF\u03baB pathway","volume":"91","author":"Bui","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118592_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-1-4939-8994-2_28","article-title":"OVA-induced allergic airway inflammation mouse model","volume":"1916","author":"Casaro","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2024.118592_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/CCID.S445008","article-title":"Essential oil of matricaria chamomilla alleviate psoriatic-like skin inflammation by inhibiting PI3K\/Akt\/mTOR and p38MAPK signaling pathway","volume":"17","author":"Chen","year":"2024","journal-title":"Clin. Cosmet. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.jep.2024.118592_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200549","article-title":"Comparative study on volatile oils among Bupleuri radix species and habitats: yields, chemical characterization and antipyretic activities","volume":"19","author":"Chen","year":"2022","journal-title":"Chem. Biodivers."},{"issue":"11","key":"10.1016\/j.jep.2024.118592_bib8","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1021\/acsomega.2c07366","article-title":"Exploring the mechanism of Bergamot essential oil against asthma based on network pharmacology and experimental verification","volume":"8","author":"Feng","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2024.118592_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152854","article-title":"Essential oils and its bioactive compounds modulating cytokines: a systematic review on anti-asthmatic and immunomodulatory properties","volume":"73","author":"Gandhi","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118592_bib10","first-page":"118","article-title":"Understanding the immunology of asthma: pathophysiology, biomarkers, and treatments for asthma endotypes","volume":"36","author":"Gans","year":"2020","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.jep.2024.118592_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-444-63855-7.00005-8","article-title":"Olfactory receptor function","volume":"164","author":"Glezer","year":"2019","journal-title":"Handb. Clin. Neurol."},{"issue":"3","key":"10.1016\/j.jep.2024.118592_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030558","article-title":"Exploring the potential effects and mechanisms of Asarum sieboldii radix essential oil for treatment of asthma","volume":"14","author":"Han","year":"2022","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.jep.2024.118592_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134057","article-title":"Vitamin D modulates expression of the airway smooth muscle transcriptome in fatal asthma","volume":"10","author":"Himes","year":"2015","journal-title":"PLoS One"},{"issue":"45","key":"10.1016\/j.jep.2024.118592_bib14","doi-asserted-by":"crossref","first-page":"28485","DOI":"10.1073\/pnas.2003111117","article-title":"The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR","volume":"117","author":"Huang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"41","key":"10.1016\/j.jep.2024.118592_bib15","doi-asserted-by":"crossref","first-page":"36598","DOI":"10.1021\/acsomega.2c04589","article-title":"Dissection of the active ingredients and potential mechanism of han-shi-yu-fei-decoction in treating COVID-19 based on in vivo substances profiling and clinical symptom-guided network pharmacology","volume":"7","author":"Jiao","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2024.118592_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2019.102063","article-title":"The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of Na(V)1.5 and RyR2 function","volume":"82","author":"Johnson","year":"2019","journal-title":"Cell Calcium"},{"issue":"7873","key":"10.1016\/j.jep.2024.118592_bib17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.118592_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3389\/fphys.2016.00339","article-title":"Olfactory receptors modulate physiological processes in human airway smooth muscle cells","volume":"7","author":"Kalbe","year":"2016","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2024.118592_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ph14010002","article-title":"Inhalation of essential oil from Mentha piperita ameliorates PM10-exposed asthma by targeting IL-6\/JAK2\/STAT3 pathway based on a network pharmacological analysis","volume":"14","author":"Kim","year":"2020","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.jep.2024.118592_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1254\/jphs.09277FP","article-title":"A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial\/peribronchial fibrosis induced by repeated antigen challenge in mice","volume":"112","author":"Komai","year":"2010","journal-title":"J. Pharmacol. Sci."},{"issue":"14","key":"10.1016\/j.jep.2024.118592_bib39","doi-asserted-by":"crossref","first-page":"RC19","DOI":"10.1523\/JNEUROSCI.19-14-j0005.1999","article-title":"Impaired odor adaptation in olfactory receptor neurons after inhibition of Ca2+\/calmodulin kinase II","volume":"19","author":"Leinders-Zufall","year":"1999","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.jep.2024.118592_bib21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1080\/02770903.2018.1493601","article-title":"Tolerance to exposure to essential oils exposure in patients with allergic asthma","volume":"56","author":"Levy","year":"2019","journal-title":"J. Asthma"},{"key":"10.1016\/j.jep.2024.118592_bib37","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.2147\/DDDT.S366597","article-title":"Study of the mechanism of antiemetic effect of Lavandula angustifolia Mill. essential oil based on Ca2+\/CaMKII\/ERK1\/2 pathway","volume":"16","author":"Li","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"issue":"5","key":"10.1016\/j.jep.2024.118592_bib22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/sj.icb.7100044","article-title":"The regulatory role of TGF-beta in airway remodeling in asthma","volume":"85","author":"Makinde","year":"2007","journal-title":"Immunol. Cell Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2024.118592_bib23","first-page":"S2","article-title":"Asthma: definitions and pathophysiology","volume":"5","author":"Mims","year":"2015","journal-title":"International forum of allergy & rhinology"},{"issue":"2","key":"10.1016\/j.jep.2024.118592_bib38","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1152\/jn.00176.2016","article-title":"CaMKII mediates stimulus specificity in early odor preference learning in rats","volume":"116","author":"Modarresi","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.jep.2024.118592_bib24","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1749-6632.1993.tb35920.x","article-title":"Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils","volume":"685","author":"Nakamura","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.jep.2024.118592_bib25","first-page":"286","article-title":"Difficult to treat and severe asthma: management strategies","volume":"103","author":"Narasimhan","year":"2021","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"10.1016\/j.jep.2024.118592_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ptr.903","article-title":"Effect of saikosaponin-A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma","volume":"16","author":"Park","year":"2002","journal-title":"Phytother Res.: PT"},{"issue":"9","key":"10.1016\/j.jep.2024.118592_bib27","first-page":"1499","article-title":"Research progress of essential oil of Bupleuri","volume":"17","author":"Qian","year":"2019","journal-title":"Central South Pharmacy"},{"issue":"1","key":"10.1016\/j.jep.2024.118592_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02770903.2018.1430828","article-title":"Essential oil of Croton Zehntneri attenuates lung injury in the OVA-induced asthma model","volume":"56","author":"Serra","year":"2019","journal-title":"J. Asthma"},{"issue":"3","key":"10.1016\/j.jep.2024.118592_bib29","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1080\/21655979.2022.2032939","article-title":"MicroRNA-885-3p alleviates bronchial epithelial cell injury induced by lipopolysaccharide via toll-like receptor 4","volume":"13","author":"Shen","year":"2022","journal-title":"Bioengineered"},{"issue":"5","key":"10.1016\/j.jep.2024.118592_bib30","first-page":"1492","article-title":"Research progress on the anti-asthma effects of plant essential oils","volume":"52","author":"Wei","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"10","key":"10.1016\/j.jep.2024.118592_bib31","first-page":"11341","article-title":"Wuling San and Xiao Chaihu Decoction affect airway inflammatory response and airway smooth muscle cell proliferation in mice with allergic asthma via miR-486-5p\/AQP5 axis","volume":"13","author":"Xue","year":"2021","journal-title":"Am. J. Tourism Res."},{"issue":"8","key":"10.1016\/j.jep.2024.118592_bib32","first-page":"459","article-title":"Study on mechanism of cytokine and NO injury in the hepatotoxical injury in rats caused by volatile oil from Bupleurum chinense","volume":"8","author":"Yang","year":"2011","journal-title":"Chinese Journal of Pharmacovigilance"},{"issue":"1","key":"10.1016\/j.jep.2024.118592_bib33","first-page":"32","article-title":"Study on the antidepressant mechanism of the essential oil in Bupleurum scorzonerifolium based on the GC-MS and network pharmacology","volume":"45","author":"Yifan","year":"2023","journal-title":"Special Wild Econ. Anim. Plant Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118592_bib34","article-title":"Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118592_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115829","article-title":"Molecular mechanism of the anti-inflammatory effects of plant essential oils: a systematic review","volume":"301","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"20","key":"10.1016\/j.jep.2024.118592_bib36","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1080\/10408398.2021.1885007","article-title":"Human ectopic olfactory receptors and their food originated ligands: a review","volume":"62","author":"Raka","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124008912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124008912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:40:11Z","timestamp":1783737611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124008912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":39,"alternative-id":["S0378874124008912"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118592","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism analysis of essential oil from Radix Bupleuri for the treatment of asthma through regulation of ectopic olfactory receptor","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118592"}}