{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:43:55Z","timestamp":1789749835321,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jep.2024.118595","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T02:14:48Z","timestamp":1721441688000},"page":"118595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Exploration of the mechanism of Qinglongyi-Buguzhi drug pair in treating vitiligo based on network pharmacology, molecular docking and experimental verification"],"prefix":"10.1016","volume":"334","author":[{"given":"Lele","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshuang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118595_bib1","article-title":"The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications","volume":"12","author":"Chang","year":"2023","journal-title":"J. Cell."},{"key":"10.1016\/j.jep.2024.118595_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13020-022-00704-6","article-title":"Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics","volume":"18","author":"Chen","year":"2023","journal-title":"J. Chin. Med."},{"key":"10.1016\/j.jep.2024.118595_bib3","first-page":"242","article-title":"Pathogenesis of vitiligo and its prevention and treatment with traditional Chinese medicine:A review","volume":"27","author":"Chen","year":"2021","journal-title":"J. Chin J Exp Tradit Med Form."},{"key":"10.1016\/j.jep.2024.118595_bib4","first-page":"2785","article-title":"Research progress on chemical composition and pharmacological effects and predictive analysis on quality markers of Qinglongyi","volume":"52","author":"Chen","year":"2021","journal-title":"J. ChinTradit Herb Drugs."},{"key":"10.1016\/j.jep.2024.118595_bib5","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/med.21754","article-title":"Mechanisms of melanocyte death in vitiligo","volume":"41","author":"Chen","year":"2021","journal-title":"J. Med Res Rev"},{"key":"10.1016\/j.jep.2024.118595_bib6","series-title":"Pharmacopoeia of the People's Republic of China","first-page":"195","year":"2020"},{"key":"10.1016\/j.jep.2024.118595_bib7","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1016\/j.cub.2019.12.042","article-title":"Melanin","volume":"30","author":"Cordero","year":"2020","journal-title":"J. Curr Biol."},{"key":"10.1016\/j.jep.2024.118595_bib8","article-title":"Comparison of the efficacy of broad-band targeted UVB phototherapy and topical psoralen with targeted UVA phototherapy in localized vitiligo","volume":"34","author":"Dincer Rota","year":"2021","journal-title":"J. Dermatol Ther"},{"key":"10.1016\/j.jep.2024.118595_bib9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s40257-021-00631-6","article-title":"Psychosocial effects of vitiligo: a systematic literature review","volume":"22","author":"Ezzedine","year":"2021","journal-title":"J. Am J Clin Dermatol."},{"key":"10.1016\/j.jep.2024.118595_bib10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-100919-023531","article-title":"Vitiligo: mechanisms of pathogenesis and treatment","volume":"38","author":"Frisoli","year":"2020","journal-title":"J. Annu Rev Immunol"},{"key":"10.1016\/j.jep.2024.118595_bib11","article-title":"NRF2, a transcription factor for stress response and beyond","volume":"21","author":"He","year":"2020","journal-title":"J. Int J Mol Sci."},{"key":"10.1016\/j.jep.2024.118595_bib12","first-page":"182","article-title":"A network pharmacology and molecular docking technology approach to uncover the potential active ingredients and mechanism of Qinglongyi for treatment of vitiligo","volume":"17","author":"He","year":"2021","journal-title":"J. Asia-Pacific Tradit Med."},{"key":"10.1016\/j.jep.2024.118595_bib13","first-page":"2079","article-title":"Experience of AI Ru-di in the treatment of childhood vitiligo from children's physiological characteristics","volume":"37","author":"He","year":"2022","journal-title":"J. China J Tradit Chin Med Pharm."},{"key":"10.1016\/j.jep.2024.118595_bib14","article-title":"Mechanistic insights into the ameliorating effect of melanogenesis of psoralen derivatives in B16F10 melanoma cells","volume":"27","author":"Lee","year":"2022","journal-title":"J. Molecules"},{"key":"10.1016\/j.jep.2024.118595_bib15","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/jamadermatol.2021.1688","article-title":"Vitiligo","volume":"157","author":"LeWitt","year":"2021","journal-title":"J. JAMA Dermatol."},{"key":"10.1016\/j.jep.2024.118595_bib16","first-page":"1865","article-title":"Simultaneous determination of five components in Vitiligo capsules by UHPLC and HPLC","volume":"43","author":"Liu","year":"2021","journal-title":"J. Chin Tradit Patent Med."},{"key":"10.1016\/j.jep.2024.118595_bib17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/ced.13409","article-title":"Geniposide prevents H2O2-induced oxidative damage in melanocytes by activating the PI3K-Akt signalling pathway","volume":"43","author":"Lu","year":"2018","journal-title":"J. Clin Exp Dermatol."},{"key":"10.1016\/j.jep.2024.118595_bib18","series-title":"Chinese Materia Medica. M. Shanghai","first-page":"380","year":"1998"},{"key":"10.1016\/j.jep.2024.118595_bib19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/biof.1912","article-title":"NRF2, a crucial modulator of skin cells protection against vitiligo, psoriasis, and cancer","volume":"49","author":"Panieri","year":"2023","journal-title":"Biofactors"},{"key":"10.1016\/j.jep.2024.118595_bib20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(20)30747-9","article-title":"First step in a new era for treatment of patients with vitiligo","volume":"396","author":"Passeron","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2024.118595_bib21","article-title":"The PI3K-Akt-mTOR and associated signaling pathways as molecular drivers of immune-mediated inflammatory skin diseases: update on therapeutic strategy using natural and synthetic compounds","volume":"12","author":"Roy","year":"2023","journal-title":"J. Cell."},{"key":"10.1016\/j.jep.2024.118595_bib22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3390\/cells10051219","article-title":"The PI3K\/Akt pathway: emerging roles in skin homeostasis and a group of non-malignant skin disorders","volume":"10","author":"Teng","year":"2021","journal-title":"J. Cell."},{"key":"10.1016\/j.jep.2024.118595_bib23","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/pcmr.12974","article-title":"Vitiligo: translational research and effective therapeutic strategies","volume":"34","author":"Thakur","year":"2021","journal-title":"J. Pigment Cell Melanoma Res."},{"key":"10.1016\/j.jep.2024.118595_bib24","doi-asserted-by":"crossref","first-page":"14460","DOI":"10.1002\/jcp.28215","article-title":"Upstream regulators of phosphoinositide 3-kinase and their role in diseases","volume":"234","author":"Wang","year":"2019","journal-title":"J. J Cell Physiol"},{"key":"10.1016\/j.jep.2024.118595_bib25","article-title":"Natural Citrus flavanone 5-demethylnobiletin stimulates melanogenesis through the activation of cAMP\/CREB pathway in B16F10 cells","volume":"98","author":"Wang","year":"2022","journal-title":"J. Phytomedicine."},{"key":"10.1016\/j.jep.2024.118595_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12016-021-08868-z","article-title":"Clinical features, immunopathogenesis, and therapeutic strategies in vitiligo","volume":"61","author":"Wang","year":"2021","journal-title":"J. Clin Rev Allergy Immunol."},{"key":"10.1016\/j.jep.2024.118595_bib27","series-title":"Study on the Mechanism of Action of Galangin Cream Onexperimental Vitiligo Model Animals","author":"Wusiman","year":"2023"},{"key":"10.1016\/j.jep.2024.118595_bib28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/jcmm.17711","article-title":"Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes","volume":"27","author":"Xie","year":"2023","journal-title":"J. J Cell Mol Med."},{"key":"10.1016\/j.jep.2024.118595_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7197533","article-title":"Mechanism of action of a Chinese herbal compound containing quercetin, luteolin, and kaempferol in the treatment of vitiligo based on network pharmacology and experimental verification","author":"Xu","year":"2022","journal-title":"J. Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2024.118595_bib30","article-title":"Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K\/Akt\/Nrf2 signaling pathway","volume":"14","author":"Zhang","year":"2023","journal-title":"J. Front Pharmacol."},{"key":"10.1016\/j.jep.2024.118595_bib31","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. J Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124008948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124008948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:45:34Z","timestamp":1783737934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124008948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":31,"alternative-id":["S0378874124008948"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118595","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of the mechanism of Qinglongyi-Buguzhi drug pair in treating vitiligo based on network pharmacology, molecular docking and experimental verification","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118595","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118595"}}