{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:10:42Z","timestamp":1777972242484,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007721","name":"School of Linguistics and Applied Language Studies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304234\/2021-4"],"award-info":[{"award-number":["304234\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408863\/2022-6"],"award-info":[{"award-number":["408863\/2022-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["380076\/2022-5"],"award-info":[{"award-number":["380076\/2022-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jep.2024.118619","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T20:13:26Z","timestamp":1721765606000},"page":"118619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Anti-inflammatory and antiophidic effects of extract of Hymenaea eriogyne benth and structure-activity relationship prediction of the major markers in silico"],"prefix":"10.1016","volume":"335","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-3836","authenticated-orcid":false,"given":"Alessandra","family":"Daniele-Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-7204","authenticated-orcid":false,"given":"Camylla Janiele","family":"Lucas Ten\u00f3rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-5453","authenticated-orcid":false,"given":"Jos\u00e9","family":"Roberto da Costa Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-1533","authenticated-orcid":false,"given":"Manoela","family":"Torres-R\u00eago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Fran\u00e7a","family":"Cavalcanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"de Sousa Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Pontes da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda Rhayanny","family":"Assun\u00e7\u00e3o Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus","family":"de Freitas Fernandes-Pedrosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-6173","authenticated-orcid":false,"given":"Luiz Alberto","family":"Lira Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.jep.2024.118619_bib1","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1080\/07391102.2021.1900916","article-title":"Methoxylated flavonols from Vellozia dasypus Seub ethyl acetate active myeloperoxidase extract: in vitro and in silico assays","volume":"40","author":"Almeida","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jep.2013.05.052","article-title":"Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L","volume":"149","author":"Bezerra","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118619_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jep.2017.05.024","article-title":"Current state of knowledge on the traditional uses, phytochemistry, and pharmacology of the genus Hymenaea","volume":"206","author":"Boniface","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118619_bib54","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Bioch."},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib55","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib4","first-page":"4","article-title":"Anti-inflammatory and antinociceptive actions of ethanolic extract from Hymenaea courbaril L. in rodents. Ci\u00eanc","volume":"25","author":"Brito","year":"2015","journal-title":"Anim."},{"key":"10.1016\/j.jep.2024.118619_bib56","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","author":"Buege","year":"1978"},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/ph15030282","article-title":"Drug discovery of new anti-inflammatory compounds by targeting cyclooxygenases","volume":"15","author":"Burayk","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2024.118619_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jtemb.2019.04.007","article-title":"Rutin protects mercuric chloride\u2010induced nephrotoxicity via targeting of aquaporin 1 level, oxidative stress, apoptosis and inflammation in rats","volume":"54","author":"Caglayan","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"38","key":"10.1016\/j.jep.2024.118619_bib7","doi-asserted-by":"crossref","first-page":"25929","DOI":"10.1074\/jbc.M109.002154","article-title":"Essential role of proximal histidine-asparagine interaction in mammalian peroxidases","volume":"284","author":"Carpena","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib8","first-page":"19","article-title":"Snakebites in the americas: a neglected problem in public health","volume":"11","author":"Cerna","year":"2024","journal-title":"Curr. Trop. Med. Rep."},{"issue":"6","key":"10.1016\/j.jep.2024.118619_bib9","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2024.118619_bib11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/toxins14090606","article-title":"Antibodies as snakebite antivenoms: past and future","volume":"14","author":"da Silva","year":"2022","journal-title":"Toxins"},{"issue":"19","key":"10.1016\/j.jep.2024.118619_bib12","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.3390\/ijms20194957","article-title":"Targeting inflammation by flavonoids: novel therapeutic strategy for metabolic disorders","volume":"20","author":"Farzaei","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118619_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jep.2017.11.002","article-title":"Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity","volume":"213","author":"F\u00e9lix-Silva","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118619_bib57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jep.2016.07.048","article-title":"Aqueous extract from Ipomoea asarifolia (Convolvulaceae) leaves and its phenolic compounds have anti-inflammatory activity in murine models of edema, peritonitis and air-pouch inflammation","volume":"192","author":"Furtado","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2024.118619_bib14","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.toxicon.2009.01.039","article-title":"Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"issue":"7","key":"10.1016\/j.jep.2024.118619_bib15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.toxicon.2009.01.038","article-title":"Experimental pathology of local tissue damage induced by Bothrops asper snake venom","volume":"54","author":"Guti\u00e9rrez","year":"2009","journal-title":"Toxicon"},{"issue":"4","key":"10.1016\/j.jep.2024.118619_bib16","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1007\/s10753-021-01438-7","article-title":"Anti-inflammatory properties of ethanolic extract and 2\u2033-O-\u03b2-D-Glucopyranosyl-vitexin obtained from Alternanthera tenella colla whole plant","volume":"44","author":"Kassuya","year":"2021","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.jep.2024.118619_bib17","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nprot.2015.043","article-title":"The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins","volume":"10","author":"Kozakov","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2024.118619_bib18","first-page":"141","article-title":"Molecular basis of carrageenan-induced cytokines production in macrophages, Cell Commun","author":"Lopes","year":"2020","journal-title":"Signal"},{"key":"10.1016\/j.jep.2024.118619_bib19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jep.2019.03.032","article-title":"Medicinal plants of the Caatinga, northeastern Brazil: Ethnopharmacopeia (1980\u20131990) of the late professor Francisco Jos\u00e9 de Abreu Matos","volume":"237","author":"Magalh\u00e3es","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2024.118619_bib20","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bcp.2006.08.028","article-title":"Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice","volume":"72","author":"Meotti","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2024.118619_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2022.107010","article-title":"Biological characterization of the Bothrops brazili snake venom and its neutralization by Brazilian Bothrops antivenom produced by the Butantan Institute","volume":"223","author":"Muniz","year":"2023","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2024.118619_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106163","article-title":"Rutin ameliorates inflammation and improves metabolic function: a comprehensive analysis of scientific literature","volume":"178","author":"Muvhulawa","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118619_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2019.02.020","article-title":"Molecular mechanism of action responsible for carrageenan-induced inflammatory response","volume":"109","author":"Myers","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jep.2024.118619_bib24","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cbi.2015.02.021","article-title":"Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: role of NF\u03baB\/MAPK pathway","volume":"231","author":"Nafees","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.jep.2024.118619_bib25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/bioinformatics\/btr651","article-title":"FTSite: high accuracy detection of ligand binding sites on unbound protein structures","volume":"28","author":"Ngan","year":"2012","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3831\/KPI.2017.20.003","article-title":"Treatment with rutin - a therapeutic strategy for neutrophil-mediated inflammatory and autoimmune diseases: - anti-inflammatory effects of rutin on neutrophils","volume":"20","author":"Nikfarjam","year":"2017","journal-title":"J. Pharmacopunct."},{"key":"10.1016\/j.jep.2024.118619_bib27","article-title":"Antioxidant and acetylcholinesterase inhibition activity from Hymenaea rubriflora Ducke (Fabaceae) leaf extract","volume":"4","author":"Oliveira de Miranda","year":"2020","journal-title":"Braz. Appl. Sci. Rev."},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib28","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jep.2013.10.056","article-title":"Hymenaea stigonocarpa Mart. ex Hayne: a tropical medicinal plant with intestinal anti-inflammatory activity in TNBS model of intestinal inflammation in rats","volume":"151","author":"Orsi","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118619_bib29","article-title":"Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice","volume":"82","author":"Pacheco","year":"2021","journal-title":"Braz. J. Biol."},{"issue":"8","key":"10.1016\/j.jep.2024.118619_bib30","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1016\/j.arabjc.2016.12.026","article-title":"Novel 5-aminosalicylic derivatives as anti-inflammatories and myeloperoxidase inhibitors evaluated in silico, in vitro and ex vivo","volume":"12","author":"P\u00e9rez","year":"2019","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.jep.2024.118619_bib31","author":"Pinto"},{"issue":"18","key":"10.1016\/j.jep.2024.118619_bib32","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.3390\/ijms20184331","article-title":"Molecular docking: shifting paradigms in drug discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2024.118619_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.bjp.0705650","article-title":"Expression of Concern: carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression","volume":"142","author":"Posadas","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib34","first-page":"328","article-title":"Snake venom metalloproteases \u2014 structure and function of catalytic and disintegrin domains","volume":"142","author":"Ramos","year":"2006","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jep.2012.06.001","article-title":"Hymenaea stigonocarpa Mart. ex Hayne: a Brazilian medicinal plant with gastric and duodenal anti-ulcer and antidiarrheal effects in experimental rodent models","volume":"143","author":"Rodrigues Orsi","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.118619_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12970","article-title":"An inflammation classification system using cytokine parameters","volume":"93","author":"Roe","year":"2021","journal-title":"Scand. J. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2174\/0929867326666190201120646","article-title":"Current anti-inflammatory therapies and the potential of secretory phospholipase A2 inhibitors in the design of new anti-inflammatory drugs: a review of 2012 - 2018","volume":"27","author":"Sales","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jep.2024.118619_bib38","doi-asserted-by":"crossref","DOI":"10.1590\/1678-9199-jvatitd-2019-0103","article-title":"Venomics and antivenomics of the poorly studied Brazil's lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Para","volume":"26","author":"Sanz","year":"2020","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.jep.2024.118619_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104894","article-title":"Astilbin: a promising unexplored compound with multidimensional medicinal and health benefits","volume":"158","author":"Sharma","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118619_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112766","article-title":"Antiophidic potential of chlorogenic acid and rosmarinic acid against Bothrops leucurus snake venom","volume":"148","author":"Silva","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118619_bib41","first-page":"1160","article-title":"HPLC-DAD analysis and antioxidant activity of Hymenaea martiana Hayne (Fabaceae)","volume":"4","author":"Silva","year":"2012","journal-title":"J. Chem. Pharm. Res."},{"issue":"17","key":"10.1016\/j.jep.2024.118619_bib42","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1080\/14786419.2019.1675066","article-title":"Phytochemical analysis and evaluation of the antimicrobial and antioxidant activities of extracts and fractions of Hymenaea eriogyne Benth","volume":"35","author":"Silva","year":"2019","journal-title":"Nat. Prod. Res."},{"issue":"24","key":"10.1016\/j.jep.2024.118619_bib43","doi-asserted-by":"crossref","first-page":"8747","DOI":"10.1021\/jm1009988","article-title":"Structure-based design, synthesis, and pharmacological evaluation of 3-(Aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors","volume":"53","author":"Soubhye","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2024.118619_bib44","series-title":"Progress in Medicinal Chemistry","first-page":"273","article-title":"Chapter Four - use of molecular docking computational tools in drug discovery","author":"Stanzione","year":"2021"},{"issue":"5","key":"10.1016\/j.jep.2024.118619_bib45","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1007\/s12011-022-03327-y","article-title":"Astilbin attenuates cadmium-induced adipose tissue damage by inhibiting NF-\u03baB pathways and regulating the expression of HSPs in chicken","volume":"201","author":"Sun","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s43450-022-00260-y","article-title":"HPLC-ESI-MSn analysis and validation of UV-vis and RP-HPLC-PDA methods for polyphenols quantification from Hymenaea eriogyne","volume":"32","author":"Ten\u00f3rio","year":"2022","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2024.118619_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115364","article-title":"Phytochemical analysis and preclinical toxicological, antioxidant, and anti-inflammatory evaluation of hydroethanol extract from the roots of Harpalyce brasiliana Benth (Leguminosae)","volume":"294","author":"Torres-R\u00eago","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118619_bib58","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12906-016-1259-x","article-title":"Anti-inflammatory activity of aqueous extract and bioactive compounds identified from the fruits of Hancornia speciosa Gomes (Apocynaceae)","volume":"16","author":"Torres-R\u00eago","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.jep.2024.118619_bib48","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcp.2018.07.050","article-title":"Polyphenols, food and pharma. Current knowledge and directions for future research","volume":"156","author":"Tresserra-Rimbau","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.118619_bib49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"3","key":"10.1016\/j.jep.2024.118619_bib50","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3390\/molecules27030684","article-title":"Isolation, characterization and in silico studies of secondary metabolites from the whole plant of Polygala inexpectata Pe\u015fmen & Erik","volume":"27","author":"\u00dcnl\u00fc","year":"2022","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jep.2024.118619_bib51","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.3390\/microorganisms9102041","article-title":"Towards advances in medicinal plant antimicrobial activity: a review study on challenges and future perspectives","volume":"9","author":"Vaou","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jep.2024.118619_bib59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.trim.2008.01.003","article-title":"Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch","volume":"19","author":"Vigil","year":"2008","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.jep.2024.118619_bib60","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuropharm.2004.12.024","article-title":"Intrathecal neostigmine reduces the zymosan-induced inflammatory response in a mouse air pouch model via adrenomedullary activity: Involvement of spinal muscarinic type 2 receptors","volume":"49","author":"Yoon","year":"2005","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.jep.2024.118619_bib52","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jnutbio.2011.06.018","article-title":"Protective effects of chlorogenic acid against ischemia\/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties","volume":"23","author":"Yun","year":"2012","journal-title":"J. Nutr. Biochem."},{"issue":"10","key":"10.1016\/j.jep.2024.118619_bib53","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1007\/s12272-016-0857-y","article-title":"Astilbin alleviates sepsis-induced acute lung injury by inhibiting the expression of macrophage inhibitory factor in rats","volume":"40","author":"Zhang","year":"2017","journal-title":"Arch Pharm. Res. (Seoul)"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:10:53Z","timestamp":1777968653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124009188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":60,"alternative-id":["S0378874124009188"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118619","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory and antiophidic effects of extract of Hymenaea eriogyne benth and structure-activity relationship prediction of the major markers in silico","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118619"}}