{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:15:13Z","timestamp":1792635313312,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20S21902600"],"award-info":[{"award-number":["20S21902600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3502000"],"award-info":[{"award-number":["2022YFC3502000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104429"],"award-info":[{"award-number":["82104429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104616"],"award-info":[{"award-number":["82104616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20516"],"award-info":[{"award-number":["U23A20516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130120"],"award-info":[{"award-number":["82130120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jep.2024.118649","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T12:48:24Z","timestamp":1722430104000},"page":"118649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Isoastragaloside I attenuates cholestatic liver diseases by ameliorating liver injury, regulating bile acid metabolism and restoring intestinal barrier"],"prefix":"10.1016","volume":"335","author":[{"given":"Linzhang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118649_bib1","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2282789","article-title":"Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis","volume":"15","author":"Ahmad","year":"2023","journal-title":"Gut Microb."},{"key":"10.1016\/j.jep.2024.118649_bib2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jcmgh.2021.04.003","article-title":"Loss of claudin-3 impairs hepatic metabolism, biliary barrier function, and cell proliferation in the murine liver","volume":"12","author":"Baier","year":"2021","journal-title":"Cellular and molecular gastroenterology and hepatology"},{"key":"10.1016\/j.jep.2024.118649_bib3","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jhep.2020.05.049","article-title":"Tissue engineering of the biliary tract and modelling of cholestatic disorders","volume":"73","author":"Brevini","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2024.118649_bib4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000450916","article-title":"The role of inflammation in the mechanisms of bile acid-induced liver damage","volume":"35","author":"Cai","year":"2017","journal-title":"Dig. Dis."},{"key":"10.1016\/j.jep.2024.118649_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-nutr-082018-124344","article-title":"Bile acids as metabolic regulators and nutrient sensors","volume":"39","author":"Chiang","year":"2019","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.jep.2024.118649_bib6","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.cgh.2013.08.039","article-title":"Cholestatic phenotypes of autoimmune hepatitis","volume":"12","author":"Czaja","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2024.118649_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu14234950","article-title":"Recent advances in the digestive, metabolic and therapeutic effects of farnesoid X receptor and fibroblast growth factor 19: from cholesterol to bile acid signaling","volume":"14","author":"Di Ciaula","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2024.118649_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/MC9.0000000000000016","article-title":"Systematic review and meta-analysis on the effect of transdermal preparations of sinomenium acutum on rheumatoid arthritis","volume":"5","author":"Du","year":"2022","journal-title":"Chin Med Cult"},{"key":"10.1016\/j.jep.2024.118649_bib9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jhep.2017.04.026","article-title":"Biliary bile acids in hepatobiliary injury - what is the link?","volume":"67","author":"Fickert","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2024.118649_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2019.09.009","article-title":"Multiple therapeutic targets in rare cholestatic liver diseases: time to redefine treatment strategies","volume":"19","author":"Gerussi","year":"2020","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.jep.2024.118649_bib11","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/liv.14800","article-title":"Rodent models of cholestatic liver disease: a practical guide for translational research","volume":"41","author":"Gijbels","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2024.118649_bib12","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/liv.13880","article-title":"Novel and emerging therapies for cholestatic liver diseases","volume":"38","author":"Goldstein","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2024.118649_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910714","article-title":"Epoxyeicosatrienoic acids and fibrosis: recent insights for the novel therapeutic strategies","volume":"22","author":"Guan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118649_bib14","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/hep.32437","article-title":"Cholestatic liver diseases of genetic etiology: advances and controversies","volume":"75","author":"Ibrahim","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2024.118649_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cld.2021.08.006","article-title":"Role of endoscopic retrograde cholangiopancreatography in the diagnosis and management of cholestatic liver diseases","volume":"26","author":"Keihanian","year":"2022","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.jep.2024.118649_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2023.09.008","article-title":"The origin and fate of liver myofibroblasts","volume":"17","author":"Kim","year":"2024","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jep.2024.118649_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1124\/pr.117.014092","article-title":"Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology","volume":"70","author":"Lay\u00e9","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2024.118649_bib18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jhep.2021.02.035","article-title":"Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism","volume":"75","author":"Li","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2024.118649_bib19","article-title":"Relationship between the structure and immune activity of components from the active polysaccharides APS-II of astragali Radix by enzymolysis of endo \u03b1-1,4-glucanase","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118649_bib20","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.3892\/ijmm.2017.3114","article-title":"Isoastragaloside I inhibits NF-\u03baB activation and inflammatory responses in BV-2 microglial cells stimulated with lipopolysaccharide","volume":"40","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2024.118649_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12943-015-0387-0","article-title":"A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment","volume":"14","author":"Lu","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2024.118649_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11010231","article-title":"Hepatoprotective efficacy of cycloastragenol alleviated the progression of liver fibrosis in carbon-tetrachloride-treated mice","volume":"11","author":"Luangmonkong","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2024.118649_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/gutjnl-2018-316975","article-title":"TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function","volume":"69","author":"Merlen","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jep.2024.118649_bib24","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2011.10.028","article-title":"Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis","volume":"142","author":"Modica","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2024.118649_bib25","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jhep.2022.10.007","article-title":"Primary biliary cholangitis as a roadmap for the development of novel treatments for cholestatic liver diseases","volume":"78","author":"Nevens","year":"2023","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.jep.2024.118649_bib26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/MC9.0000000000000029","article-title":"Clinical application of gaofang (medicated paste) in cardiovascular disease","volume":"5","author":"Nian","year":"2022","journal-title":"Chin Med Cult"},{"key":"10.1016\/j.jep.2024.118649_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1021\/acscentsci.9b00147","article-title":"Chemoproteomic profiling of gut microbiota-associated bile salt hydrolase activity","volume":"5","author":"Parasar","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jep.2024.118649_bib28","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.jaad.2019.04.035","article-title":"Cholestatic pruritus: emerging mechanisms and therapeutics","volume":"81","author":"Patel","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jep.2024.118649_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100073","article-title":"The lipidome in nonalcoholic fatty liver disease: actionable targets","volume":"62","author":"Pirola","year":"2021","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jep.2024.118649_bib30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/CS20220674","article-title":"Potential therapeutic action of tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr\/Nrf2 and CHOP-DR5-caspase-8 pathway","volume":"137","author":"Song","year":"2023","journal-title":"Clin. Sci."},{"key":"10.1016\/j.jep.2024.118649_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.609994","article-title":"Arachidonic acid is a safe and efficacious schistosomicide, and an endoschistosomicide in natural and experimental infections, and cysteine peptidase vaccinated hosts","volume":"11","author":"Tallima","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118649_bib32","doi-asserted-by":"crossref","first-page":"5855","DOI":"10.18632\/aging.204189","article-title":"Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury","volume":"14","author":"Tang","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jep.2024.118649_bib33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-pharmtox-010818-021059","article-title":"Drug therapies for chronic cholestatic liver diseases","volume":"60","author":"Wagner","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2024.118649_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153155","article-title":"Discovery of chemical markers for identifying species, growth mode and production area of Astragali Radix by using ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometry","volume":"67","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118649_bib35","article-title":"Mechanism of Astragalus membranaceus alleviating acquired hyperlipidemia induced by high-fat diet through regulating lipid metabolism","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2024.118649_bib36","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/jphp.12706","article-title":"Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy","volume":"69","author":"Wang","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2024.118649_bib37","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1080\/10408398.2018.1544542","article-title":"n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: a critical review","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2024.118649_bib38","article-title":"The regulation of tissue-specific farnesoid X receptor on genes and diseases involved in bile acid homeostasis","volume":"168","author":"Xiang","year":"2023","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.jep.2024.118649_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103290","article-title":"Conjugated secondary 12\u03b1-hydroxylated bile acids promote liver fibrogenesis","volume":"66","author":"Xie","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jep.2024.118649_bib40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12916-020-01595-w","article-title":"Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection","volume":"18","author":"Xie","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.jep.2024.118649_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113781","article-title":"Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3\/GSDMD signaling in mice","volume":"432","author":"Xu","year":"2023","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2024.118649_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3350\/cmh.2022.0327","article-title":"Taurocholic acid promotes hepatic stellate cell activation via S1PR2\/p38 MAPK\/YAP signaling under cholestatic conditions","volume":"29","author":"Yang","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.jep.2024.118649_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154190","article-title":"A saponin from astragalus promotes pancreatic ductal organoids differentiation into insulin-producing cells","volume":"102","author":"Yu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118649_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154444","article-title":"Astragaloside IV ameliorates diet-induced hepatic steatosis in obese mice by inhibiting intestinal FXR via intestinal flora remodeling","volume":"107","author":"Zhai","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118649_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2323236","article-title":"Multi-omics reveals deoxycholic acid modulates bile acid metabolism via the gut microbiota to antagonize carbon tetrachloride-induced chronic liver injury","volume":"16","author":"Zhang","year":"2024","journal-title":"Gut Microb."},{"key":"10.1016\/j.jep.2024.118649_bib46","article-title":"Elucidating the hepatoprotective mechanisms of cholic acid against CCl4-Induced acute liver injury: a transcriptomic and metabolomic study","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118649_bib47","article-title":"Primary biliary cholangitis: molecular pathogenesis perspectives and therapeutic potential of natural products","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118649_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/cells12232725","article-title":"Bile acids in autoimmune liver disease: unveiling the nexus of inflammation, inflammatory cells, and treatment strategies","volume":"12","author":"Zhou","year":"2023","journal-title":"Cells"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:16:51Z","timestamp":1777969011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124009486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":48,"alternative-id":["S0378874124009486"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118649","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoastragaloside I attenuates cholestatic liver diseases by ameliorating liver injury, regulating bile acid metabolism and restoring intestinal barrier","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118649","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118649"}}