{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:41:03Z","timestamp":1790876463466,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118678","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T01:07:40Z","timestamp":1723079260000},"page":"118678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Exploring the action mechanism and effective components of Yupingfeng powder on influenza based on computational system pharmacology and metabolomics"],"prefix":"10.1016","volume":"336","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6123-9205","authenticated-orcid":false,"given":"Ruifeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaorong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9447-0892","authenticated-orcid":false,"given":"Ya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-4171","authenticated-orcid":false,"given":"Zifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jep.2024.118678_bib1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.2337\/dc09-2215","article-title":"Diabetes and the severity of pandemic influenza A (H1N1) infection","volume":"33","author":"Allard","year":"2010","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.jep.2024.118678_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines11030561","article-title":"Susceptibility of diabetic patients to COVID-19 infections: clinico-hematological and complications analysis","volume":"11","author":"Atwah","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.jep.2024.118678_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fviro.2021.682136","article-title":"GAPDH, interferon \u03b3, and nitric oxide: inhibitors of coronaviruses","volume":"1","author":"Awan","year":"2021","journal-title":"Frontiers in Virology"},{"key":"10.1016\/j.jep.2024.118678_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2022.105385","article-title":"Advances in the chemical constituents, pharmacological properties and clinical applications of TCM formula Yupingfeng San","volume":"164","author":"Bai","year":"2023","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2505","article-title":"Virus-induced host cell metabolic alteration","volume":"34","author":"Bappy","year":"2024","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.jep.2024.118678_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.688485","article-title":"Lactate is a metabolic mediator that shapes immune cell fate and function","volume":"12","author":"Caslin","year":"2021","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2024.118678_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41423-019-0219-z","article-title":"The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection","volume":"17","author":"Chen","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"12","key":"10.1016\/j.jep.2024.118678_bib8","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/cdd.2009.137","article-title":"Novel roles for GAPDH in cell death and carcinogenesis","volume":"16","author":"Colell","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.118678_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101044","article-title":"Diabetes, infection risk and COVID-19","volume":"39","author":"Erener","year":"2020","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.jep.2024.118678_bib10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biopha.2017.05.138","article-title":"Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo","volume":"93","author":"Fan","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2024.118678_bib11","first-page":"1","article-title":"Expert consensus on Chinese medicine prevention and treatment of adult influenza in spring 2023","volume":"46","author":"Fang","year":"2023","journal-title":"Journal of Shaanxi College of Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-virology-091919-102416","article-title":"Viruses and metabolism: the effects of viral infections and viral insulins on host metabolism","volume":"8","author":"Girdhar","year":"2021","journal-title":"Annual review of virology"},{"issue":"12","key":"10.1016\/j.jep.2024.118678_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.tim.2015.08.007","article-title":"Stealing the keys to the kitchen: viral manipulation of the host cell metabolic network","volume":"23","author":"Goodwin","year":"2015","journal-title":"Trends Microbiol."},{"issue":"11","key":"10.1016\/j.jep.2024.118678_bib14","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.cmet.2023.10.005","article-title":"Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice","volume":"35","author":"Green","year":"2023","journal-title":"Cell Metabol."},{"issue":"9","key":"10.1016\/j.jep.2024.118678_bib15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1158\/2159-8290.CD-19-0152","article-title":"Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation","volume":"9","author":"Gu","year":"2019","journal-title":"Cancer Discov."},{"issue":"15","key":"10.1016\/j.jep.2024.118678_bib16","first-page":"85","article-title":"Effect of Scutellariae radix on Metabolism in mice by metabolomics","volume":"22","author":"Han","year":"2016","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib17","first-page":"514","article-title":"Study on the blocking and inhibiting effect of streamlined formula of Yinqiaopowder and Yupingfeng powder extracton influenza-A FM1 strains in chicken embryo","volume":"5","author":"Hu","year":"2013","journal-title":"Chinese Pediatrics of Integrated Traditional and Western Medicine"},{"issue":"11","key":"10.1016\/j.jep.2024.118678_bib18","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/1873-3468.13105","article-title":"Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells","volume":"592","author":"Hu","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jep.2024.118678_bib19","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.2147\/COPD.S374782","article-title":"Cost-Effectiveness analysis of the TCM \"yupingfeng granules\" in the treatment of acute exacerbations of COPD based on a randomized clinical trial","volume":"17","author":"Hu","year":"2022","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"issue":"4","key":"10.1016\/j.jep.2024.118678_bib20","first-page":"283","article-title":"Correlation analysis of HPLC fingerprint of medicinal pieces of Yupingfeng decoction and Yupingfeng decoction","volume":"14","author":"Huang","year":"2008","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"issue":"10127","key":"10.1016\/j.jep.2024.118678_bib21","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","article-title":"Estimates of global seasonal influenza-associated respiratory mortality: a modelling study","volume":"391","author":"Iuliano","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib22","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1128\/JVI.03176-12","article-title":"Influenza A virus NS1 induces G0\/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein","volume":"87","author":"Jiang","year":"2013","journal-title":"J. Virol."},{"issue":"25","key":"10.1016\/j.jep.2024.118678_bib23","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1056\/NEJM199912163412507","article-title":"Infections in patients with diabetes mellitus","volume":"341","author":"Joshi","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.jep.2024.118678_bib24","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.03.004","article-title":"Glutathione restricts serine metabolism to preserve regulatory T cell function","volume":"31","author":"Kurniawan","year":"2020","journal-title":"Cell Metabol."},{"issue":"2","key":"10.1016\/j.jep.2024.118678_bib25","first-page":"191","article-title":"Establishment of HPLC figerprint of Yupignfeng decoction","volume":"45","author":"Li","year":"2010","journal-title":"Acta Univ. Med. Anhui"},{"issue":"8","key":"10.1016\/j.jep.2024.118678_bib26","first-page":"11","article-title":"Study on compound YuPingFengSan oral liquid improving cellular immunity of mice","volume":"26","author":"Li","year":"2013","journal-title":"Western Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2024.118678_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jep.2017.01.054","article-title":"Yupingfeng Powder relieves the immune suppression induced by dexamethasone in mice","volume":"200","author":"Li","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib28","first-page":"84","article-title":"Network pharmacology analysis and experimental validation of Anemarrhenae Rhizoma in treating Alzheimer's disease. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University","volume":"53","author":"Li","year":"2023","journal-title":"Medical sciences"},{"issue":"9","key":"10.1016\/j.jep.2024.118678_bib29","first-page":"3566","article-title":"Effect of viral infection on host cell metabolism: a review","volume":"39","author":"Li","year":"2023","journal-title":"Chin. J. Biotechnol."},{"issue":"9","key":"10.1016\/j.jep.2024.118678_bib30","first-page":"1398","article-title":"Mechanisms of glyceraldehyde 3-phosphosphate dehydrogenaseis in bacteria adhesion-A review","volume":"56","author":"Li Liu","year":"2016","journal-title":"Acta Microbiol. Sin."},{"issue":"4","key":"10.1016\/j.jep.2024.118678_bib31","first-page":"357","article-title":"Effects and molecular mechanism of histone methyltransferase enhancer of zeste homolog 2 on regulating sepsis-induced T cell dysfunction","volume":"34","author":"Li Zhe","year":"2022","journal-title":"Chin. Crit. Care Med."},{"issue":"15","key":"10.1016\/j.jep.2024.118678_bib32","first-page":"1302","article-title":"Plasma metabonomics characteristics of lung and defensive qi deficiency syndrome in repeated upper respiratory infection patients and clinical effects of yupingfeng particles intervention","volume":"56","author":"Lin","year":"2015","journal-title":"J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.jep.2024.118678_bib34","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3892\/etm.2015.2309","article-title":"Increased glyceraldehyde-3-phosphate dehydrogenase expression indicates higher survival rates in male patients with hepatitis B virus-accociated hepatocellular carcinoma and cirrhosis","volume":"9","author":"Liu","year":"2015","journal-title":"Exp. Ther. Med."},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062935","article-title":"Cyclin-dependent kinases (CDK) and their role in diseases development-review","volume":"22","author":"Lukasik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118678_bib36","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.2147\/COPD.S170555","article-title":"Effects of YuPingFeng granules on acute exacerbations of COPD: a randomized, placebo-controlled study","volume":"13","author":"Ma","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"issue":"4","key":"10.1016\/j.jep.2024.118678_bib37","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2017.03.019","article-title":"Glutathione primes T cell metabolism for inflammation","volume":"46","author":"Mak","year":"2017","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jep.2024.118678_bib38","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s15010-023-02001-2","article-title":"Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients: a multicenter prospective observational cohort study","volume":"51","author":"Mayerh\u00f6fer","year":"2023","journal-title":"Infection"},{"key":"10.1016\/j.jep.2024.118678_bib39","series-title":"Diagnostic and Treatment Protocol for Human H7N9 Avian Influenza","year":"2013"},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib40","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.celrep.2018.01.040","article-title":"Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T cell effector functions","volume":"22","author":"Menk","year":"2018","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/biof.1379","article-title":"A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation","volume":"44","author":"Nakano","year":"2018","journal-title":"Biofactors"},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cmet.2016.09.018","article-title":"Metabolomics and metabolic diseases: where do we stand?","volume":"25","author":"Newgard","year":"2017","journal-title":"Cell Metabol."},{"issue":"39","key":"10.1016\/j.jep.2024.118678_bib44","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1038\/s41388-021-01982-4","article-title":"Going beyond Polycomb: EZH2 functions in prostate cancer","volume":"40","author":"Park","year":"2021","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.jep.2024.118678_bib45","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib42","first-page":"401","article-title":"Protocol for diagnosis and treatment of influenza (2020 version)","author":"PRC","year":"2020","journal-title":"Chin. J. Clin. Infect. Dis."},{"issue":"11","key":"10.1016\/j.jep.2024.118678_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108500","article-title":"Lactate limits T cell proliferation via the NAD(H) redox state","volume":"33","author":"Quinn","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s43587-020-00006-2","article-title":"Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice","volume":"1","author":"Richardson","year":"2021","journal-title":"Nat Aging"},{"key":"10.1016\/j.jep.2024.118678_bib48","series-title":"Guidelines on Home Chinese Medicine Interventions for New Coronavirus Infected Persons","year":"2022"},{"key":"10.1016\/j.jep.2024.118678_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114189","article-title":"Influenza-existing drugs and treatment prospects","volume":"232","author":"Sarker","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.jep.2024.118678_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006322","article-title":"Proteomic analysis of the differential protein expression reveals nuclear GAPDH in activated T lymphocytes","volume":"4","author":"Sheng","year":"2009","journal-title":"PLoS One"},{"issue":"Pt 19","key":"10.1016\/j.jep.2024.118678_bib51","first-page":"4279","article-title":"Moonlighting cell-surface GAPDH recruits apotransferrin to effect iron egress from mammalian cells","volume":"127","author":"Sheokand","year":"2014","journal-title":"J. Cell Sci."},{"issue":"12","key":"10.1016\/j.jep.2024.118678_bib52","first-page":"2364","article-title":"Effect of yupingfeng droppill in treatment of allergic rhinitis","volume":"39","author":"Shi","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"issue":"29","key":"10.1016\/j.jep.2024.118678_bib53","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011598","article-title":"Adjuvant treatment with Yupingfeng formula for primary nephrotic syndrome in children: a PRISMA systematic review and meta-analysis of randomized controlled trials","volume":"97","author":"Shi","year":"2018","journal-title":"Medicine."},{"issue":"7","key":"10.1016\/j.jep.2024.118678_bib54","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/ptr.5628","article-title":"Adjuvant treatment with yupingfeng formula for recurrent respiratory tract infections in children: a meta-analysis of randomized controlled trials","volume":"30","author":"Song","year":"2016","journal-title":"Phytother Res. : PT"},{"key":"10.1016\/j.jep.2024.118678_bib55","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.fsi.2020.07.003","article-title":"Effects of Yu-Ping-Feng polysaccharides (YPS) on the immune response, intestinal microbiota, disease resistance and growth performance of Litopenaeus vannamei","volume":"105","author":"Su","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jep.2024.118678_bib56","article-title":"Gentamicin induced microbiome adaptations associate with increased BCAA levels and enhance severity of influenza infection","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118678_bib57","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1038\/srep05204","article-title":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice","volume":"4","author":"Takaoka","year":"2014","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13626","article-title":"Protein restriction and branched-chain amino acid restriction promote geroprotective shifts in metabolism","volume":"21","author":"Trautman","year":"2022","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.jep.2024.118678_bib59","first-page":"742","article-title":"Clinical observation of effect of jiawei yupingfeng mixture for prevention and treatment of 100 children with repeated respiratory tract infection","volume":"29","author":"Wang","year":"2009","journal-title":"Chin. J. Integrated Tradit. West Med."},{"issue":"3","key":"10.1016\/j.jep.2024.118678_bib60","first-page":"335","article-title":"HPLC fingerprint study of the alcoholic extracted parts of Yupingfengsan","volume":"31","author":"Wang","year":"2009","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2024.118678_bib61","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3389\/fphar.2020.01035","article-title":"Uncovering the complexity mechanism of different formulas treatment for rheumatoid arthritis based on a novel network pharmacology model","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118678_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107824","article-title":"Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds","volume":"224","author":"Wang","year":"2021","journal-title":"Pharmacol. Therapeut."},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib63","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s12185-022-03466-x","article-title":"The pleiotropic roles of EZH2 in T-cell immunity and immunotherapy","volume":"116","author":"Wang","year":"2022","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.jep.2024.118678_bib64","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1016\/j.csbj.2023.07.034","article-title":"GAPDH: a common housekeeping gene with an oncogenic role in pan-cancer","volume":"21","author":"Wang","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"6427","key":"10.1016\/j.jep.2024.118678_bib65","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1126\/science.aav0558","article-title":"Branched-chain amino acids in disease","volume":"363","author":"White","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jep.2024.118678_bib66","series-title":"Fact Sheet on Influenza (seasonal)","year":"2023"},{"issue":"4","key":"10.1016\/j.jep.2024.118678_bib67","first-page":"334","article-title":"Effects of histone methyltransferase EZH2 on the metabolic pathway of CD4+ T cells during acute viral infection","author":"Wu","year":"2019","journal-title":"Immunological Journal"},{"issue":"2","key":"10.1016\/j.jep.2024.118678_bib68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ped4.12326","article-title":"Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection: a randomized clinical trial","volume":"6","author":"Xu","year":"2022","journal-title":"Pediatric investigation"},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3736\/jcim20100105","article-title":"Prevention of hospital-acquired pneumonia with Yupingfeng Powder in patients with acute cerebral vascular diseases: a randomized controlled trial","volume":"8","author":"Yan","year":"2010","journal-title":"J. Chin. Integr. Med."},{"issue":"3","key":"10.1016\/j.jep.2024.118678_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112186","article-title":"Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8(+) T cells with enhanced effector function and anti-tumor response","volume":"42","author":"Yao","year":"2023","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.jep.2024.118678_bib71","first-page":"884","article-title":"Simultaneous determination of six components in Yupingfeng decoction by high-performance liquid chromatography","author":"You","year":"2007","journal-title":"J. South. Med. Univ."},{"issue":"3","key":"10.1016\/j.jep.2024.118678_bib72","first-page":"31.36","article-title":"HPLC figerprints analysis of Yupingfeng granules","volume":"15","author":"Yuan","year":"2012","journal-title":"China Pharm."},{"issue":"2","key":"10.1016\/j.jep.2024.118678_bib73","first-page":"269","article-title":"Comparative study of Radix Hedyseri as sulstitute for Radix Astragali of yupingfeng oral liquid on cellular immunity in immunosuppressed mice","volume":"35","author":"Zhang","year":"2012","journal-title":"Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials"},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib74","first-page":"43","article-title":"The miaoyao fanggan sachets regulate humoral immunity and cellular immunity in mice","volume":"12","author":"Zhang","year":"2015","journal-title":"J. Compl. Integr. Med."},{"issue":"20","key":"10.1016\/j.jep.2024.118678_bib75","first-page":"4379","article-title":"Systematic evaluation and Meta-analysis on effectiveness and safety of Yupingfeng Granules on recurrent respiratory tract infection","volume":"44","author":"Zhang","year":"2019","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118678_bib76","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2019.05.003","article-title":"Lactate is a natural suppressor of RLR signaling by targeting MAVS","volume":"178","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.118678_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.1005745","article-title":"Adjuvant treatment with yupingfeng granules for recurrent respiratory tract infections in children: a systematic review and meta-analysis","volume":"10","author":"Zhang","year":"2022","journal-title":"Frontiers in pediatrics"},{"issue":"11","key":"10.1016\/j.jep.2024.118678_bib78","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11112774","article-title":"Effects of yupingfeng polysaccharides as feed supplement on immune function and intestinal microbiome in chickens","volume":"11","author":"Zheng","year":"2023","journal-title":"Microorganisms"},{"issue":"4","key":"10.1016\/j.jep.2024.118678_bib79","first-page":"815","article-title":"Studies on protein function of cyclin-dependent kinase 2 and its inhibitors","volume":"43","author":"Zheng Nan","year":"2021","journal-title":"Chinese journal of cell biology"},{"key":"10.1016\/j.jep.2024.118678_bib80","first-page":"37","article-title":"Effect of Yupingfeng oral solution on influenza virus inhibition and on the immune function of the body","author":"Zhou","year":"1990","journal-title":"ournal of Chinese Medicinal Materials(01)"},{"issue":"11","key":"10.1016\/j.jep.2024.118678_bib81","first-page":"2604","article-title":"Metabolomic-based study of metabolic changes in liver tissues of senescence accelerated mouse prone 8 (SAMP8) treated with baicalein","volume":"50","author":"Zhou","year":"2019","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"8","key":"10.1016\/j.jep.2024.118678_bib82","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13038","article-title":"Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle","volume":"21","author":"Zhu","year":"2019","journal-title":"Cell Microbiol."},{"issue":"12","key":"10.1016\/j.jep.2024.118678_bib83","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001697","article-title":"Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle","volume":"102","author":"Zhu","year":"2021","journal-title":"J. Gen. Virol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T12:49:45Z","timestamp":1725972585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124009772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":83,"alternative-id":["S0378874124009772"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118678","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the action mechanism and effective components of Yupingfeng powder on influenza based on computational system pharmacology and metabolomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118678"}}