{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:43:34Z","timestamp":1787741014389,"version":"build-2784847793"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006302","name":"University of Alcala de Henares","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012371","name":"Faculty of Science and Engineering, University of Manchester","doi-asserted-by":"publisher","award":["CENTRO-04-3559-FSE-000142"],"award-info":[{"award-number":["CENTRO-04-3559-FSE-000142"]}],"id":[{"id":"10.13039\/100012371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/146441\/2019"],"award-info":[{"award-number":["SFRH\/BD\/146441\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/145531\/2019"],"award-info":[{"award-number":["SFRH\/BD\/145531\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0058\/2020"],"award-info":[{"award-number":["LA\/P\/0058\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Fundacao para a Ciencia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jep.2024.118689","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T05:40:04Z","timestamp":1723614004000},"page":"118689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Unveiling the antitumor mechanism of 7\u03b1-acetoxy-6\u03b2-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma"],"prefix":"10.1016","volume":"335","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-1611","authenticated-orcid":false,"given":"Mariana","family":"Magalh\u00e3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Mar\u00eda","family":"Dom\u00ednguez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-7546","authenticated-orcid":false,"given":"Francesca","family":"Massenzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Spigarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ribeiro-Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-6960","authenticated-orcid":false,"given":"Steve","family":"Catarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Gir\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Spisni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2637-1681","authenticated-orcid":false,"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-6683","authenticated-orcid":false,"given":"C\u00e9lia","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118689_bib1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrc2657","article-title":"p21 in cancer: intricate networks and multiple activities","volume":"9","author":"Abbas","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jep.2024.118689_bib2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1042\/BST20140070","article-title":"PI3K\/Akt-mediated regulation of p53 in cancer","volume":"42","author":"Abraham","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jep.2024.118689_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12032-019-1253-5","article-title":"Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia","volume":"36","author":"Alves","year":"2019","journal-title":"Med. Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/neup.12931","article-title":"O-methylguanine methyltransferase promoter methylation status of glioblastoma cell line clonal population","volume":"44","author":"Anan","year":"2024","journal-title":"Neuropathology"},{"key":"10.1016\/j.jep.2024.118689_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13111536","article-title":"Advances in glioblastoma therapy: an update on current approaches","volume":"13","author":"Angom","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.jep.2024.118689_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155634","article-title":"Anticancer diterpenes of African natural products: mechanistic pathways and preclinical developments","volume":"129","author":"Bangay","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118689_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097929","article-title":"A promising way to overcome temozolomide resistance through inhibition of protein neddylation in glioblastoma cell lines","volume":"24","author":"Brandt","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118689_bib8","first-page":"E87","article-title":"A pipeline for multidimensional confocal analysis of mitochondrial morphology, function, and dynamics in pancreatic \u03b2-cells","volume":"318","author":"Chaudhry","year":"2019","journal-title":"Am. J. Physiol. Metab"},{"key":"10.1016\/j.jep.2024.118689_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12929-021-00717-7","article-title":"Dissecting the mechanism of temozolomide resistance and its association with the regulatory roles of intracellular reactive oxygen species in glioblastoma","volume":"28","author":"Chien","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jep.2024.118689_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2165\/00124363-200104000-00012","article-title":"Ethical considerations","volume":"15","author":"Clarke","year":"2001","journal-title":"Int. J. Pharmaceut. Med."},{"key":"10.1016\/j.jep.2024.118689_bib11","author":"Clinic"},{"key":"10.1016\/j.jep.2024.118689_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27123813","article-title":"Phytochemical study and antiglioblastoma activity assessment of plectranthus hadiensis (forssk.) Schweinf. Ex sprenger var. hadiensis stems","volume":"27","author":"Dom\u00ednguez-Mart\u00edn","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118689_bib13","series-title":"New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics","first-page":"227","article-title":"Chapter 12 - terpenes: A hope for glioblastoma patients","author":"Dom\u00ednguez-Mart\u00edn","year":"2023"},{"key":"10.1016\/j.jep.2024.118689_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ani13071223","article-title":"The importance of animal models in biomedical research: current insights and applications","volume":"13","author":"Dom\u00ednguez-Oliva","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.jep.2024.118689_bib15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/sj.bjc.6605127","article-title":"Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy","volume":"101","author":"Dunn","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jep.2024.118689_bib16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a Review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jep.2024.118689_bib17","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.tiv.2013.03.009","article-title":"Oxidative stress mediates apoptotic effects of ascorbate and dehydroascorbate in human Myelodysplasia cells in vitro","volume":"27","author":"Gon\u00e7alves","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jep.2024.118689_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23794-6","article-title":"Prognostic differences and implications on treatment strategies between butterfly glioblastoma and glioblastoma with unilateral corpus callosum infiltration","volume":"12","author":"Hazaymeh","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118689_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1470-2045(18)30136-0","article-title":"The evolution of anticancer drug discovery from plants","volume":"19","author":"Howes","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.canlet.2018.11.027","article-title":"Isolinderalactone regulates the BCL-2\/caspase-3\/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model","volume":"443","author":"Hwang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2024.118689_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29081807","article-title":"Anticancer effects of abietane diterpene 7\u03b1-Acetoxy-6\u03b2-hydroxyroyleanone from plectranthus grandidentatus and its semi-synthetic analogs: an in silico computational approach","volume":"29","author":"Isca","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118689_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature03097","article-title":"Cell-cycle checkpoints and cancer","volume":"432","author":"Kastan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.118689_bib23","first-page":"E255","article-title":"Ethical considerations regarding animal experimentation","volume":"63","author":"Kiani","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"10.1016\/j.jep.2024.118689_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.trsl.2016.05.006","article-title":"Ethical considerations and challenges in first-in-human research","volume":"177","author":"Koonrungsesomboon","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.jep.2024.118689_bib25","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4161\/cbt.7.9.6954","article-title":"PTEN signaling pathways in glioblastoma","volume":"7","author":"Koul","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jep.2024.118689_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jocn.2020.08.023","article-title":"Extent of resection affects prognosis for patients with glioblastoma in non-eloquent regions","volume":"80","author":"Kow","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.jep.2024.118689_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s42003-019-0560-x","article-title":"Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping","volume":"2","author":"Lane","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jep.2024.118689_bib28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11060-017-2379-y","article-title":"Molecular markers in glioma","volume":"134","author":"Ludwig","year":"2017","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib30","series-title":"New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics","first-page":"81","article-title":"Chapter 5 - secretome analysis of patient-derived glioblastoma cells for potential biomarker identification","author":"Magalh\u00e3es","year":"2023"},{"key":"10.1016\/j.jep.2024.118689_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2022.1006832","article-title":"Parvifloron D-based potential therapy for glioblastoma: inducing apoptosis via the mitochondria dependent pathway","volume":"13","author":"Magalh\u00e3es","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118689_bib32","first-page":"4979","article-title":"Increased gene delivery efficiency and specificity of a lipid-based nanosystem incorporating a glycolipid","volume":"9","author":"Magalh\u00e3es","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jep.2024.118689_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14030726","article-title":"Glioblastoma cells counteract PARP inhibition through pro-survival induction of lipid droplets synthesis and utilization","volume":"14","author":"Majuelos-Melguizo","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2024.118689_bib34","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1016\/j.bbadis.2018.10.013","article-title":"Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment , activation and neurotoxicity and is counteracted by the autophagy inducer trehalose","volume":"1864","author":"Massenzio","year":"2018","journal-title":"BBA - Mol. Basis Dis."},{"key":"10.1016\/j.jep.2024.118689_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084529","article-title":"Exploring the anticancer potential of semisynthetic derivatives of 7\u03b1-Acetoxy-6\u03b2-hydroxyroyleanone from plectranthus sp.: an in silico approach","volume":"25","author":"Merecz-Sadowska","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118689_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41598-017-18582-6","article-title":"Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner","volume":"8","author":"Miyazono","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118689_bib37","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.18013","article-title":"PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma","volume":"8","author":"Murny\u00e1k","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2024.118689_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27238367","article-title":"Natural products as anticancer agents: current status and future perspectives","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118689_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41416-021-01359-0","article-title":"Bridging the gap between cancer cell line models and tumours using gene expression data","volume":"125","author":"Noorbakhsh","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jep.2024.118689_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ph14050402","article-title":"Preliminary biological activity screening of Plectranthus spp. extracts for the search of anticancer lead molecules","volume":"14","author":"Ntungwe","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2024.118689_bib41","first-page":"513","article-title":"Temozolomide: an updated overview of resistance mechanisms, nanotechnology advances and clinical applications","volume":"19","author":"Ortiz","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jep.2024.118689_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.00853","article-title":"Cinobufagin induces cell cycle arrest at the G2\/M phase and promotes apoptosis in malignant melanoma cells","volume":"9","author":"Pan","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib43","article-title":"Targeting cellular pathways in glioblastoma multiforme","volume":"2","author":"Pearson","year":"2017","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2024.118689_bib44","series-title":"Programmed Cell Death, the Biology and Therapeutic Implications of Cell Death","first-page":"107","article-title":"DNA damage response and apoptosis","author":"Plesca","year":"2008"},{"key":"10.1016\/j.jep.2024.118689_bib45","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1471-4159.2009.06117.x","article-title":"Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2","volume":"110","author":"Polazzi","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jep.2024.118689_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib47","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1007\/s11696-021-01700-0","article-title":"Restoring chemo-sensitivity to temozolomide via targeted inhibition of poly (ADP-ribose) polymerase-1 by naringin in glioblastoma","volume":"75","author":"Rao","year":"2021","journal-title":"Chem. Pap."},{"key":"10.1016\/j.jep.2024.118689_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0187925","article-title":"Nature is the best source of anticancer drugs: indexing natural products for their anticancer bioactivity","volume":"12","author":"Rayan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118689_bib49","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","article-title":"Counting on natural products for drug design","volume":"8","author":"Rodrigues","year":"2016","journal-title":"Nat. Chem."},{"key":"10.1016\/j.jep.2024.118689_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11061579","article-title":"Personalized treatment of glioblastoma: current state and future perspective","volume":"11","author":"Ron\u010devi\u0107","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2024.118689_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11081178","article-title":"p21 in cancer research","volume":"11","author":"Shamloo","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2024.118689_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1279806","article-title":"TP53-PTEN-NF1 depletion in human brain organoids produces a glioma phenotype in vitro","volume":"13","author":"Singh","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom10020194","article-title":"Insight the biological activities of selected abietane diterpenes isolated from plectranthus spp","volume":"10","author":"Sitarek","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2024.118689_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ph13060123","article-title":"Diterpenoids from Plectranthus spp. as potential chemotherapeutic agents via apoptosis","volume":"13","author":"\u015aliwi\u0144ski","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2024.118689_bib55","first-page":"299","article-title":"Management of glioblastoma: state of the art and future directions","volume":"70","author":"Tan","year":"2020","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.jep.2024.118689_bib56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jep.2024.118689_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.804962","article-title":"PARP1 upregulation in recurrent oral cancer and treatment resistance","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2024.118689_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108412","article-title":"Curcumin suppresses glioblastoma cell proliferation by p-AKT\/mTOR pathway and increases the PTEN expression","volume":"689","author":"Wang","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2024.118689_bib59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41419-019-1407-6","article-title":"BCL-2 family isoforms in apoptosis and cancer","volume":"10","author":"Warren","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2024.118689_bib60","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/sj.cdd.4401786","article-title":"BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells","volume":"13","author":"Weiler","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.118689_bib61","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/neuonc\/noab120","article-title":"The 2021 WHO classification of tumors of the central nervous system: clinical implications","volume":"23","author":"Wen","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.jep.2024.118689_bib62","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/cbdd.13860","article-title":"Caspase-3: a primary target for natural and synthetic compounds for cancer therapy","volume":"98","author":"Yadav","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2024.118689_bib63","article-title":"Advances in pharmacological activities of terpenoids","volume":"15","author":"Yang","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2024.118689_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10090297","article-title":"The p53 pathway in glioblastoma","volume":"10","author":"Zhang","year":"2018","journal-title":"Cancers"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124009887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:15:37Z","timestamp":1777968937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124009887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":64,"alternative-id":["S0378874124009887"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118689","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the antitumor mechanism of 7\u03b1-acetoxy-6\u03b2-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118689"}}