{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:49:23Z","timestamp":1792813763122,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118717","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T05:05:27Z","timestamp":1724389527000},"page":"118717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Exploring antithrombotic mechanisms and effective constituents of Lagopsis supina using an integrated strategy based on network pharmacology, molecular docking, metabolomics, and experimental verification in rats"],"prefix":"10.1016","volume":"336","author":[{"given":"Qingcui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-7694","authenticated-orcid":false,"given":"Xiaobin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-3505","authenticated-orcid":false,"given":"Junwei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118717_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115453","article-title":"Berberis dictyophylla F. inhibits angiogenesis and apoptosis of diabetic retinopathy via suppressing HIF-1\u03b1\/VEGF\/DLL-4\/Notch-1 pathway","volume":"296","author":"Ai","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118717_bib2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1165\/rcmb.2018-0324OC","article-title":"Palmitic acid-rich high-fat diet exacerbates experimental pulmonary fibrosis by modulating endoplasmic reticulum stress","volume":"61","author":"Chu","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jep.2024.118717_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jep.2015.12.025","article-title":"Anti-osteoporotic activity of harpagide by regulation of bone formation in osteoblast cell culture and ovariectomy-induced bone loss mouse models","volume":"179","author":"Chung","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2024.118717_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0006-2952(75)90130-6","article-title":"Metabolism of (1-14C) gamma-hydroxybutyric acid by rat brain after intraventricular injection","volume":"24","author":"Doherty","year":"1975","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118717_bib5","first-page":"763","article-title":"Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil","volume":"69","author":"Fujii","year":"1978","journal-title":"Gan"},{"issue":"11","key":"10.1016\/j.jep.2024.118717_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11622","article-title":"Acteoside attenuates acute lung injury following administration of cobra venom factor to mice","volume":"8","author":"Guo","year":"2022","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.jep.2024.118717_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1748-1716.1981.tb06735.x","article-title":"Influence of adenosine on responses to vagal nerve stimulation in the anesthetized rabbit","volume":"111","author":"Gustafsson","year":"1981","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.jep.2024.118717_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114235","article-title":"Chemical profiling and in-vitro anti-inflammatory activity of bioactive fraction(s) from Trichodesma indicum (L.) R.Br. against LPS induced inflammation in RAW 264.7 murine macrophage cells","volume":"279","author":"Hamsalakshmi","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.jep.2018.10.034","article-title":"Lagopsis supina exerts its diuretic effect via inhibition of aquaporin-1, 2 and 3 expression in a rat model of traumatic blood stasis","volume":"231","author":"He","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib10","first-page":"4576","article-title":"Comparison of clinical application and modern research of Lagopsis supina used in different ethnic medicine cultures","volume":"51","author":"He","year":"2020","journal-title":"Chin. Tradit. Herbal Drugs"},{"key":"10.1016\/j.jep.2024.118717_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111554","article-title":"Diuretic effect of Lagopsis supina fraction in saline-loaded rats is mediated through inhibition of aquaporin and renin-angiotensin-aldosterone systems and up-regulation of atriopeptin","volume":"139","author":"He","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118717_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155050","article-title":"Lagopsis supina ameliorates myocardial ischemia injury by regulating angiogenesis, thrombosis, inflammation, and energy metabolism through VEGF, ROS and HMGB1 signaling pathways in rats","volume":"120","author":"He","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118717_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-96683-z","article-title":"Reveals of candidate active ingredients in Justicia and its anti-thrombotic action of mechanism based on network pharmacology approach and experimental validation","volume":"11","author":"Hong","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2024.118717_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76797-6","article-title":"Involvement of 8-O-acetylharpagide for Ajuga taiwanensis mediated suppression of senescent phenotypes in human dermal fibroblasts","volume":"10","author":"Hsu","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2024.118717_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139357","article-title":"Vascular smooth muscle cells stimulate platelets and facilitate thrombus formation through platelet CLEC-2: implications in atherothrombosis","volume":"10","author":"Inoue","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jep.2024.118717_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtho.2020.10.006","article-title":"Dual EGFR-VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC","volume":"16","author":"Le","year":"2020","journal-title":"J. Thorac. Oncol."},{"issue":"9","key":"10.1016\/j.jep.2024.118717_bib17","doi-asserted-by":"crossref","first-page":"H2079","DOI":"10.1111\/1750-3841.12975","article-title":"HPLC\/Q-TOF-MS-based identification of absorbed constituents and their metabolites in rat serum and urine after oral administration of Cistanche deserticola extract","volume":"80","author":"Li","year":"2015","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2024.118717_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114855","article-title":"Vanillin derivative VND3207 activates DNA-PKcs conferring protection against radiation-induced intestinal epithelial cells injury in vitro and in vivo","volume":"387","author":"Li","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6927374","article-title":"Diuretic and anti-diuretic activities of ethanol extract and fractions of Lagopsis supina in normal rats","volume":"2019","author":"Liu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2024.118717_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113358","article-title":"Study on the antithrombotic effect and physiological mechanism of okanin","volume":"153","author":"Liu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118717_bib21","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.2147\/DDDT.S353088","article-title":"The antithrombotic effect of recombinant Neorudin on thrombi","volume":"16","author":"Liu","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2024.118717_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.107007","article-title":"Network pharmacology and molecular docking combined with widely targeted metabolomics to elucidate the potential compounds and targets of Euphorbia helioscopia seeds for the treatment of pulmonary fibrosis","volume":"160","author":"Liu","year":"2023","journal-title":"Comput. Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2024.118717_bib23","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s11418-013-0760-5","article-title":"Anti-allergic effects of enzymatically modified isoquercitrin (\u03b1-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, \u03b1-oligoglucosyl rutin, and quercetin, when administered orally to mice","volume":"67","author":"Makino","year":"2013","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2024.118717_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153490","article-title":"Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an A\u03b21-42-induced mouse model of Alzheimer's disease","volume":"83","author":"Mirza","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118717_bib25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s10600-022-03671-4","article-title":"Chemical constituents of Lagopsis supina","volume":"58","author":"Niu","year":"2022","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.jep.2024.118717_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.phymed.2017.05.006","article-title":"Kinetics and metabolism of apocynin in the mouse brain assessed with positron-emission tomography","volume":"38","author":"Okamura","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118717_bib27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.msec.2018.06.055","article-title":"In-vivo sustained release of nanoencapsulated ferulic acid and its impact in induced diabetes","volume":"92","author":"Panwar","year":"2018","journal-title":"Mater. Sci. Eng., C"},{"issue":"6","key":"10.1016\/j.jep.2024.118717_bib28","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4162\/nrp.2019.13.6.473","article-title":"Luteolin and luteolin-7-O-glucoside protect against acute liver injury through regulation of inflammatory mediators and antioxidative enzymes in GalN\/LPS-induced hepatitic ICR mice","volume":"13","author":"Park","year":"2019","journal-title":"Nutr. Res. Prac."},{"key":"10.1016\/j.jep.2024.118717_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174973","article-title":"Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model","volume":"925","author":"Rana","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118717_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-2999(02)02953-9","article-title":"Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside","volume":"461","author":"Sala","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118717_bib31","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/1028415X.2020.1764290","article-title":"Phytol loaded PLGA nanoparticles ameliorate scopolamine-induced cognitive dysfunction by attenuating cholinesterase activity, oxidative stress and apoptosis in wistar rat","volume":"25","author":"Sathya","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.jep.2024.118717_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153263","article-title":"Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade","volume":"76","author":"Sheng","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118717_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106777","article-title":"Molecular and metabolic mechanisms of bufalin against lung adenocarcinoma: new and comprehensive evidences from network pharmacology, metabolomics and molecular biology experiment","volume":"157","author":"Shi","year":"2023","journal-title":"Comput. Biol. Med."},{"issue":"2\u20133","key":"10.1016\/j.jep.2024.118717_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1078\/094471103321659807","article-title":"Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension","volume":"10","author":"Somova","year":"2003","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2024.118717_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.2042-7158.1978.tb13171.x","article-title":"Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat","volume":"30","author":"Vargaftig","year":"1978","journal-title":"J. Pharm. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2024.118717_bib36","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ptr.910","article-title":"Bioactivity studies on beta-sitosterol and its glucoside","volume":"16","author":"Villase\u00f1or","year":"2002","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2024.118717_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1163367","article-title":"Guianensin, a simulium guianense salivary protein, has broad anti-hemostatic and anti-inflammatory properties","volume":"14","author":"Valenzuela-Leon","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2024.118717_bib38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3892\/mmr.2021.11926","article-title":"Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis","volume":"23","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2024.118717_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113809","article-title":"Naoxintong restores ischemia injury and inhibits thrombosis via COX2-VEGF\/NF\u03baB signaling","volume":"270","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115701","article-title":"Exploring the mechanism of the antithrombotic effects of Pueraria lobata and Pueraria lobata var. thomsonii based on network pharmacology","volume":"300","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bse.2022.104572","article-title":"Chemical constituents from Lagopsis supina and their chemotaxonomic significance","volume":"106","author":"Wang","year":"2023","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.jep.2024.118717_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105611","article-title":"Labdane diterpenoids from Lagopsis supina and their anti-neuroinflammatory activity","volume":"169","author":"Wang","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2024.118717_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116245","article-title":"Amelioration of chronic prostatitis by fractions of Mongolian medicine Hosta plantaginea flowers via inhibition of NF-\u03baB, MAPKs, JAK-STAT, and PI3K-Akt signaling pathways in rats","volume":"307","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116966","article-title":"Therapeutic effect of Hosta plantaginea (Lam.) Aschers flowers on acute pharyngitis through inhibition of multi-inflammatory pathways in rats","volume":"318","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e11176","article-title":"The therapeutic effects of Lagopsis supina (Steph. ex. Willd.) Ikonn.-Gal. fractions in trauma-induced blood stasis model rats","volume":"8","author":"Xia","year":"2022","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.jep.2024.118717_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200916","article-title":"Revealing the active constituents and mechanisms of Semiliquidambar cathayensis Chang roots against rheumatoid arthritis through network pharmacology, molecular docking, and in vivo experiment","volume":"20","author":"Xia","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2024.118717_bib47","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902021000x32e19359","article-title":"Efficacy of Lagopsis supina to promote blood circulation, remove blood stasis, and block inflammation in a rat model of traumatic blood stasis","volume":"58","author":"Xu","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2024.118717_bib48","first-page":"137","article-title":"Inhibitory effects of Qushuanling capsule on thrombus formation and platelet aggregation in rats. Chin","volume":"19","author":"Xue","year":"2013","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.jep.2024.118717_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154271","article-title":"Danshensu prevents thrombosis bu inhibiting platelet activation via SIRT1\/ROS\/mtDNA pathways without increasing bleeding risk","volume":"104","author":"Xue","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118717_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110899","article-title":"Lagopsis supina extract and its fractions exert prophylactic effects against blood stasis in rats via anti-coagulation, anti-platelet activation and anti-fibrinolysis and chemical characterization by UHPLC-qTOF-MS\/MS","volume":"132","author":"Yang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118717_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113323","article-title":"Traditional uses, phytochemistry, pharmacology and toxicological aspects of the genus Hosta (Liliaceae): a comprehensive review","volume":"265","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113951","article-title":"The chemical profiling of aqueous soluble fraction from Lagopsis supina and its diuretic effects via suppression of AQP and RAAS pathways in saline-loaded rats","volume":"272","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107463","article-title":"Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-\u03b1-induced MH7A cells via inhibition of NF-\u03baB, Akt and JNK signaling pathways","volume":"94","author":"Yang","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.118717_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113631","article-title":"Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats","volume":"267","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12906-022-03540-1","article-title":"Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NF-kB signaling pathway","volume":"22","author":"Yang","year":"2022","journal-title":"BMC Complement. Med."},{"key":"10.1016\/j.jep.2024.118717_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106165","article-title":"Natural phenylethanoid glycosides diuretics derived from Lagopsis supina: biological activity, mechanism, molecular docking, and structure-activity relationship","volume":"129","author":"Yang","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2024.118717_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116922","article-title":"Extraction optimization and constituent analysis of total flavonoid from Hosta plantaginea (Lam.) Aschers flowers and its ameliorative effect on chronic prostatitis via inhibition of multiple inflammatory pathways in rats","volume":"318","author":"Yang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118717_bib58","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1080\/21655979.2022.2044253","article-title":"Attenuating oxidized low density lipoprotein (ox-LDL)-induced macrophages damage via inhibiting C-type lectin domain family 2 (CLEC2) expression through janus kinase 1 (JAK1)\/signal transducers and activators of transcription-1 (STAT1) pathway","volume":"13","author":"Yu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.jep.2024.118717_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105964","article-title":"Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease","volume":"174","author":"Zhang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118717_bib60","article-title":"Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation","volume":"14","author":"Zhang","year":"2023","journal-title":"Font. Immunol."},{"key":"10.1016\/j.jep.2024.118717_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154664","article-title":"Pushen capsule treatment promotes functionals recovery after ischemic stroke","volume":"111","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2024.118717_bib62","first-page":"65","article-title":"Mechanisms of apigenin-7-glucoside as a hepatoprotective agent","volume":"18","author":"Zheng","year":"2005","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.jep.2024.118717_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154831","article-title":"The activities and mechanisms of intestinal microbiota metabolites of TCM herbal ingredients could be illustrated by a strategy integrating spectrum-effects, network pharmacology, metabolomics and molecular docking analysis: platycodin D as an example","volume":"115","author":"Zhong","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118717_bib64","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.biopha.2017.11.135","article-title":"Evaluation of the antithrombotic activity of Zhi-Xiong Capsules, a traditional Chinese medicinal formula, via the pathway of anti-coagulation, anti-platelet activation and anti-fibrinolysi","volume":"97","author":"Zhou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118717_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104963","article-title":"Interactions of antithrombotic herbal medicines with western cardiovascular drugs","volume":"159","author":"Zuo","year":"2020","journal-title":"Pharmacol. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412401016X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412401016X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T03:37:20Z","timestamp":1732678640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412401016X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":65,"alternative-id":["S037887412401016X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118717","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring antithrombotic mechanisms and effective constituents of Lagopsis supina using an integrated strategy based on network pharmacology, molecular docking, metabolomics, and experimental verification in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118717"}}