{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:33:45Z","timestamp":1791999225763,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118733","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T22:33:27Z","timestamp":1724366007000},"page":"118733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Engeletin attenuates the inflammatory response via inhibiting TLR4-NF\u03baB signaling pathway in Crohn's disease-like colitis"],"prefix":"10.1016","volume":"336","author":[{"given":"Ziyun","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8550-7676","authenticated-orcid":false,"given":"Jieyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0852-698X","authenticated-orcid":false,"given":"Yunwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2024.118733_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900633","article-title":"Resveratrol downregulates miR-31 to promote T regulatory cells during prevention of TNBS-induced colitis","volume":"64","author":"Alrafas","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2024.118733_bib2","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3389\/fimmu.2018.02733","article-title":"Origin, differentiation, and function of intestinal macrophages","volume":"9","author":"Bain","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118733_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691480","article-title":"Glucocorticoid therapy in inflammatory bowel disease: mechanisms and clinical practice","volume":"12","author":"Bruscoli","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118733_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.812774","article-title":"Toll-like receptor signaling and its role in cell-mediated immunity","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118733_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114439","article-title":"Engeletin mediates antiarrhythmic effects in mice with isoproterenol-induced cardiac remodeling","volume":"161","author":"Fang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118733_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112785","article-title":"The flavonoid-enriched extract from the root of Smilax China L. inhibits inflammatory responses via the TLR-4-mediated signaling pathway","volume":"256","author":"Feng","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118733_bib7","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.2147\/JIR.S401519","article-title":"The molecular mechanisms study of engeletin suppresses RANKL-induced osteoclastogenesis and inhibits ovariectomized murine model bone loss","volume":"16","author":"Feng","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118733_bib8","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1039\/D0NR08106J","article-title":"Impact of titanium dioxide nanoparticles on intestinal community in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis mice and the intervention effect of vitamin E","volume":"13","author":"Gao","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.jep.2024.118733_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117956","article-title":"Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2\/Th1 and Tregs\/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota","volume":"328","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2024.118733_bib10","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1021\/jf2002969","article-title":"Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties","volume":"59","author":"Huang","year":"2011","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jep.2024.118733_bib11","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s10753-020-01250-9","article-title":"Engeletin attenuates a\u03b21-42-induced oxidative stress and neuroinflammation by keap1\/nrf2 pathway","volume":"43","author":"Huang","year":"2020","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.jep.2024.118733_bib12","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.jep.2024.118733_bib13","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.2147\/JIR.S371809","article-title":"Engeletin alleviates the inflammation and apoptosis in intervertebral disc degeneration via inhibiting the NF-kappaB and MAPK pathways","volume":"15","author":"Li","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2024.118733_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111886","article-title":"Sophoricoside improved Crohn's disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K\/AKT signaling","volume":"131","author":"Li","year":"2024","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.118733_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155651","article-title":"Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4\/MyD88\/NF-\u03baB pathway","volume":"129","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118733_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112664","article-title":"Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt\/mTOR\/HIF 1\u03b1 signaling pathway","volume":"224","author":"Liu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2024.118733_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110221","article-title":"Engeletin suppresses lung cancer progression by inducing apoptotic cell death through modulating the XIAP signaling pathway: a molecular mechanism involving ER stress","volume":"128","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118733_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105802","article-title":"Flavonoids from Smilax China L. Rhizome improve chronic pelvic inflammatory disease by promoting macrophage reprogramming via the NLRP3 inflammasome-autophagy pathway","volume":"109","author":"Ma","year":"2023","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2024.118733_bib42","first-page":"14","article-title":"Using AutoDock for ligand-receptor docking. Curr Protoc Bioinformatics Chapter 8","volume":"8","author":"Morris","year":"2008","journal-title":"Unit"},{"issue":"2","key":"10.1016\/j.jep.2024.118733_bib19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2014.04.050","article-title":"Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility","volume":"158","author":"Muller","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2024.118733_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1365-2249.2000.01183.x","article-title":"Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis","volume":"120","author":"Murano","year":"2000","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.jep.2024.118733_bib21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41575-020-0326-4","article-title":"Cell death in the gut epithelium and implications for chronic inflammation","volume":"17","author":"Patankar","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.jep.2024.118733_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2174\/1871530322666220520162251","article-title":"Medicinal importance, pharmacological activities, and analytical aspects of engeletin in medicine: therapeutic benefit through scientific data analysis","volume":"23","author":"Patel","year":"2023","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"issue":"1","key":"10.1016\/j.jep.2024.118733_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13062-020-00280-5","article-title":"Pathophysiology of Crohn's disease inflammation and recurrence","volume":"15","author":"Petagna","year":"2020","journal-title":"Biol. Direct"},{"key":"10.1016\/j.jep.2024.118733_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118671","article-title":"Mesua assamica (King & Prain) kosterm. bark ethanolic extract attenuates rheumatoid arthritis via down-regulating TLR4\/NF-kappaB\/COX-2\/iNOS and activation of Nrf2\/HO-1 pathways: a comprehensive study on in-vitro and in-vivo models","volume":"335","author":"Puppala","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118733_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn's disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"1","key":"10.1016\/j.jep.2024.118733_bib26","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1038\/ctg.2015.63","article-title":"Loss of response to anti-TNFs: definition, epidemiology, and management","volume":"7","author":"Roda","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"4","key":"10.1016\/j.jep.2024.118733_bib27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/gut.42.4.477","article-title":"Activation of nuclear factor kappa B inflammatory bowel disease","volume":"42","author":"Schreiber","year":"1998","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jep.2024.118733_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/mi.2010.66","article-title":"Intestinal macrophages and response to microbial encroachment","volume":"4","author":"Smith","year":"2011","journal-title":"Mucosal Immunol."},{"issue":"3","key":"10.1016\/j.jep.2024.118733_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jphs.2019.06.011","article-title":"Engeletin inhibits Lipopolysaccharide\/d-galactosamine-induced liver injury in mice through activating PPAR-gamma","volume":"140","author":"Tian","year":"2019","journal-title":"J. Pharmacol. Sci."},{"issue":"10080","key":"10.1016\/j.jep.2024.118733_bib30","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn's disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"issue":"42","key":"10.1016\/j.jep.2024.118733_bib31","doi-asserted-by":"crossref","first-page":"11747","DOI":"10.1021\/acs.jafc.0c05102","article-title":"Aldose reductase inhibitor engeletin suppresses pelvic inflammatory disease by blocking the phospholipase C\/protein kinase C-dependent\/NF-kappaB and MAPK cascades","volume":"68","author":"Wang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2024.118733_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2147\/JIR.S297166","article-title":"Engeletin protects against TNF-alpha-induced apoptosis and reactive oxygen species generation in chondrocytes and alleviates osteoarthritis in vivo","volume":"14","author":"Wang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2024.118733_bib33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.intimp.2019.02.050","article-title":"M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds","volume":"70","author":"Wang","year":"2019","journal-title":"Int. Immunopharm."},{"issue":"4","key":"10.1016\/j.jep.2024.118733_bib34","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ajpath.2019.12.006","article-title":"Intercellular adhesion molecule 1 functions as an efferocytosis receptor in inflammatory macrophages","volume":"190","author":"Wiesolek","year":"2020","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.jep.2024.118733_bib35","doi-asserted-by":"crossref","first-page":"e4680","DOI":"10.1002\/bmc.4680","article-title":"Simultaneous ultra-performance liquid chromatography-tandem mass spectrometry determination of six components in rat plasma after oral administration of Smilacis glabrae Roxb. extract","volume":"33","author":"Xie","year":"2019","journal-title":"Biomed. Chromatogr."},{"issue":"12","key":"10.1016\/j.jep.2024.118733_bib36","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/jcmm.17758","article-title":"Engeletin alleviates cerebral ischemia reperfusion-induced neuroinflammation via the HMGB1\/TLR4\/NF-\u03baB network","volume":"27","author":"Xu","year":"2023","journal-title":"J. Cell Mol. Med."},{"issue":"23","key":"10.1016\/j.jep.2024.118733_bib37","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1111\/jcmm.17975","article-title":"Engeletin alleviates depression-like phenotype by increasing synaptic plasticity via the BDNF-TrkB-mTORC1 signalling pathway","volume":"27","author":"Xu","year":"2023","journal-title":"J. Cell Mol. Med."},{"issue":"8","key":"10.1016\/j.jep.2024.118733_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18285","article-title":"Engeletin alleviates depressive-like behaviours by modulating microglial polarization via the LCN2\/CXCL10 signalling pathway","volume":"28","author":"Zhang","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2024.118733_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117874","article-title":"Shaoyao decoction improves damp-heat colitis by activating the AHR\/IL-22\/STAT3 pathway through tryptophan metabolism driven by gut microbiota","volume":"326","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118733_bib40","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.2147\/DDDT.S437703","article-title":"A review on the pharmacological aspects of engeletin as natural compound","volume":"17","author":"Zhong","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2024.118733_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jep.2017.02.034","article-title":"Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-kappaB pathway","volume":"202","author":"Zou","year":"2017","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124010328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124010328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T08:52:17Z","timestamp":1725958337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124010328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"alternative-id":["S0378874124010328"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118733","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engeletin attenuates the inflammatory response via inhibiting TLR4-NF\u03baB signaling pathway in Crohn's disease-like colitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118733","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118733"}}