{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:30:38Z","timestamp":1793017838800,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118761","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T16:44:18Z","timestamp":1725036258000},"page":"118761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"P1","title":["Eriodictyol regulates white adipose tissue browning and hepatic lipid metabolism in high fat diet-induced obesity mice via activating AMPK\/SIRT1 pathway"],"prefix":"10.1016","volume":"337","author":[{"given":"Song-Xia","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Kui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-2147","authenticated-orcid":false,"given":"Chun-Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118761_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111315","article-title":"Adipose tissue and insulin resistance in obese","volume":"137","author":"Ahmed","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118761_bib2","article-title":"Role of the AMPK\/SIRT1 pathway in non-alcoholic fatty liver disease","volume":"27","author":"Anggreini","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2024.118761_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154735","article-title":"Plant compounds for obesity treatment through neuroendocrine regulation of hunger: a systematic review","volume":"113","author":"Boix-Castejon","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118761_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.plipres.2011.11.003","article-title":"Re-evaluating lipotoxic triggers in skeletal muscle: relating intramyocellular lipid metabolism to insulin sensitivity","volume":"51","author":"Bosma","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jep.2024.118761_bib5","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00424-020-02417-x","article-title":"Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease","volume":"472","author":"Chadt","year":"2020","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.jep.2024.118761_bib6","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1080\/10408398.2021.1917508","article-title":"Absorption, metabolism and bioavailability of flavonoids: a review","volume":"62","author":"Chen","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2024.118761_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26175377","article-title":"Plant flavonoids: chemical characteristics and biological activity","volume":"26","author":"Dias","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118761_bib8","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1039\/D2FO03781E","article-title":"Role of carotenoids in adipose tissue through the AMPK-mediated pathway","volume":"14","author":"Ferreira","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.118761_bib9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2024.118761_bib10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2337\/diabetes.54.2.322","article-title":"Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity","volume":"54","author":"Ishigaki","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2024.118761_bib11","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s12272-020-01243-0","article-title":"The pharmacological and biological roles of eriodictyol","volume":"43","author":"Islam","year":"2020","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2024.118761_bib12","doi-asserted-by":"crossref","first-page":"11840","DOI":"10.1039\/D2FO02790A","article-title":"Okra (Abelmoschus esculentus L. Moench) prevents obesity by reducing lipid accumulation and increasing white adipose browning in high-fat diet-fed mice","volume":"13","author":"Jin","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.118761_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2013.01.041","article-title":"The origins and drivers of insulin resistance","volume":"152","author":"Johnson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.118761_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2021.12.012","article-title":"Why does obesity cause diabetes?","volume":"34","author":"Klein","year":"2022","journal-title":"Cell Metabol."},{"key":"10.1016\/j.jep.2024.118761_bib15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.118761_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051227","article-title":"Dietary eriodictyol alleviates adiposity, hepatic steatosis, insulin resistance, and inflammation in diet-induced obese mice","volume":"20","author":"Kwon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118761_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1016004","article-title":"Chinese medicinal herbs as potential prodrugs for obesity","volume":"13","author":"Law","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118761_bib18","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.jhep.2023.01.024","article-title":"An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease","volume":"78","author":"Lee","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2024.118761_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jhepr.2019.02.004","article-title":"Macrophages in obesity and non -alcoholic fatty liver disease: crosstalk with metabolism","volume":"1","author":"Lefere","year":"2019","journal-title":"JHEP REPORTS"},{"key":"10.1016\/j.jep.2024.118761_bib20","article-title":"Evidence of flavonoids on disease prevention","volume":"12","author":"Li","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2024.118761_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.phymed.2021.153634","article-title":"Inhibitory effect of chloroform extracts from Citrus aurantium L. var. amara Engl. on fat accumulation","volume":"90","author":"Li","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118761_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2017.10.009","article-title":"AMPK: sensing glucose as well as cellular energy status","volume":"27","author":"Lin","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.jep.2024.118761_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117749","article-title":"Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice","volume":"324","author":"Lin","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118761_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2022.106175","article-title":"Natural bioactive constituents from herbs and nutraceuticals promote browning of white adipose tissue","volume":"178","author":"Ma","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118761_bib25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.physbeh.2013.07.009","article-title":"Biological mechanisms that promote weight regain following weight loss in obese humans","volume":"120","author":"Ochner","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jep.2024.118761_bib26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.celrep.2018.09.069","article-title":"Transforming growth factor-\u03b23 regulates adipocyte number in subcutaneous white adipose tissue","volume":"25","author":"Petrus","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2024.118761_bib27","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a long -standing partnership?","volume":"298","author":"Ruderman","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.jep.2024.118761_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.phrs.2019.104347","article-title":"Citrus aurantium L. var. amara Engl. inhibited lipid accumulation in 3T3-L1 cells and Caenorhabditis elegans and prevented obesity in high-fat diet-fed mice","volume":"147","author":"Shen","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118761_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1021\/acs.jafc.7b02244","article-title":"Various antioxidant effects were attributed to different components in the dried blossoms of Citrus aurantium L. var. amara Engl","volume":"65","author":"Shen","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2024.118761_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154012","article-title":"Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol","volume":"99","author":"Sohag","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118761_bib46","series-title":"Chinese Materia Medica","year":"1999"},{"key":"10.1016\/j.jep.2024.118761_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051122","article-title":"The role of ampk signaling in brown adipose tissue activation","volume":"10","author":"van der Vaart","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jep.2024.118761_bib32","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/ptr.7334","article-title":"Activation of PGC-1\u03b1 via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease","volume":"36","author":"Wang","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2024.118761_bib33","article-title":"Seabuckthorn reverses high-fat-diet-induced obesity and enhances fat browning via activation of AMPK\/SIRT1 pathway","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2024.118761_bib34","article-title":"PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118761_bib35","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4904","article-title":"Adipose tissue and age-dependent insulin resistance: new insights into WAT browning","volume":"47","author":"Wu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2024.118761_bib36","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/CIRCRESAHA.119.315896","article-title":"Metabolic inflammation and insulin resistance in obesity","volume":"126","author":"Wu","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2024.118761_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116955","article-title":"Ginsenoside Rg1, lights up the way for the potential prevention of Alzheimer's disease due to its therapeutic effects on the drug-controllable risk factors of Alzheimer's disease","volume":"318","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118761_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117251","article-title":"Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1\/PI3K\/AKT\/GLUT4 pathway","volume":"319","author":"Yang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118761_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.phrs.2018.03.017","article-title":"Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1\/AMPK signaling pathway","volume":"131","author":"Yao","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118761_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.650975","article-title":"Globin Digest Improves Visceral Adiposity through UCP1 upregulation in diet-induced obese zebrafish and mice","volume":"8","author":"Zang","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2024.118761_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155113","article-title":"Hydroxy-\u03b1-sanshool from the fruits of Zanthoxylum bungeanum Maxim. promotes browning of white fat by activating TRPV1 to induce PPAR-\u03b3 deacetylation","volume":"121","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118761_bib42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-023-01025-w","article-title":"Metabolic health and adiposity transitions and risks of type 2 diabetes and cardiovascular diseases: a systematic review and meta-analysis","volume":"15","author":"Zhang","year":"2023","journal-title":"Diabetol. Metab. Syndrome"},{"key":"10.1016\/j.jep.2024.118761_bib43","first-page":"1","article-title":"Flavonoids from Lophatherum gracile Brongn. ameliorate liver damages in high-fat diet and streptozotocin-induced diabetic mice by regulating PI3K\/AKT and NF-Kappa B pathways","author":"Zheng","year":"2023","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.jep.2024.118761_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/nu15204349","article-title":"Eriodictyol alleviated LPS\/D-GalN-induced acute liver injury by inhibiting oxidative stress and cell apoptosis via PI3K\/AKT signaling pathway","volume":"15","author":"Zheng","year":"2023","journal-title":"Nutrients"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124010602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124010602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T23:27:59Z","timestamp":1731281279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124010602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0378874124010602"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118761","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eriodictyol regulates white adipose tissue browning and hepatic lipid metabolism in high fat diet-induced obesity mice via activating AMPK\/SIRT1 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118761"}}