{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:51:04Z","timestamp":1794289864556,"version":"4.9.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074180"],"award-info":[{"award-number":["82074180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118825","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T17:45:25Z","timestamp":1726249525000},"page":"118825","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"P1","title":["Metabolic reprogramming and AMPK activation: Key players in the therapeutic effects of Cooling Blood and Detoxicating Formular on psoriasis"],"prefix":"10.1016","volume":"337","author":[{"given":"Yazhuo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huike","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoquan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-109X","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2024.118825_bib1","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1038\/s41467-022-32849-1","article-title":"Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells","volume":"13","author":"Adamik","year":"2022","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.jep.2024.118825_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1517\/14728222.2016.1086752","article-title":"The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders","volume":"20","author":"Antonioli","year":"2016","journal-title":"Expert Opin. Ther. Targets"},{"issue":"19","key":"10.1016\/j.jep.2024.118825_bib3","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.jep.2024.118825_bib4","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/jdv.14433","article-title":"The role of IL-23 and the IL-23\/T(H) 17 immune axis in the pathogenesis and treatment of psoriasis","volume":"31","author":"Girolomoni","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"10281","key":"10.1016\/j.jep.2024.118825_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2024.118825_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107680","article-title":"Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines","volume":"216","author":"Han","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.jep.2024.118825_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/JLB.3HI0220-130","article-title":"Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells","volume":"109","author":"Hurley","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.jep.2024.118825_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/1753-0407.12553","article-title":"Effect of AMP-activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population","volume":"10","author":"Li","year":"2018","journal-title":"J. Diabetes"},{"issue":"2","key":"10.1016\/j.jep.2024.118825_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12020310","article-title":"Ferroptosis activation contributes to the formation of skin lesions in psoriasis vulgaris","volume":"12","author":"Li","year":"2023","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.jep.2024.118825_bib10","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1039\/D0FO00442A","article-title":"Fucoxanthin alleviates palmitate-induced inflammation in RAW 264.7 cells through improving lipid metabolism and attenuating mitochondrial dysfunction","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.118825_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cyto.2019.02.018","article-title":"IL-23 and dendritic cells: what are the roles of their mutual attachment in immune response and immunotherapy?","volume":"120","author":"Li","year":"2019","journal-title":"Cytokine"},{"issue":"39","key":"10.1016\/j.jep.2024.118825_bib12","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302878120","article-title":"CPT1A-mediated fatty acid oxidation confers cancer cell resistance to immune-mediated cytolytic killing","volume":"120","author":"Liu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2024.118825_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13020-018-0174-0","article-title":"Psoriasis therapy by Chinese medicine and modern agents","volume":"13","author":"Meng","year":"2018","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118825_bib14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nri3771","article-title":"Dendritic cell metabolism","volume":"15","author":"Pearce","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2024.118825_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cmet.2019.10.004","article-title":"Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4(+) T cell metabolic rewiring","volume":"30","author":"Pucino","year":"2019","journal-title":"Cell Metabol."},{"issue":"16","key":"10.1016\/j.jep.2024.118825_bib16","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1111\/febs.13698","article-title":"AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours","volume":"283","author":"Ross","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.jep.2024.118825_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1201912","article-title":"Psoriasis immunometabolism: progress on metabolic biomarkers and targeted therapy","volume":"10","author":"Sarandi","year":"2023","journal-title":"Front. Mol. Biosci."},{"issue":"11","key":"10.1016\/j.jep.2024.118825_bib18","first-page":"12626","article-title":"The roles of AMPK-mediated autophagy and mitochondrial autophagy in a mouse model of imiquimod-induced psoriasis","volume":"13","author":"Shen","year":"2021","journal-title":"Am J. Transl. Res."},{"issue":"11","key":"10.1016\/j.jep.2024.118825_bib19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41419-021-04284-5","article-title":"Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation","volume":"12","author":"Shou","year":"2021","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.jep.2024.118825_bib20","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/jmg.2006.041988","article-title":"AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women","volume":"43","author":"Spencer-Jones","year":"2006","journal-title":"J. Med. Genet."},{"issue":"2","key":"10.1016\/j.jep.2024.118825_bib21","first-page":"296","article-title":"Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study","volume":"40","author":"Sun","year":"2020","journal-title":"J. Traditional Chinese Med. = Chung i tsa chih ying wen pan"},{"issue":"5","key":"10.1016\/j.jep.2024.118825_bib22","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1172\/JCI123839","article-title":"miR-142 controls metabolic reprogramming that regulates dendritic cell activation","volume":"129","author":"Sun","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jep.2024.118825_bib23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/1346-8138.15184","article-title":"Dendritic cells: the driver of psoriasis","volume":"47","author":"Wang","year":"2020","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jep.2024.118825_bib24","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.2147\/JIR.S416417","article-title":"Resveratrol ameliorates imiquimod-induced psoriasis-like mouse model via reducing macrophage infiltration and inhibiting glycolysis","volume":"16","author":"Wang","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2024.118825_bib25","article-title":"Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118825_bib26","article-title":"Adenosine 5'monophosphate-activated protein kinase activation reduces the risks of psoriasis and its comorbidities: a mendelian randomisation study in the UK Biobank","author":"Xiao","year":"2023","journal-title":"Rheumatology"},{"key":"10.1016\/j.jep.2024.118825_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116807","article-title":"Liangxue Jiedu formula improves imiquimod-induced psoriasiform dermatitis with circadian desynchrony by regulating Th17 cell differentiation based on network pharmacological analysis","volume":"317","author":"Xie","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118825_bib28","first-page":"2341","article-title":"Cooling blood detoxification decoction and nursing countermeasures in the treatment of acute psoriasis from the perspective of immune function and inflammatory factors","volume":"34","author":"Xing","year":"2021","journal-title":"Pak. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.jep.2024.118825_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106791","article-title":"Loss of AMPKalpha2 promotes melanoma tumor growth and brain metastasis","volume":"26","author":"Yuan","year":"2023","journal-title":"iScience"},{"issue":"10","key":"10.1016\/j.jep.2024.118825_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12100946","article-title":"Sinomenine ameliorates colitis-associated cancer by modulating lipid metabolism via enhancing CPT1A expression","volume":"12","author":"Zhang","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.jep.2024.118825_bib31","article-title":"Systems pharmacology approach and experiment evaluation reveal multidimensional treatment strategy of LiangXueJieDu formula for psoriasis","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T23:29:34Z","timestamp":1731281374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124011243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":31,"alternative-id":["S0378874124011243"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118825","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic reprogramming and AMPK activation: Key players in the therapeutic effects of Cooling Blood and Detoxicating Formular on psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118825","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118825"}}