{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:44:00Z","timestamp":1786992240571,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"am","delay-in-days":265,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005839","name":"Garden Club of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["1F31 AT011471-01A1"],"award-info":[{"award-number":["1F31 AT011471-01A1"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118830","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T20:48:31Z","timestamp":1726174111000},"page":"118830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P1","title":["Caribbean medicinal plant Argemone mexicana L.: Metabolomic analysis and in vitro effect on the vaginal microbiota"],"prefix":"10.1016","volume":"337","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4960-0723","authenticated-orcid":false,"given":"Ella T.","family":"Vardeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Vandebroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1682-2696","authenticated-orcid":false,"given":"Edward J.","family":"Kennelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118830_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fmed.2018.00181","article-title":"The vaginal microenvironment: the physiologic role of lactobacilli","volume":"5","author":"Amabebe","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2024.118830_bib2","first-page":"967","article-title":"Influence of habitat characteristics and altitude on berberine content in Berberis jaeschkeana CK Schneid","volume":"89","author":"Andola","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jep.2024.118830_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/B978-0-12-819489-8.00016-8","article-title":"Antibacterial and antifungal activities of isoquinoline alkaloids of the Papaveraceae and Fumariaceae families and their implications in structure\u2013activity relationships","volume":"70","author":"Avci","year":"2021","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.jep.2024.118830_bib4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF02864786","article-title":"Medicinal plants used by Latino healers for women's health conditions in New York City","volume":"54","author":"Balick","year":"2000","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2024.118830_bib5","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/s41396-018-0337-0","article-title":"Unveiling the role of Gardnerella vaginalis in polymicrobial bacterial vaginosis biofilms: the impact of other vaginal pathogens living as neighbors","volume":"13","author":"Castro","year":"2019","journal-title":"ISME J."},{"key":"10.1016\/j.jep.2024.118830_bib6","first-page":"219","article-title":"Natural antimicrobials and their role in vaginal health: a short review","volume":"3","author":"Dover","year":"2008","journal-title":"Int. J. Probiotics Prebiotics"},{"key":"10.1016\/j.jep.2024.118830_bib7","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1055\/s-0030-1250606","article-title":"Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition","volume":"77","author":"Ettefagh","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2024.118830_bib8","doi-asserted-by":"crossref","first-page":"28997","DOI":"10.1074\/jbc.M113.488585","article-title":"Dioxygenases catalyze O-demethylation and O, O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy","volume":"288","author":"Farrow","year":"2013","journal-title":"JBC"},{"key":"10.1016\/j.jep.2024.118830_bib9","first-page":"49","article-title":"Western herbal remedies for urinary tract infections","volume":"4","author":"Gatea Kaabi","year":"2020","journal-title":"Arch. Urol. Res"},{"key":"10.1016\/j.jep.2024.118830_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2019.111480","article-title":"GC\u2013MS, UPLC-QTOF-MS, and bioactivity characterization of Acer truncatum seeds","volume":"138","author":"Gu","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.jep.2024.118830_bib11","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1099\/jmm.0.001542","article-title":"Antifungal activity and potential mechanism of berberine hydrochloride against fluconazole-resistant Candida albicans","volume":"71","author":"Huang","year":"2022","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.jep.2024.118830_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1746-4269-9-61","article-title":"A comparison of traditional food and health strategies among Taiwanese and Chinese immigrants in Atlanta, Georgia, USA","volume":"9","author":"Jiang","year":"2013","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"10.1016\/j.jep.2024.118830_bib13","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jksus.2018.05.009","article-title":"Analysis of medicinally important phytocompounds from Argemone mexicana","volume":"31","author":"Khan","year":"2019","journal-title":"J. King Saud Univ. Sci."},{"key":"10.1016\/j.jep.2024.118830_bib14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.chroma.2014.08.049","article-title":"Merging bioactivity with liquid chromatography-mass spectrometry-based chemometrics to identify minor immunomodulatory compounds from a Micronesian adaptogen, Phaleria nisidai","volume":"1364","author":"Kulakowski","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2024.118830_bib15","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejphar.2015.05.068","article-title":"Current knowledge and pharmacological profile of berberine: an update","volume":"761","author":"Kumar","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.118830_bib16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.5740\/jaoacint.12-328","article-title":"Simultaneous determination of matrine and berberine in fruits, vegetables, and soil using ultra-performance liquid chromatography\/tandem mass spectrometry","volume":"97","author":"Liu","year":"2014","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jep.2024.118830_bib17","first-page":"2122","article-title":"Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis","volume":"18","author":"Ma","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2024.118830_bib18","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3389\/fmicb.2015.01528","article-title":"Bacterial vaginosis biofilms: challenges to current therapies and emerging solutions","volume":"6","author":"Machado","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2024.118830_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2217\/fmb-2016-0184","article-title":"Thymbra capitata essential oil as potential therapeutic agent against Gardnerella vaginalis biofilm-related infections","volume":"12","author":"Machado","year":"2017","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jep.2024.118830_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mimet.2015.09.007","article-title":"Optimization of culture conditions for Gardnerella vaginalis biofilm formation","volume":"118","author":"Machado","year":"2015","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.jep.2024.118830_bib21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1039\/C8FO01910J","article-title":"Calluna vulgaris (L.) Hull: chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota","volume":"10","author":"Mandim","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.118830_bib22","first-page":"QC04","article-title":"Comparison of the effects of Myrtus communis L, Berberis vulgaris and metronidazole vaginal gel alone for the treatment of bacterial vaginosis","volume":"10","author":"Masoudi","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.jep.2024.118830_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105606","article-title":"Vaginosis: advances in new therapeutic development and microbiome restoration","volume":"168","author":"Mohankumar","year":"2022","journal-title":"Microb. Pathog."},{"issue":"4","key":"10.1016\/j.jep.2024.118830_bib24","first-page":"358","article-title":"Berberine and sanguinarine quantitation in Argemone mexicana L.(Papaveraceae) tissues by TLC-in situ fluorography","volume":"25","author":"Monforte-Gonz\u00e1lez","year":"2012","journal-title":"JPC"},{"key":"10.1016\/j.jep.2024.118830_bib25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.18388\/abp.2017_1621","article-title":"Berberine from Argemone mexicana L. exhibits a broadspectrum antibacterial activity","volume":"64","author":"More","year":"2017","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.jep.2024.118830_bib26","doi-asserted-by":"crossref","first-page":"931","DOI":"10.31925\/farmacia.2019.6.1","article-title":"Herbal medicines against bacterial vaginosis in women of reproductive age: a systematic review","volume":"67","author":"Najafi","year":"2019","journal-title":"FARMACIA"},{"key":"10.1016\/j.jep.2024.118830_bib27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fphar.2018.00557","article-title":"Berberine: botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders","volume":"9","author":"Neag","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118830_bib28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41592-020-0933-6","article-title":"Feature-based molecular networking in the GNPS analysis environment","volume":"17","author":"Nothias","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jep.2024.118830_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136486","article-title":"Castanea sativa (European Chestnut) leaf extracts rich in ursene and oleanene derivatives block Staphylococcus aureus virulence and pathogenesis without detectable resistance","volume":"10","author":"Quave","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118830_bib30","first-page":"569","article-title":"Berberis vulgaris: specifications and traditional uses. Iran J","volume":"20","author":"Rahimi-Madiseh","year":"2017","journal-title":"Basic Med. Sci."},{"key":"10.1016\/j.jep.2024.118830_bib31","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.2174\/15680266113139990152","article-title":"Pharmaceutical applications of the benzylisoquinoline alkaloids from Argemone mexicana L","volume":"13","author":"Rubio-Pi\u00f1a","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jep.2024.118830_bib32","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1353\/hpu.2017.0102","article-title":"Vaginal infections in Haitian immigrant women living in Miami, Florida","volume":"28","author":"Seay","year":"2017","journal-title":"J. Health Care Poor Underserved"},{"issue":"11","key":"10.1016\/j.jep.2024.118830_bib33","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jep.2024.118830_bib34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/14786419.2010.529809","article-title":"Alkaloids and flavonoids of Argemone mexicana","volume":"26","author":"Singh","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2024.118830_bib35","series-title":"Ethnopharmacology","first-page":"199","article-title":"Gynaecological, andrological and urological problems: an ethnopharmacological perspective","author":"van Andel","year":"2015"},{"key":"10.1016\/j.jep.2024.118830_bib36","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jep.2013.05.039","article-title":"Intercultural health and ethnobotany: how to improve healthcare for underserved and minority communities?","volume":"148","author":"Vandebroek","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118830_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12231-014-9268-5","article-title":"Lime for chest congestion, bitter orange for diabetes: foods as medicines in the Dominican community in New York City","volume":"68","author":"Vandebroek","year":"2014","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2024.118830_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037643","article-title":"Globalization and loss of plant knowledge: challenging the paradigm","volume":"7","author":"Vandebroek","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118830_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jep.2009.12.013","article-title":"The importance of botellas and other plant mixtures in Dominican traditional medicine","volume":"128","author":"Vandebroek","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118830_bib40","series-title":"Popular Medicinal Plants in Portland and Kingston","first-page":"45","article-title":"Argemone mexicana L. (Papaveraceae)","author":"Vandebroek","year":"2020"},{"key":"10.1016\/j.jep.2024.118830_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12231-021-09526-3","article-title":"Caribbean women's health and transnational ethnobotany","volume":"76","author":"Vardeman","year":"2022","journal-title":"Econ. Bot."},{"key":"10.1016\/j.jep.2024.118830_bib42","series-title":"CABI Compendium","article-title":"Argemone mexicana (Mexican poppy)","author":"V\u00e9lez-Gavil\u00e1n","year":"2024"},{"key":"10.1016\/j.jep.2024.118830_bib43","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.archoralbio.2010.11.021","article-title":"In vitro synergism between berberine and miconazole against planktonic and biofilm Candida cultures","volume":"56","author":"Wei","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jep.2024.118830_bib44","first-page":"92","article-title":"Multivariate analysis in metabolomics","volume":"1","author":"Worley","year":"2013","journal-title":"Curr. Metabolomics"},{"key":"10.1016\/j.jep.2024.118830_bib45","article-title":"Berberine inhibits the adhesion of Candida albicans to vaginal epithelial cells","volume":"511","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T18:29:52Z","timestamp":1731263392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124011292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0378874124011292"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118830","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caribbean medicinal plant Argemone mexicana L.: Metabolomic analysis and in vitro effect on the vaginal microbiota","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118830"}}