{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:56:46Z","timestamp":1792202206880,"version":"4.4.0"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118832","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T01:07:47Z","timestamp":1726794467000},"page":"118832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"P2","title":["An overview of the research progress on Aconitum carmichaelii Debx.:active compounds, pharmacology, toxicity, detoxification, and applications"],"prefix":"10.1016","volume":"337","author":[{"given":"Xv","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xipei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118832_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116009","article-title":"Detoxification mechanisms of ginseng to aconite: a review","volume":"304","author":"Bao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114604","article-title":"Comparative efficacy of five Chinese medicine injections for treating dilated cardiomyopathy with heart failure: a Bayesian network meta-analysis","volume":"282","author":"Cao","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2024.118832_bib3","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.3390\/toxins6092605","article-title":"Alkaloid poisoning related to the culinary uses of aconite roots","volume":"6","author":"Chan","year":"2014","journal-title":"Toxins"},{"issue":"39","key":"10.1016\/j.jep.2024.118832_bib4","doi-asserted-by":"crossref","first-page":"24129","DOI":"10.1039\/C7RA02869E","article-title":"Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum","volume":"7","author":"Chen","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2024.118832_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113831","article-title":"Changes to PUFA-PPAR pathway during mesaconitine induced myocardial coagulative necrosis","volume":"177","author":"Chen","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2024.118832_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154071","article-title":"Fuzi decoction ameliorates pain and cartilage degeneration of osteoarthritic rats through PI3K-Akt signaling pathway and its clinical retrospective evidence","volume":"100","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112581","article-title":"A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids","volume":"252","author":"Cong","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"13","key":"10.1016\/j.jep.2024.118832_bib8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1055\/a-1676-4371","article-title":"cis-Aconitic acid, a constituent of Echinodorus grandiflorus leaves, inhibits antigen-induced arthritis and gout in mice","volume":"88","author":"de Oliveira","year":"2022","journal-title":"Planta Med."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1371\/journal.pone.0249276","article-title":"Comparison of analgesic activities of aconitine in different mice pain models","volume":"16","author":"Deng","year":"2021","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib10","doi-asserted-by":"crossref","first-page":"510","DOI":"10.7150\/thno.80066","article-title":"Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin induced cardiomyopathy","volume":"13","author":"Ding","year":"2023","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/10286020.2018.1454436","article-title":"New dianthramide and cinnamic ester glucosides from the roots of Aconitum carmichaelii","volume":"21","author":"Do","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3390\/molecules18010757","article-title":"In vitro and in vivo anticancer activity of aconitine on melanoma cell line B16","volume":"18","author":"Du","year":"2013","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib13","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1111\/jcmm.14803","article-title":"Fuziline alleviates isoproterenol-induced myocardial injury by inhibiting ROS-triggered endoplasmic reticulum stress via PERK\/eIF2\u03b1\/ATF4\/Chop pathway","volume":"24","author":"Fan","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02167-5","article-title":"Revealing the efficacy-toxicity relationship of Fuzi in treating rheumatoid arthritis by systems pharmacology","volume":"11","author":"Feng","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118832_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139499","article-title":"Paotianxiong polysaccharides potential prebiotics: structural analysis and prebiotic properties","volume":"451","author":"Fu","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2024.118832_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113767","article-title":"Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition","volume":"155","author":"Fu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118832_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119655","article-title":"Polysaccharides from Aconitum carmichaelii leaves: structure, immunomodulatory and anti-inflammatory activities","volume":"291","author":"Fu","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib18","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/jsfa.12967","article-title":"Bioactive polysaccharides in different plant parts of Aconitum carmichaelii","volume":"104","author":"Fu","year":"2023","journal-title":"J. Sci. Food Agric."},{"issue":"5","key":"10.1016\/j.jep.2024.118832_bib19","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.3390\/molecules17055187","article-title":"Diterpenoid alkaloids from the Chinese traditional herbal \"fuzi\" and their cytotoxic activity","volume":"17","author":"Gao","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118832_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135629","article-title":"A comprehensive review on Ginger (Zingiber officinale) as a potential source of nutraceuticals for food formulations: towards the polishing of gingerol and other present biomolecules","volume":"413","author":"Garza-Cadena","year":"2023","journal-title":"Food Chem."},{"issue":"15","key":"10.1016\/j.jep.2024.118832_bib21","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.jacc.2018.02.021","article-title":"Myocardial interstitial fibrosis in heart failure biological and translational perspectives","volume":"71","author":"Gonz\u00e1lez","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.jep.2024.118832_bib22","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3736\/jcim20111012","article-title":"Inhibitory effects of osthole, psoralen and aconitine on invasive activities of breast cancer MDA-MB-231BO cell line and the mechanisms","volume":"9","author":"Guo","year":"2011","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"10.1016\/j.jep.2024.118832_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155809","article-title":"Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1\u03b2-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-\u03baB and MAPKs signaling pathways and inducing apoptosis","volume":"151","author":"Guo","year":"2022","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.jep.2024.118832_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.apsb.2018.03.009","article-title":"C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities","volume":"8","author":"Guo","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.jep.2024.118832_bib25","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1021\/acs.orglett.7b03956","article-title":"Aconicarmisulfonine A, a sulfonated C20-diterpenoid alkaloid from the lateral roots of Aconitum carmichaelii","volume":"20","author":"Guo","year":"2018","journal-title":"Org. Lett."},{"issue":"10","key":"10.1016\/j.jep.2024.118832_bib26","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.apsb.2020.01.013","article-title":"Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from","volume":"10","author":"Guo","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1371\/journal.pone.0086539","article-title":"Fuzi attenuates diabetic neuropathy in rats and protects Schwann cells from apoptosis induced by high glucose","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.118832_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116160","article-title":"Chemical constituents, pharmacological effects, toxicology, processing and compatibility of Fuzi (lateral root of Aconitum carmichaelii Debx): a review","volume":"307","author":"He","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2024.118832_bib29","first-page":"644","article-title":"Stems and leaves of Aconitum carmichaelii Debx. as potential herbal resources for treating rheumatoid arthritis: chemical analysis, toxicity and activity evaluation","volume":"16","author":"He","year":"2018","journal-title":"Chin. J. Nat. Med."},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib30","first-page":"575","article-title":"Analytically confirmed aconitine poisoning as a result of mistaking monkshood leaves for lovage","volume":"56","author":"Hermanns-Clausen","year":"2018","journal-title":"Clin. Toxicol."},{"issue":"9932","key":"10.1016\/j.jep.2024.118832_bib31","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2024.118832_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1151092","article-title":"The protective effect and antitumor activity of Aconiti Lateralis Radix Praeparata (Fuzi) polysaccharide on cyclophosphamide-induced immunosuppression in H22 tumor-bearing mice","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2024.118832_bib33","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.3390\/ijms19113506","article-title":"Study on cardiotoxicity and mechanism of \"fuzi\" extracts based on metabonomics","volume":"19","author":"Huang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118832_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-511X-9-9","article-title":"Polysaccharide from fuzi (FPS) prevents hypercholesterolemia in rats","volume":"9","author":"Huang","year":"2010","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jep.2024.118832_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.phytochem.2014.07.026","article-title":"Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-Q-TOF-MS and LC-MS\/MS techniques","volume":"107","author":"Jaiswal","year":"2014","journal-title":"Phytochemistry"},{"issue":"23","key":"10.1016\/j.jep.2024.118832_bib36","first-page":"4955","article-title":"Aconitine induces cell apoptosis in human pancreatic cancer via NF-\u03baB signaling pathway","volume":"20","author":"Ji","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11060353","article-title":"Tissue accumulations of toxic Aconitum alkaloids after short-term and long-term oral administrations of clinically used radix aconiti lateralis preparations in rats","volume":"11","author":"Ji","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.jep.2024.118832_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115801","article-title":"Safety evaluations of the processed lateral root of Aconitum carmichaelii Debx. and its hepatotoxicity mechanisms in rats","volume":"301","author":"Ji","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib39","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/np300225t","article-title":"Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii","volume":"75","author":"Jiang","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2024.118832_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114284","article-title":"Aconitine-A promising candidate for treating cold and mechanical allodynia in cancer induced bone pain","volume":"161","author":"Jin","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118832_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154425","article-title":"Ginseng total saponins and Fuzi total alkaloids exert antidepressant-like effects in ovariectomized mice through BDNF-mTORC1, autophagy and peripheral metabolic pathways","volume":"107","author":"Jin","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101659","article-title":"SERCA overexpression reduces reperfusion-mediated cardiac microvascular damage through inhibition of the calcium\/MCU\/mPTP\/necroptosis signaling pathways","volume":"36","author":"Li","year":"2020","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib43","first-page":"155","article-title":"Carmichaeline A: a new C20-diterpenoid alkaloid from Aconitum carmichaelii","volume":"8","author":"Li","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2024.118832_bib44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fphar.2016.00367","article-title":"Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: involvement of spinal microglial dynorphin expression and implications for Aconitum processing","volume":"7","author":"Li","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115879","article-title":"Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: in vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations","volume":"303","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154907","article-title":"Diversity-oriented synthesis of diterpenoid alkaloids yields a potent anti-inflammatory agent","volume":"117","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101771","article-title":"Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis","volume":"38","author":"Li","year":"2021","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.jep.2024.118832_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201800147","article-title":"Four new diterpenoid alkaloids from the roots of Aconitum carmichaelii","volume":"15","author":"Li","year":"2018","journal-title":"Chem. Biodivers."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib49","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/pca.2760","article-title":"Qualitative and quantitative analysis of lipo-alkaloids and fatty acids in Aconitum carmichaelii using LC-MS and GC-MS","volume":"29","author":"Liang","year":"2018","journal-title":"Phytochem. Anal."},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1142\/S0192415X13500262","article-title":"Polysaccharide from fuzi likely protects against starvation-induced cytotoxicity in H9c2 cells by increasing autophagy through activation of the AMPK\/mTOR pathway","volume":"41","author":"Liao","year":"2013","journal-title":"Am. J. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib51","first-page":"5109","article-title":"Polysaccharide from Fuzi protects against Ox-LDL-induced calcification of human vascular smooth muscle cells by increasing autophagic activity","volume":"17","author":"Liao","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib52","first-page":"324","article-title":"Monoester-type C19-diterpenoid alkaloids from Aconitum carmichaelii and their cardiotoxicity","volume":"16","author":"Lin","year":"2022","journal-title":"Record Nat. Prod."},{"issue":"9","key":"10.1016\/j.jep.2024.118832_bib53","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1590\/S0100-40422013000900015","article-title":"Preparative separation of C19-diterpenoid alkaloids from Aconitum carmichaelii Debx by pH-zone-refining counter current chromatography","volume":"36","author":"Liu","year":"2013","journal-title":"Quim. Nova"},{"issue":"7","key":"10.1016\/j.jep.2024.118832_bib54","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/10286020.2021.1931141","article-title":"Denudatine-type diterpenoid alkaloids from an aqueous extract of the lateral root of Aconitum carmichaelii","volume":"23","author":"Liu","year":"2021","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1254\/jphs.12163FP","article-title":"Antidepressant-like effect of fuzi total alkaloid on ovariectomized mice","volume":"120","author":"Liu","year":"2012","journal-title":"J. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib56","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1248\/cpb.60.144","article-title":"Cardioactive C19-diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii \u201cfu zi\u201d","volume":"60","author":"Liu","year":"2012","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.jep.2024.118832_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104699","article-title":"Synthesis and structure-activity relationship of lipo-diterpenoid alkaloids with potential target of topoisomerase II\u03b1 for breast cancer treatment","volume":"109","author":"Luan","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.jep.2024.118832_bib58","first-page":"980","article-title":"Comprehensive quality evaluation of the lateral root of Aconitum carmichaelii Debx. (Fuzi): simultaneous determination of nine alkaloids and chemical fingerprinting coupled with chemometric analysis","volume":"42","author":"Luo","year":"2019","journal-title":"J. Separ. Sci."},{"issue":"10","key":"10.1016\/j.jep.2024.118832_bib59","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/s41401-020-00587-z","article-title":"6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway","volume":"42","author":"Ma","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.jep.2024.118832_bib60","first-page":"884","article-title":"Effects of the ephedra, aconite and asarum decoction to the cardiac function of bradyarrhythmia rats","volume":"29","author":"Ma","year":"2014","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"8","key":"10.1016\/j.jep.2024.118832_bib61","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.cclet.2017.04.026","article-title":"Unprecedented C19-diterpenoid alkaloid glycosides from an aqueous extract of \u201cfuzi\u201d: neoline 14-O-L-arabinosides with four isomeric L-anabinosyls","volume":"28","author":"Meng","year":"2017","journal-title":"Chin. Chem. Lett."},{"issue":"7","key":"10.1016\/j.jep.2024.118832_bib62","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cclet.2016.05.013","article-title":"Napelline-type C20-diterpenoid alkaloid iminiums from an aqueous extract of \u2018\u2018fu zi\u2019\u2019: solvent-\/base-\/acid-dependent transformation and equilibration between alcohol iminium and aza acetal form","volume":"27","author":"Meng","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jep.2024.118832_bib63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jpba.2017.01.003","article-title":"Assessment of cardiotoxicity of extract fractions and diterpene alkaloids from Worosch: a short communication","volume":"137","author":"Nie","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jphp.12310","article-title":"A review on phytochemistry, pharmacology and toxicology studies of","volume":"67","author":"Nyirimigabo","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib65","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.etap.2016.01.012","article-title":"Aconitum carmichaelii protects against acetaminophen-induced hepatotoxicity via B-cell lymphoma-2 protein-mediated inhibition of mitochondrial dysfunction","volume":"42","author":"Park","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2024.118832_bib66","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s12272-009-2105-1","article-title":"Study of neurotoxic effects and underlying mechanisms of aconitine on cerebral cortex neuron cells","volume":"32","author":"Peng","year":"2009","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12701","article-title":"Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNF\u03b1-NLRP3 signalling axis","volume":"53","author":"Peng","year":"2020","journal-title":"Cell Prolif."},{"issue":"11","key":"10.1016\/j.jep.2024.118832_bib68","first-page":"5278","article-title":"Aconitine inhibits the proliferation of hepatocellular carcinoma by inducing apoptosis","volume":"11","author":"Qi","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2024.118832_bib69","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.phytol.2015.07.017","article-title":"Five new C19-diterpenoid alkaloids from Aconitum carmichaelii","volume":"13","author":"Qin","year":"2015","journal-title":"Phytochem. Lett."},{"issue":"35","key":"10.1016\/j.jep.2024.118832_bib70","doi-asserted-by":"crossref","first-page":"21259","DOI":"10.1039\/D1RA03628A","article-title":"Study on extraction methods of polysaccharides from a processed product of Aconitum carmichaelii Debx","volume":"11","author":"Qiu","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2024.118832_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154059","article-title":"Discovery of the directionally detoxification effect and chemical mechanism of Ginseng-Fuzi co-decoction based on real-time online filtration electrospray ionization mass spectrometry","volume":"100","author":"Qiu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib72","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jep.2016.07.017","article-title":"Mahuang-Xixin-Fuzi decoction reduces the infection of influenza A virus in Kidney-Yang deficiency syndrome mice","volume":"192","author":"Rong","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib73","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12974-019-1696-9","article-title":"Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK\/CREB signaling pathway-mediated microglial dynorphin A expression","volume":"17","author":"Shao","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib74","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1039\/D0NP00002G","article-title":"Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids","volume":"37","author":"Shen","year":"2020","journal-title":"Nat. Prod. Rep."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib75","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/hlca.201000152","article-title":"Two new C20-diterpenoid alkaloids from Aconitum carmichaelii","volume":"94","author":"Shen","year":"2011","journal-title":"Helv. Chim. Acta"},{"issue":"8","key":"10.1016\/j.jep.2024.118832_bib76","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1248\/cpb.51.999","article-title":"Norditerpenoid alkaloids from the processed tubers of Aconitum carmichaelii","volume":"51","author":"Shim","year":"2003","journal-title":"Chem. Pharmaceut. Bull."},{"issue":"11","key":"10.1016\/j.jep.2024.118832_bib77","first-page":"866","article-title":"Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum","volume":"16","author":"Shu","year":"2018","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2014.05.005","article-title":"Aconitine-induced Ca2 + overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats","volume":"279","author":"Sun","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118832_bib79","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/pca.2407","article-title":"UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach","volume":"24","author":"Sun","year":"2013","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jep.2024.118832_bib80","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ijbiomac.2020.04.140","article-title":"In vitro and in vivo evaluation of the influences of polysaccharides derived from Glycyrrhiza uralensis on three alkaloids and potential interaction mechanisms","volume":"157","author":"Sun","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2024.118832_bib81","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jep.2016.03.056","article-title":"Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain","volume":"186","author":"Suzuki","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01134","article-title":"A correlation between intestinal microbiota dysbiosis and osteoarthritis","volume":"5","author":"Szychlinska","year":"2019","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.jep.2024.118832_bib83","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1039\/C4MB00072B","article-title":"Serum metabolomics reveals betaine and phosphatidylcholine as potential biomarkers for the toxic responses of processed Aconitum carmichaelii Debx","volume":"10","author":"Tan","year":"2014","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.jep.2024.118832_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154641","article-title":"Efficacy and safety of Shenfu injection on acute heart failure: a systematic review and meta-analysis","volume":"110","author":"Tao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1002774","article-title":"Preparation, structural characterization, antioxidant activity and protection against cisplatin-induced acute kidney injury by polysaccharides from the lateral root of Aconitum carmichaelii","volume":"13","author":"Tian","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118832_bib86","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jep.2013.11.048","article-title":"Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaelii Debx against severe-stage osteoarthritis model induced by mono-iodoacetate","volume":"151","author":"Tong","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2024.118832_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18244","article-title":"Fuzi polysaccharides improve immunity in immunosuppressed mouse models by regulating gut microbiota composition","volume":"9","author":"Tu","year":"2023","journal-title":"Heliyon"},{"issue":"11","key":"10.1016\/j.jep.2024.118832_bib88","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3390\/molecules21111496","article-title":"Sugar composition analysis of fuzi polysaccharides by HPLC-MSn and their protective effects on Schwann cells exposed to high glucose","volume":"21","author":"Wang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118832_bib89","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12967-015-0636-4","article-title":"Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund's Adjuvant-induced mice: roles of dynorpin\/kappa-opioid system and transient receptor potential vanilloid type-1 ion channel","volume":"13","author":"Wang","year":"2015","journal-title":"J. Transl. Med."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib90","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1039\/b916679c","article-title":"Diterpenoid alkaloids","volume":"27","author":"Wang","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jep.2024.118832_bib91","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.rvsc.2022.01.001","article-title":"Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line","volume":"143","author":"Wang","year":"2022","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jep.2024.118832_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115838","article-title":"Ethnopharmacological use, pharmacology, toxicology, phytochemistry, and progress in Chinese crude drug processing of the lateral root of Aconitum carmichaelii Debeaux. (Fuzi): a review","volume":"301","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153468","article-title":"Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis","volume":"83","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"issue":"40","key":"10.1016\/j.jep.2024.118832_bib94","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.3748\/wjg.v27.i40.6888","article-title":"Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats","volume":"27","author":"Wang","year":"2021","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib95","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41401-020-0467-6","article-title":"Inhibition of the INa\/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in Guinea pigs","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib96","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1021\/pr200963e","volume":"11","author":"Wang","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jep.2024.118832_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104822","article-title":"Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii","volume":"149","author":"Wang","year":"2021","journal-title":"Fitoterapia"},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib98","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jchromb.2006.07.059","article-title":"Characterization of metabolites and cytochrome P450 isoforms involved in the microsomal metabolism of aconitine","volume":"844","author":"Wang","year":"2006","journal-title":"J. Chromatogr. B"},{"issue":"2","key":"10.1016\/j.jep.2024.118832_bib99","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/jphp.13191","article-title":"Therapeutic effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats based on an integrated approach","volume":"72","author":"Wen","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111880","article-title":"Cardioprotective effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats and potential mechanisms","volume":"238","author":"Wen","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"19","key":"10.1016\/j.jep.2024.118832_bib101","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/ijms20194837","article-title":"Anti-myocardial infarction effects of radix aconiti lateralis preparata extracts and their influence on small molecules in the heart using matrix-assisted laser desorption\/ionization-mass spectrometry imaging","volume":"20","author":"Wu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.118832_bib102","article-title":"Coadministration of pinellia ternata can significantly reduce Aconitum carmichaelii to inhibit CYP3A activity in rats. Evid.-based complement","volume":"2014","author":"Wu","year":"2014","journal-title":"Altern. Med."},{"issue":"17","key":"10.1016\/j.jep.2024.118832_bib103","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1021\/acs.orglett.9b02479","article-title":"Aconicatisulfonines A and B, analgesic zwitterionic C(20)-diterpenoid alkaloids with a rearranged atisane skeleton from Aconitum carmichaelii","volume":"21","author":"Wu","year":"2019","journal-title":"Org. Lett."},{"key":"10.1016\/j.jep.2024.118832_bib104","article-title":"Aconiti lateralis radix praeparata total alkaloids exert anti-RA effects by regulating NF-\u03baB and JAK\/STAT signaling pathways and promoting apoptosis","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1172939","article-title":"Antitumor effects and potential mechanisms of aconitine based on preclinical studies: an updated systematic review and meta-analysis","volume":"14","author":"Xiang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib106","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/ijms24065838","article-title":"Aconitum carmichaelii Debx. Attenuates heart failure through inhibiting inflammation and abnormal vascular remodeling","volume":"24","author":"Xing","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.jep.2024.118832_bib107","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.3390\/molecules17089939","article-title":"Alkaloids isolated from the lateral root of Aconitum carmichaelii","volume":"17","author":"Xiong","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118832_bib108","article-title":"Shenfu injection: a review of pharmacological effects on cardiovascular diseases","volume":"15","author":"Xu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115989","article-title":"Compositions analysis and insecticidal activity of Aconitum polycarpum Chang ex W.T.Wang petroleum ether fractions and essential oils","volume":"303","author":"Xu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111184","article-title":"Water-soluble alkaloids extracted from Aconiti Radix lateralis praeparata protect against chronic heart failure in rats via a calcium signaling pathway","volume":"135","author":"Xu","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.jep.2024.118832_bib111","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1017\/S1461145709990733","article-title":"Fuzi polysaccharide-1 produces antidepressant-like effects in mice","volume":"13","author":"Yan","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib112","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5270508","article-title":"Crude radix aconiti lateralis preparata (fuzi) with Glycyrrhiza reduces inflammation and ventricular remodeling in mice through the TLR4\/NF-kappaB pathway","volume":"2020","author":"Yan","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2024.118832_bib113","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6640184","article-title":"Pharmacokinetics of 10-hydroxy mesaconitine in rat plasma by ultra-performance liquid chromatography-tandem quadrupole mass spectrometry","volume":"2021","author":"Yang","year":"2021","journal-title":"J. Anal. Methods Chem."},{"key":"10.1016\/j.jep.2024.118832_bib114","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.toxlet.2021.04.020","article-title":"Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells","volume":"347","author":"Yang","year":"2021","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.jep.2024.118832_bib115","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/toxins10100391","article-title":"Relationships between the toxicities of radix aconiti lateralis preparata (fuzi) and the toxicokinetics of its main diester-diterpenoid alkaloids","volume":"10","author":"Yang","year":"2018","journal-title":"Toxins"},{"issue":"7","key":"10.1016\/j.jep.2024.118832_bib116","first-page":"542","article-title":"Identification and comparative analysis of the major chemical constituents in the extracts of single fuzi herb and fuzi-gancao herb-pair by UPLC-IT-TOF\/MS","volume":"12","author":"Yang","year":"2014","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2024.118832_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153161","article-title":"Circadian clock regulates metabolism and toxicity of Fuzi (lateral root of Aconitum carmichaelii Debx.) in mice","volume":"67","author":"Yang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.618844","article-title":"How aconiti radix Cocta can treat gouty arthritis based on systematic pharmacology and UPLC-QTOF-MS\/MS","volume":"12","author":"Ye","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"18","key":"10.1016\/j.jep.2024.118832_bib119","doi-asserted-by":"crossref","first-page":"10184","DOI":"10.1039\/C9RA01219B","article-title":"Non-alkaloidal constituents from the genus Aconitum: a review","volume":"9","author":"Yin","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2024.118832_bib120","article-title":"Panax ginseng inhibits intestinal absorption of toxic Aconitum carmichaelii alkaloids in Vitro","volume":"8","author":"You","year":"2015","journal-title":"Chin. J. Integr. Med."},{"issue":"6","key":"10.1016\/j.jep.2024.118832_bib121","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jccs.201200077","article-title":"A new alkaloid from the roots of Aconitum carmichaelii Debx","volume":"59","author":"Yu","year":"2012","journal-title":"J. Chin. Chem. Soc."},{"issue":"22","key":"10.1016\/j.jep.2024.118832_bib122","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1080\/14786419.2022.2155821","article-title":"Chemical profile, anti-hepatoma activity, anti-acetylcholinesterase and antioxidant activity of aerial part of Aconitum carmichaelii Debx","volume":"37","author":"Yu","year":"2023","journal-title":"Nat. Prod. Res."},{"issue":"43","key":"10.1016\/j.jep.2024.118832_bib123","doi-asserted-by":"crossref","first-page":"26594","DOI":"10.1039\/D1RA04223H","article-title":"Structurally diverse diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii Debx. and their anti-tumor activities based on in vitro systematic evaluation and network pharmacology analysis","volume":"11","author":"Yu","year":"2021","journal-title":"RSC Adv."},{"issue":"22","key":"10.1016\/j.jep.2024.118832_bib124","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.201600567","article-title":"Investigation of the chemical markers for experiential quality evaluation of crude aconite by UHPLC-Q-TOF-MS","volume":"39","author":"Zhang","year":"2016","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2024.118832_bib125","article-title":"Processed lateral root of Aconitum carmichaelii Debx.: a review of cardiotonic effects and cardiotoxicity on molecular mechanisms","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114102","article-title":"Assessment of reproductive toxicity and genotoxicity of Aconiti Lateralis Radix Praeparata and its processed products in male mice","volume":"275","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118832_bib127","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.tiv.2017.09.011","article-title":"Human intestine and liver microsomal metabolic differences between C19-diester and monoester diterpenoid alkaloids from the roots of Aconitum carmichaelii Debx","volume":"45","author":"Zhang","year":"2017","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.jep.2024.118832_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124822","article-title":"Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: an in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx","volume":"244","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.jep.2024.118832_bib129","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.carres.2005.11.032","article-title":"Isolation and structural characterization of an immunostimulating polysaccharide from fuzi, Aconitum carmichaelii","volume":"341","author":"Zhao","year":"2006","journal-title":"Carbohydr. Res."},{"issue":"10","key":"10.1016\/j.jep.2024.118832_bib130","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1111\/jipb.13565","article-title":"Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum","volume":"65","author":"Zhao","year":"2023","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.jep.2024.118832_bib131","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.phytochem.2018.04.022","article-title":"Probing the transcriptome of Aconitum carmichaelii reveals the candidate genes associated with the biosynthesis of the toxic aconitine-type C19-diterpenoid alkaloids","volume":"152","author":"Zhao","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2024.118832_bib132","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phymed.2017.01.009","article-title":"Serum metabolomics analysis reveals that obvious cardioprotective effects of low dose Sini decoction against isoproterenol-induced myocardial injury in rats","volume":"31","author":"Zhou","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118832_bib133","article-title":"Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118832_bib134","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1002\/med.21777","article-title":"Cardiac efficacy and toxicity of aconitine: a new frontier for the ancient poison","volume":"41","author":"Zhou","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"9","key":"10.1016\/j.jep.2024.118832_bib135","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.7150\/ijms.6541","article-title":"Arrhythmogenesis toxicity of aconitine is related to intracellular Ca2+ signals","volume":"10","author":"Zhou","year":"2013","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jep.2024.118832_bib136","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phytochem.2022.113558","article-title":"Diverse alkaloids from the aerial parts of Aconitum carmichaelii and antiproliferative activity of costemline via inhibiting SIRT1\/ROCK1\/P-STAT3 pathways","volume":"207","author":"Zhou","year":"2023","journal-title":"Phytochemistry"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T03:41:30Z","timestamp":1731469290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124011310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":136,"alternative-id":["S0378874124011310"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118832","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An overview of the research progress on Aconitum carmichaelii Debx.:active compounds, pharmacology, toxicity, detoxification, and applications","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118832"}}