{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:20:59Z","timestamp":1790709659718,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374311"],"award-info":[{"award-number":["82374311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2022CXGC020514"],"award-info":[{"award-number":["2022CXGC020514"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118837","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T12:06:37Z","timestamp":1726747597000},"page":"118837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"P1","title":["Kemin capsule ameliorates post-infectious cough by modulating the PI3K\/AKT signaling pathway and TRPA1\/TRPV1 channels"],"prefix":"10.1016","volume":"337","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3602-3345","authenticated-orcid":false,"given":"Zhicong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiguo","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-2981","authenticated-orcid":false,"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118837_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.27","article-title":"Searching online mendelian inheritance in man (OMIM): a knowledgebase of human genes and genetic phenotypes","volume":"58","author":"Amberger","year":"2017","journal-title":"Current protocols in bioinformatics"},{"key":"10.1016\/j.jep.2024.118837_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: its role for host defense, inflammation, and neutrophil function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.jep.2024.118837_bib3","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201637","article-title":"A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment","volume":"218","author":"Balestrini","year":"2021","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139481","article-title":"Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD","volume":"131","author":"Benjamin","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2024.118837_bib5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1152\/physiol.00026.2008","article-title":"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control","volume":"23","author":"Bessac","year":"2008","journal-title":"Physiology"},{"issue":"1 Suppl. l","key":"10.1016\/j.jep.2024.118837_bib6","doi-asserted-by":"crossref","first-page":"138s","DOI":"10.1378\/chest.129.1_suppl.138S","article-title":"Postinfectious cough: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Braman","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jep.2024.118837_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2016.10.010","article-title":"TRPV4 antagonist GSK2193874 does not modulate cough response to osmotic stimuli","volume":"236","author":"Buday","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"6","key":"10.1016\/j.jep.2024.118837_bib8","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.21037\/jtd-21-876","article-title":"Prevalence and risk factors for postinfectious cough in discharged patients with coronavirus disease 2019 (COVID-19)","volume":"14","author":"Chen","year":"2022","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.jep.2024.118837_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155103","article-title":"Effectiveness and safety of Xingbei Zhike granules in patients with postinfectious cough: a multicenter, randomized, double-blinded, placebo-controlled trial","volume":"121","author":"Chi","year":"2023","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"Suppl. 4","key":"10.1016\/j.jep.2024.118837_bib10","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1871528112666131119211002","article-title":"Antagonism by bioactive polyphenols against inflammation: a systematic view","volume":"13","author":"Chu","year":"2014","journal-title":"Inflamm. Allergy - Drug Targets"},{"issue":"12","key":"10.1016\/j.jep.2024.118837_bib12","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1586\/eri.10.125","article-title":"The use of a neonatal mouse model to study respiratory syncytial virus infections","volume":"8","author":"Cormier","year":"2010","journal-title":"Expert Rev. Anti-infect. Ther."},{"issue":"24","key":"10.1016\/j.jep.2024.118837_bib13","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3465","article-title":"Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol","volume":"9","author":"Crowe","year":"2019","journal-title":"Bio-protocol"},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib14","doi-asserted-by":"crossref","first-page":"812","DOI":"10.3892\/ijmm.2016.2691","article-title":"Histone deacetylase inhibitors suppress RSV infection and alleviate virus-induced airway inflammation","volume":"38","author":"Feng","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2024.118837_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154684","article-title":"Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT\/mTOR and NF-\u03baB pathway in macrophages to reduce atherosclerosis in ApoE-\/- mice","volume":"112","author":"Feng","year":"2023","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"4","key":"10.1016\/j.jep.2024.118837_bib16","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.chmed.2022.09.002","article-title":"Post-infectious cough of different syndromes treated by traditional Chinese medicines: a review","volume":"14","author":"Jiang","year":"2022","journal-title":"Chinese herbal medicines"},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/jssc.202100651","article-title":"Classification of diterpenoid alkaloids from Aconitum kusnezoffii Reichb. by liquid chromatography-tandem mass spectrometry-based on molecular networking","volume":"45","author":"Jiang","year":"2022","journal-title":"J. Separ. Sci."},{"issue":"12","key":"10.1016\/j.jep.2024.118837_bib18","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1007\/s11033-020-06021-1","article-title":"Akt1 is involved in tubular apoptosis and inflammatory response during renal ischemia-reperfusion injury","volume":"47","author":"Kim","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"11","key":"10.1016\/j.jep.2024.118837_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3928\/02793695-20221005-02","article-title":"Dextromethorphan: from cough suppressant to antidepressant","volume":"60","author":"Kverno","year":"2022","journal-title":"J. Psychosoc. Nurs. Ment. Health Serv."},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib20","first-page":"163","article-title":"Neurogenic inflammation of the upper airway mucosa","volume":"46","author":"Lacroix","year":"2008","journal-title":"Rhinology"},{"issue":"36","key":"10.1016\/j.jep.2024.118837_bib21","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2022.37.e275","article-title":"Effectiveness and safety of codeine and levodropropizine in patients with chronic cough","volume":"37","author":"Lee","year":"2022","journal-title":"J. Kor. Med. Sci."},{"issue":"8","key":"10.1016\/j.jep.2024.118837_bib22","first-page":"4121","article-title":"The anti-inflammatory properties of licorice (Glycyrrhiza glabra)-derived compounds in intestinal disorders","volume":"23","author":"Leite","year":"2022"},{"issue":"32","key":"10.1016\/j.jep.2024.118837_bib23","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1021\/acs.jafc.7b02285","article-title":"UPLC-Q-Exactive orbitrap\/MS-based lipidomics approach to characterize lipid extracts from bee pollen and their in vitro anti-inflammatory properties","volume":"65","author":"Li","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2024.118837_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105389","article-title":"Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis","volume":"144","author":"Li","year":"2022","journal-title":"Comput. Biol. Med."},{"issue":"Pt 3","key":"10.1016\/j.jep.2024.118837_bib25","article-title":"Xingbei antitussive granules ameliorate cough hypersensitivity in post-infectious cough Guinea pigs by regulating tryptase\/PAR2\/TRPV1 pathway","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118837_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114664","article-title":"Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway","volume":"283","author":"Liang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118837_bib27","article-title":"Chinese herbal medicine for postinfectious cough: a systematic review of randomized controlled trials","volume":"2013","author":"Liu","year":"2013","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"issue":"12","key":"10.1016\/j.jep.2024.118837_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22782","article-title":"Investigation into actions of Xiebai and Zengye decoction on cough sensitivity, airway inflammation and gut microbiota in the rat model of post-infectious cough","volume":"9","author":"Luo","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2024.118837_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105842","article-title":"Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K\/AKT pathway in acute lung injury","volume":"76","author":"Luo","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.118837_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155231","article-title":"Mechanisms of multi-omics and network pharmacology to explain traditional Chinese medicine for vascular cognitive impairment: a narrative review","volume":"123","author":"Lv","year":"2024","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"6","key":"10.1016\/j.jep.2024.118837_bib31","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/bib\/bbq090","article-title":"Principal component analysis based methods in bioinformatics studies","volume":"12","author":"Ma","year":"2011","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.jep.2024.118837_bib32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/abr.abr_247_22","article-title":"The effect of half percent oxymetazoline nasal drops on post-tonsillectomy cough, sore throat and bleeding in children; A double-blind randomized clinical trial","volume":"12","author":"Masoudifar","year":"2023","journal-title":"Adv. Biomed. Res."},{"issue":"5","key":"10.1016\/j.jep.2024.118837_bib33","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jaci.2018.09.004","article-title":"Translational review: neuroimmune mechanisms in cough and emerging therapeutic targets","volume":"142","author":"McGovern","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2024.118837_bib34","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1378\/chest.08-2408","article-title":"Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy","volume":"136","author":"Meduri","year":"2009","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.jep.2024.118837_bib35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.jep.2024.118837_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/lungindia.lungindia_250_22","article-title":"Approach to post COVID-19 persistent cough: a narrative review","volume":"40","author":"Rai","year":"2023","journal-title":"Lung India : official organ of Indian Chest Society"},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib37","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"3 Suppl. l","key":"10.1016\/j.jep.2024.118837_bib38","first-page":"1027","article-title":"Efficacy and safety of Linkus, Aminophylline diphenhydramine and acefyllin piperazine for the treatment of cough in children","volume":"29","author":"Rehman","year":"2016","journal-title":"Pak. J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.jep.2024.118837_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s41030-022-00183-y","article-title":"The effect of anti-chemokine oral drug XC8 on cough triggered by the agonists of TRPA1 but not TRPV1 channels in Guinea pigs","volume":"8","author":"Romanova","year":"2022","journal-title":"Pulmonary therapy"},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.rmed.2011.10.007","article-title":"Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection","volume":"106","author":"Ryan","year":"2012","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12974-019-1561-x","article-title":"Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT\/STAT3 signaling","volume":"16","author":"Ryu","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2024.118837_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104817","article-title":"Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs","volume":"179","author":"Salinas","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jep.2024.118837_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115686","article-title":"Chemical analysis of the Chinese herbal medicine licorice (Gan-Cao): an update review","volume":"299","author":"Shang","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib45","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/1479972315583043","article-title":"Natural products for chronic cough: text mining the East Asian historical literature for future therapeutics","volume":"12","author":"Shergis","year":"2015","journal-title":"Chron. Respir. Dis."},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00281-018-0673-1","article-title":"A historical perspective on the role of sensory nerves in neurogenic inflammation","volume":"40","author":"Sousa-Valente","year":"2018","journal-title":"Semin. Immunopathol."},{"issue":"1.30","key":"10.1016\/j.jep.2024.118837_bib47","first-page":"31","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Current protocols in bioinformatics"},{"issue":"2","key":"10.1016\/j.jep.2024.118837_bib48","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.gene.2015.08.009","article-title":"Pitfalls of the MTT assay: direct and off-target effects of inhibitors can result in over\/underestimation of cell viability","volume":"574","author":"Stepanenko","year":"2015","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.jep.2024.118837_bib49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1389200220666190227224748","article-title":"PI3K\/Akt-Nrf2 and anti-inflammation effect of macrolides in chronic obstructive pulmonary disease","volume":"20","author":"Sun","year":"2019","journal-title":"Curr. Drug Metabol."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-1759(96)00236-0","article-title":"A murine model of pulmonary damage induced by lipopolysaccharide via intranasal instillation","volume":"202","author":"Szarka","year":"1997","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2024.118837_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.641530","article-title":"Uncovering modern clinical applications of fuzi and fuzi-based formulas: a nationwide descriptive study with market basket analysis","volume":"12","author":"Tai","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1465-9921-9-57","article-title":"The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice","volume":"9","author":"Tate","year":"2008","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118837_bib53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ceca.2016.03.007","article-title":"Role of reactive oxygen species and TRP channels in the cough reflex","volume":"60","author":"Taylor-Clark","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jep.2024.118837_bib54","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.3389\/fphar.2019.01422","article-title":"Suhuang antitussive capsules-ameliorative effects on LPS-induced sputum obstruction in mice through promoting HGF secretion","volume":"10","author":"Tong","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.118837_bib55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"12","key":"10.1016\/j.jep.2024.118837_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/plants10122751","article-title":"Glycyrrhiza glabra (licorice): a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology","volume":"10","author":"Wahab","year":"2021","journal-title":"Plants"},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41392-020-00345-x","article-title":"Progress in the mechanism and targeted drug therapy for COPD","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2024.118837_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115838","article-title":"Ethnopharmacological use, pharmacology, toxicology, phytochemistry, and progress in Chinese crude drug processing of the lateral root of Aconitum carmichaelii Debeaux. (Fuzi): a review","volume":"301","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118837_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113342","article-title":"Effect of San\u2019ao decoction with scorpio and bombyx batryticatus on CVA mice model via airway inflammation and regulation of TRPA1\/TRPV1\/TRPV5 channels","volume":"264","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118837_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107116","article-title":"Riparin II potentials the effect of ephedrine on inflammation and remodelling in the airway of rats suffering from asthma by regulating transforming growth factor-\u03b2\/Smad3 signalling pathway","volume":"90","author":"Wang","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.118837_bib61","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.2147\/DDDT.S351264","article-title":"Mahuang decoction attenuates airway inflammation and remodeling in asthma via suppression of the SP1\/FGFR3\/PI3K\/AKT Axis","volume":"16","author":"Wei","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2024.118837_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153173","article-title":"Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-\u03baB and STAT3 pathways","volume":"68","author":"Wu","year":"2020","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"7","key":"10.1016\/j.jep.2024.118837_bib63","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1177\/0300060518778951","article-title":"Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel Guinea pig model of citric acid-induced chronic cough","volume":"46","author":"Xu","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.jep.2024.118837_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117741","article-title":"Zhisou powder suppresses airway inflammation in LPS and CS-induced post-infectious cough model mice via TRPA1\/TRPV1 channels","volume":"324","author":"Xu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2024.118837_bib65","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1002\/ptr.6486","article-title":"Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db\/db mice","volume":"33","author":"Yang","year":"2019","journal-title":"Phytother Res. : PTR"},{"issue":"2","key":"10.1016\/j.jep.2024.118837_bib66","first-page":"818","article-title":"Epigallocatechin-3-gallate inhibits inflammation and epithelial-mesenchymal transition through the PI3K\/AKT pathway via upregulation of PTEN in asthma","volume":"41","author":"Yang","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118837_bib67","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/10942912.2023.2293461","article-title":"Advances for anti-inflammatory ingredients and activities of Fuzi (lateral root of Aconitum carmichaelii Debx.)","volume":"27","author":"Zhang","year":"2024","journal-title":"Int. J. Food Prop."},{"key":"10.1016\/j.jep.2024.118837_bib68","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2018.02.040","article-title":"Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice","volume":"218","author":"Zhao","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118837_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116153","article-title":"Ephedrae herba: a comprehensive review of its traditional uses, phytochemistry, pharmacology, and toxicology","volume":"307","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118837_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117614","article-title":"A comprehensive study of Ephedra sinica Stapf-Schisandra chinensis (Turcz.) Baill herb pair on airway protection in asthma","volume":"322","author":"Zhuo","year":"2024","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412401136X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412401136X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:06:59Z","timestamp":1778540819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412401136X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":70,"alternative-id":["S037887412401136X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118837","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kemin capsule ameliorates post-infectious cough by modulating the PI3K\/AKT signaling pathway and TRPA1\/TRPV1 channels","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118837","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118837"}}