{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:00:44Z","timestamp":1792166444369,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","award":["2111520269"],"award-info":[{"award-number":["2111520269"]}],"id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118839","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T03:01:11Z","timestamp":1726628471000},"page":"118839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P1","title":["Quercus dentata Thunb. leaves extract inhibits CaOx crystallization and ameliorates ethylene glycol-induced CaOx kidney stones via the OPN\/CD44 and NLRP3 pathways"],"prefix":"10.1016","volume":"337","author":[{"given":"Qing-zhu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-yuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ni","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-meng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-2075","authenticated-orcid":false,"given":"Xiao-qiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118839_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/292953","article-title":"Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators","volume":"2013","author":"Aggarwal","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2024.118839_bib2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.eeus.2007.03.002","article-title":"The role of urinary kidney stone inhibitors and promoters in the pathogenesis of calcium containing renal stones","volume":"5","author":"Basavaraj","year":"2007","journal-title":"EAU-EBU Update Ser."},{"key":"10.1016\/j.jep.2024.118839_bib3","first-page":"1312","article-title":"Prise en charge pharmacologique de la lithiase urinaire","volume":"23","author":"Doizi","year":"2013","journal-title":"Progr\u00e8s en Urologie, Rapport AFU 2013. Le m\u00e9dicament en urologie"},{"key":"10.1016\/j.jep.2024.118839_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120258","article-title":"Inhibition of EZH2 ameliorates hyperoxaluria-induced kidney injury through the JNK\/FoxO3a pathway","volume":"291","author":"Gao","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.118839_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tox.2006.11.046","article-title":"Aluminum citrate inhibits cytotoxicity and aggregation of oxalate crystals","volume":"230","author":"Guo","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2024.118839_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27533","article-title":"Flavonoids: a treasure house of prospective pharmacological potentials","volume":"10","author":"Hasnat","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2024.118839_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ekir.2024.05.005","article-title":"The role of mitochondrial dysfunction in CKD-related vascular calcification: from mechanisms to therapeutics","author":"Huang","year":"2024","journal-title":"Kidney International Reports"},{"key":"10.1016\/j.jep.2024.118839_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113871","article-title":"Soluble thrombomodulin alleviates Diquat-induced acute kidney injury by inhibiting the HMGB1\/I\u03baB\u03b1\/NF-\u03baB signalling pathway","volume":"178","author":"Huang","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2024.118839_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/01.ju.0000141311.51003.87","article-title":"Preventive effects of green tea on Renal Stone Formation and the role of oxidative stress in Nephrolithiasis","volume":"173","author":"Itoh","year":"2005","journal-title":"J. Urol."},{"key":"10.1016\/j.jep.2024.118839_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5863617","article-title":"miR-155-5p promotes oxalate- and calcium-induced kidney oxidative stress injury by suppressing MGP expression","volume":"2020","author":"Jiang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2024.118839_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108847","article-title":"IL-1\u03b2 induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1","volume":"703","author":"Jung","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2024.118839_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jep.2017.03.038","article-title":"Herbal remedies for urinary stones used in India and China: a review","volume":"203","author":"Kasote","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118839_bib13","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ijbiomac.2022.09.051","article-title":"Pectin-type polysaccharide from galangal: an efficient emulsifier to construct the emulsion-based delivery system for galangal flavonoids","volume":"221","author":"Ke","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2024.118839_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41581-020-00392-1","article-title":"Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation","volume":"17","author":"Khan","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2024.118839_bib15","article-title":"Kidney stones","volume":"2","author":"Khan","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jep.2024.118839_bib16","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.urology.2015.07.006","article-title":"Urinary stone disease: progress, status, and needs","volume":"86","author":"Kirkali","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.jep.2024.118839_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00240-016-0900-y","article-title":"Kinetics of calcium oxalate crystal formation in urine","volume":"45","author":"Laube","year":"2017","journal-title":"Urolithiasis"},{"key":"10.1016\/j.jep.2024.118839_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2021.106641","article-title":"Monosaccharide composition analysis of polysaccharides from natural sources: hydrolysis condition and detection method development","volume":"116","author":"Liu","year":"2021","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.jep.2024.118839_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115621","article-title":"Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic\/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway","volume":"167","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118839_bib20","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3390\/molecules28031246","article-title":"Identification of unstable ellagitannin metabolites in the leaves of quercus dentata by chemical derivatization","volume":"28","author":"Liu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2024.118839_bib21","first-page":"399","article-title":"Study of the chemical ingredients of live oak chloroform extraction parts","volume":"31","author":"Lu","year":"2013","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2024.118839_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hermed.2017.01.003","article-title":"Scientific appraisal of urolithiasis and its remedial measures in Unani medicine","volume":"8","author":"Makbul","year":"2017","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.jep.2024.118839_bib23","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3109\/15563650903344793","article-title":"Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?","volume":"47","author":"McMartin","year":"2009","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jep.2024.118839_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0009-8981(01)00403-X","article-title":"Effect of five flavonoid compounds isolated from Quercus dentata Thunb on superoxide generation in human neutrophils and phosphorylation of neutrophil proteins","volume":"306","author":"Meng","year":"2001","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jep.2024.118839_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrysgro.2022.126859","article-title":"Inhibition of crystallization of calcium oxalate monohydrate using leaves from different species of Moringa \u2013 experimental and theoretical studies","volume":"598","author":"Menon","year":"2022","journal-title":"J. Cryst. Growth"},{"key":"10.1016\/j.jep.2024.118839_bib26","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/polym10121407","article-title":"Biological activity and pharmacological application of pectic polysaccharides: a review","volume":"10","author":"Minzanova","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.jep.2024.118839_bib27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1442-2042.2009.02268.x","article-title":"Inhibitions of urinary oxidative stress and renal calcium level by an extract of Quercus salicina Blume\/Quercus stenophylla Makino in a rat calcium oxalate urolithiasis model","volume":"16","author":"Moriyama","year":"2009","journal-title":"Int. J. Urol."},{"key":"10.1016\/j.jep.2024.118839_bib28","first-page":"83","article-title":"Study on antioxidant activity of flavonoids from the leaves of quercus dentata","author":"Nan","year":"2013","journal-title":"China Food Additives, YAN Zhen-min, ZHANG, WANG Wei"},{"key":"10.1016\/j.jep.2024.118839_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/jpp\/rgac092","article-title":"Dietary supplements and medicinal plants in urolithiasis: diet, prevention, and cure","volume":"75","author":"Oswal","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2024.118839_bib30","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.msec.2010.05.002","article-title":"Degradation of sulfated polysaccharide extracted from algal Laminaria japonica and its modulation on calcium oxalate crystallization","volume":"30","author":"Ouyang","year":"2010","journal-title":"Mater. Sci. Eng., C"},{"key":"10.1016\/j.jep.2024.118839_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.advnut.2023.03.002","article-title":"Kidney stone prevention","volume":"14","author":"Peerapen","year":"2023","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jep.2024.118839_bib32","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.2298\/TSCI190512037P","article-title":"Extracts of Quercus dentata leaf","volume":"24","author":"Peng","year":"2020","journal-title":"Therm. Sci."},{"key":"10.1016\/j.jep.2024.118839_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1471-4914(01)01963-3","article-title":"A crucial role for CD44 in inflammation","volume":"7","author":"Pur\u00e9","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jep.2024.118839_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/10826068.2022.2090003","article-title":"Synthesize and characterization of CaOx crystals against various citrus waste peel extracts: an in vitro study","volume":"53","author":"Pushparani","year":"2023","journal-title":"Prep. Biochem. Biotechnol."},{"key":"10.1016\/j.jep.2024.118839_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113945","article-title":"Anti-inflammatory and anti-allergic potential of dietary flavonoids: a review","volume":"156","author":"Rakha","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118839_bib36","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1053\/j.ajkd.2023.03.017","article-title":"Kidney stone pathophysiology, evaluation and management: core curriculum 2023","volume":"82","author":"Shastri","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jep.2024.118839_bib37","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cytogfr.2023.08.007","article-title":"The critical role of osteopontin (OPN) in fibrotic diseases","volume":"74","author":"Tang","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2024.118839_bib38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41581-020-0320-7","article-title":"Determining the true burden of kidney stone disease","volume":"16","author":"Thongprayoon","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jep.2024.118839_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3892\/ijmm.2021.4982","article-title":"Recent advances on the mechanisms of kidney stone formation","volume":"48","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2024.118839_bib40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/MOU.0000000000000024","article-title":"Extracorporeal shockwave lithotripsy for upper tract urolithiasis","volume":"24","author":"Weaver","year":"2014","journal-title":"Curr. Opin. Urol."},{"key":"10.1016\/j.jep.2024.118839_bib41","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3390\/cells10081926","article-title":"The molecular aspect of nephrolithiasis development","volume":"10","author":"Wigner","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jep.2024.118839_bib42","first-page":"1","article-title":"TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches","volume":"19","author":"Xin","year":"2021","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2024.118839_bib43","first-page":"5","article-title":"Inhibition of calcium oxalate monohydrate crystallisation by chemical components in quercus dentata Thunb. Leaves","author":"Xu","year":"2003","journal-title":"J. Pharmaceut. Res."},{"key":"10.1016\/j.jep.2024.118839_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115165","article-title":"The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against renal injury and inflammation in mice with diabetic kidney disease","volume":"292","author":"Yang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118839_bib45","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.carbpol.2012.05.056","article-title":"Inhibition on calcium oxalate crystallization and repair on injured renal epithelial cells of degraded soybean polysaccharide","volume":"90","author":"Yao","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2024.118839_bib46","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3746\/jkfn.2004.33.3.463","article-title":"Antimicrobial effect of ethanol extracts of quercus spp. against foodborne pathogens","volume":"33","author":"Yoon","year":"2004","journal-title":"Journal of the Korean Society of Food Science and Nutrition"},{"key":"10.1016\/j.jep.2024.118839_bib47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.sajb.2014.08.007","article-title":"Effects of exogenous salicylic acid on polysaccharides production of Dendrobium officinale","volume":"95","author":"Yuan","year":"2014","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2024.118839_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/bju.13828","article-title":"Prevalence of kidney stones in China: an ultrasonography based cross-sectional study","volume":"120","author":"Zeng","year":"2017","journal-title":"BJU Int."},{"key":"10.1016\/j.jep.2024.118839_bib49","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/separations11010002","article-title":"Effects of hydrolysis condition and detection method on the monosaccharide composition analysis of polysaccharides from natural sources","volume":"11","author":"Zhao","year":"2024","journal-title":"Separations"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:45:11Z","timestamp":1777571111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124011383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":49,"alternative-id":["S0378874124011383"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118839","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercus dentata Thunb. leaves extract inhibits CaOx crystallization and ameliorates ethylene glycol-induced CaOx kidney stones via the OPN\/CD44 and NLRP3 pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118839"}}