{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:12Z","timestamp":1791081972202,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118847","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T04:33:06Z","timestamp":1728016386000},"page":"118847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"P2","title":["Immunomodulatory effects and multi-omics analysis of Codonopsis Pilosula Extract in septic rats"],"prefix":"10.1016","volume":"337","author":[{"given":"Zhaodi","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-7303","authenticated-orcid":false,"given":"Pu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.jep.2024.118847_bib1","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1039\/D2FO01119K","article-title":"Codonopsis pilosula oligosaccharides modulate the gut microbiota and change serum metabolomic profiles in high-fat diet-induced obese mice","volume":"13","author":"Bai","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.118847_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113180","article-title":"Anti-inflammatory and immunoregulatory effects of icariin and icaritin","volume":"151","author":"Bi","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib3","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbalip.2012.09.018","article-title":"Phospholipids: \"greasing the wheels\" of humoral immunity","volume":"1831","author":"Brewer","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/EBC20190083","article-title":"Eicosanoids","volume":"64","author":"Calder","year":"2020","journal-title":"Essays Biochem."},{"issue":"7","key":"10.1016\/j.jep.2024.118847_bib5","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3979","article-title":"Using the cecal ligation and puncture model of sepsis to induce rats to multiple organ dysfunction","volume":"11","author":"Capcha","year":"2021","journal-title":"Bio Protoc"},{"issue":"6640","key":"10.1016\/j.jep.2024.118847_bib6","article-title":"Transforming the understanding of brain immunity","volume":"380","author":"Castellani","year":"2023","journal-title":"Sci"},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122374","article-title":"Specific medicinal plant polysaccharides effectively enhance the potency of a DC-based vaccine against mouse mammary tumor metastasis","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.jep.2024.118847_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115598","article-title":"Systemic immunomodulatory effects of Codonopsis pilosula glucofructan on S180 solid-tumor-bearing mice","volume":"24","author":"Fan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.jep.2024.118847_bib10","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.ajpath.2020.06.010","article-title":"Eicosanoids: the overlooked storm in coronavirus disease 2019 (COVID-19)?","volume":"190","author":"Hammock","year":"2020","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.jep.2024.118847_bib11","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00240-022-01319-0","article-title":"Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) in predicting systemic inflammatory response syndrome (SIRS) and sepsis after percutaneous nephrolithotomy (PNL)","volume":"50","author":"Kriplani","year":"2022","journal-title":"Urolithiasis"},{"issue":"6","key":"10.1016\/j.jep.2024.118847_bib13","doi-asserted-by":"crossref","first-page":"868","DOI":"10.14336\/AD.2017.0816","article-title":"Anti-Aging implications of Astragalus membranaceus (huangqi): a well-known Chinese tonic","volume":"8","author":"Liu","year":"2017","journal-title":"Aging Dis"},{"key":"10.1016\/j.jep.2024.118847_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fimmu.2020.00045","article-title":"Editorial: BCR signaling and B cell activation","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118847_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117863","article-title":"Extraction, purification, structural characteristics and biological properties of the polysaccharides from Codonopsis pilosula: a review","volume":"261","author":"Luan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2024.118847_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110180","article-title":"A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4\/NF-kappaB and TGF-beta1\/Smad3 signaling pathway","volume":"119","author":"Meng","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.118847_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110180","article-title":"A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4\/NF-\u03baB and TGF-\u03b21\/Smad3 signaling pathway","volume":"119","author":"Meng","year":"2023","journal-title":"Int. Immunopharm."},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2024.118847_bib19","unstructured":"Pharmacopoeia of the People's Republic of China (Part 1). 2020. ed. N. P. Commission, 168. Beijing: China Medical Science and Technology Press."},{"issue":"1","key":"10.1016\/j.jep.2024.118847_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.jep.2024.118847_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/sur.2015.184","article-title":"Persistent inflammation, immunosuppression, and catabolism: evolution of multiple organ dysfunction","volume":"17","author":"Rosenthal","year":"2016","journal-title":"Surg. Infect."},{"issue":"10219","key":"10.1016\/j.jep.2024.118847_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"2 Suppl. 2","key":"10.1016\/j.jep.2024.118847_bib23","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","article-title":"Structure and function of immunoglobulins","volume":"125","author":"Schroeder","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2024.118847_bib24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a new definition and assessing new clinical criteria for septic shock for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Shankar-Hari","year":"2016","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.jep.2024.118847_bib25","article-title":"Traditional Chinese medicine for treatment of sepsis and related multi-organ injury","volume":"14","author":"Song","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2024.118847_bib26","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41576-019-0150-2","article-title":"RNA sequencing: the teenage years","volume":"20","author":"Stark","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib28","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.immuni.2021.01.007","article-title":"Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties","volume":"54","author":"Tang","year":"2021","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.jep.2024.118847_bib29","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221105","article-title":"Inborn errors of human B cell development, differentiation, and function","volume":"220","author":"Tangye","year":"2023","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.jep.2024.118847_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI200113416","article-title":"Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes","volume":"108","author":"Tilley","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.jep.2024.118847_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.jep.2024.118847_bib32","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"issue":"327","key":"10.1016\/j.jep.2024.118847_bib34","article-title":"Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism","volume":"12","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118847_bib35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"issue":"13","key":"10.1016\/j.jep.2024.118847_bib36","first-page":"4334","article-title":"Research progress on immunomodulatory activity and mechanism of Codonopsis Radix","volume":"54","author":"Xia","year":"2023","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib37","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1097\/CCM.0000000000004155","article-title":"The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey","volume":"48","author":"Xie","year":"2020","journal-title":"Crit. Care Med."},{"issue":"21","key":"10.1016\/j.jep.2024.118847_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28217355","article-title":"The mechanisms of polysaccharides from tonic Chinese herbal medicine on the enhancement immune function: a review","volume":"28","author":"Xie","year":"2023","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.jep.2024.118847_bib39","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1182\/blood.2020006784","article-title":"Targeting B-cell receptor and PI3K signaling in diffuse large B-cell lymphoma","volume":"138","author":"Xu","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jep.2024.118847_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408347.2023.2242953","article-title":"Insights into genus Codonopsis: from past achievements to future perspectives","author":"Yue","year":"2023","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"3","key":"10.1016\/j.jep.2024.118847_bib41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/SHK.0000000000000091","article-title":"Codonopsis pilosula polysaccharide attenuates cecal ligation and puncture sepsis via circuiting regulatory T cells in mice","volume":"41","author":"Zheng","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.jep.2024.118847_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1031051","article-title":"Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.jep.2024.118847_bib43","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.3390\/molecules24203632","article-title":"A polysaccharide isolated from Codonopsis pilosula with immunomodulation effects both in vitro and in vivo","volume":"24","author":"Zou","year":"2019","journal-title":"Molecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T03:41:16Z","timestamp":1731469276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124011462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":41,"alternative-id":["S0378874124011462"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118847","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory effects and multi-omics analysis of Codonopsis Pilosula Extract in septic rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118847"}}