{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:10:05Z","timestamp":1791288605095,"version":"4.3.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118896","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T06:07:43Z","timestamp":1728540463000},"page":"118896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P3","title":["Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells"],"prefix":"10.1016","volume":"337","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-6755","authenticated-orcid":false,"given":"Yadong","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinala","family":"Jialiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8612-2097","authenticated-orcid":false,"given":"Zhuyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118896_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fnut.2019.00121","article-title":"Anti-hypertensive effect of cereal antioxidant ferulic acid and its mechanism of action","volume":"6","author":"Alam","year":"2019","journal-title":"Front. Nutr."},{"issue":"4","key":"10.1016\/j.jep.2024.118896_bib2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/cvr\/cvy022","article-title":"Smooth muscle cell fate and plasticity in atherosclerosis","volume":"114","author":"Allahverdian","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"18","key":"10.1016\/j.jep.2024.118896_bib3","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1161\/CIRCULATIONAHA.121.057178","article-title":"Oviductal glycoprotein 1 promotes hypertension by inducing vascular remodeling through an interaction with MYH9","volume":"146","author":"Bai","year":"2022","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.jep.2024.118896_bib4","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/cvr\/cvab171","article-title":"Central role of c-Src in NOX5- mediated redox signalling in vascular smooth muscle cells in human hypertension","volume":"118","author":"Camargo","year":"2022","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.jep.2024.118896_bib5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.6052","article-title":"Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia","volume":"259","author":"Cao","year":"2023","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2024.118896_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jvssci.2021.04.001","article-title":"Targeting smooth muscle cell phenotypic switching in vascular disease","volume":"2","author":"Chakraborty","year":"2021","journal-title":"JVS Vasc Sci"},{"issue":"5","key":"10.1016\/j.jep.2024.118896_bib7","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1093\/cvr\/cvaa200","article-title":"Additive protective effects of sacubitril\/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension","volume":"117","author":"Chaumais","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.jep.2024.118896_bib8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00424-016-1821-x","article-title":"Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders","volume":"468","author":"Coll-Bonfill","year":"2016","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jep.2024.118896_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154238","article-title":"Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation","volume":"103","author":"Dai","year":"2022","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2024.118896_bib10","first-page":"872","article-title":"Clinical study on improving vascular function of Qiyangyuyin Granules in middle-aged patients with hypertension","volume":"22","author":"Dai","year":"2024","journal-title":"Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease"},{"key":"10.1016\/j.jep.2024.118896_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111689","article-title":"Mdivi-1, a mitochondrial fission inhibitor, reduces angiotensin-II- induced hypertension by mediating VSMC phenotypic switch","volume":"140","author":"Deng","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.118896_bib12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12906-015-0619-2","article-title":"Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway","volume":"15","author":"Ding","year":"2015","journal-title":"BMC Complement Altern Med"},{"issue":"4","key":"10.1016\/j.jep.2024.118896_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9040404","article-title":"Vascular calcification in chronic kidney disease: diversity in the vessel wall","volume":"9","author":"Dube","year":"2021","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.jep.2024.118896_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030502","article-title":"Luteolin attenuates hypertension via inhibiting NF-kappaB-Mediated inflammation and PI3K\/akt signaling pathway in the hypothalamic paraventricular nucleus","volume":"15","author":"Gao","year":"2023","journal-title":"Nutrients"},{"issue":"20","key":"10.1016\/j.jep.2024.118896_bib15","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1056\/NEJM199405193302008","article-title":"The emerging concept of vascular remodeling","volume":"330","author":"Gibbons","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2024.118896_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5862361","article-title":"Speckle tracking echocardiography verified the efficacy of qianyangyuyin granules in alleviating left ventricular remodeling in a hypertensive rat model","volume":"2021","author":"He","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/CIRCRESAHA.123.322835","article-title":"CD4+ T-cell legumain deficiency attenuates hypertensive damage via preservation of TRAF6","volume":"134","author":"He","year":"2024","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.jep.2024.118896_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10060218","article-title":"The impact of uremic toxins on vascular smooth muscle cell function","volume":"10","author":"Henaut","year":"2018","journal-title":"Toxins"},{"issue":"17","key":"10.1016\/j.jep.2024.118896_bib19","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.scib.2023.07.032","article-title":"Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies","volume":"68","author":"Hu","year":"2023","journal-title":"Sci. Bull."},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib20","article-title":"HIF-1alpha contributes to hypoxia-induced VSMC proliferation and migration by regulating autophagy in type A aortic dissection","volume":"8","author":"Huang","year":"2024","journal-title":"Adv Biol (Weinh)"},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41401-021-00639-y","article-title":"Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy","volume":"43","author":"Huang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.jep.2024.118896_bib22","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/ajh\/hpaa195","article-title":"Mechanisms of vascular remodeling in hypertension","volume":"34","author":"Humphrey","year":"2021","journal-title":"Am. J. Hypertens."},{"issue":"3","key":"10.1016\/j.jep.2024.118896_bib23","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/cvr\/cvu061","article-title":"Smooth muscle cell-specific Hif-1alpha deficiency suppresses angiotensin II-induced vascular remodelling in mice","volume":"102","author":"Imanishi","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.jep.2024.118896_bib24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1161\/CIRCRESAHA.122.321005","article-title":"PHB2 maintains the contractile phenotype of VSMCs by counteracting PKM2 splicing","volume":"131","author":"Jia","year":"2022","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.jep.2024.118896_bib25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/08037051.2017.1393311","article-title":"Retinal vascular resistance in arterial hypertension","volume":"27","author":"Kannenkeril","year":"2018","journal-title":"Blood Press"},{"issue":"1\u20132","key":"10.1016\/j.jep.2024.118896_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-015-2464-5","article-title":"Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression","volume":"407","author":"Kim","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"19","key":"10.1016\/j.jep.2024.118896_bib27","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"issue":"15","key":"10.1016\/j.jep.2024.118896_bib28","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1111\/bph.14708","article-title":"Strain-selective efficacy of sacubitril\/valsartan on carotid fibrosis in response to injury in two inbred mouse strains","volume":"176","author":"Korshunov","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/ph3010237","article-title":"Quercetin: a treatment for hypertension?-A review of efficacy and mechanisms","volume":"3","author":"Larson","year":"2010","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.jep.2024.118896_bib30","first-page":"184","article-title":"Clinical study on the protective effect of Qiyang Yuyin Granules on blood vessel function of Yin deficiency and Yang hyperactivity type hypertension","volume":"37","author":"Li","year":"2021","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"issue":"11","key":"10.1016\/j.jep.2024.118896_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1060","article-title":"TGF-beta\/Smads signaling pathway, Hippo-YAP\/TAZ signaling pathway, and VEGF: their mechanisms and roles in vascular remodeling related diseases","volume":"11","author":"Liu","year":"2023","journal-title":"Immun Inflamm Dis"},{"issue":"8","key":"10.1016\/j.jep.2024.118896_bib32","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.7150\/thno.71722","article-title":"Twist1 downregulation of PGC-1alpha decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.jep.2024.118896_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11122378","article-title":"Peroxisome proliferator-activated receptor alpha attenuates hypertensive vascular remodeling by protecting vascular smooth muscle cells from angiotensin II-induced ROS production","volume":"11","author":"Liu","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2024.118896_bib34","article-title":"Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: role of mitochondria","volume":"9","author":"Liu","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"Pt A","key":"10.1016\/j.jep.2024.118896_bib35","article-title":"Qian Yang Yu Yin granule improves hypertensive renal damage: a potential role for TRPC6-CaMKKbeta-AMPK-mTOR-mediated autophagy","volume":"302","author":"Ma","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2024.118896_bib36","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1161\/CIRCRESAHA.121.318052","article-title":"Hypertension: do inflammation and immunity hold the key to solving this epidemic?","volume":"128","author":"Madhur","year":"2021","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.jep.2024.118896_bib37","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","volume":"41","author":"Mancia","year":"2023","journal-title":"J. Hypertens."},{"issue":"7","key":"10.1016\/j.jep.2024.118896_bib38","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1007\/s13197-014-1488-2","article-title":"Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats","volume":"52","author":"Mnafgui","year":"2015","journal-title":"J. Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008538","article-title":"Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases","volume":"16","author":"Nurnberg","year":"2020","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.jep.2024.118896_bib40","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/00004872-200105000-00013","article-title":"Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension","volume":"19","author":"Park","year":"2001","journal-title":"J. Hypertens."},{"key":"10.1016\/j.jep.2024.118896_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pbiomolbio.2023.03.003","article-title":"Glycometabolism reprogramming: implications for cardiovascular diseases","volume":"179","author":"Peng","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"8","key":"10.1016\/j.jep.2024.118896_bib42","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41419-019-1757-0","article-title":"Hypoxia inducible factor 1alpha in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment","volume":"10","author":"Qi","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2024.118896_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.667433","article-title":"Qian Yang Yu Yin granule improves renal injury of hypertension by regulating metabolic reprogramming mediated by HIF-1alpha\/PKM2 positive feedback loop","volume":"12","author":"Qian","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2024.118896_bib44","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006617","article-title":"Angiotensin II receptor-neprilysin inhibitor sacubitril\/valsartan improves endothelial dysfunction in spontaneously hypertensive rats","volume":"6","author":"Seki","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"6","key":"10.1016\/j.jep.2024.118896_bib45","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jep.2024.118896_bib46","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/HYPERTENSIONAHA.120.15636","article-title":"Renal natriuretic peptide receptor-C deficiency attenuates NaCl cotransporter activity in angiotensin II-induced hypertension","volume":"77","author":"Shao","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2024.118896_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114825","article-title":"Ziziphus Oxyphylla hydro-methanolic extract ameliorates hypertension in L-NAME induced hypertensive rats through NO\/cGMP pathway and suppression of oxidative stress related inflammatory biomarkers","volume":"285","author":"Shaukat","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2024.118896_bib48","doi-asserted-by":"crossref","first-page":"H613","DOI":"10.1152\/ajpheart.00220.2020","article-title":"Metabolism of vascular smooth muscle cells in vascular diseases","volume":"319","author":"Shi","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.jep.2024.118896_bib49","first-page":"862","article-title":"Clinical value of qianyangyuyin granules in improving subclinical myocardial damage in patients with hypertension","volume":"21","author":"Tao","year":"2019","journal-title":"Journal of Clinical Ultrasound in Medicine"},{"issue":"6","key":"10.1016\/j.jep.2024.118896_bib64","first-page":"583","article-title":"Summary of China cardiovascular Health and Disease Report 2022","volume":"38","year":"2023","journal-title":"Chin. Circ. J."},{"issue":"4","key":"10.1016\/j.jep.2024.118896_bib50","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111713","article-title":"TWIST1 transcriptionally regulates glycolytic genes to promote the Warburg metabolism in pancreatic cancer","volume":"386","author":"Wang","year":"2020","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118896_bib52","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/HYPERTENSIONAHA.116.08556","article-title":"Effects of sacubitril\/valsartan versus olmesartan on central hemodynamics in the elderly with systolic hypertension: the PARAMETER study","volume":"69","author":"Williams","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2024.118896_bib53","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3389\/fphar.2018.01059","article-title":"Luteolin inhibits vascular smooth muscle cell proliferation and migration by inhibiting TGFBR1 signaling","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2024.118896_bib54","first-page":"291","article-title":"Clinical study on early intervention of Qianyang Yuyin granules to slow progression of leukoencephalopathy in hypertensive patients with cognitive impairment","volume":"38","author":"Yan","year":"2022","journal-title":"Journal of Nanjing University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2024.118896_bib55","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3389\/fphar.2020.01121","article-title":"Gallic acid attenuates angiotensin II-induced hypertension and vascular dysfunction by inhibiting the degradation of endothelial nitric oxide synthase","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118896_bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pcad.2019.11.009","article-title":"Left ventricular hypertrophy and hypertension","volume":"63","author":"Yildiz","year":"2020","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"12","key":"10.1016\/j.jep.2024.118896_bib57","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1158\/1541-7786.MCR-17-0298","article-title":"A first-in-class TWIST1 inhibitor with activity in oncogene-driven lung cancer","volume":"15","author":"Yochum","year":"2017","journal-title":"Mol. Cancer Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118896_bib58","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/2211-5463.13092","article-title":"TWIST1 induces phenotypic switching of vascular smooth muscle cells by downregulating p68 and microRNA-143\/145","volume":"11","author":"Zhang","year":"2021","journal-title":"FEBS Open Bio"},{"issue":"12","key":"10.1016\/j.jep.2024.118896_bib59","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1161\/HYPERTENSIONAHA.123.21348","article-title":"Resolvin E1\/ChemR23 protects against hypertension and vascular remodeling in angiotensin II-induced hypertensive mice","volume":"80","author":"Zhang","year":"2023","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2024.118896_bib60","article-title":"Prevalence, awareness, treatment, and control of hypertension in China, 2004-18: findings from six rounds of a national survey","volume":"380","author":"Zhang","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.jep.2024.118896_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112738","article-title":"Qian Yang Yu Yin Granule protects against hypertension-induced renal injury by epigenetic mechanism linked to Nicotinamide N-Methyltransferase (NNMT) expression","volume":"255","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118896_bib62","first-page":"897","article-title":"Effect of Qianyang Yuyin granule on early renal damage index of hypertension","volume":"19","author":"Zou","year":"2021","journal-title":"Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease"},{"issue":"6","key":"10.1016\/j.jep.2024.118896_bib63","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/HYPERTENSIONAHA.121.17584","article-title":"DP1 (prostaglandin D(2) receptor 1) activation protects against vascular remodeling and vascular smooth muscle cell transition to myofibroblasts in angiotensin II-induced hypertension in mice","volume":"79","author":"Zou","year":"2022","journal-title":"Hypertension"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124011954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T15:56:02Z","timestamp":1731340562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124011954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":64,"alternative-id":["S0378874124011954"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118896","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118896"}}