{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:11:03Z","timestamp":1791385863144,"version":"4.3.3"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002660","name":"Islamic Azad University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118913","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T02:46:43Z","timestamp":1728096403000},"page":"118913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"P2","title":["Antinociceptive and antineuropathic effects of Trifolium resupinatum L. on formalin-induced nociception and cervical spinal cord hemi-contusion: Underlying Mechanisms"],"prefix":"10.1016","volume":"337","author":[{"given":"Sajjad","family":"Jabbari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainul Amiruddin","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6966-7493","authenticated-orcid":false,"given":"Saeed","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118913_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115638","article-title":"Insight into the possible mechanism (s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil","volume":"298","author":"Abed","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118913_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114695","article-title":"Thymus persicus (Ronniger ex Rech. f.) Jalas alleviates nociceptive and neuropathic pain behavior in mice: multiple mechanisms of action","volume":"283","author":"Abed","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2024.118913_bib3","first-page":"31","article-title":"The analgesic effect of Echinophora platyloba hydroalcoholic extract in male rats","volume":"18","author":"Asgari Nematian","year":"2016","journal-title":"J. Babol. Univ. Med. Sci."},{"key":"10.1016\/j.jep.2024.118913_bib4","series-title":"Great Books of the Islamic World","first-page":"123","article-title":"The canon of medicine","year":"1999"},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neuropharm.2009.08.008","article-title":"Comparison of mechanical allodynia and the affective component of inflammatory pain in rats","volume":"58","author":"Boyce-Rustay","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2024.118913_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10787-010-0038-4","article-title":"Analgesic, anti-inflammatory and anti-platelet activities of the methanolic extract of Acacia modesta leaves","volume":"18","author":"Bukhari","year":"2010","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.neuro.24.1.487","article-title":"The vanilloid receptor: a molecular gateway to the pain pathway","volume":"24","author":"Caterina","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jep.2024.118913_bib8","first-page":"803","article-title":"Neuropathic pain and cytokines: current perspectives","volume":"21","author":"Clark","year":"2013","journal-title":"J. Pain Res."},{"issue":"3","key":"10.1016\/j.jep.2024.118913_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0304-3959(01)00454-7","article-title":"CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain","volume":"96","author":"Clayton","year":"2002","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.14336\/AD.2023.0515","article-title":"Targeting the JAK2\/STAT3 signaling pathway for chronic pain","volume":"15","author":"Dai","year":"2024","journal-title":"Aging. Dis."},{"issue":"10","key":"10.1016\/j.jep.2024.118913_bib11","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1089\/neu.2012.2632","article-title":"Chronic at-and below-level pain after moderate unilateral cervical spinal cord contusion in rats","volume":"30","author":"Detloff","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jep.2024.118913_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2024.118913_bib13","first-page":"69","article-title":"The value of plants used in traditional medicine for drug discovery","volume":"109","author":"Fabricant","year":"2001","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib14","first-page":"162","article-title":"Assessment of the antinociceptive, anti-inflammatory, and acute toxicity effects of solanum dulcamara essential oil in male mice","volume":"22","author":"Fallahzadeh","year":"2020","journal-title":"J. Babol. Univ. Med. Sci."},{"key":"10.1016\/j.jep.2024.118913_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s12272-001-1217-2","article-title":"Quercetin: further investigation of its antinociceptive properties and mechanisms of action","volume":"31","author":"Filho","year":"2008","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"12","key":"10.1016\/j.jep.2024.118913_bib16","first-page":"1058","article-title":"Evaluation of antinociceptive effect of methanolic extract of Lallemantia iberica in adult male rats","volume":"19","author":"Golshani","year":"2015","journal-title":"Armaghane danesh."},{"key":"10.1016\/j.jep.2024.118913_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113862","article-title":"Peripheral nitric oxide signaling directly blocks inflammatory pain","volume":"176","author":"Gomes","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118913_bib18","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1007\/s10787-023-01342-6","article-title":"Effects of Chaerophyllum macropodum Boiss. leaves essential oil in inflammatory and neuropathic pain: uncovering the possible mechanism of action","volume":"31","author":"Jabbari","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2024.118913_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117181","article-title":"The oral administration of Lotus corniculatus L. attenuates acute and chronic pain models in male rats","volume":"319","author":"Jabbari","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2024.118913_bib20","article-title":"Acute inflammation reveals GABAA receptor\u2010mediated nociception in mouse dorsal root ganglion neurons via PGE 2 receptor 4 signaling","volume":"5","author":"Jang","year":"2017","journal-title":"Phys. Rep."},{"issue":"4","key":"10.1016\/j.jep.2024.118913_bib21","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1039\/C6FO00194G","article-title":"A phytochemical and computational study on flavonoids isolated from Trifolium resupinatum L. and their novel hepatoprotective activity","volume":"7","author":"Kamel","year":"2016","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.2174\/1570163817666200316105658","article-title":"An evidence-based review of medicinal plants used in traditional Persian medicine for treatment of osteoarthritis","volume":"18","author":"Karami","year":"2021","journal-title":"Curr. Drug Discov. Technol."},{"issue":"4","key":"10.1016\/j.jep.2024.118913_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1049\/iet-nbt.2015.0078","article-title":"Plant\u2010mediated green synthesis of silver nanoparticles using Trifolium resupinatum seed exudate and their antifungal efficacy on Neofusicoccum parvum and Rhizoctonia solani","volume":"10","author":"Khatami","year":"2016","journal-title":"IET Nanobiotechnol."},{"issue":"11","key":"10.1016\/j.jep.2024.118913_bib24","first-page":"1258","article-title":"Central mechanisms of pathological pain","volume":"16","author":"Kuner","year":"2010","journal-title":"Nat. Med. (N. Y., NY, U. S.)"},{"issue":"12","key":"10.1016\/j.jep.2024.118913_bib25","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.2174\/1570159X20666220812122437","article-title":"The emerging role of quercetin in the treatment of chronic pain","volume":"20","author":"Liu","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jep.2024.118913_bib26","first-page":"174","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) for musculoskeletal pain","volume":"372","author":"Machado","year":"2021","journal-title":"B.M.J."},{"issue":"6","key":"10.1016\/j.jep.2024.118913_bib27","first-page":"36","article-title":"Antinociceptive effect of hydroalcoholic leaf extract of tribulus terrestris L. in male rat","volume":"15","author":"Mahmoodi","year":"2013","journal-title":"J. Babol. Univ. Med. Sci."},{"issue":"3","key":"10.1016\/j.jep.2024.118913_bib28","first-page":"201","article-title":"Evaluation of the antinociceptive effect of hydroalcoholic extract of Potentilla reptans L. in the adult male rat","volume":"24","author":"Mahmoodi","year":"2016","journal-title":"S.S.U. J."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.5114\/fn.2023.125599","article-title":"Antioxidant properties of Trifolium resupinatum and its therapeutic potential for Alzheimer's disease","volume":"61","author":"Mardi","year":"2023","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.jep.2024.118913_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11694-020-00614-x","article-title":"Evaluation of stability, physicochemical and antioxidant properties of extracted chlorophyll from Persian clover (Trifolium resupinatum L.)","volume":"15","author":"Mehdipoor Damiri","year":"2021","journal-title":"J. Food Meas. Char."},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.15379\/2409-3564.2017.04.02.03","article-title":"Neuroprotective effects of rhamnazin as a flavonoid on chronic stress-induced cognitive impairment","volume":"4","author":"Mohammadi","year":"2017","journal-title":"J. Adv. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pbb.2008.06.008","article-title":"Additive interaction between peripheral and central mechanisms involved in the antinociceptive effect of diclofenac in the formalin test in rats","volume":"91","author":"Ortiz","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib33","first-page":"784","article-title":"Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone","volume":"277","author":"Ossipov","year":"1996","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"8","key":"10.1016\/j.jep.2024.118913_bib34","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/heapol\/czw022","article-title":"Use of traditional medicine in middle-income countries: a WHO-SAGE study","volume":"31","author":"Oyebode","year":"2016","journal-title":"Health Pol. Plann."},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jep.2013.04.031","article-title":"Comparative assessment of dermal wound healing potentials of various Trifolium L. extracts and determination of their isoflavone contents as potential active ingredients","volume":"148","author":"Renda","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib37","first-page":"110","article-title":"Antiinflammatory and antioxidant activities of Trifolium resupinatum var. microcephalum extracts","volume":"20","author":"Sabudak","year":"2008","journal-title":"Asian J. Chem."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(00)00355-1","article-title":"Activation of ATP-sensitive K+ channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside","volume":"400","author":"Soares","year":"2000","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2024.118913_bib39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2220\/biomedres.42.43","article-title":"The diversity in sensitivity of TRPA1 and TRPV1 of various animals to polyphenols","volume":"42","author":"Takahashi","year":"2021","journal-title":"Biomed. Res."},{"issue":"14","key":"10.1016\/j.jep.2024.118913_bib40","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/S0024-3205(02)01491-1","article-title":"Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test","volume":"70","author":"Torres-L\u00f3pez","year":"2002","journal-title":"Life Sci."},{"issue":"41","key":"10.1016\/j.jep.2024.118913_bib41","doi-asserted-by":"crossref","first-page":"13879","DOI":"10.1523\/JNEUROSCI.2711-15.2015","article-title":"Pain and poppies: the good, the bad, and the ugly of opioid analgesics","volume":"35","author":"Trang","year":"2015","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/j.pain.0000000000001384","article-title":"Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD-11)","volume":"160","author":"Treede","year":"2019","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pharep.2016.10.004","article-title":"Antinociceptive tolerance to NSAIDs in the rat formalin test is mediated by the opioid mechanism","volume":"69","author":"Tsiklauri","year":"2017","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib44","article-title":"Medicinal plants of the family Lamiaceae in pain therapy: a review. Pain","volume":"20","author":"Uritu","year":"2018","journal-title":"Res. Manag."},{"issue":"11","key":"10.1016\/j.jep.2024.118913_bib45","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1021\/np900259y","article-title":"Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production","volume":"72","author":"Val\u00e9rio","year":"2009","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0014-2999(01)00970-0","article-title":"Antisera against endogenous opioids increase the nocifensive response to formalin: demonstration of inhibitory \u03b2-endorphinergic control","volume":"421","author":"Wu","year":"2001","journal-title":"Euro. J. pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.118913_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14714-0","article-title":"Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.118913_bib49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2014.07.015","article-title":"STAT3 inhibitor WP1066 as a novel therapeutic agent for bCCl neuropathic pain rats","volume":"1583","author":"Xue","year":"2014","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2024.118913_bib50","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2147\/JPR.S298727","article-title":"Quercetin alleviates neuropathic pain in the rat CCI model by mediating AMPK\/MAPK pathway","author":"Ye","year":"2021","journal-title":"J. Pain Res."},{"key":"10.1016\/j.jep.2024.118913_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113604","article-title":"Artemisia biennis Willd.: anti-Nociceptive effects and possible mechanisms of action","volume":"268","author":"Zarei","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2024.118913_bib52","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4103\/1673-5374.357912","article-title":"Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury","volume":"18","author":"Zhou","year":"2023","journal-title":"Neural. Regen. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124012121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124012121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T03:44:53Z","timestamp":1731469493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124012121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":50,"alternative-id":["S0378874124012121"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118913","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive and antineuropathic effects of Trifolium resupinatum L. on formalin-induced nociception and cervical spinal cord hemi-contusion: Underlying Mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118913"}}