{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:56:54Z","timestamp":1788458214502,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.118941","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T10:57:31Z","timestamp":1729335451000},"page":"118941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"P3","title":["Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages"],"prefix":"10.1016","volume":"337","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-0381","authenticated-orcid":false,"given":"Shiying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linkun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118941_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellimm.2014.03.012","article-title":"The monocyte-macrophage axis in the intestine","volume":"291","author":"Bain","year":"2014","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jep.2024.118941_bib2","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161944","article-title":"A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages","volume":"133","author":"Bedard","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2024.118941_bib3","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1080\/15548627.2022.2116833","article-title":"FOXP3+macrophage represses acute ischemic stroke-induced neural inflammation","volume":"19","author":"Cai","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.118941_bib4","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/s41385-022-00572-1","article-title":"Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism","volume":"15","author":"Cavounidis","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jep.2024.118941_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14309\/ajg.0000000000002485","article-title":"A review of available medical therapies to treat moderate-to-severe inflammatory bowel disease","volume":"119","author":"Chang","year":"2024","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2024.118941_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.524287","article-title":"Shaoyao decoction inhibits inflammation and improves intestinal barrier function in mice with dextran sulfate sodium-induced colitis","volume":"12","author":"Chi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.118941_bib7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/ecco-jcc\/jjy181","article-title":"A molecular targeted immunotherapeutic strategy for ulcerative colitis via dual-targeting nanoparticles delivering miR-146b to intestinal macrophages","volume":"13","author":"Deng","year":"2019","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jep.2024.118941_bib8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/15548627.2017.1332567","article-title":"BNIP3L\/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming","volume":"14","author":"Esteban-Mart\u00ednez","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.118941_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-5793(98)01273-3","article-title":"PPAR\u03b33 mRNA: a distinct PPAR\u03b3 mRNA subtype transcribed from an independent promoter","volume":"438","author":"Fajas","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jep.2024.118941_bib10","article-title":"Shaoyao decoction restores the mucus layer in mice with DSS-induced colitis by regulating Notch signaling pathway","volume":"308","author":"Fang","year":"2023"},{"key":"10.1016\/j.jep.2024.118941_bib39","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/ecco-jcc\/jjz193","article-title":"Zinc Deficiency Activates the IL-23\/Th17 Axis to Aggravate Experimental Colitis in Mice","volume":"14","author":"Higashimura","year":"2020","journal-title":"J. Crohns. Colitis"},{"key":"10.1016\/j.jep.2024.118941_bib11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1080\/15548627.2019.1582743","article-title":"SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions","volume":"15","author":"Kim","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.118941_bib12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/apt.17570","article-title":"Efficacy of biologic and small molecule agents as second-line therapy after exposure to TNF inhibitors in patients with ulcerative colitis: a propensity-matched cohort study","volume":"58","author":"Kochhar","year":"2023","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2024.118941_bib13","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1053\/j.gastro.2019.07.007","article-title":"Inhibiting PGGT1B disrupts function of RHOA, resulting in T-cell expression of integrin \u03b14\u03b27 and development of colitis in mice","volume":"157","author":"L\u00f3pez-Posadas","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2024.118941_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2024.118941_bib15","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/ecco-jcc\/jjac101","article-title":"Intestinal epithelial responses to IL-17 in adult stem cell-derived human intestinal organoids","volume":"16","author":"Lee","year":"2022","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jep.2024.118941_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mucimm.2022.12.005","article-title":"TLE3 and TLE4-coordinated colonic macrophage-CD4(+) T cell crosstalk maintains intestinal immune homeostasis","volume":"16","author":"Li","year":"2023","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jep.2024.118941_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13046-018-0938-5","article-title":"Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages","volume":"37","author":"Li","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jep.2024.118941_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74690","article-title":"Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses","volume":"11","author":"Lundahl","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jep.2024.118941_bib19","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1074\/jbc.M115.676817","article-title":"Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression","volume":"291","author":"Meiser","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2024.118941_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.637778","article-title":"Lysosome-dependent LXR and PPAR\u03b4 activation upon efferocytosis in human macrophages","volume":"12","author":"Mota","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118941_bib21","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1016\/j.cell.2022.08.018","article-title":"mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity","volume":"185","author":"Pag\u00e1n","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.118941_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.apsb.2023.10.019","article-title":"Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming","volume":"14","author":"Pham","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2024.118941_bib23","doi-asserted-by":"crossref","first-page":"I72","DOI":"10.1093\/ecco-jcc\/jjad212.0041","article-title":"Definitions of histological abnormalities in inflammatory bowel disease: an ECCO position paper","volume":"18","author":"Rosini","year":"2024","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jep.2024.118941_bib24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/ecco-jcc\/jjz170","article-title":"The TLR9 agonist cobitolimod induces IL10-producing wound healing macrophages and regulatory T cells in ulcerative colitis","volume":"14","author":"Schmitt","year":"2020","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jep.2024.118941_bib25","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/ecco-jcc\/jjad111","article-title":"Clinical features and natural history of paediatric patients with ulcerative proctitis: a multicentre study from the paediatric ibd porto group of espghan","volume":"17","author":"Tal","year":"2023","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jep.2024.118941_bib26","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.21037\/atm-21-6034","article-title":"Thrombospondin-1 aggravates colonic mucosal inflammatory injuries via promoting the differentiation of CD11c+macrophages with lysosomal activity limited in colitis","volume":"9","author":"Tao","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jep.2024.118941_bib27","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.7150\/thno.62046","article-title":"Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the microbiota","volume":"11","author":"Tong","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2024.118941_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5498115","article-title":"Alpha-bisabolol mitigates colon inflammation by stimulating colon PPAR-gamma transcription factor: in vivo and in vitro study","volume":"2022","author":"Venkataraman","year":"2022","journal-title":"PPAR Res."},{"issue":"22","key":"10.1016\/j.jep.2024.118941_bib29","first-page":"5997","article-title":"[Chinese medicinal formulae treat inflammatory bowel diseases through maintaining gut flora homeostasis]","volume":"47","author":"Wang","year":"2022","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2024.118941_bib30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/MIB.0000000000001055","article-title":"The different effects of VEGFA121 and VEGFA165 on regulating angiogenesis depend on phosphorylation sites of VEGFR2","volume":"23","author":"Wang","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jep.2024.118941_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153743","article-title":"Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-\u03baB pathway","volume":"92","author":"Wei","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.118941_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105796","article-title":"Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"172","author":"Wu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2024.118941_bib33","first-page":"1495","article-title":"Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR\/IL-22 pathway in ILC3s","volume":"43","author":"Yan-Yang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2024.118941_bib34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/stem.3144","article-title":"Mesenchymal stem cells elicit macrophages into M2 phenotype via improving transcription factor EB-mediated autophagy to alleviate diabetic nephropathy","volume":"38","author":"Yuan","year":"2020","journal-title":"Stem Cell."},{"key":"10.1016\/j.jep.2024.118941_bib35","article-title":"Paeoniflorin promotes intestinal stem cell-mediated epithelial regeneration and repair via PI3K-AKT-mTOR signalling in ulcerative colitis","volume":"119","author":"Yujing","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.118941_bib36","article-title":"Interleukin 17 B regulates colonic myeloid cell infiltration in a mouse model of DSS-induced colitis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.118941_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117874","article-title":"Shaoyao decoction improves damp-heat colitis by activating the AHR\/IL-22\/STAT3 pathway through tryptophan metabolism driven by gut microbiota","volume":"326","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.118941_bib38","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/mi.2016.5","article-title":"T-bet expression by Th cells promotes type 1 inflammation but is dispensable for colitis","volume":"9","author":"Zimmermann","year":"2016","journal-title":"Mucosal Immunol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124012406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124012406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T15:56:22Z","timestamp":1731340582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124012406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"alternative-id":["S0378874124012406"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118941","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"118941"}}