{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:04:59Z","timestamp":1788901499782,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jep.2024.118993","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T06:44:41Z","timestamp":1730270681000},"page":"118993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P1","title":["In vivo evaluation of anti-diarrheal activity of hydroalcoholic extract and solvent fractions of the leaf of Leucas de\ufb02exa Hook.f (Lamiaceae) in rodents"],"prefix":"10.1016","volume":"338","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-3468","authenticated-orcid":false,"given":"Workineh Woldeselassie","family":"Hammeso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebeyi","family":"Fisseha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadele","family":"Abera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejen","family":"Nureye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behailu Desalegn","family":"Woldeselassie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.118993_bib1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jep.2012.11.029","article-title":"An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines","volume":"145","author":"Abe","year":"2013","journal-title":"J.ethnopharmacology"},{"key":"10.1016\/j.jep.2024.118993_bib2","first-page":"1","article-title":"Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. ex Del.(Euphorbiaceae) in mice model","volume":"16","author":"Amsalu Degu","year":"2016","journal-title":"BMC"},{"key":"10.1016\/j.jep.2024.118993_bib3","first-page":"233","article-title":"Antidiarrheal activity of three medicinal plants in swiss albino mice","volume":"6","author":"Ashrafuzzaman","year":"2016","journal-title":"Inter. J.Bio.med."},{"key":"10.1016\/j.jep.2024.118993_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-62703-131-8_4","article-title":"The OECD guidelines for the testing of chemicals and pesticides","author":"Buschmann","year":"2013","journal-title":"Teratogenicity Testing: Methods and Protocols"},{"key":"10.1016\/j.jep.2024.118993_bib5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1053\/j.gastro.2016.10.014","article-title":"Pathophysiology, evaluation, and management of chronic watery diarrhea","volume":"152","author":"Camilleri","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2024.118993_bib6","series-title":"Guide for the Care and Use of Laboratory Animals","author":"Care","year":"1986"},{"key":"10.1016\/j.jep.2024.118993_bib7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.tips.2010.04.008","article-title":"Current and emerging therapies in irritable bowel syndrome: from pathophysiology to treatment","volume":"31","author":"Chang","year":"2010","journal-title":"Tre. in pharma.sci."},{"key":"10.1016\/j.jep.2024.118993_bib8","first-page":"30","article-title":"Effect of curcuma angustifolia rhizome powder on intestinal motility against Castor oil induced diarrhea in rats","volume":"8","author":"D\u2019Almeida","year":"2017","journal-title":"Inter. J.Pharma and Bio Sci."},{"key":"10.1016\/j.jep.2024.118993_bib9","article-title":"Antidiarrheal effect of 80% methanol extract and fractions of clerodendrum myricoides (hochst.) vatke (lamiaceae) leaf in swiss albino mice","volume":"2021","author":"Desta","year":"2021","journal-title":"Evi. Comple. and Alter. Med"},{"key":"10.1016\/j.jep.2024.118993_bib10","series-title":"Evaluation of the Anti-diarrheal Activity of the Aqueous Stem Extract of Lantana Camara Linn (Verbenaceae) in Mice","author":"Edlam Tadesse","year":"2017"},{"key":"10.1016\/j.jep.2024.118993_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.11648\/j.jddmc.20160206.11","article-title":"In vivo antiplasmodial activity of fractions and chromatographic sub fractionions of ethanol extract of Clerodendrum myricoides leaves","volume":"12","author":"Gebretsadik","year":"2016","journal-title":"J. Dru. Desi. and Medicinal Chemi."},{"key":"10.1016\/j.jep.2024.118993_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2458-14-395","article-title":"Risk factors of diarrhoeal disease in under-five children among health extension model and non-model families in Sheko district rural community, Southwest Ethiopia: comparative cross-sectional study","volume":"14","author":"Gebru","year":"2014","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.jep.2024.118993_bib13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5099\/aj130300208","article-title":"In vivo antidiarrheal and cytotoxic potential of different fractions of Pandanus Foetidus leaves","volume":"5","author":"Islam","year":"2013","journal-title":"Am J Biomed Sci"},{"key":"10.1016\/j.jep.2024.118993_bib14","first-page":"3","article-title":"The evolving role of natural products from the tropical rainforests as a replenishable source of new drug leads","author":"Jantan","year":"2015","journal-title":"Dru. Disc. and Devel-From Mole. to Med."},{"key":"10.1016\/j.jep.2024.118993_bib15","article-title":"Methanolic crude extract of hagenia abyssinica possesses significant antidiarrheal effect: evidence for in vivo antidiarrheal activity","volume":"2021","author":"Kifle","year":"2021","journal-title":"Evi. Bas.Compl.and Alter. Med."},{"key":"10.1016\/j.jep.2024.118993_bib16","first-page":"209","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"The lan"},{"key":"10.1016\/j.jep.2024.118993_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115560","article-title":"Antidiarrheal activity of the extracts of Valeriana jatamansi Jones on castor oil-induced diarrhea mouse by regulating multiple signal pathways","volume":"298","author":"Ma","year":"2022","journal-title":"J.Ethnopharmacology"},{"key":"10.1016\/j.jep.2024.118993_bib18","first-page":"287","article-title":"Antidiarrheal activity of flowers of ixora coccinea linn","volume":"1","author":"Maniyar","year":"2010","journal-title":"rats. J.Ayu. and Integ. Med."},{"key":"10.1016\/j.jep.2024.118993_bib19","article-title":"Antidiarrheal activity of 80% methanolic leaf extract of Justicia schimperiana","volume":"2018","author":"Mekonnen","year":"2018","journal-title":"Evi. Bas.Compl.and Alter. Med."},{"key":"10.1016\/j.jep.2024.118993_bib20","series-title":"Ethnomedicinal Study of Plants Used by Sheko Ethnic Group of Ethiopia","author":"Mirutse Giday","year":"2010"},{"key":"10.1016\/j.jep.2024.118993_bib21","series-title":"Evaluation of Anti-diarrheal Activity of 80% Methanol Extracts of Vernonia Amygdalina Delile (Asteraceae) Leaves in Mice","first-page":"455","author":"Mosisa Gudeta","year":"2020"},{"key":"10.1016\/j.jep.2024.118993_bib22","doi-asserted-by":"crossref","first-page":"23129","DOI":"10.3390\/ijms141123129","article-title":"GC and GC\/MS analysis of essential oil composition of the endemic Soqotraen Leucas virgata Balf. f. and its antimicrobial and antioxidant activities","volume":"14","author":"Mothana","year":"2013","journal-title":"Inter. J.Mole.Sci"},{"key":"10.1016\/j.jep.2024.118993_bib23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s13237-022-00405-3","article-title":"Plant-derived natural products for drug discovery: current approaches and prospects","volume":"65","author":"Nasim","year":"2022","journal-title":"The Nucle"},{"key":"10.1016\/j.jep.2024.118993_bib24","first-page":"11","article-title":"Preliminary evaluation of the antidiarrheal effects of ethanol leaf extract and fractions of rauwolfia vomitoria afzel","volume":"15","author":"Odenigbo","year":"2020","journal-title":"Apocynaceae).Inter.J.Pharma.,Phyto.and Ethnomedicine"},{"key":"10.1016\/j.jep.2024.118993_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jopr.2013.03.013","article-title":"Anti-motility and reductions in the concentrations of gut electrolytes: bases for the anti-spastic use of the leaves of Persea americana in folk medicine","volume":"6","author":"Odo","year":"2013","journal-title":"J. pharmacy research"},{"key":"10.1016\/j.jep.2024.118993_bib26","first-page":"2691","article-title":"Jatropha curcas: plant of medical benefits","volume":"6","author":"Prasad","year":"2012","journal-title":"J. medi. plants research"},{"key":"10.1016\/j.jep.2024.118993_bib27","article-title":"Evaluation of antidiarrheal activity of methanolic extract of Maranta arundinacea Linn. leaves","volume":"2015","author":"Rahman","year":"2015","journal-title":"Adv.Pharma.and Pharmaceu. Sci."},{"key":"10.1016\/j.jep.2024.118993_bib28","series-title":"Anti Diarrhoeal Activity of Ziziphus Jujuba Leaf Extract in Rats","author":"Rao","year":"2012"},{"key":"10.1016\/j.jep.2024.118993_bib29","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3390\/jcm8111923","article-title":"Management of dehydration in patients suffering swallowing difficulties","volume":"8","author":"Reber","year":"2019","journal-title":"J.cli. med."},{"key":"10.1016\/j.jep.2024.118993_bib30","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ajg.2016.126","article-title":"ACG clinical guideline: diagnosis, treatment, and prevention of acute diarrheal infections in adults","volume":"111","author":"Riddle","year":"2016","journal-title":"Offi. J.Am. C.Gastroenterology| ACG"},{"key":"10.1016\/j.jep.2024.118993_bib31","first-page":"1","article-title":"Phytochemistry and effects of ethanol leaf extract of Meytenus Senengalensis (Lam) on castor-oil induced diarrhoea in albino rats","volume":"17","author":"Sanda","year":"2020","journal-title":"Sah. J.Vet.Sci."},{"key":"10.1016\/j.jep.2024.118993_bib32","series-title":"Physio.G.I.T","article-title":"Pathophysiology of diarrhea and its clinical implications","author":"Sheikh","year":"2018"},{"key":"10.1016\/j.jep.2024.118993_bib33","series-title":"Antidiarrhoeal and Antimicrobial Activity of Calpurnia Aurea Leaf Extract","author":"Shemsu Umer","year":"2013"},{"key":"10.1016\/j.jep.2024.118993_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2431-14-102","article-title":"Determinants of childhood diarrhea among underfive children in Benishangul Gumuz regional state, north West Ethiopia","volume":"14","author":"Sinmegn Mihrete","year":"2014","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.jep.2024.118993_bib35","article-title":"Evaluation of the antispasmodic and antisecretory activities of the 80% methanol extracts of verbena officinalis L: evidence from in vivo antidiarrheal study","volume":"24","author":"Sisay","year":"2019","journal-title":"J.evid-bas. integ. med."},{"key":"10.1016\/j.jep.2024.118993_bib36","first-page":"1","article-title":"Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model","volume":"17","author":"Sisay","year":"2017","journal-title":"BMC (Biomed. Chromatogr.)"},{"key":"10.1016\/j.jep.2024.118993_bib37","first-page":"1","article-title":"Evaluation of the anti-diarrheal activity of the aqueous stem extract of Lantana camara Linn (Verbenaceae) in mice","volume":"17","author":"Tadesse","year":"2017","journal-title":"BMC (Biomed. Chromatogr.)"},{"key":"10.1016\/j.jep.2024.118993_bib38","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1073\/pnas.1201627109","article-title":"Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors","volume":"109","author":"Tunaru","year":"2012","journal-title":"Pro.Nati. Acad.of Sci."},{"key":"10.1016\/j.jep.2024.118993_bib39","series-title":"AVMA Guidelines for the Euthanasia of Animals","first-page":"2020","author":"Underwood","year":"2020"},{"key":"10.1016\/j.jep.2024.118993_bib40","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/978-3-030-53893-4_20","article-title":"Antibacterial clays: scientific investigations of their practical applications in medicine","author":"Williams","year":"2021","journal-title":"Pract. Appli. of Medical Geology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124012923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124012923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T07:58:59Z","timestamp":1734076739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124012923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"alternative-id":["S0378874124012923"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.118993","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo evaluation of anti-diarrheal activity of hydroalcoholic extract and solvent fractions of the leaf of Leucas de\ufb02exa Hook.f (Lamiaceae) in rodents","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.118993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118993"}}