{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T13:06:07Z","timestamp":1788440767414,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.119133","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T08:27:41Z","timestamp":1732004861000},"page":"119133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study"],"prefix":"10.1016","volume":"339","author":[{"given":"Abdullah","family":"Haikal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-3206","authenticated-orcid":false,"given":"Mona","family":"El-Neketi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar G.","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-6567","authenticated-orcid":false,"given":"Laila A.","family":"Abou-zeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha A.","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-1543","authenticated-orcid":false,"given":"Ahmed A.","family":"Gohar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jep.2024.119133_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1358\/mf.2009.31.10.1441861","article-title":"Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice","volume":"31","author":"Amabeoku","year":"2009","journal-title":"Method. Find. Exp. Clin."},{"issue":"9","key":"10.1016\/j.jep.2024.119133_bib3","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0165-6147(94)90027-2","article-title":"TH2 and \u2018TH2-like\u2019cells in allergy and asthma: pharmacological perspectives","volume":"15","author":"Anderson","year":"1994","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.jep.2024.119133_bib4","first-page":"639","article-title":"Approved recommendation on ifcc methods for the measurement of catalytic concentration of enzymes. Part 8. Ifcc method for lactate dehydrogenase (l-lactate: Nad+oxidoreductase, ec 1.1.1.27). International federation of clinical chemistry (ifcc)","volume":"32","author":"Bais","year":"1994","journal-title":"Eur. J. Clin. Chem. Clin."},{"issue":"20","key":"10.1016\/j.jep.2024.119133_bib5","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1021\/jm00046a016","article-title":"Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-Amino-6-phenyl-2-pyridinyl trifluoromethyl ketones","volume":"37","author":"Bernstein","year":"1994","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.jep.2024.119133_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0003-2697(83)90580-8","article-title":"A rapid biuret assay for protein of whole fatty tissues","volume":"129","author":"Beyer","year":"1983","journal-title":"Anal. Biochem."},{"issue":"11","key":"10.1016\/j.jep.2024.119133_bib7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1055\/s-2003-45141","article-title":"Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor \u03ba B (NF-\u03baB)","volume":"69","author":"Calixto","year":"2003","journal-title":"Planta Med."},{"issue":"2","key":"10.1016\/j.jep.2024.119133_bib8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/01902148.2016.1143537","article-title":"Recombinant human deoxyribonuclease therapy improves airway resistance and reduces DNA extracellular traps in a murine acute asthma model","volume":"42","author":"Da Cunha","year":"2016","journal-title":"Exp. Lung Res."},{"issue":"3","key":"10.1016\/j.jep.2024.119133_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s000110300021","article-title":"Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice","volume":"52","author":"Das","year":"2003","journal-title":"Inflamm. Res."},{"issue":"4","key":"10.1016\/j.jep.2024.119133_bib10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.5530\/ijper.57.4.126","article-title":"In silico discovery of STRA 6 vitamin A receptor, as a novel binding receptor of COVID-19","volume":"57","author":"Elkazzaz","year":"2023","journal-title":"Ind. J. Pharm. Edu. Res"},{"issue":"2","key":"10.1016\/j.jep.2024.119133_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1183\/09031936.00047306","article-title":"\u03b11-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients","volume":"29","author":"Griese","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2024.119133_bib12","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s10600-021-03516-6","article-title":"Mentha longifolia subsp. typhoides and subsp. schimperi: antimicrobial and Antiquorum-Sensing Bioactivities","volume":"57","author":"Haikal","year":"2021","journal-title":"Chem. Nat. Compd."},{"issue":"8","key":"10.1016\/j.jep.2024.119133_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102356","article-title":"Essential oils from wild Mentha longifolia subspecies typhoides and subspecies schimperi: burn wound healing and antimicrobial candidates","volume":"34","author":"Haikal","year":"2022","journal-title":"J. King Saud Univ. Sci."},{"issue":"3","key":"10.1016\/j.jep.2024.119133_bib14","first-page":"1460","article-title":"Linarin prevents lps-induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of txnip\/nlrp3 and nf-\u03bab pathways","volume":"42","author":"Han","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2024.119133_bib15","series-title":"An Evaluation of the Bronchodilator Properties of Mentha longifolia and Artemisia afra, Traditional Medicinal Plants Used in the Western Cape.\u200f Master Thesis","author":"Harris","year":"2002"},{"key":"10.1016\/j.jep.2024.119133_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117017","article-title":"Saxagliptin mitigates airway inflammation in a mouse model of acute asthma via modulation of nf-kb and tlr4","volume":"239","author":"Helal","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.119133_bib17","series-title":"Diagnosis and Management of Asthma","first-page":"36","author":"Kavuru","year":"1998"},{"issue":"3","key":"10.1016\/j.jep.2024.119133_bib18","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.2500\/ajra.2015.29.4195","article-title":"Protective effects of rutin through regulation of vascular endothelial growth factor in allergic rhinitis","volume":"29","author":"Kim","year":"2015","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.jep.2024.119133_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112082","article-title":"Eriobotrya japonica leaf extract attenuates airway inflammation in ovalbumin-induced mice model of asthma","volume":"253","author":"Kim","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2024.119133_bib20","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1055\/s-2004-835838","article-title":"Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness","volume":"70","author":"Ko","year":"2004","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2024.119133_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125124","article-title":"Anti-inflammatory effects of flavonoids","volume":"299","author":"Maleki","year":"2019","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2024.119133_bib22","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.jep.2024.119133_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jep.2024.119133_bib24","first-page":"69","article-title":"Medicinal and nutritional importance of Adhatoda vasica in human health","volume":"1","author":"Mohanty","year":"2024"},{"issue":"1","key":"10.1016\/j.jep.2024.119133_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione s-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2024.119133_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114574","article-title":"Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma","volume":"282","author":"Nam","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.119133_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117426","article-title":"Melia azedarach L. reduces pulmonary inflammation and mucus hypersecretion on a murine model of ovalbumin exposed asthma","volume":"320","author":"Pak","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2024.119133_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s00011-007-7005-6","article-title":"Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma","volume":"56","author":"Rogerio","year":"2007","journal-title":"Inflamm. Res."},{"issue":"7","key":"10.1016\/j.jep.2024.119133_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/nu9070699","article-title":"Reduction of asthmatic parameters by sea hare hydrolysates in a mouse model of allergic asthma","volume":"9","author":"Ryu","year":"2017","journal-title":"Nutrients"},{"issue":"21","key":"10.1016\/j.jep.2024.119133_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112791","article-title":"Nontoxic and naturally occurring active compounds as potential inhibitors of biological targets in Liriomyza trifolii","volume":"23","author":"Shamkh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"34","key":"10.1016\/j.jep.2024.119133_bib31","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.2174\/0113816128260449231017091824","article-title":"AI-Driven discovery of celecoxib and Dexamethasone for exploring their mode of action as human interleukin (IL-6) inhibitors to treat COVID-19-induced cytokine storm in humans","volume":"29","author":"Shamkh","year":"2023","journal-title":"Curr. Pharmaceut. Des."},{"issue":"1","key":"10.1016\/j.jep.2024.119133_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0944-7113(97)80024-4","article-title":"Inhibition of lipid peroxidation by ternatin, a tetramethoxyflavone from Egletes viscosa L","volume":"4","author":"Souza","year":"1997","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2024.119133_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1359-6446(97)01167-7","article-title":"Exploration of nature's chemodiversity: the role of secondary metabolites as leads in drug development","volume":"3","author":"Verpoorte","year":"1998","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2024.119133_bib34","series-title":"The Medicinal and Poisonous Plants of South Africa","author":"Watt","year":"1962"},{"key":"10.1016\/j.jep.2024.119133_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s10753-011-9295-7","article-title":"Hesperidin suppresses ovalbumin\u2010induced airway inflammation in a mouse allergic asthma model","volume":"35","author":"Wei","year":"2012","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.jep.2024.119133_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.immunol.17.1.255","article-title":"Immunologic basis of antigen-induced airway hyperresponsiveness","volume":"17","author":"Wills-Karp","year":"1999","journal-title":"Annu. Rev. Immunol."},{"issue":"23","key":"10.1016\/j.jep.2024.119133_bib38","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1016\/j.lfs.2005.10.029","article-title":"Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms","volume":"78","author":"Wu","year":"2006","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jep.2024.119133_bib39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1573409911309030012","article-title":"Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity","volume":"9","author":"Yadav","year":"2013","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"1","key":"10.1016\/j.jep.2024.119133_bib40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jep.2008.03.012","article-title":"Inhibitory effects of Duchesnea chrysantha extract on ovalbumin-induced lung inflammation in a mouse model of asthma","volume":"118","author":"Yang","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2024.119133_bib41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/10717544.2019.1704941","article-title":"In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity","volume":"27","author":"Yao","year":"2020","journal-title":"Drug Deliv."},{"issue":"10","key":"10.1016\/j.jep.2024.119133_bib42","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.3390\/molecules23102547","article-title":"Recent trends in potential therapeutic applications of the dietary flavonoid didymin","volume":"23","author":"Yao","year":"2018","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jep.2024.119133_bib43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/cea.12298","article-title":"Direct comparison of the dynamics of il-25- and 'allergen'-induced airways inflammation, remodelling and hypersensitivity in a murine asthma model","volume":"44","author":"Yao","year":"2014","journal-title":"Clin. Exp. Allergy : j. Brit. Soc. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2024.119133_bib44","first-page":"481","article-title":"Latest research topics on allergic asthma","volume":"34","author":"Yu","year":"2018","journal-title":"Chin. J. Immunol."},{"key":"10.1016\/j.jep.2024.119133_bib45","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.intimp.2017.08.015","article-title":"Propofol inhibits nf-kappa b activation to ameliorate airway inflammation in ovalbumin (ova)-induced allergic asthma mice","volume":"51","author":"Zhang","year":"2017","journal-title":"Int. Immunopharm."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124014326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124014326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T12:49:28Z","timestamp":1738673368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124014326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"alternative-id":["S0378874124014326"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.119133","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbumin-induced allergic asthma in mice: In-vivo and in-silico study","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.119133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119133"}}