{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:46:59Z","timestamp":1793296019521,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305055"],"award-info":[{"award-number":["82305055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A04612"],"award-info":[{"award-number":["CI2021A04612"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021B017"],"award-info":[{"award-number":["CI2021B017"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2024T171046"],"award-info":[{"award-number":["2024T171046"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024T171047"],"award-info":[{"award-number":["2024T171047"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M743919"],"award-info":[{"award-number":["2023M743919"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.119214","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T21:29:41Z","timestamp":1733347781000},"page":"119214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Angong Niuhuang Pill pretreatment alleviates cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through the SIRT1-H4K16ac axis"],"prefix":"10.1016","volume":"340","author":[{"given":"Lihan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-9184","authenticated-orcid":false,"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.119214_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jep.2024.119214_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2013.02.041","article-title":"Effect of berberine on cell cycle arrest and cell survival during cerebral ischemia and reperfusion and correlations with p53\/cyclin D1 and PI3K\/Akt","volume":"708","author":"Chai","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2024.119214_bib3","article-title":"Treatment of brain edema by wogonoside is associated with inhibition of neuronal apoptosis and SIRT1 activation in rats","volume":"26","author":"Cheng","year":"2020","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.jep.2024.119214_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110886","article-title":"Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK\/SIRT1","volume":"207","author":"Cheng","year":"2024","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2024.119214_bib5","series-title":"Pharmacopoeia of the People's Republic of China (2020 Edition)","year":"2020"},{"key":"10.1016\/j.jep.2024.119214_bib6","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2024.119214_bib7","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.4161\/auto.25803","article-title":"Histone post-translational modifications regulate autophagy flux and outcome","volume":"9","author":"F\u00fcllgrabe","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.119214_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrm3716","article-title":"The return of the nucleus: transcriptional and epigenetic control of autophagy","volume":"15","author":"F\u00fcllgrabe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2024.119214_bib9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nature12313","article-title":"The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy","volume":"500","author":"F\u00fcllgrabe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jep.2024.119214_bib10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13046-022-02338-w","article-title":"Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification","volume":"41","author":"Fu","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jep.2024.119214_bib11","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2024.119214_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101336","article-title":"Post-translational modifications: regulators of neurodegenerative proteinopathies","volume":"68","author":"Gupta","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2024.119214_bib13","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/onc.2009.505","article-title":"Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide","volume":"29","author":"Hajji","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2024.119214_bib14","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nsmb.2165","article-title":"Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8","volume":"18","author":"Hong","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jep.2024.119214_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113703","article-title":"Integrated transcriptomics and metabolomics analysis reveals that C3 and C5 are vital targets of DuZhi Wan in protecting against cerebral ischemic injury","volume":"155","author":"Hou","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.119214_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114671","article-title":"The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury","volume":"162","author":"Huang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2024.119214_bib17","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/jacs.0c10836","article-title":"A SIRT1 activator, ginsenoside Rc, promotes energy metabolism in cardiomyocytes and neurons","volume":"143","author":"Huang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jep.2024.119214_bib18","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1089\/ars.2018.7649","article-title":"p62\/SQSTM1 and selective autophagy in cardiometabolic diseases","volume":"31","author":"Jeong","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2024.119214_bib19","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s12276-022-00812-1","article-title":"Gene regulation by histone-modifying enzymes under hypoxic conditions: a focus on histone methylation and acetylation","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2024.119214_bib20","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.jep.2024.119214_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2024.119214_bib22","volume":"35","author":"Liu","year":"2021"},{"key":"10.1016\/j.jep.2024.119214_bib23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2024.119214_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2024.119214_bib25","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1080\/15548627.2020.1851492","article-title":"PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1)","volume":"17","author":"Luo","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.119214_bib26","doi-asserted-by":"crossref","first-page":"W501","DOI":"10.1093\/nar\/gkx372","article-title":"Pathview Web: user friendly pathway visualization and data integration","volume":"45","author":"Luo","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2024.119214_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.720866","article-title":"Berberine potentiates insulin secretion and prevents \u03b2-cell dysfunction through the miR-204\/SIRT1 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.119214_bib28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1039\/D1FO02579A","article-title":"Diosmetin alleviated cerebral ischemia\/reperfusion injury in vivo and in vitro by inhibiting oxidative stress via the SIRT1\/Nrf2 signaling pathway","volume":"13","author":"Mei","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2024.119214_bib29","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jep.2024.119214_bib30","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.4103\/1673-5374.274331","article-title":"Autophagy and inflammation in ischemic stroke","volume":"15","author":"Mo","year":"2020","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jep.2024.119214_bib31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.molcel.2011.08.035","article-title":"Structural basis of Atg8 activation by a homodimeric E1, Atg7","volume":"44","author":"Noda","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2024.119214_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nsmb.2431","article-title":"Structure of the human ATG12\u223cATG5 conjugate required for LC3 lipidation in autophagy","volume":"20","author":"Otomo","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jep.2024.119214_bib33","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkab1038","article-title":"The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences","volume":"50","author":"Perez-Riverol","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2024.119214_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2024.119214_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154971","article-title":"Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1\/FXR signaling in bile duct ligation-induced liver fibrosis","volume":"118","author":"Qin","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.119214_bib36","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1096\/fj.201600698R","article-title":"LC3\/GABARAP family proteins: autophagy-(un)related functions","volume":"30","author":"Schaaf","year":"2016","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2024.119214_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone protein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2024.119214_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s10020-018-0054-1","article-title":"Propofol inhibited autophagy through Ca(2+)\/CaMKK\u03b2\/AMPK\/mTOR pathway in OGD\/R-induced neuron injury","volume":"24","author":"Sun","year":"2018","journal-title":"Mol. Med."},{"key":"10.1016\/j.jep.2024.119214_bib39","article-title":"Transcriptomics and metabolomics unveil the neuroprotection mechanism of AnGong NiuHuang (AGNH) Pill against ischaemic stroke injury","author":"Tian","year":"2024","journal-title":"Mol. Neurobiol. 61, 7500-7516"},{"key":"10.1016\/j.jep.2024.119214_bib40","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3389\/fphar.2019.00593","article-title":"Neuroprotective effects and hepatorenal toxicity of Angong Niuhuang wan against ischemia-reperfusion brain injury in rats","volume":"10","author":"Tsoi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.119214_bib41","doi-asserted-by":"crossref","first-page":"286","DOI":"10.5853\/jos.2017.00234","article-title":"Stroke epidemiology in South, East, and South-East Asia: a review","volume":"19","author":"Venketasubramanian","year":"2017","journal-title":"J Stroke"},{"key":"10.1016\/j.jep.2024.119214_bib42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jep.2014.03.057","article-title":"An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of Bcl-2 and down-regulation of Bax and caspase-3","volume":"154","author":"Wang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.119214_bib43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41593-018-0285-z","article-title":"Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop","volume":"22","author":"Wang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jep.2024.119214_bib44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","article-title":"Autophagy in ischemic stroke","volume":"163\u2013164","author":"Wang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jep.2024.119214_bib45","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/cns.12005","article-title":"A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury","volume":"18","author":"Wei","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2024.119214_bib46","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2013.08.020","article-title":"Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury","volume":"150","author":"Xu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2024.119214_bib47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/15548627.2022.2062112","article-title":"Acetylation in the regulation of autophagy","volume":"19","author":"Xu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2024.119214_bib48","first-page":"284","volume":"16","author":"Yu","year":"2012"},{"key":"10.1016\/j.jep.2024.119214_bib49","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1091\/mbc.10.5.1353","article-title":"Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein","volume":"10","author":"Yuan","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jep.2024.119214_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153613","article-title":"Proteomics and transcriptome reveal the key transcription factors mediating the protection of Panax notoginseng saponins (PNS) against cerebral ischemia\/reperfusion injury","volume":"92","author":"Zhang","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2024.119214_bib51","article-title":"Protective effect of an-Gong-Niu-Huang wan pre-treatment against experimental cerebral ischemia injury via regulating GSK-3\u03b2\/HO-1 pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2024.119214_bib52","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1080\/15548627.2020.1840796","article-title":"Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons","volume":"17","author":"Zhang","year":"2021","journal-title":"Autophagy"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124015137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124015137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:46Z","timestamp":1787847826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124015137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":52,"alternative-id":["S0378874124015137"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.119214","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angong Niuhuang Pill pretreatment alleviates cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through the SIRT1-H4K16ac axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.119214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119214"}}