{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:34:57Z","timestamp":1792438497111,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.119224","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:34:38Z","timestamp":1734003278000},"page":"119224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress"],"prefix":"10.1016","volume":"340","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-0169","authenticated-orcid":false,"given":"Hyeongyeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Son","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisoo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansup","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Joo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-9798","authenticated-orcid":false,"given":"Yejin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2\u20133","key":"10.1016\/j.jep.2024.119224_bib1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.exger.2010.08.023","article-title":"HPA axis responsiveness to stress: implications for healthy aging","volume":"46","author":"Aguilera","year":"2011","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1080\/13880209.2021.1949356","article-title":"Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model","volume":"59","author":"Ahn","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2024.119224_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.exger.2016.03.004","article-title":"Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans","volume":"78","author":"Akhoon","year":"2016","journal-title":"Exp. Gerontol."},{"issue":"12","key":"10.1016\/j.jep.2024.119224_bib4","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1038\/s12276-020-00532-4","article-title":"Stress and the dopaminergic reward system","volume":"52","author":"Baik","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"10","key":"10.1016\/j.jep.2024.119224_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105311","article-title":"Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia","volume":"9","author":"Baitharu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2024.119224_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2023.100530","article-title":"In vitro modeling of the neurobiological effects of glucocorticoids: a review","volume":"23","author":"Bassil","year":"2023","journal-title":"Neurobiol Stress"},{"key":"10.1016\/j.jep.2024.119224_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0810as55","article-title":"Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice","author":"Castagne","year":"2011","journal-title":"Curr Protoc Neurosci"},{"issue":"9","key":"10.1016\/j.jep.2024.119224_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0006-3223(00)01114-8","article-title":"Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect","volume":"49","author":"Chen","year":"2001","journal-title":"Biol. Psychiatr."},{"issue":"6","key":"10.1016\/j.jep.2024.119224_bib9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1515\/REVNEURO.2008.19.6.395","article-title":"Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis","volume":"19","author":"Conrad","year":"2008","journal-title":"Rev. Neurosci."},{"issue":"23","key":"10.1016\/j.jep.2024.119224_bib10","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1007\/s00018-015-2012-1","article-title":"Pharmacologic overview of withania somnifera, the Indian ginseng","volume":"72","author":"Dar","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.jep.2024.119224_bib11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrn1683","article-title":"Stress and the brain: from adaptation to disease","volume":"6","author":"de Kloet","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.jep.2024.119224_bib12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10495-016-1247-0","article-title":"Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12","volume":"21","author":"de la Cadena","year":"2016","journal-title":"Apoptosis"},{"issue":"4","key":"10.1016\/j.jep.2024.119224_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/ayu.AYU_219_16","article-title":"Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice","volume":"39","author":"Dey","year":"2018","journal-title":"Ayu"},{"issue":"7","key":"10.1016\/j.jep.2024.119224_bib14","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.npp.1300433","article-title":"Effects of chronic fluoxetine in animal models of anxiety and depression","volume":"29","author":"Dulawa","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.jep.2024.119224_bib15","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatr."},{"issue":"3","key":"10.1016\/j.jep.2024.119224_bib16","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1007\/s12035-014-8827-1","article-title":"Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line","volume":"51","author":"Freitas","year":"2015","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.jep.2024.119224_bib17","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s10571-010-9606-9","article-title":"Adrenal responses to stress","volume":"30","author":"Goldstein","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.jep.2024.119224_bib18","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s11064-013-1150-9","article-title":"Vatairea macrocarpa lectin (VML) induces depressive-like behavior and expression of neuroinflammatory markers in mice","volume":"38","author":"Goncalves","year":"2013","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S1092852921000791","article-title":"Novel antidepressant drugs: beyond monoamine targets","volume":"28","author":"Gonda","year":"2023","journal-title":"CNS Spectr."},{"key":"10.1016\/j.jep.2024.119224_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8254344","article-title":"Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study","volume":"2021","author":"Gopukumar","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2024.119224_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4137\/DTI.S13870","article-title":"The antidepressant agomelatine improves memory deterioration and upregulates CREB and BDNF gene expression levels in unpredictable chronic mild stress (UCMS)-Exposed mice","volume":"8","author":"Gumuslu","year":"2014","journal-title":"Drug Target Insights"},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12974-016-0650-3","article-title":"Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study","volume":"13","author":"Gupta","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.jep.2024.119224_bib23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/YCO.0000000000000531","article-title":"Inflammation and depression but where does the inflammation come from?","volume":"32","author":"Halaris","year":"2019","journal-title":"Curr. Opin. Psychiatr."},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.21608\/ajps.2013.7112","article-title":"Quantitative evaluation of withanolides content of egyptian Withania somnifera (l.) roots","volume":"47","author":"Ismail","year":"2013","journal-title":"Al-Azhar Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.jep.2024.119224_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yebeh.2013.10.020","article-title":"Early-life stress and HPA axis trigger recurrent adulthood depression","volume":"38","author":"Juruena","year":"2014","journal-title":"Epilepsy Behav."},{"issue":"6","key":"10.1016\/j.jep.2024.119224_bib27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1179\/135100003225003393","article-title":"Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors","volume":"8","author":"Khanzode","year":"2003","journal-title":"Redox Rep."},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13765-022-00757-z","article-title":"Ishige foliacea ameliorates depressive-like behaviors in stress hormone treated mice","volume":"65","author":"Kim","year":"2022","journal-title":"Applied Biological Chemistry"},{"issue":"7","key":"10.1016\/j.jep.2024.119224_bib29","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2174\/1570159X14666151208113700","article-title":"Inflammation in depression and the potential for anti-inflammatory treatment","volume":"14","author":"Kohler","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"7215","key":"10.1016\/j.jep.2024.119224_bib30","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jep.2024.119224_bib31","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/sj.bjp.0706122","article-title":"Neuritic regeneration and synaptic reconstruction induced by withanolide A","volume":"144","author":"Kuboyama","year":"2005","journal-title":"Br. J. Pharmacol."},{"issue":"22","key":"10.1016\/j.jep.2024.119224_bib32","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1007\/s00213-017-4720-8","article-title":"Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis","volume":"234","author":"Li","year":"2017","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jep.2024.119224_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1284214","article-title":"To re-examine the intersection of microglial activation and neuroinflammation in neurodegenerative diseases from the perspective of pyroptosis","volume":"15","author":"Li","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7586\/jkbns.23.345","article-title":"Antidepressant effects of capsaicin in rats with chronic unpredictable mild stress-induced depression","volume":"25","author":"Lim","year":"2023","journal-title":"Journal of Korean Biological Nursing Science"},{"issue":"10","key":"10.1016\/j.jep.2024.119224_bib35","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1038\/s41401-022-00879-6","article-title":"Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases","volume":"43","author":"Lin","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.jep.2024.119224_bib36","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.jep.2024.119224_bib37","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jad.2011.08.003","article-title":"Interleukin (IL)-6, tumour necrosis factor alpha (TNF-\u03b1) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression","volume":"139","author":"Liu","year":"2012","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.jep.2024.119224_bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2024.119224_bib39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"10","key":"10.1016\/j.jep.2024.119224_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12101287","article-title":"Sucrose preference test as a measure of anhedonic behavior in a chronic unpredictable mild stress model of depression: outstanding issues","volume":"12","author":"Markov","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.jep.2024.119224_bib41","article-title":"Neurobiological and systemic effects of chronic stress","volume":"1","author":"McEwen","year":"2017","journal-title":"Chronic Stress (Thousand Oaks)"},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2006.07.029","article-title":"Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice","volume":"175","author":"Mineur","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/j.jep.2024.119224_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.208","article-title":"Models of depression: unpredictable chronic mild stress in mice","volume":"1","author":"Nollet","year":"2021","journal-title":"Curr Protoc"},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib44","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2024.119224_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112175","article-title":"Withania somnifera (L.) Dunal (Ashwagandha): a comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects","volume":"143","author":"Paul","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.jep.2024.119224_bib46","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00702-019-02084-y","article-title":"Animal models of major depression: drawbacks and challenges","volume":"126","author":"Planchez","year":"2019","journal-title":"J. Neural. Transm."},{"issue":"4","key":"10.1016\/j.jep.2024.119224_bib47","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0733-8627(05)70151-6","article-title":"Antidepressants, old and new. A review of their adverse effects and toxicity in overdose","volume":"18","author":"Sarko","year":"2000","journal-title":"Emerg. Med. Clin."},{"key":"10.1016\/j.jep.2024.119224_bib48","article-title":"Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice","volume":"96","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"3","key":"10.1016\/j.jep.2024.119224_bib49","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1086\/302562","article-title":"Monoamine oxidase in neuropsychiatry and behavior","volume":"65","author":"Shih","year":"1999","journal-title":"Am. J. Hum. Genet."},{"issue":"8","key":"10.1016\/j.jep.2024.119224_bib50","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","article-title":"Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression","volume":"22","author":"Shirayama","year":"2002","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.jep.2024.119224_bib51","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s40263-013-0097-3","article-title":"Current place of monoamine oxidase inhibitors in the treatment of depression","volume":"27","author":"Shulman","year":"2013","journal-title":"CNS Drugs"},{"issue":"9","key":"10.1016\/j.jep.2024.119224_bib52","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2174\/1570159X19666210712151556","article-title":"Effects of withania somnifera (ashwagandha) on stress and the stress- related neuropsychiatric disorders anxiety, depression, and insomnia","volume":"19","author":"Speers","year":"2021","journal-title":"Curr. Neuropharmacol."},{"issue":"9","key":"10.1016\/j.jep.2024.119224_bib53","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.biopsych.2004.08.022","article-title":"Cellular changes in the postmortem hippocampus in major depression","volume":"56","author":"Stockmeier","year":"2004","journal-title":"Biol. Psychiatr."},{"issue":"2","key":"10.1016\/j.jep.2024.119224_bib54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.physbeh.2009.09.008","article-title":"The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: implications for hippocampal volume reductions in depression","volume":"99","author":"Tata","year":"2010","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.jep.2024.119224_bib55","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41418-022-01094-w","article-title":"Mitochondria and cell death-associated inflammation","volume":"30","author":"Vringer","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2024.119224_bib56","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2020.00082","article-title":"The role of BDNF on neural plasticity in depression","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.jep.2024.119224_bib57","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.pnpbp.2009.03.020","article-title":"Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression","volume":"33","author":"Yoshimura","year":"2009","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"issue":"4","key":"10.1016\/j.jep.2024.119224_bib58","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrn1883","article-title":"The therapeutic potential of monoamine oxidase inhibitors","volume":"7","author":"Youdim","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2024.119224_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/aps.2010.184","article-title":"The role of BDNF in depression on the basis of its location in the neural circuitry","volume":"32","author":"Yu","year":"2011","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412401523X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412401523X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:20:52Z","timestamp":1787847652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412401523X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":58,"alternative-id":["S037887412401523X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.119224","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.119224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119224"}}