{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:48:27Z","timestamp":1793162907891,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460803"],"award-info":[{"award-number":["82460803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074095"],"award-info":[{"award-number":["82074095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360850"],"award-info":[{"award-number":["82360850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jep.2024.119231","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T14:08:20Z","timestamp":1734444500000},"page":"119231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Palmatine, an isoquinoline alkaloid from Phellodendron amurense Rupr., ameliorated gouty inflammation by inhibiting pyroptosis via NLRP3 inflammasome"],"prefix":"10.1016","volume":"340","author":[{"given":"Yin-Jing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Xing","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2024.119231_bib3","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.3389\/fimmu.2019.02519","article-title":"Caspase-11 mediates neutrophil chemotaxis and extracellular trap formation during acute gouty arthritis through alteration of cofilin phosphorylation","volume":"10","author":"Caution","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.119231_bib4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0024-3205(98)00602-X","article-title":"Effects of palmatine on isometric force and intracellular calcium levels of arterial smooth muscle","volume":"64","author":"Chang","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2024.119231_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aar6676","article-title":"Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps","volume":"3","author":"Chen","year":"2018","journal-title":"Science Immunology"},{"key":"10.1016\/j.jep.2024.119231_bib6","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2147\/DDDT.S356307","article-title":"Palmatine protects against MSU-induced gouty arthritis via regulating the NF-\u03baB\/NLRP3 and Nrf2 pathways","volume":"16","author":"Cheng","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2024.119231_bib7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJMoa035700","article-title":"Purine-rich foods, dairy and protein intake, and the risk of gout in men","volume":"350","author":"Choi","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2024.119231_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/bmj.39449.819271.BE","article-title":"Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study","volume":"336","author":"Choi","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jep.2024.119231_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010434","article-title":"New proteins contributing to immune cell infiltration and pannus formation of synovial membrane from arthritis diseases","volume":"23","author":"De Seny","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.119231_bib11","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.4081\/ejh.2014.2423","article-title":"Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. A morphological study","volume":"58","author":"Di Rosa","year":"2014","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.jep.2024.119231_bib12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.lpm.2011.03.016","article-title":"[Mechanisms of gout inflammation]","volume":"40","author":"Ea","year":"2011","journal-title":"Presse Med."},{"key":"10.1016\/j.jep.2024.119231_bib13","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1126\/science.1240988","article-title":"Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock","volume":"341","author":"Hagar","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jep.2024.119231_bib14","first-page":"831","volume":"vol. 90","author":"Hainer","year":"2014"},{"key":"10.1016\/j.jep.2024.119231_bib15","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jep.2024.119231_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2024.119231_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep38622","article-title":"Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2024.119231_bib18","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1248\/bpb.33.1733","article-title":"Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-\u03bab ligand expression in osteoblast cells","volume":"33","author":"Lee","year":"2010","journal-title":"Biol. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2024.119231_bib36","doi-asserted-by":"crossref","first-page":"110466","DOI":"10.1016\/j.intimp.2023.110466","article-title":"Immune and inflammatory mechanisms and therapeutic targets of gout: an update","volume":"121","author":"Liu","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.119231_bib19","article-title":"Role of NLRP3 in the pathogenesis and treatment of gout arthritis","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.119231_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2024.119231_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase-1-induced pyroptotic cell death","volume":"243","author":"Miao","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2024.119231_bib22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41590-022-01192-4","article-title":"Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome","volume":"23","author":"Moretti","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2024.119231_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/ar325","article-title":"Articular cartilage and changes in arthritis: matrix degradation","volume":"3","author":"Mort","year":"2001","journal-title":"Arthritis Res."},{"key":"10.1016\/j.jep.2024.119231_bib25","doi-asserted-by":"crossref","first-page":"C870","DOI":"10.1152\/ajpcell.00322.2002","article-title":"Activation of gene expression in human neutrophils by high mobility group box 1 protein","volume":"284","author":"Park","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jep.2024.119231_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.rdc.2019.08.001","article-title":"Gout","volume":"45","author":"Perez-Ruiz","year":"2019","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.jep.2024.119231_bib27","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s10787-022-01014-x","article-title":"Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy","volume":"30","author":"Piao","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2024.119231_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jjcc.2020.12.013","article-title":"Uric acid and cardiovascular disease: a clinical review","volume":"78","author":"Saito","year":"2021","journal-title":"J. Cardiol."},{"key":"10.1016\/j.jep.2024.119231_bib29","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2015-000046","article-title":"Why does the gout attack stop? A roadmap for the immune pathogenesis of gout","volume":"1","author":"Schett","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.jep.2024.119231_bib30","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fimmu.2012.00376","article-title":"Bonding the foe - NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals","volume":"3","author":"Schorn","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2024.119231_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00011-016-1008-0","article-title":"Macrophage-derived IL-1\u03b2 enhances monosodium urate crystal-triggered NET formation","volume":"66","author":"Sil","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2024.119231_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00011-016-1008-0","article-title":"Macrophage-derived IL-1beta enhances monosodium urate crystal-triggered NET formation","volume":"66","author":"Sil","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2024.119231_bib1","first-page":"i12","article-title":"The role of IL-1 in gout: from bench to bedside","volume":"57","author":"So","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jep.2024.119231_bib32","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2024.119231_bib33","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1172\/JCI84538","article-title":"Neutrophil extracellular traps - the dark side of neutrophils","volume":"126","author":"S\u00f8rensen","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2024.119231_bib34","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.semarthrit.2020.06.001","article-title":"The experience of a gout flare: a meta-synthesis of qualitative studies","volume":"50","author":"Stewart","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jep.2024.119231_bib35","first-page":"20","article-title":"Imaging of gout: findings and pitfalls. A pictorial review","volume":"45","author":"Sudo\u0142-Szopi\u0144ska","year":"2020","journal-title":"Acta reumatologica portuguesa."},{"key":"10.1016\/j.jep.2024.119231_bib37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41419-022-05138-4","article-title":"GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2024.119231_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jot.2017.12.004","article-title":"Distinct metabolic programs induced by TGF-\u03b21 and BMP2 in human articular chondrocytes with osteoarthritis","volume":"12","author":"Wang","year":"2018","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.jep.2024.119231_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.csm.2017.02.007","article-title":"Allografts: osteochondral, shell, and paste","volume":"36","author":"Wydra","year":"2017","journal-title":"Clin. Sports Med."},{"key":"10.1016\/j.jep.2024.119231_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.intimp.2016.02.029","article-title":"Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: a possible mechanism of inhibiting the Wnt\/\u03b2-catenin and Hedgehog signaling pathways","volume":"34","author":"Zhou","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2024.119231_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.171565","article-title":"Estimation of the spatial pattern of gout prevalence across China by wastewater-based epidemiology","volume":"924","author":"Zhou","year":"2024","journal-title":"Sci. Total Environ."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124015307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874124015307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:24:13Z","timestamp":1787847853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874124015307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"alternative-id":["S0378874124015307"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2024.119231","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Palmatine, an isoquinoline alkaloid from Phellodendron amurense Rupr., ameliorated gouty inflammation by inhibiting pyroptosis via NLRP3 inflammasome","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2024.119231","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119231"}}