{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:02:37Z","timestamp":1774677757358,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["[2020]-1Y432"],"award-info":[{"award-number":["[2020]-1Y432"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260708"],"award-info":[{"award-number":["82260708"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760653"],"award-info":[{"award-number":["81760653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jep.2025.119321","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T15:03:45Z","timestamp":1735830225000},"page":"119321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways"],"prefix":"10.1016","volume":"341","author":[{"given":"Yi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoying","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8018-348X","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanzhan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4804-1787","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119321_bib1","article-title":"Efficacy, safety, and role of antiplatelet drugs in the management of acute coronary syndrome: a comprehensive review of literature","volume":"15","author":"Abubakar","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jep.2025.119321_bib2","first-page":"60","article-title":"Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions","volume":"63","author":"Angiolillo","year":"2010","journal-title":"Rev. Esp."},{"key":"10.1016\/j.jep.2025.119321_bib3","article-title":"Ferric chloride-induced thrombosis mouse model on carotid artery and mesentery vessel","volume":"100","author":"Bonnard","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jep.2025.119321_bib4","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/jth.14887","article-title":"Non-additive effect on thrombin generation when a plasma-derived factor VIII\/von Willebrand factor (FVIII\/VWF) is combined with emicizumab in vitro","volume":"18","author":"Bravo","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib5","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180458","article-title":"Sorting machineries: how platelet-dense granules differ from \u03b1-granules","volume":"38","author":"Chen","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2025.119321_bib6","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/eurheartj\/ehac706","article-title":"Dual antiplatelet therapy duration after percutaneous coronary intervention in high bleeding risk: a meta-analysis of randomized trials","volume":"44","author":"Costa","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2025.119321_bib7","first-page":"84","article-title":"Systems pharmacology for traditional Chinese medicine with application to cardio-cerebrovascular diseases","volume":"1","author":"Fu","year":"2014","journal-title":"J. Tradit. Chin. Med. Sci."},{"key":"10.1016\/j.jep.2025.119321_bib8","doi-asserted-by":"crossref","first-page":"175B","DOI":"10.1016\/S0735-1097(85)80552-0","article-title":"Role of platelets and thrombosis in coronary atherosclerotic disease and sudden death","volume":"5","author":"Fuster","year":"1985","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2025.119321_bib9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1160\/TH07-11-0673","article-title":"P2 receptors, platelet function and pharmacological implications","volume":"99","author":"Gachet","year":"2008","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s11302-012-9303-x","article-title":"P2Y (12) receptors in platelets and other hematopoietic and non-hematopoietic cells","volume":"8","author":"Gachet","year":"2012","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.jep.2025.119321_bib11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1080\/17512433.2022.2121702","article-title":"Clinical pharmacology of antiplatelet drugs","volume":"15","author":"Gelbenegger","year":"2022","journal-title":"Expet Rev. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20061489","article-title":"Exploring the specificity of the PI3K family inhibitor LY294002","volume":"404","author":"Gharbi","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.jep.2025.119321_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.blre.2014.10.003","article-title":"Platelet secretion: from haemostasis to wound healing and beyond","volume":"29","author":"Golebiewska","year":"2015","journal-title":"Blood Rev."},{"key":"10.1016\/j.jep.2025.119321_bib14","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/ATVBAHA.118.310224","article-title":"Platelet signaling pathways and new inhibitors","volume":"38","author":"Grover","year":"2018","journal-title":"Arterioscl. Throm. Vas."},{"key":"10.1016\/j.jep.2025.119321_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jbior.2015.06.001","article-title":"PI3K\/Akt in platelet integrin signaling and implications in thrombosis","volume":"59","author":"Guidetti","year":"2015","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.jep.2025.119321_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1127219","article-title":"Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone","volume":"14","author":"He","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib17","first-page":"1","article-title":"Platelet integrin \u03b1IIb\u03b23: signal transduction, regulation, and its therapeutic targeting","volume":"12","author":"Huang","year":"2019","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.jep.2025.119321_bib18","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1160\/TH16-12-0911","article-title":"Platelet receptors as therapeutic targets: past, present and future","volume":"117","author":"Jamasbi","year":"2017","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib19","first-page":"785","article-title":"Thrombosis and platelets: an update","volume":"38","author":"Koupenova","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2025.119321_bib20","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s12272-014-0410-9","article-title":"Antiplatelet, anticoagulant, and profibrinolytic activities of baicalin","volume":"38","author":"Lee","year":"2015","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2025.119321_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111332","article-title":"A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Salvia miltiorrhiza","volume":"137","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119321_bib22","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1055\/s-0041-1735192","article-title":"Tetrahydrocurcumin downregulates MAPKs\/cPLA2 signaling and attenuates platelet thromboxane A2 generation, granule secretion, and thrombus growth","volume":"122","author":"Li","year":"2022","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib23","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/mnfr.201500801","article-title":"Antiplatelet activity of Chrysin via inhibiting platelet \u03b1IIb\u03b23-mediated signaling pathway","volume":"60","author":"Liu","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.119321_bib24","article-title":"Pimpinellin inhibits collagen-induced platelet aggregation and activation through inhibiting granule secretion and PI3K\/Akt pathway","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117346","article-title":"Mechanism of cryptotanshinone to improve endocrine and metabolic functions in the endometrium of PCOS rats","volume":"319","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib26","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/j.1538-7836.2012.04903.x","article-title":"Regulators of G protein signaling: role in hematopoiesis, megakaryopoiesis and platelet function","volume":"10","author":"Louwette","year":"2012","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41573-020-0061-0","article-title":"Therapeutic strategies for thrombosis: new targets and approaches","volume":"19","author":"Mackman","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2025.119321_bib28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fitote.2014.11.024","article-title":"Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis","volume":"100","author":"Maione","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.119321_bib29","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1182\/blood-2009-04-217224","article-title":"Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo","volume":"115","author":"Martin","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jep.2025.119321_bib30","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0006-2952(03)00069-8","article-title":"Inhibition of the MEK\/ERK pathway has no effect on agonist-induced aggregation of human platelets","volume":"65","author":"McNicol","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib31","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bpj.2013.07.055","article-title":"On the activation of integrin \u03b1IIb\u03b23: outside-in and inside-out pathways","volume":"105","author":"Mehrbod","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.jep.2025.119321_bib32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12959-023-00522-2","article-title":"Aspirin and clopidogrel resistance; a neglected gap in stroke and cardiovascular practice in Iran: a systematic review and meta-analysis","volume":"21","author":"Parsa-Kondelaji","year":"2023","journal-title":"Thromb. J."},{"key":"10.1016\/j.jep.2025.119321_bib33","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/jth.14967","article-title":"Platelet MAPKs\u2014a 20+ year history: what do we really know?","volume":"18","author":"Patel","year":"2020","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib34","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/09537104.2018.1557614","article-title":"Arachidonic acid causes lysis of blood cells and ADP-dependent platelet activation responses in platelet function tests","volume":"30","author":"Ramstr\u00f6m","year":"2019","journal-title":"Platelets"},{"key":"10.1016\/j.jep.2025.119321_bib35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3389\/fphar.2019.00753","article-title":"Salvia miltiorrhiza in treating cardiovascular diseases: a review on its pharmacological and clinical applications","volume":"10","author":"Ren","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/jth.14343","article-title":"High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor","volume":"17","author":"Rietveld","year":"2019","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.jep.2025.119321_bib37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ctrv.2013.03.009","article-title":"Targeting the PI3K\/AKT\/mTOR and Raf\/MEK\/ERK pathways in the treatment of breast cancer","volume":"39","author":"Saini","year":"2013","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.jep.2025.119321_bib38","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1074\/jbc.271.12.6586","article-title":"Role for P38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue","volume":"271","author":"Saklatvala","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2025.119321_bib39","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3349\/ymj.2021.62.11.1032","article-title":"Characterization of ferric chloride-induced arterial thrombosis model of mice and the role of red blood cells in thrombosis acceleration","volume":"62","author":"Shim","year":"2021","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.jep.2025.119321_bib40","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1158\/0008-5472.CAN-22-3407","article-title":"AKT blocks SIK1-mediated repression of STAT3 to promote breast tumorigenesis","volume":"83","author":"Sun","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2025.119321_bib41","first-page":"390","article-title":"Long-term dual antiplatelet therapy for secondary prevention of cardiovascular events in the subgroup of patients with previous myocardial infarction: a collaborative meta-analysis of randomized trials","volume":"37","author":"Udell","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2025.119321_bib42","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s10753-018-0824-5","article-title":"PI3K\/AKT and CD40L signaling regulate platelet activation and endothelial cell damage in sepsis","volume":"41","author":"Wan","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.119321_bib43","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/FJC.0000000000000971","article-title":"Cryptotanshinone attenuates ischemia\/reperfusion-induced apoptosis in myocardium by upregulating MAPK3","volume":"77","author":"Wang","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejpb.2022.02.012","article-title":"Inhalable cryptotanshinone spray-dried swellable microparticles for pulmonary fibrosis therapy by regulating TGF-\u03b21\/Smad3, STAT3 and SIRT3 pathways","volume":"172","author":"Wang","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jep.2025.119321_bib45","first-page":"647","article-title":"Anti-platelet therapy: ADP receptor antagonists. Brit","volume":"72","author":"Wijeyeratne","year":"2011","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2025.119321_bib46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/aps.2016.155","article-title":"A novel STAT3 inhibitor negatively modulates platelet activation and aggregation","volume":"38","author":"Xu","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2025.119321_bib47","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1182\/blood-2015-07-659185","article-title":"Misshapen\/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation","volume":"127","author":"Yue","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jep.2025.119321_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00044-023-03165-0","article-title":"Research progress on the mechanism of anti-myocardial infarction effect and clinical application of effective components of Salvia miltiorrhiza","volume":"33","author":"Zhang","year":"2024","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.jep.2025.119321_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104307","article-title":"Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways","volume":"147","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119321_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116871","article-title":"Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza Bunge via network pharmacology: unveiling their roles in the modulation of platelet activation and thrombus formation","volume":"484","author":"Zhang","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125000042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125000042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:52:44Z","timestamp":1762307564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125000042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":50,"alternative-id":["S0378874125000042"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119321","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P2Y12 receptor-independent antiplatelet mechanism of cryptotanshinone: Network pharmacology and experimental validation of multi-target signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119321"}}