{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:47:39Z","timestamp":1791654459459,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jep.2025.119362","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T23:49:45Z","timestamp":1737157785000},"page":"119362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Pseudostellaria heterophylla (Miq.) Pax, a traditional folk medicine, ameliorates colorectal cancer by remodeling the tumor immune microenvironment"],"prefix":"10.1016","volume":"342","author":[{"given":"Yang","family":"Gui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1100-0757","authenticated-orcid":false,"given":"Heng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119362_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1178337","article-title":"The generation, activation, and polarization of monocyte-derived macrophages in human malignancies","volume":"14","author":"Chaintreuil","year":"2023","journal-title":"Front. Immunol."},{"issue":"15","key":"10.1016\/j.jep.2025.119362_bib2","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163841","article-title":"SCCA1\/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production","volume":"133","author":"Chen","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2025.119362_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111576","article-title":"Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v.A\u03b2-induced mice","volume":"158","author":"Deng","year":"2022","journal-title":"Food Res. Int."},{"issue":"9","key":"10.1016\/j.jep.2025.119362_bib4","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s11427-023-2499-2","article-title":"Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K\/Akt\/mTOR pathway","volume":"67","author":"Ganesan","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.jep.2025.119362_bib5","article-title":"Rabdosia rubescens (Hemsl.) H. Hara: a potent anti-tumor herbal remedy - botany, phytochemistry, and clinical applications and insights","volume":"340","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"Pt 4","key":"10.1016\/j.jep.2025.119362_bib6","article-title":"Polysaccharides from Lonicera japonica Thunb.: extraction, purification, structural features and biological activities-A review","volume":"281","author":"Gao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.119362_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118001","volume":"329","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119362_bib8","first-page":"1224","article-title":"Effect of Fuzheng Quyu Jiedu formula on the immune function of patients with advanced intestinal cancer","volume":"40","author":"Hu","year":"2024","journal-title":"J. Changchun Univer. Chinese Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13046-023-02860-5","article-title":"FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression","volume":"42","author":"Hu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jep.2025.119362_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.787816","article-title":"Impact of qi-invigorating traditional Chinese medicines on diffuse large B cell lymphoma based on network pharmacology and experimental validation","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1142\/S0192415X24500058","article-title":"Cancer pain management with traditional Chinese medicine: current status and future perspectives","volume":"52","author":"Ji","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.119362_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105126","article-title":"Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study","volume":"103","author":"Jiang","year":"2024","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.jep.2025.119362_bib13","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.7150\/ijbs.70691","article-title":"New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials","volume":"18","author":"Jin","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.119362_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in tumor progression and regression: a review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark. Res."},{"issue":"11","key":"10.1016\/j.jep.2025.119362_bib15","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1002\/fsn3.2979","article-title":"The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice","volume":"10","author":"Kan","year":"2022","journal-title":"Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1186\/s12964-024-01930-1","article-title":"MyD88 protein destabilization mitigates NF-\u03baB-dependent protection against macrophage apoptosis","volume":"22","author":"Lain\u0161\u010dek","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"14","key":"10.1016\/j.jep.2025.119362_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/nu15143091","article-title":"N,N-Dimethyl-anthranilic acid from calvatia nipponica mushroom fruiting bodies induces apoptotic effects on MDA-MB-231 human breast cancer cells","volume":"15","author":"Lee","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.119362_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.568759","article-title":"Combinational immunotherapy for hepatocellular carcinoma: radiotherapy, immune checkpoint blockade and beyond","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Immunol."},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.119362_bib19","article-title":"Traditional uses, phytochemical constituents, pharmacological properties, and quality control of Pseudostellaria heterophylla (Miq.) Pax","volume":"337","author":"Lei","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119362_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156003","article-title":"Mechanisms of traditional Chinese medicine in the treatment and prevention of gastric cancer","volume":"135","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119362_bib21","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fphar.2020.00850","article-title":"Cyclic peptide extracts derived from pseudostellaria heterophylla ameliorates COPD via regulation of the TLR4\/MyD88 pathway proteins","volume":"11","author":"Lu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib22","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2327692","article-title":"Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma","volume":"13","author":"Ma","year":"2024","journal-title":"OncoImmunology"},{"issue":"4","key":"10.1016\/j.jep.2025.119362_bib23","doi-asserted-by":"crossref","DOI":"10.14309\/ctg.0000000000000690","article-title":"Celestial insights: unraveling the role of miR-3682-3p in hepatocellular carcinoma","volume":"15","author":"Miao","year":"2024","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib24","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/s12885-024-12224-7","article-title":"Exercise accelerates recruitment of CD8+ T cell to promotes anti-tumor immunity in lung cancer via epinephrine","volume":"24","author":"Miao","year":"2024","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.jep.2025.119362_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24055026","article-title":"Why don't the mutant cells that evade DNA repair cause cancer more frequently? Importance of the innate immune system in the tumor microenvironment","volume":"24","author":"Mohapatra","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.jep.2025.119362_bib26","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1158\/1078-0432.CCR-18-3421","article-title":"Breast phyllodes tumors recruit and repolarize tumor-associated macrophages via secreting CCL5 to promote malignant progression, which can Be inhibited by CCR5 inhibition therapy","volume":"25","author":"Nie","year":"2019","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.jep.2025.119362_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1158\/0008-5472.CAN-21-1428","article-title":"Polypharmacologic reprogramming of tumor-associated macrophages toward an inflammatory phenotype","volume":"82","author":"Nishida-Aoki","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2025.119362_bib28","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.ijbiomac.2022.08.111","article-title":"Antitumor effect of a polysaccharide from Pseudostellaria heterophylla through reversing tumor-associated macrophages phenotype","volume":"220","author":"Pu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.jep.2025.119362_bib29","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008722","article-title":"CCR5 and CCL5 in metastatic colorectal cancer","volume":"12","author":"Schlechter","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jep.2025.119362_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1295684","article-title":"Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs","volume":"14","author":"Shao","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119362_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1213947","article-title":"Identification and validation of a dysregulated TME-related gene signature for predicting prognosis, and immunological properties in bladder cancer","volume":"14","author":"Shen","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib32","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1186\/s12967-023-04709-z","article-title":"Improving the therapeutic efficacy of oncolytic viruses for cancer: targeting macrophages","volume":"21","author":"Shen","year":"2023","journal-title":"J. Transl. Med."},{"issue":"10","key":"10.1016\/j.jep.2025.119362_bib33","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1158\/0008-5472.CAN-23-2521","article-title":"PABPC1L induces Ido1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma","volume":"84","author":"Shu","year":"2024","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2025.119362_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.omto.2020.03.007","article-title":"Pseudostellaria heterophylla extract polysaccharide H-1-2 suppresses pancreatic cancer by inhibiting hypoxia-induced AG2","volume":"17","author":"Sun","year":"2020","journal-title":"Mol Ther Oncolytics"},{"issue":"2","key":"10.1016\/j.jep.2025.119362_bib35","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3892\/mmr.2015.4659","article-title":"Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K\/AKT\/\u03b2-catenin signaling","volume":"13","author":"Tantai","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.119362_bib36","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"CD147-K148me2-Driven tumor cell-macrophage crosstalk provokes NSCLC immunosuppression via the CCL5\/CCR5 Axis","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"issue":"21","key":"10.1016\/j.jep.2025.119362_bib37","doi-asserted-by":"crossref","first-page":"20573","DOI":"10.1002\/cam4.6623","article-title":"Metabolic reprogramming, autophagy, and ferroptosis: novel arsenals to overcome immunotherapy resistance in gastrointestinal cancer","volume":"12","author":"Wang","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.jep.2025.119362_bib38","article-title":"ACE2 enhances sensitivity to PD-L1 blockade by inhibiting macrophage-induced immunosuppression and angiogenesis","author":"Xie","year":"2024","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13578-023-01144-x","article-title":"Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment","volume":"13","author":"Xie","year":"2023","journal-title":"Cell Biosci."},{"issue":"4","key":"10.1016\/j.jep.2025.119362_bib40","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-006808","article-title":"Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression","volume":"11","author":"Xu","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jep.2025.119362_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156065","article-title":"Huang-Jin-Shuang-Shen Decoction promotes CD8+ T-cell-mediated anti-tumor immunity by regulating chemokine CXCL10 in gastric cancer","volume":"135","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.jep.2025.119362_bib42","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.7150\/ijbs.82317","article-title":"CXCL12-CXCR4\/CXCR7 Axis in cancer: from mechanisms to clinical applications","volume":"19","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.119362_bib43","doi-asserted-by":"crossref","DOI":"10.1142\/S0192415X2450071X","article-title":"Isoliquiritigenin suppresses breast tumor development by enhancing host antitumor immunity","author":"Yuan","year":"2024","journal-title":"Am. J. Chin. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.119362_bib44","first-page":"e521","article-title":"MedComm (2020)","volume":"5","author":"Zhang","year":"2024"},{"key":"10.1016\/j.jep.2025.119362_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.984480","article-title":"Identification and validation of immunotherapy for four novel clusters of colorectal cancer based on the tumor microenvironment","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119362_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116557","article-title":"Quercetin serves as the major component of Xiang-lian Pill to ameliorate ulcerative colitis via tipping the balance of STAT1\/PPAR\u03b3 and dictating the alternative activation of macrophage","volume":"313","author":"Zhou","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119362_bib47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12943-024-02059-y","article-title":"PD1\/PD-L1 blockade in clear cell renal cell carcinoma: mechanistic insights, clinical efficacy, and future perspectives","volume":"23","author":"Zhu","year":"2024","journal-title":"Mol. Cancer"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T06:31:06Z","timestamp":1740465066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":47,"alternative-id":["S0378874125000455"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119362","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pseudostellaria heterophylla (Miq.) Pax, a traditional folk medicine, ameliorates colorectal cancer by remodeling the tumor immune microenvironment","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119362"}}