{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:49:08Z","timestamp":1793396948351,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0054"],"award-info":[{"award-number":["2024NSFSC0054"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872991"],"award-info":[{"award-number":["81872991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022072"],"award-info":[{"award-number":["82022072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jep.2025.119432","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T10:04:22Z","timestamp":1738490662000},"page":"119432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Effect of Leonurus japonicus alkaloids on endometrial inflammation and its mechanisms"],"prefix":"10.1016","volume":"342","author":[{"given":"Ou","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqiu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119432_bib1","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.3390\/ani12212975","article-title":"In vivo efficacy of Echinops spinosus decoction as a therapeutic for cows at risk of clinical endometritis","volume":"12","author":"Boudelal","year":"2022","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.jep.2025.119432_bib2","doi-asserted-by":"crossref","first-page":"e1380","DOI":"10.1038\/cddis.2014.334","article-title":"Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo (b) pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt\/\u03b2-catenin signaling and PI3K\/Akt survival pathway","volume":"5","author":"Chandra","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.119432_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116639","article-title":"The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA sequencing","volume":"315","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2014.08.016","article-title":"PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing","volume":"194","author":"Chereddy","year":"2014","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jep.2025.119432_bib5","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00210-019-01696-1","article-title":"Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model","volume":"392","author":"Demirel","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib6","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1111\/1751-7915.14127","article-title":"Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites","volume":"15","author":"Ding","year":"2022","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.jep.2025.119432_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2014.11.002","article-title":"Berberine hydrochloride attenuates lipopolysaccharide-induced endometritis in mice by suppressing activation of NF-\u03baB signal pathway","volume":"24","author":"Fu","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib8","first-page":"146","article-title":"Purification technology of total alkali from Leonurus japonicus Houtt. by different eluents of cation exchange resin. Chin. Tradit. Pat","volume":"32","author":"Gao","year":"2010","journal-title":"M\u00e9dica Sur"},{"key":"10.1016\/j.jep.2025.119432_bib9","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.3168\/jds.2012-6154","article-title":"Therapy of bovine endometritis with prostaglandin F2\u03b1: a meta-analysis","volume":"96","author":"Haimerl","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jep.2025.119432_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fitote.2018.05.002","article-title":"Angiogenic effect of motherwort (Leonurus japonicus) alkaloids and toxicity of motherwort essential oil on zebrafish embryos","volume":"128","author":"He","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.119432_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.fitote.2005.03.014","article-title":"Analgesic and anti-inflammatory activity of Leonurus sibiricus","volume":"76","author":"Islam","year":"2005","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.119432_bib12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3168\/jds.2022-22983","article-title":"Interferon-tau protects bovine endometrial epithelial cells against inflammatory injury by regulating the PI3K\/AKT\/\u03b2-catenin\/FoxO1 signaling axis","volume":"107","author":"Jiang","year":"2024","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jep.2025.119432_bib13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.intimp.2019.02.033","article-title":"Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-\u03baB activation","volume":"70","author":"Jiang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/jcmm.14744","article-title":"miR-148a suppresses inflammation in lipopolysaccharide-induced endometritis","volume":"24","author":"Jiang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2025.119432_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/biomedicines8050101","article-title":"The role of IL-6 in skin fibrosis and cutaneous wound healing","volume":"8","author":"Johnson","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2025.119432_bib16","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1093\/humrep\/deu222","article-title":"Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis","volume":"29","author":"Khan","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jep.2025.119432_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.fertnstert.2018.04.012","article-title":"Endometritis: new time, new concepts","volume":"110","author":"Kitaya","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jep.2025.119432_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116489","article-title":"Protective effect of the total flavonoids from Clinopodium chinense against LPS-induced mice endometritis by inhibiting NLRP3 inflammasome-mediated pyroptosis","volume":"312","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fphar.2020.00064","article-title":"Protective effect of stachydrine against cerebral ischemia-reperfusion injury by reducing inflammation and apoptosis through P65 and JAK2\/STAT3 signaling pathway","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111021","article-title":"Protection against acute cerebral ischemia\/reperfusion injury by Leonuri Herba Total Alkali via modulation of BDNF-TrKB-PI3K\/Akt signaling pathway in rats","volume":"133","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119432_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.phytochem.2017.11.003","article-title":"Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle","volume":"145","author":"Liu","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2025.119432_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109060","article-title":"Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: a comprehensive overview","volume":"117","author":"Miao","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119432_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tvjl.2019.03.008","article-title":"Impact of endometritis on post-partum ovarian cyclicity in dairy cows","volume":"248","author":"Mohammed","year":"2019","journal-title":"Vet. J."},{"issue":"6","key":"10.1016\/j.jep.2025.119432_bib24","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/bju.12452","article-title":"Inflammation and prostate cancer: the role of interleukin 6 (IL-6)","volume":"113","author":"Nguyen","year":"2014","journal-title":"Bju. Int."},{"key":"10.1016\/j.jep.2025.119432_bib25","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jep.2017.05.029","article-title":"The ethanol extract of Leonurus sibiricus L. induces antioxidant, antinociceptive and topical anti-inflammatory effects","volume":"206","author":"Oliveira","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.theriogenology.2010.01.023","article-title":"Risk factors for clinical endometritis in postpartum dairy cattle","volume":"74","author":"Potter","year":"2010","journal-title":"Theriogenology"},{"key":"10.1016\/j.jep.2025.119432_bib28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.cveq.2016.08.002","article-title":"Endometritis: nontraditional therapies","volume":"32","author":"Scoggin","year":"2016","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"10.1016\/j.jep.2025.119432_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jep.2013.12.052","article-title":"Leonurus japonicus Houtt.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"152","author":"Shang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115396","article-title":"Total alkaloid fraction of Leonurus japonicus Houtt. promotes angiogenesis and wound healing through SRC\/MEK\/ERK signaling pathway","volume":"295","author":"Shi","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib32","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1038\/s41467-019-11403-6","article-title":"ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion","volume":"10","author":"Wilson","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.119432_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113051","article-title":"Revealing active ingredients, potential targets, and action mechanism of Ermiao fang for treating endometritis based on network pharmacology strategy","volume":"260","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib34","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI64931","article-title":"IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality","volume":"123","author":"Zhang","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.119432_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.phytochem.2017.12.016","article-title":"Phytochemistry and pharmacology of the genus Leonurus: the herb to benefit the mothers and more","volume":"147","author":"Zhang","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2025.119432_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.intimp.2017.05.002","article-title":"Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-\u03baB and JAK\/STAT signaling pathways in rats","volume":"48","author":"Zhao","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib37","first-page":"2348","article-title":"Study on extraction process and antioxidant activity of total alkaloids from Leonurus japonicus Houtt","volume":"30","author":"Zhou","year":"2019","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2025.119432_bib38","first-page":"494","article-title":"Treating gynaecological disorders with traditional Chinese medicine: a review","volume":"6","author":"Zhou","year":"2009","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"10.1016\/j.jep.2025.119432_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jep.2017.02.034","article-title":"Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-\u03baB pathway","volume":"202","author":"Zou","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119432_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117337","article-title":"Essential oil from Ligusticum chuanxiong Hort. alleviates lipopolysaccharide-induced neuroinflammation: integrating network pharmacology and molecular mechanism evaluation","volume":"319","author":"Zuo","year":"2024","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:13:33Z","timestamp":1778692413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":38,"alternative-id":["S0378874125001151"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119432","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Leonurus japonicus alkaloids on endometrial inflammation and its mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119432"}}