{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:45:07Z","timestamp":1792028707892,"version":"4.4.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jep.2025.119435","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T02:14:13Z","timestamp":1738548853000},"page":"119435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke"],"prefix":"10.1016","volume":"343","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-0229","authenticated-orcid":false,"given":"Yu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119435_bib1","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut microbiota-derived metabolites as central regulators in metabolic disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jep.2025.119435_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.834649","article-title":"Neuro-inflammatory response and brain-peripheral crosstalk in sepsis and stroke","volume":"13","author":"Bourhy","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119435_bib3","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1039\/D2FO01490D","article-title":"Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation","volume":"13","author":"Chang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119435_bib4","first-page":"3009","article-title":"Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia\/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial biogenesis","volume":"19","author":"Chen","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.119435_bib5","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1111\/jgh.14281","article-title":"Parasutterella, in association with irritable bowel syndrome and intestinal chronic inflammation","volume":"33","author":"Chen","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2025.119435_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.fct.2018.02.050","article-title":"A systematic review on the rhizome of Ligusticum chuanxiong Hort. (Chuanxiong)","volume":"119","author":"Chen","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119435_bib69","series-title":"Pharmacopoeia of People\u2019s Republic of China","author":"Commission","year":"2020"},{"key":"10.1016\/j.jep.2025.119435_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","article-title":"The gut microbiome in neurological disorders","volume":"19","author":"Cryan","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2025.119435_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1209436","article-title":"Editorial: intra and inter organ cross-talk and cellular communication","volume":"14","author":"Denechaud","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.119435_bib9","first-page":"1899","article-title":"Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR-4-mediated NF-\u03baB signal pathway","volume":"18","author":"Fang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.119435_bib10","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.pnpbp.2007.06.005","article-title":"Proline-rich polypeptides in Alzheimer's disease and neurodegenerative disorders -- therapeutic potential or a mirage?","volume":"31","author":"Gladkevich","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jep.2025.119435_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.phrs.2019.01.024","article-title":"The cardioprotective properties and the involved mechanisms of NaoXinTong Capsule","volume":"141","author":"Han","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119435_bib12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1161\/CIRCRESAHA.122.319983","article-title":"Aging microbiota-gut-brain Axis in stroke risk and outcome","volume":"130","author":"Honarpisheh","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.119435_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.119435_bib14","first-page":"1316","article-title":"Protective effects of Ginkgo biloba extract on rats during cerebral ischemia\/reperfusion","volume":"115","author":"Hu","year":"2002","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jep.2025.119435_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114142","article-title":"Quercetin inclusion complex gels ameliorate radiation-induced brain injury by regulating gut microbiota","volume":"158","author":"Hu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119435_bib16","article-title":"Ginkgolide B alleviates learning and memory impairment in rats with vascular dementia by reducing neuroinflammation via regulating NF-\u03baB pathway","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib17","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/antiox11081448","article-title":"Ferulic acid as a protective antioxidant of human intestinal epithelial cells","volume":"11","author":"Hwang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.119435_bib18","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41385-018-0042-3","article-title":"Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice","volume":"11","author":"Jang","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jep.2025.119435_bib19","first-page":"18","article-title":"Lysine and arginine reduce the effects of cerebral ischemic insults and inhibit glutamate-induced neuronal activity in rats","volume":"4","author":"Kondoh","year":"2010","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.jep.2025.119435_bib20","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/STROKEAHA.114.008022","article-title":"Dietary cysteine and other amino acids and stroke incidence in women","volume":"46","author":"Larsson","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.jep.2025.119435_bib21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jnutbio.2010.03.002","article-title":"Ginkgo biloba extract suppresses endotoxin-mediated monocyte activation by inhibiting nitric oxide- and tristetraprolin-mediated toll-like receptor 4 expression","volume":"22","author":"Lee","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jep.2025.119435_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153918","article-title":"Biological active ingredients of Astragali Radix and its mechanisms in treating cardiovascular and cerebrovascular diseases","volume":"98","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119435_bib23","first-page":"1998","article-title":"[Study progress on chemical compounds, pharmacological action and clinical application of Naoxintong capsule]","volume":"43","author":"Li","year":"2018","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.119435_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112365","article-title":"Ginkgo diterpene lactones inhibit cerebral ischemia\/reperfusion induced inflammatory response in astrocytes via TLR4\/NF-\u03baB pathway in rats","volume":"249","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13020-022-00578-8","article-title":"Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis","volume":"17","author":"Li","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.119435_bib26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jep.2013.03.045","article-title":"Tanshinone IIA, a constituent of Danshen, inhibits the release of glutamate in rat cerebrocortical nerve terminals","volume":"147","author":"Lin","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.843409","article-title":"Naoxintong capsule alternates gut microbiota and prevents hyperlipidemia in high-fat-diet fed rats","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112201","article-title":"Ginkgo biloba extract (EGb 761) mitigates methotrexate-induced testicular insult in rats: targeting oxidative stress, energy deficit and spermatogenesis","volume":"143","author":"Mansour","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119435_bib29","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1001\/jamaneurol.2015.0835","article-title":"Progress in intravenous thrombolytic therapy for acute stroke","volume":"72","author":"Marshall","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jep.2025.119435_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cmet.2022.04.001","article-title":"Microbiota alterations in proline metabolism impact depression","volume":"34","author":"Mayneris-Perxachs","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2025.119435_bib31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-065X.2012.01149.x","article-title":"Amino acid catabolism: a pivotal regulator of innate and adaptive immunity","volume":"249","author":"McGaha","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2025.119435_bib32","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1038\/onc.2009.467","article-title":"Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors","volume":"29","author":"Mej\u00edas-Luque","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2025.119435_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.nmni.2016.06.012","article-title":"\u201cIhubacter massiliensis\u201d: a new bacterium isolated from the human gut","volume":"13","author":"Ndongo","year":"2016","journal-title":"New Microbes New Infect"},{"key":"10.1016\/j.jep.2025.119435_bib34","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1111\/bph.15642","article-title":"Sphingolipid metabolism during Toll-like receptor 4 (TLR4)-mediated macrophage activation","volume":"178","author":"Olona","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00018-014-1762-5","article-title":"Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling","volume":"72","author":"P\u0142\u00f3ciennikowska","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2025.119435_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.604179","article-title":"The gut-brain Axis: how microbiota and host inflammasome influence brain physiology and pathology","volume":"11","author":"Rutsch","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119435_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109021","article-title":"Salvianolic acid C improves cerebral ischemia reperfusion injury through suppressing microglial cell M1 polarization and promoting cerebral angiogenesis","volume":"110","author":"Shen","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/bph.15965","article-title":"Aberrant branched-chain amino acid accumulation along the microbiota-gut-brain axis: crucial targets affecting the occurrence and treatment of ischaemic stroke","volume":"180","author":"Shen","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib39","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1523\/JNEUROSCI.1114-16.2016","article-title":"Microbiota dysbiosis controls the neuroinflammatory response after stroke","volume":"36","author":"Singh","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2025.119435_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ana.25250","article-title":"Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome","volume":"84","author":"Spychala","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jep.2025.119435_bib41","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nm.4194","article-title":"Translocation and dissemination of commensal bacteria in post-stroke infection","volume":"22","author":"Stanley","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jep.2025.119435_bib42","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1002\/jnr.22365","article-title":"Neuroprotective effect of L-serine against temporary cerebral ischemia in rats","volume":"88","author":"Wang","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jep.2025.119435_bib43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12974-022-02606-8","article-title":"Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.119435_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40168-022-01452-3","article-title":"Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.jep.2025.119435_bib45","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s10753-016-0384-5","article-title":"Salvianolic acid B ameliorates cerebral ischemia\/reperfusion injury through inhibiting TLR4\/MyD88 signaling pathway","volume":"39","author":"Wang","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.119435_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105640","article-title":"Medioresinol as a novel PGC-1\u03b1 activator prevents pyroptosis of endothelial cells in ischemic stroke through PPAR\u03b1-GOT1 axis","volume":"169","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119435_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-023-02721-0","article-title":"Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4\/MyD88\/NF-\u03baB pathway in LPC-induced demyelination","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2025.119435_bib48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcmm.12915","article-title":"Naoxintong attenuates Ischaemia\/reperfusion Injury through inhibiting NLRP3 inflammasome activation","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2025.119435_bib49","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1039\/D0FO03061A","article-title":"H. Zhang","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119435_bib50","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/19490976.2017.1344809","article-title":"An unexplored brain-gut microbiota axis in stroke","volume":"8","author":"Wen","year":"2017","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jep.2025.119435_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153158","article-title":"Shengui Sansheng Pulvis maintains blood-brain barrier integrity by vasoactive intestinal peptide after ischemic stroke","volume":"67","author":"Xia","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119435_bib52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fphar.2016.00134","article-title":"Salvianolic acid B restored impaired barrier function via downregulation of MLCK by microRNA-1 in rat colitis model","volume":"7","author":"Xiong","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib53","article-title":"Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn","author":"Xu","year":"2021","journal-title":"Gut gutjnl-2020-323263"},{"key":"10.1016\/j.jep.2025.119435_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67362-2","article-title":"Integrated metabolomics and gut microbiome to the effects and mechanisms of naoxintong capsule on type 2 diabetes in rats","volume":"10","author":"Yan","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.119435_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123767","article-title":"Astragalus polysaccharides alleviate type 1 diabetes via modulating gut microbiota in mice","volume":"234","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.119435_bib56","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fphar.2019.00268","article-title":"Gut microbiota-based pharmacokinetics and the antidepressant mechanism of paeoniflorin","volume":"10","author":"Yu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib57","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1111\/jnc.15242","article-title":"Mulberroside A repairs high fructose diet-induced damage of intestinal epithelial and blood-brain barriers in mice: a potential for preventing hippocampal neuroinflammatory injury","volume":"157","author":"Yu","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jep.2025.119435_bib58","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3390\/pharmaceutics15122746","article-title":"Ginkgo biloba extract drives gut flora and microbial metabolism variation in a mouse model of alzheimer's disease","volume":"15","author":"Yu","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jep.2025.119435_bib59","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s11655-022-3586-8","article-title":"Naoxintong capsule for secondary prevention of ischemic stroke: a multicenter, randomized, and placebo-controlled trial","volume":"28","author":"Yu","year":"2022","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2025.119435_bib60","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1021\/acs.jafc.8b00054","article-title":"Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.119435_bib61","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3389\/fphar.2019.01128","article-title":"Naoxintong capsule inhibits the development of cardiovascular pathological changes in bama minipig through improving gut microbiota","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119435_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2025.119435_bib63","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.apsb.2021.03.020","article-title":"Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4\/MyD88\/NF-\u03baB pathway through microbiota-gut-brain axis","volume":"11","author":"Zhao","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2025.119435_bib64","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","article-title":"Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis","volume":"9","author":"Zhao","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.jep.2025.119435_bib65","first-page":"745","article-title":"Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism","volume":"21","author":"Zhou","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2025.119435_bib66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jff.2017.10.026","article-title":"Serine prevents LPS-induced intestinal inflammation and barrier damage via p53-dependent glutathione synthesis and AMPK activation","volume":"39","author":"Zhou","year":"2017","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.jep.2025.119435_bib67","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s12012-024-09928-4","article-title":"Tanshinone IIA exerts cardioprotective effects through improving gut-brain Axis post-myocardial infarction","volume":"24","author":"Zhu","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.jep.2025.119435_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124689","article-title":"Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4\/MyD88\/NF-\u03baB pathway","volume":"242","author":"Zou","year":"2023","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:29:09Z","timestamp":1740986949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125001187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":69,"alternative-id":["S0378874125001187"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119435","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119435"}}