{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:33:30Z","timestamp":1790346810855,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104531"],"award-info":[{"award-number":["82104531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074121"],"award-info":[{"award-number":["82074121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jep.2025.119452","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T07:47:50Z","timestamp":1738828070000},"page":"119452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Integration of tissue distribution, PK-PD modeling and metabolomics reveals inflammatory-immune response alterations in Gaultheria leucocarpa var. yunnanensis alleviating rheumatoid arthritis"],"prefix":"10.1016","volume":"343","author":[{"given":"Xiuhuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianling","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-2140","authenticated-orcid":false,"given":"Gaimei","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2025.119452_bib1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jbspin.2015.11.009","article-title":"GC\/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis","volume":"83","author":"Ahn","year":"2016","journal-title":"Jt. Bone Spine"},{"issue":"19","key":"10.1016\/j.jep.2025.119452_bib2","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.3390\/molecules28196751","article-title":"Investigation of the mechanism of action of periploca forrestii schltr. Extract on adjuvant collagen rats based on UPLC-Q-orbitrap-HRMS non-targeted lipidomics","volume":"28","author":"An","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119452_bib3","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.biopha.2017.05.055","article-title":"Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy","volume":"92","author":"Alam","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"13","key":"10.1016\/j.jep.2025.119452_bib4","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.jep.2025.119452_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1517\/17425255.2015.1037276","article-title":"Physiologically based pharmacokinetic and pharmacodynamic modeling in cancer drug development: status, potential and gaps","volume":"11","author":"Block","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"5","key":"10.1016\/j.jep.2025.119452_bib6","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.4103\/jfmpc.jfmpc_307_20","article-title":"Cognitive dysfunction in patients of rheumatoid arthritis","volume":"9","author":"Chaurasia","year":"2020","journal-title":"J Family Med Prim Care"},{"key":"10.1016\/j.jep.2025.119452_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114413","article-title":"Pharmacokinetics of metformin in collagen-induced arthritis rats","volume":"185","author":"Chen","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.119452_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5605","article-title":"The tissue distribution of Jinzhen oral liquid in healthy and influenza mice","volume":"37","author":"Chen","year":"2023","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2025.119452_bib9","article-title":"Evaluation and clinical implications of interactions between compound Danshen dropping pill and warfarin associated with the epoxide hydrolase gene","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.119452_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tips.2008.01.007","article-title":"Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research","volume":"29","author":"Danhof","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.119452_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115474","article-title":"Biotransformation and metabolism of three methyl salicylate glycosides by gut microbiota in vitro","volume":"233","author":"Dong","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jep.2025.119452_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s40262-018-0659-0","article-title":"Pharmacokinetic-pharmacodynamic modeling in pediatric drug development, and the importance of standardized scaling of clearance","volume":"58","author":"Germovsek","year":"2019","journal-title":"Clin. Pharmacokinet."},{"issue":"5","key":"10.1016\/j.jep.2025.119452_bib13","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.18632\/aging.202739","article-title":"Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites","volume":"13","author":"Grajeda-Iglesias","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.jep.2025.119452_bib14","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1002\/ijc.34229","article-title":"Untargeted plasma metabolomics for risk prediction of hepatocellular carcinoma: a prospective study in two Chinese cohorts","volume":"151","author":"Hang","year":"2022","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jep.2025.119452_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116605","article-title":"A screening strategy for bioactive components of Bu-Zhong-Yi-Qi-Tang regulating spleen-qi deficiency based on \"endobiotics-targets-xenobiotics\" association network","volume":"314","author":"Hu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119452_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/1756-185X.13062","article-title":"Role of amino acids in rheumatoid arthritis studied by metabolomics","volume":"22","author":"He","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.jep.2025.119452_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jpba.2019.04.001","article-title":"In vivo metabolic profiles of Bu-Zhong-Yi-Qi-Tang, a famous traditional Chinese medicine prescription, in rats by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry","volume":"171","author":"Hu","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.119452_bib18","article-title":"Promising therapeutic targets for treatment of rheumatoid arthritis","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2025.119452_bib19","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1039\/C8RA05528A","article-title":"Metabolomics study of the therapeutic mechanism of a Chinese herbal formula on collagen-induced arthritis mice","volume":"9","author":"Jin","year":"2019","journal-title":"RSC Adv."},{"issue":"7","key":"10.1016\/j.jep.2025.119452_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11306-022-01893-9","article-title":"Metabolic discrimination of synovial fluid between rheumatoid arthritis and osteoarthritis using gas chromatography\/time-of-flight mass spectrometry","volume":"18","author":"Kim","year":"2022","journal-title":"Metabolomics"},{"issue":"1","key":"10.1016\/j.jep.2025.119452_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1445-5994.2012.02727.x","article-title":"How many life years are lost in patients with rheumatoid arthritis? Secular cause-specific and all-cause mortality in rheumatoid arthritis, and their predictors in a long-term Australian cohort study","volume":"43","author":"Lassere","year":"2013","journal-title":"Intern. Med. J."},{"issue":"5","key":"10.1016\/j.jep.2025.119452_bib22","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/cpt.2729","article-title":"Semimechanistic physiologically-based pharmacokinetic\/pharmacodynamic model informing epcoritamab dose selection for patients with B-cell lymphomas","volume":"112","author":"Li","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2025.119452_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113281","article-title":"Integrated network pharmacology and metabolomics to dissect the combination mechanisms of Bupleurum chinense DC-Paeonia lactiflora Pall herb pair for treating depression","volume":"264","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119452_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112959","article-title":"Metabolism, tissue distribution and excretion of taxifolin in rat","volume":"150","author":"Li","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119452_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bcp.2017.06.118","article-title":"Differential changes in the pharmacokinetics of statins in collagen-induced arthritis rats","volume":"142","author":"Lin","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"20","key":"10.1016\/j.jep.2025.119452_bib26","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.3390\/molecules27206988","article-title":"Sex differences of cardiolipin in tissue distribution based on targeted lipidomic analysis by UHPLC-QTOF-MS\/MS","volume":"27","author":"Lin","year":"2022","journal-title":"Molecules"},{"issue":"22","key":"10.1016\/j.jep.2025.119452_bib27","doi-asserted-by":"crossref","first-page":"16001","DOI":"10.1021\/acs.est.2c05547","article-title":"Metabolome-wide association study of multiple plasma metals with serum metabolomic profile among middle-to-older-aged Chinese adults","volume":"56","author":"Lin","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.jep.2025.119452_bib28","doi-asserted-by":"crossref","first-page":"12071","DOI":"10.3390\/molecules181012071","article-title":"Gaultheria: phytochemical and pharmacological characteristics","volume":"18","author":"Liu","year":"2013","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.jep.2025.119452_bib29","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1248\/cpb.c14-00407","article-title":"A rapid new approach for the quality evaluation of the folk medicine Dianbaizhu based on chemometrics","volume":"62","author":"Liu","year":"2024","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.jep.2025.119452_bib30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bse.2015.10.001","article-title":"Ultra-performance liquid chromatography fingerprint combined with chemometrics as an effective strategy for Dianbaizhu species discrimination","volume":"63","author":"Liu","year":"2015","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jep.2025.119452_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116640","article-title":"Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke","volume":"314","author":"Luo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119452_bib32","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3389\/fphar.2017.00826","article-title":"The clinical pharmacokinetics and pharmacodynamics of warfarin when combined with compound danshen: a case study for combined treatment of coronary heart diseases with atrial fibrillation","volume":"8","author":"Lv","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2025.119452_bib33","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3390\/pharmaceutics13101708","article-title":"Pharmacokinetic\/pharmacodynamic model of neutropenia in real-life palbociclib-treated patients","volume":"13","author":"Marouille","year":"2021","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.jep.2025.119452_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s10753-021-01604-x","article-title":"Metabolomics of synovial fluid and infrapatellar fat pad in patients with osteoarthritis or rheumatoid arthritis","volume":"45","author":"Nieminen","year":"2022","journal-title":"Inflammation"},{"issue":"11","key":"10.1016\/j.jep.2025.119452_bib35","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.jep.2025.119452_bib36","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1007\/s11095-015-1626-1","article-title":"Application of pharmacokinetic-pharmacodynamic modeling and simulation for antibody-drug conjugate development","volume":"32","author":"Singh","year":"2015","journal-title":"Pharm. Res."},{"issue":"11","key":"10.1016\/j.jep.2025.119452_bib37","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/molecules22111911","article-title":"Ferulaldehyde improves the effect of methotrexate in experimental arthritis","volume":"22","author":"Slov\u00e1k","year":"2017","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.jep.2025.119452_bib38","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1001\/jama.2022.0786","article-title":"What is rheumatoid arthritis?","volume":"327","author":"Smith","year":"2022","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jep.2025.119452_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cmet.2020.06.016","article-title":"Omics-driven systems interrogation of metabolic dysregulation in COVID-19 pathogenesis","volume":"32","author":"Song","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2025.119452_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152882","article-title":"Pharmacokinetics, tissue distribution and excretion study of trans-resveratrol-3-O-glucoside and its two metabolites in rats","volume":"58","author":"Su","year":"2019","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.jep.2025.119452_bib41","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/17460441.2018.1446935","article-title":"Bundling arrows: improving translational CNS drug development by integrated PK\/PD-metabolomics","volume":"13","author":"van den Brink","year":"2018","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.jep.2025.119452_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153313","article-title":"A stepwise integrated multi-system to screen quality markers of Chinese classic prescription Qingzao Jiufei decoction on the treatment of acute lung injury by combining 'network pharmacology-metabolomics-PK\/PD modeling'","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119452_bib43","volume":"175","author":"Wang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.119452_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114844","article-title":"Intestinal metabolism and absorption mechanism of multi-components in Gaultheria leucocarpa var. yunnanensis - an assessment using in situ and in vitro models, comparing gut segments in pathological with physiological conditions","volume":"286","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119452_bib45","article-title":"Gaultheria leucocarpa var. yunnanensis for treating rheumatoid arthritis-an assessment combining machine learning-guided ADME properties prediction, network pharmacology, and pharmacological assessment","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119452_bib46","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2015.12.061","article-title":"UHPLC\/Q-TOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica","volume":"179","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119452_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115438","article-title":"Sijunzi Tang improves gefitinib resistance by regulating glutamine metabolism","volume":"167","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.jep.2025.119452_bib48","first-page":"1773","article-title":"The anti-rheumatoid arthritis property of the folk medicine Dianbaizhu (Gaultheria leucocarpa var. yunnanensis, Ericaceae)","volume":"9","author":"Xie","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2025.119452_bib49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10600-016-1621-8","article-title":"Salicylic acid derivatives and other components from Gaultheria trichoclada","volume":"52","author":"Xu","year":"2016","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.jep.2025.119452_bib50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jconrel.2017.07.018","article-title":"Development of PEGylated carboxylic acid-modified polyamidoamine dendrimers as bone-targeting carriers for the treatment of bone diseases","volume":"262","author":"Yamashita","year":"2017","journal-title":"J Control Release"},{"issue":"8","key":"10.1016\/j.jep.2025.119452_bib51","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1039\/D1FO04386B","article-title":"Network pharmacology combined with metabolomics and lipidomics to reveal the hypolipidemic mechanism of Alismatis rhizoma in hyperlipidemic mice","volume":"13","author":"Yan","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119452_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1036732","article-title":"Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119452_bib53","series-title":"Application of Pharmacokinetics Property Evaluation in Drug Discovery and Development","author":"Zhang","year":"2007"},{"issue":"1","key":"10.1016\/j.jep.2025.119452_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s13318-021-00724-x","article-title":"Pharmacokinetics and pharmacodynamics of huanglian-houpo decoction based on berberine hydrochloride and magnolol against H1N1 influenza virus","volume":"47","author":"Zhang","year":"2022","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"issue":"23","key":"10.1016\/j.jep.2025.119452_bib55","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1002\/jssc.202200654","article-title":"A liquid chromatography-mass spectrometry untargeted urinary metabonomics combined with quantitative analysis of seven amino acids biomarkers on yaobitong capsule in the intervention of rheumatoid arthritis rats","volume":"45","author":"Zhang","year":"2022","journal-title":"J Sep Sci"},{"key":"10.1016\/j.jep.2025.119452_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117647","article-title":"Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K\/AKT\/Nrf2 pathway and metabolic profiling","volume":"323","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.119452_bib57","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/0113892002263771230920092659","article-title":"Pharmacokinetics and tissue distribution of isovitexin-2''-O-\u03b2-D-glucopyranoside (IVG) in sprague-dawley rats","volume":"24","author":"Zhao","year":"2023","journal-title":"Curr Drug Metab"},{"issue":"4","key":"10.1016\/j.jep.2025.119452_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5026","article-title":"Tissue distribution and molecular docking research on the active components of Bidens bipinnata L. against hyperlipidemia","volume":"35","author":"Zhuang","year":"2021","journal-title":"Biomed. Chromatogr."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T12:29:44Z","timestamp":1741004984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125001357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":58,"alternative-id":["S0378874125001357"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119452","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integration of tissue distribution, PK-PD modeling and metabolomics reveals inflammatory-immune response alterations in Gaultheria leucocarpa var. yunnanensis alleviating rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119452"}}