{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:43:12Z","timestamp":1787164992104,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jep.2025.119456","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T02:48:10Z","timestamp":1738810090000},"page":"119456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sini decoction alleviates LPS-induced sepsis partly via restoration of metabolic impairments in the hypothalamic-pituitary-adrenal microenvironment"],"prefix":"10.1016","volume":"343","author":[{"given":"Yan","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangguo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2025.119456_bib1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10753-016-0500-6","article-title":"Alteration of Lysophosphatidylcholine-related metabolic parameters in the plasma of mice with experimental sepsis","volume":"40","author":"Ahn","year":"2017","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.jep.2025.119456_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1189\/jlb.4MR0216-066R","article-title":"Cellular metabolism of myeloid cells in sepsis","volume":"101","author":"Arts","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.jep.2025.119456_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1530\/JOE-13-0249","article-title":"Leptin fails to blunt the lipopolysaccharide-induced activation of the hypothalamic-pituitary- adrenal axis in rats","volume":"221","author":"Basharat","year":"2014","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2025.119456_bib4","first-page":"3","article-title":"Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis","volume":"9","author":"Beishuizen","year":"2003","journal-title":"J. Endotoxin Res."},{"issue":"7","key":"10.1016\/j.jep.2025.119456_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1055\/s-2004-825750","article-title":"Toll-like receptor 2 and Toll-like receptor 4 expression in human adrenals","volume":"36","author":"Bornstein","year":"2004","journal-title":"Horm. Metab. Res."},{"issue":"5","key":"10.1016\/j.jep.2025.119456_bib6","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1097\/CCM.0b013e3182416f05","article-title":"Sepsis-associated changes of the arachidonic acid metabolism and their diagnostic potential in septic patients","volume":"40","author":"Bruegel","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jep.2025.119456_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1745-6215-12-199","article-title":"Simultaneous use of traditional Chinese medicine (Si-Ni-Tang) to treat septic shock patients: study protocol for a randomized controlled trial","volume":"12","author":"Chen","year":"2011","journal-title":"Trials"},{"issue":"7","key":"10.1016\/j.jep.2025.119456_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jpha.2023.02.006","article-title":"Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis","volume":"13","author":"Chen","year":"2023","journal-title":"Journal of Pharmaceutical Analysis"},{"key":"10.1016\/j.jep.2025.119456_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108971","article-title":"Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway","volume":"115","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"20","key":"10.1016\/j.jep.2025.119456_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011078","article-title":"Research progress in Chinese herbal medicines for treatment of sepsis: pharmacological action, phytochemistry, and pharmacokinetics","volume":"22","author":"Cheng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119456_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1431791","article-title":"Current perspectives in the management of sepsis and septic shock","volume":"11","author":"Chiscano-Camon","year":"2024","journal-title":"Front. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.119456_bib12","first-page":"453","article-title":"Study on the component-target correlation of Sini Decoction against sepsis by integrating chemomics and network pharmacology","volume":"40","author":"Ding","year":"2023","journal-title":"J. Shenyang Pharm. Univ."},{"issue":"2","key":"10.1016\/j.jep.2025.119456_bib13","doi-asserted-by":"crossref","first-page":"510","DOI":"10.7150\/thno.80066","article-title":"Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin induced cardiomyopathy","volume":"13","author":"Ding","year":"2023","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.jep.2025.119456_bib14","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1142\/S0192415X20500640","article-title":"Application of Chinese medicine in the management of critical conditions: a review on sepsis","volume":"48","author":"Fan","year":"2020","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119456_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41590-023-01660-5","article-title":"The pathophysiology of sepsis and precision-medicine-based immunotherapy","volume":"25","author":"Giamarellos-Bourboulis","year":"2024","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2025.119456_bib16","first-page":"791","article-title":"Plasma adrenocorticotropin, cortisol, and adrenocorticotropin\/cortisol ratios in septic and normal-term foals","volume":"21","author":"Gold","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.jep.2025.119456_bib17","article-title":"Sepsis: pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ Br. Med. J. (Clin. Res. Ed.)"},{"key":"10.1016\/j.jep.2025.119456_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155212","article-title":"Exploring the efficacious constituents and underlying mechanisms of sini decoction for sepsis treatment through network pharmacology and multi-omics","volume":"123","author":"Gu","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2025.119456_bib19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000026393","article-title":"Role of several mediators of inflammation on the mouse hypothalamo-pituitary-adrenal axis response during acute endotoxemia","volume":"6","author":"Hadid","year":"1999","journal-title":"Neuroimmunomodulation"},{"issue":"3","key":"10.1016\/j.jep.2025.119456_bib20","first-page":"184","article-title":"Effect of Sini decoction on function of hypothalamic-pituitary-adrenal axis in patients with sepsis","volume":"26","author":"Huang","year":"2014","journal-title":"Zhonghua wei zhong bing ji jiu yi xue"},{"key":"10.1016\/j.jep.2025.119456_bib21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fendo.2016.00156","article-title":"Adrenal gland microenvironment and its involvement in the regulation of stress-induced hormone secretion during sepsis","volume":"7","author":"Kanczkowski","year":"2016","journal-title":"Front. Endocrinol."},{"issue":"C","key":"10.1016\/j.jep.2025.119456_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.mce.2014.12.019","article-title":"The role of adrenal gland microenvironment in the HPA axis function and dysfunction during sepsis","volume":"408","author":"Kanczkowski","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.119456_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2008.10.028","article-title":"Differential expression and action of Toll-like receptors in human adrenocortical cells","volume":"300","author":"Kanczkowski","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"13","key":"10.1016\/j.jep.2025.119456_bib24","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically III patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA, J. Am. Med. Assoc."},{"issue":"9","key":"10.1016\/j.jep.2025.119456_bib25","first-page":"789","article-title":"Effects of sini decoction on immune function in the severe sepsis patients with yin syndrome","volume":"61","author":"Lai","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.119456_bib26","article-title":"Sini decoction improves adrenal function and the short-term outcome of septic rats through downregulation of adrenal toll-like receptor 4 expression","volume":"2018","author":"Lai","year":"2018","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"7\u20138","key":"10.1016\/j.jep.2025.119456_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000523965","article-title":"The role of kynurenines produced by indolamine-2,3-dioxygenase 1 in sepsis","volume":"107","author":"Lerch","year":"2022","journal-title":"Pharmacology"},{"issue":"2","key":"10.1016\/j.jep.2025.119456_bib28","doi-asserted-by":"crossref","first-page":"976","DOI":"10.7150\/thno.63751","article-title":"Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2025.119456_bib29","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.2147\/JIR.S481171","article-title":"Shenfu injection mediated NLRP3\/caspase 1 through (R)-Norcoclaurinee alleviates sepsis-induced cognitive dysfunction","volume":"17","author":"Liu","year":"2024","journal-title":"J. Inflamm. Res."},{"issue":"9","key":"10.1016\/j.jep.2025.119456_bib30","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1097\/CCM.0000000000001740","article-title":"Metabolite profiles in sepsis: developing prognostic tools based on the type of infection","volume":"44","author":"Neugebauer","year":"2016","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119456_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s13054-021-03736-w","article-title":"Initial antimicrobial management of sepsis","volume":"25","author":"Niederman","year":"2021","journal-title":"Crit. Care"},{"issue":"W1","key":"10.1016\/j.jep.2025.119456_bib32","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"C","key":"10.1016\/j.jep.2025.119456_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mce.2014.11.012","article-title":"The HPA axis response to critical illness: new study results with diagnostic and therapeutic implications","volume":"408","author":"Peeters","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.jep.2025.119456_bib34","first-page":"209","article-title":"Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma","volume":"23","author":"Pellegrin","year":"2005","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.jep.2025.119456_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/SHK.0000000000001687","article-title":"Serum levels of branched chain amino acids predict duration of cardiovascular organ failure in septic shock","volume":"56","author":"Puskarich","year":"2021","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.jep.2025.119456_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1515\/hsz-2015-0206","article-title":"Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors","volume":"397","author":"Qadri","year":"2016","journal-title":"Biol. Chem."},{"key":"10.1016\/j.jep.2025.119456_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2024.102223","article-title":"Spatial metabolomics in tissue injury and regeneration","volume":"87","author":"Rietjens","year":"2024","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"3","key":"10.1016\/j.jep.2025.119456_bib38","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/ac051437y","article-title":"XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification","volume":"78","author":"Smith","year":"2006","journal-title":"Analytical chemistry"},{"issue":"4","key":"10.1016\/j.jep.2025.119456_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034157","article-title":"Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats","volume":"7","author":"Tan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.119456_bib40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jpba.2014.03.028","article-title":"A strategy for rapid analysis of xenobiotic metabolome of Sini decoction in vivo using ultra-performance liquid chromatography-electrospray ionization quadrupole-time-of-flight mass spectrometry combined with pattern recognition approach","volume":"96","author":"Tan","year":"2014","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"8","key":"10.1016\/j.jep.2025.119456_bib41","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/bmc.1544","article-title":"Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry","volume":"25","author":"Tan","year":"2011","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.jep.2025.119456_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/0968051907078607","article-title":"The mRNA expression of fatty acid amide hydrolase in human whole blood correlates with sepsis","volume":"13","author":"Tanaka","year":"2007","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.jep.2025.119456_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104284","article-title":"The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: gaps in current knowledge and future translational research directions","volume":"84","author":"Van den Berghe","year":"2022","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.jep.2025.119456_bib44","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/nutrit\/nuad156","article-title":"Therapeutic effects and mechanisms of action of ginger and its bioactive components on inflammatory response, oxidative stress, the immune system, and organ failure in sepsis: a comprehensive systematic review","volume":"82","author":"Velayati","year":"2023","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jep.2025.119456_bib45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aca.2019.01.043","article-title":"Tutorial on lipidomics","volume":"1061","author":"Wang","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"12","key":"10.1016\/j.jep.2025.119456_bib46","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1073\/pnas.0712365105","article-title":"Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia","volume":"105","author":"Wang","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jep.2025.119456_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103956","article-title":"Sini decoction ameliorates interrelated lung injury in septic mice by modulating the composition of gut microbiota","volume":"140","author":"Wang","year":"2020","journal-title":"Microb. Pathog."},{"issue":"3","key":"10.1016\/j.jep.2025.119456_bib48","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4314\/tjpr.v19i3.11","article-title":"Aqueous extract of Aconitum carmichaelii Debeaux attenuates sepsis-induced acute lung injury via regulation of TLR4\/NF-\u039aB pathway","volume":"19","author":"You","year":"2020","journal-title":"Trop. J. Pharmaceut. Res."},{"issue":"2","key":"10.1016\/j.jep.2025.119456_bib49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jpha.2023.09.007","article-title":"Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong","volume":"14","author":"Zhao","year":"2024","journal-title":"Journal of Pharmaceutical Analysis"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:29:51Z","timestamp":1740986991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125001394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":49,"alternative-id":["S0378874125001394"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119456","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sini decoction alleviates LPS-induced sepsis partly via restoration of metabolic impairments in the hypothalamic-pituitary-adrenal microenvironment","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119456"}}