{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:31:19Z","timestamp":1792013479332,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1706101"],"award-info":[{"award-number":["2018YFC1706101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1706161"],"award-info":[{"award-number":["2018YFC1706161"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jep.2025.119460","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T17:04:19Z","timestamp":1739379859000},"page":"119460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Integrating metabolomics, network pharmacology and pharmacological verification analysis provides new insights into the anti-inflammatory and anti-tussive properties of Fritillaria cirrhosa bulbs"],"prefix":"10.1016","volume":"343","author":[{"given":"Can","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-3652","authenticated-orcid":false,"given":"Zhuyun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.jep.2025.119460_bib1","doi-asserted-by":"crossref","first-page":"13002","DOI":"10.1080\/07391102.2023.2274966","article-title":"Network pharmacology and experimental validation for deciphering the action mechanism of Fritillaria cirrhosa D. Don constituents in suppressing breast carcinoma","volume":"42","author":"Bhat","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jep.2025.119460_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/minf.201700048","article-title":"Network-based approaches in pharmacology","volume":"36","author":"Boezio","year":"2017","journal-title":"Mol. Inform"},{"issue":"8","key":"10.1016\/j.jep.2025.119460_bib3","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/jcb.25138","article-title":"Inhibition of transforming growth factor-\u03b2 (TGF-\u03b2) signaling by Scutellaria baicalensis and Fritillaria cirrhosa extracts in endometrial cancer","volume":"116","author":"Bokhari","year":"2015","journal-title":"J. Cell. Biochem."},{"issue":"15","key":"10.1016\/j.jep.2025.119460_bib4","first-page":"63","article-title":"Comparative study on the content determination and the anti-tussive and anti-inflammatory effects of the total alkaloids of Pingbeimu and Chuanbeimu","volume":"38","author":"Chen","year":"2017","journal-title":"Science and Technology of Food Industry"},{"key":"10.1016\/j.jep.2025.119460_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2020.112447","article-title":"Antioxidant and anti-inflammatory activities and bioactive compounds of the leaves of Trichodesma khasianum clarke","volume":"151","author":"Chen","year":"2020","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2025.119460_bib6","series-title":"Pharmacopoeia of the People's Republic of China (2020) Volume I","year":"2020"},{"key":"10.1016\/j.jep.2025.119460_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jep.2018.05.004","article-title":"High altitude species, high profits: can the trade in wild harvested Fritillaria cirrhosa (Liliaceae) be sustained?","volume":"223","author":"Cunningham","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119460_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2017.03.028","article-title":"Characterization of white tea metabolome: comparison against green and black tea by a nontargeted metabolomics approach","author":"Dai","year":"2017","journal-title":"Food Res. Int."},{"issue":"12","key":"10.1016\/j.jep.2025.119460_bib9","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1039\/C9FO02209K","article-title":"Efficient, accurate and comprehensive evaluation of polysaccharides from Fritillaria and their inhibitory responses to mouse inflammation","volume":"10","author":"Fan","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119460_bib10","article-title":"Roles of organic acids in plant stress tolerance, food security, and soil remediation","volume":"vol. 1","author":"Farhad","year":"2023"},{"key":"10.1016\/j.jep.2025.119460_bib11","first-page":"485","article-title":"Study on establishment and comparative analysis of fingerprints of the cultivated Fritillaria unibracteata and the cultivated F.cirrhosa by HPLC-ELSD","volume":"34","author":"Gong","year":"2019","journal-title":"West China J. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.119460_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2020.610026","article-title":"Intercropping system and N2 fixing bacteria can increase land use efficiency and improve the essential oil quantity and quality of sweet basil (Ocimum basilicum L.)","volume":"11","author":"Kordi","year":"2020","journal-title":"Front. Plant Sci."},{"issue":"5","key":"10.1016\/j.jep.2025.119460_bib13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1039\/b609306j","article-title":"Chemistry, bioactivity and geographical diversity of steroidal alkaloids from the Liliaceae family","volume":"23","author":"Li","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jep.2025.119460_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2019.08.037","article-title":"Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine","volume":"311\u2013312","author":"Lin","year":"2019","journal-title":"J. Contr. Release"},{"issue":"14","key":"10.1016\/j.jep.2025.119460_bib15","doi-asserted-by":"crossref","first-page":"7694","DOI":"10.3390\/ijms23147694","article-title":"Anti-inflammatory activity of mulberry leaf flavonoids in vitro and in vivo","volume":"23","author":"Lin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.jep.2025.119460_bib16","first-page":"3935","article-title":"Trichostatin A exerts anti-inflammation functions in LPS-induced acute lung injury model through inhibiting TNF-\u03b1 and upregulating micorRNA-146a expression","volume":"24","author":"Ling","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.119460_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106047","article-title":"Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae Bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway","volume":"78","author":"Liu","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119460_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.talanta.2016.01.027","article-title":"A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection","volume":"151","author":"Long","year":"2016","journal-title":"Talanta"},{"issue":"6","key":"10.1016\/j.jep.2025.119460_bib19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.21037\/atm.2020.02.105","article-title":"Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization","volume":"8","author":"Lv","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jep.2025.119460_bib20","first-page":"1944","article-title":"Resources and identification of Bulbus Fritillariae cirrhosae:A review","volume":"17","author":"Ma","year":"2022","journal-title":"World Chinese Medicine"},{"key":"10.1016\/j.jep.2025.119460_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s43621-021-00048-5","article-title":"Hue and cry for Fritillaria cirrhosa D.Don, a threatened medicinal plant in the Western Himalaya","volume":"2","author":"Mathela","year":"2021","journal-title":"Discov. Sustain"},{"issue":"6","key":"10.1016\/j.jep.2025.119460_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109923","article-title":"Impaired tryptophan metabolism by type 2 inflammation in epithelium worsening asthma","volume":"27","author":"Miao","year":"2024","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.jep.2025.119460_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"3","key":"10.1016\/j.jep.2025.119460_bib24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"3","key":"10.1016\/j.jep.2025.119460_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/pca.3338","article-title":"An insight into recent updates on analytical techniques for bioactive alkaloids","volume":"35","author":"Saini","year":"2024","journal-title":"Phytochem. Anal."},{"issue":"1","key":"10.1016\/j.jep.2025.119460_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.molp.2022.09.007","article-title":"Metabolomics-centered mining of plant metabolic diversity and function: past decade and future perspectives","volume":"16","author":"Shen","year":"2023","journal-title":"Mol. Plant"},{"key":"10.1016\/j.jep.2025.119460_bib27","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3389\/fimmu.2019.02565","article-title":"Tryptophan metabolism in inflammaging: from biomarker to therapeutic target","volume":"10","author":"Sorgdrager","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119460_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.1120613","article-title":"The role of indole derivative in the growth of plants: a review","volume":"13","author":"Sun","year":"2023","journal-title":"Front. Plant Sci."},{"issue":"10","key":"10.1016\/j.jep.2025.119460_bib29","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.jep.2025.119460_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jep.2016.08.009","article-title":"The total alkaloid fraction of bulbs of Fritillaria cirrhosa displays anti-inflammatory activity and attenuates acute lung injury","volume":"193","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.119460_bib31","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.fitote.2011.09.006","article-title":"Antitussive, expectorant and anti-inflammatory alkaloids from bulbus fritillariae cirrhosae","volume":"82","author":"Wang","year":"2011","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/j.jep.2025.119460_bib32","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2741\/4363","article-title":"Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation","volume":"20","author":"Wang","year":"2015","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"23","key":"10.1016\/j.jep.2025.119460_bib33","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.3390\/cells11233844","article-title":"Primary investigation of phenotypic plasticity in Fritillaria cirrhosa based on metabolome and transcriptome analyses","volume":"11","author":"Wang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.119460_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2024.118999","article-title":"Integrated microbiology and target metabolomics analysis reveal the interaction of plant-microbe-soil interactions leading to the phenotypic plasticity of Fritillaria cirrhosa","volume":"219","author":"Wang","year":"2024","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2025.119460_bib35","article-title":"Exploring the potential mechanism of Fritiliariae irrhosae Bulbus on ischemic stroke based on network pharmacology and experimental validation","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119460_bib36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nprot.2012.135","article-title":"Global metabolic profiling of animal and human tissues via UPLC-MS","volume":"8","author":"Want","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2025.119460_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envexpbot.2024.105814","article-title":"Transcriptomics combined with physiology reveals the effect of different light qualities on the development of Fritillaria cirrhosa in the Qinghai Tibet Plateau","volume":"224","author":"Yang","year":"2024","journal-title":"Environ. Exp. Bot."},{"issue":"3","key":"10.1016\/j.jep.2025.119460_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1742-7843.2007.00043.x","article-title":"Fritillaria cirrhosa, Anemarrhena asphodeloides, Lee-Mo-Tang and cyclosporine a inhibit ovalbumin-induced eosinophil accumulation and Th2-mediated bronchial hyperresponsiveness in a murine model of asthma","volume":"100","author":"Yeum","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2025.119460_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tplants.2021.10.008","article-title":"Arbuscular mycorrhizal fungi conducting the hyphosphere bacterial orchestra","volume":"27","author":"Zhang","year":"2022","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.jep.2025.119460_bib41","article-title":"Botanical characterization, phytochemistry, biosynthesis, pharmacology clinical application, and breeding techniques of the Chinese herbal medicine Fritillaria unibracteata","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119460_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.plaphy.2021.01.048","article-title":"Comprehensive dissection of primary metabolites in response to diverse abiotic stress in barley at seedling stage","volume":"161","author":"Zhao","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jep.2025.119460_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109181","article-title":"Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNF\u03b1-induced MAPK pathways","volume":"111","author":"Zhou","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119460_bib44","first-page":"225","article-title":"Identification and quality research on Fritillariae cirrhosae bulbus (Cultivation)of sichuan dao-di Herbs","volume":"15","author":"Zhou","year":"2020","journal-title":"World Chinese Medicine"},{"key":"10.1016\/j.jep.2025.119460_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1646905","article-title":"Applications of network pharmacology in traditional Chinese medicine research","volume":"2020","author":"Zhou","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125001436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T12:29:52Z","timestamp":1741004992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125001436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":44,"alternative-id":["S0378874125001436"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119460","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating metabolomics, network pharmacology and pharmacological verification analysis provides new insights into the anti-inflammatory and anti-tussive properties of Fritillaria cirrhosa bulbs","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119460"}}