{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:43:35Z","timestamp":1785523415259,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473390"],"award-info":[{"award-number":["81473390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474055"],"award-info":[{"award-number":["82474055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2060302"],"award-info":[{"award-number":["2060302"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20241913"],"award-info":[{"award-number":["BK20241913"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jep.2025.119638","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T13:15:13Z","timestamp":1743081313000},"page":"119638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Hydrogen sulfide-mediated cardiovascular protection involved in the antihypertensive effect of the saiga antelope horn"],"prefix":"10.1016","volume":"346","author":[{"given":"Miao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8346-2246","authenticated-orcid":false,"given":"Hongyun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqin","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-ao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"342","key":"10.1016\/j.jep.2025.119638_bib1","doi-asserted-by":"crossref","first-page":"ra87","DOI":"10.1126\/scisignal.2005478","article-title":"The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide","volume":"7","author":"Altaany","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jep.2025.119638_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115381","article-title":"Hydrogen sulfide in the experimental models of arterial hypertension","volume":"208","author":"Be\u0142towski","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.119638_bib3","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/ATVBAHA.118.311229","article-title":"Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension","volume":"38","author":"Brown","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jep.2025.119638_bib4","series-title":"Chinese Pharmacopoeia","year":"2020"},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2025.119638_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110240","article-title":"Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms","volume":"128","author":"Cui","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119638_bib7","series-title":"Diagnostic Atlas of Renal Pathology","author":"Fogo","year":"2007"},{"key":"10.1016\/j.jep.2025.119638_bib8","article-title":"Antelope Angle Drops Pills for the treatment of 40 cases of liver-yang hyperactivity-type headache in essential hypertension","volume":"4","author":"Gan","year":"2005","journal-title":"Clin. J. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.119638_bib9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00467-021-05144-2","article-title":"Relationship between endothelin and nitric oxide pathways in the onset and maintenance of hypertension in children and adolescents","volume":"37","author":"Genovesi","year":"2021","journal-title":"Pediatr. Nephrol."},{"issue":"2","key":"10.1016\/j.jep.2025.119638_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119388","article-title":"H(2)S contributed from CSE during cellular senescence suppresses inflammation and nitrosative stress","volume":"1870","author":"Gupta","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.jep.2025.119638_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/srep40227","article-title":"Discovery and mechanistic characterization of selective inhibitors of H(2)S-producing enzyme: 3-mercaptopyruvate sulfurtransferase (3MST) targeting active-site cysteine persulfide","volume":"7","author":"Hanaoka","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jep.2025.119638_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052298","article-title":"Targeting the renin-angiotensin-aldosterone system to prevent hypertension and kidney disease of developmental origins","volume":"22","author":"Hsu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.119638_bib13","first-page":"556","article-title":"Mangiferin alleviates renal inflammatory injury in spontaneously hypertensive rats by inhibiting MCP-1\/CCR2 signaling pathway","volume":"15","author":"Hu","year":"2023","journal-title":"Chin. Herb Med."},{"key":"10.1016\/j.jep.2025.119638_bib14","article-title":"Traditional Chinese Medicine's liver yang ascendant hyperactivity pattern of essential hypertension and its treatment approaches: a narrative review","volume":"43","author":"Huang","year":"2021","journal-title":"Compl. Ther. Clin. Pract."},{"issue":"9","key":"10.1016\/j.jep.2025.119638_bib15","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20221006","article-title":"Reactive sulfur species and their significance in health and disease","volume":"42","author":"Iciek","year":"2022","journal-title":"Biosci. Rep."},{"issue":"13\u201315","key":"10.1016\/j.jep.2025.119638_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1089\/ars.2023.0261","article-title":"Reactive sulfur species in human diseases","volume":"39","author":"Iciek","year":"2023","journal-title":"Antioxidants Redox Signal."},{"issue":"6","key":"10.1016\/j.jep.2025.119638_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11906-019-0949-4","article-title":"New approaches in hypertension management: a review of current and developing technologies and their potential impact on hypertension care","volume":"21","author":"Kitt","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"issue":"10324","key":"10.1016\/j.jep.2025.119638_bib18","article-title":"Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants","volume":"399","author":"Krokstad","year":"2022","journal-title":"Lancet (N. Am. Ed.)"},{"issue":"5","key":"10.1016\/j.jep.2025.119638_bib19","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s40620-020-00803-3","article-title":"Blood pressure reduction and RAAS inhibition in diabetic kidney disease: therapeutic potentials and limitations","volume":"33","author":"Leoncini","year":"2020","journal-title":"J. Nephrol."},{"issue":"Pt 1","key":"10.1016\/j.jep.2025.119638_bib20","article-title":"The anticonvulsant effect of saiga horn on febrile seizures by regulating brain serotonin content and inhibiting neuroinflammation","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119638_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1209890","article-title":"Natural compounds targeting mitochondrial dysfunction: emerging therapeutics for target organ damage in hypertension","volume":"14","author":"Liao","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib22","article-title":"Available sustainable alternatives replace endangered animal horn based on their proteomic analysis and bio-effect evaluation","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.jep.2025.119638_bib23","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1002\/elps.201900078","article-title":"Comparison of the peptidome released from keratins in Saiga antelope horn and goat horn under simulated gastrointestinal digestion","volume":"40","author":"Liu","year":"2019","journal-title":"Electrophoresis"},{"issue":"10","key":"10.1016\/j.jep.2025.119638_bib24","first-page":"857","article-title":"Progress and prospects of modern research methodology of animal derived traditional Chinese medicines","volume":"38","author":"Liu","year":"2022","journal-title":"J. Nanjing Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.119638_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113802","article-title":"Hypertensive vascular and cardiac remodeling protection by allicin in spontaneous hypertension rats via CaMK \u2161\/NF-\u03baB pathway","volume":"155","author":"Liu","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jep.2011.04.053","article-title":"Substitutes for endangered medicinal animal horns and shells exposed by antithrombotic and anticoagulation effects","volume":"136","author":"Luo","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/st9.0000000000000009","article-title":"Clinical evidence and mechanisms of traditional Chinese medicine in major diseases","volume":"1","author":"Luo","year":"2023","journal-title":"Sci. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.119638_bib28","first-page":"1532","article-title":"The effects of Lingjiaojiangyafang and its disassembled on the symptoms of ganyangshangkang hypertension","volume":"26","author":"Lv","year":"2010","journal-title":"Chin. Pharmacol. Bull."},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib29","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41392-023-01430-7","article-title":"Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions","volume":"8","author":"Ma","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.jep.2025.119638_bib30","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/bph.13825","article-title":"Protein S\u2010sulfhydration by hydrogen sulfide in cardiovascular system","volume":"175","author":"Meng","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119638_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.14","article-title":"Hypertension","volume":"4","author":"Oparil","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cmet.2023.11.012","article-title":"Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation","volume":"36","author":"Ou","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2025.119638_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111933","article-title":"Animal-derived medicinal products in Russia: current nomenclature and specific aspects of quality control","volume":"240","author":"Prokopov","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"22","key":"10.1016\/j.jep.2025.119638_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212305","article-title":"Angiotensin II and the cardiac parasympathetic nervous system in hypertension","volume":"22","author":"Shanks","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.jep.2025.119638_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/nu14194069","article-title":"Positive effect of a pea-clam two-peptide composite on hypertension and organ protection in spontaneously hypertensive rats","volume":"14","author":"Sun","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jep.2025.119638_bib36","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/HYPERTENSIONAHA.117.10562","article-title":"Cystathionine \u03b3-lyase-produced hydrogen sulfide controls endothelial NO bioavailability and blood pressure","volume":"71","author":"Szij\u00e1rt\u00f3","year":"2018","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.jep.2025.119638_bib37","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.pharep.2019.05.009","article-title":"GABA(A) receptor, K(ATP) channel and L-type Ca(2+) channel is associated with facilitation effect of H(2)S on the baroreceptor reflex in spontaneous hypertensive rats","volume":"71","author":"Teng","year":"2019","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.jep.2025.119638_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/st9.0000000000000008","article-title":"Dominant cardiovascular diseases treated by traditional Chinese medicine: clinical evidence and distinctive therapeutic characteristics","volume":"1","author":"Wang","year":"2023","journal-title":"Sci. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.119638_bib39","article-title":"Study on efficacy of Fufang Lingjiao Jiangya Wan with different proportions of goat horn instead of antelope horn on spontaneous hypertensive rats","volume":"12","author":"Wang","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.119638_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118193","article-title":"Mechanism and functional substances of Saiga antelope horn in treating hypertension with Liver-Yang Hyperactivity syndrome explored using network pharmacology and metabolomics","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119638_bib41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.freeradbiomed.2024.07.023","article-title":"Thiols-rich peptide from water buffalo horn keratin alleviates oxidative stress and inflammation through co-regulating Nrf2\/Hmox-1 and NF-\u03baB signaling pathway","volume":"223","author":"Wu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2025.119638_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115968","article-title":"Protective effect of novel angiotensin receptor neprilysin inhibitor S086 on target organ injury in spontaneously hypertensive rats","volume":"170","author":"Xiao","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2025.119638_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/dna.2019.5067","article-title":"Role of hydrogen sulfide in chronic diseases","volume":"39","author":"Yang","year":"2020","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.jep.2025.119638_bib47","first-page":"168","article-title":"Clinical observation on treatment of 50 cases of hypertension with hyperactivityof liver-yang by Antelope Horn Decoction combined with valsartan amlodipine tablet","volume":"4","author":"Yao","year":"2016","journal-title":"Cardiovasc. Dis. Electron. J. Integrated Tradit. Chin. West. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.119638_bib44","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004971","article-title":"Endogenous hydrogen sulfide enhances carotid sinus baroreceptor sensitivity by activating the transient receptor potential cation channel subfamily v member 1 (TRPV1) channel","volume":"6","author":"Yu","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.jep.2025.119638_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25042317","article-title":"Unveiling the role of endothelial dysfunction: a possible key to enhancing catheter ablation success in atrial fibrillation","volume":"25","author":"Zakynthinos","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2025.119638_bib46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jpha.2023.06.010","article-title":"Protective effects of catalpol on cardio-cerebrovascular diseases: a comprehensive review","volume":"13","author":"Zhang","year":"2023","journal-title":"J. Pharm. Anal."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:56:05Z","timestamp":1762307765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125003228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":47,"alternative-id":["S0378874125003228"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119638","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide-mediated cardiovascular protection involved in the antihypertensive effect of the saiga antelope horn","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119638"}}