{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:29:12Z","timestamp":1792463352031,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["23JRRA1720"],"award-info":[{"award-number":["23JRRA1720"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060829"],"award-info":[{"award-number":["82060829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204759"],"award-info":[{"award-number":["82204759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jep.2025.119645","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T12:43:55Z","timestamp":1742301835000},"page":"119645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["The Codonopsis pilosula water extract improves testicular inflammatory aging in D-galactose induced aging mice by modulating the CLEC7A\/inflammasome pathway"],"prefix":"10.1016","volume":"346","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119645_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10875-010-9456-8","article-title":"TLR1\/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors","volume":"31","author":"Agrawal","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jep.2025.119645_bib2","doi-asserted-by":"crossref","DOI":"10.1530\/REP-24-0070","article-title":"Population decline: where demography, social science, and biology intersect","volume":"168","author":"Aitken","year":"2024","journal-title":"Reproduction"},{"key":"10.1016\/j.jep.2025.119645_bib3","first-page":"123","article-title":"Impact of inflammation on male reproductive tract","volume":"16","author":"Azenabor","year":"2015","journal-title":"J. Reproduction Infertil."},{"key":"10.1016\/j.jep.2025.119645_bib4","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.3390\/ijms23073535","article-title":"The role of testosterone in the elderly: what do we know?","volume":"23","author":"Barone","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119645_bib5","series-title":"Age-related Changes in the Male Reproductive System","year":"2020"},{"key":"10.1016\/j.jep.2025.119645_bib6","first-page":"274","article-title":"B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans. Ageing","volume":"10","author":"Bulati","year":"2011","journal-title":"Res. Rev."},{"key":"10.1016\/j.jep.2025.119645_bib7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/CIRCRESAHA.119.316470","article-title":"Impact of local alloimmunity and recipient cells in transplant arteriosclerosis","volume":"127","author":"Cai","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.119645_bib8","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20165793","article-title":"Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis","volume":"50","author":"Chen","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jep.2025.119645_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104426","article-title":"CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues","volume":"25","author":"Davila","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.jep.2025.119645_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.729539","article-title":"Varicocele-mediated male infertility: from the perspective of testicular immunity and inflammation","volume":"12","author":"Fang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119645_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jep.2025.119645_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/and.13034","article-title":"Ageing and inflammation in the male reproductive tract","volume":"50","author":"Frungieri","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.jep.2025.119645_bib13","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/molecules23071801","article-title":"The Polysaccharides from Codonopsis pilosula modulates the immunity and intestinal microbiota of cyclophosphamide-treated immunosuppressed mice","volume":"23","author":"Fu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119645_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41413-024-00375-z","article-title":"Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis","volume":"12","author":"Han","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.jep.2025.119645_bib15","first-page":"469","article-title":"Ciradian clock protein Rev-erb\u03b1 agonist inhibits high-fat diet-induced inflammation of the prostate tissue in mice","volume":"30","author":"He","year":"2022","journal-title":"Acta Lab. Anim. Sci. Sin."},{"key":"10.1016\/j.jep.2025.119645_bib16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2174\/1573406413666170510103030","article-title":"C-type Lectin receptor: old friend and new player","volume":"13","author":"Hou","year":"2017","journal-title":"Med. Chem."},{"key":"10.1016\/j.jep.2025.119645_bib17","first-page":"55","article-title":"Effects of Codonopsis pilosula decoction on thymus function in D-galactose-induced immunosenescent mice","volume":"30","author":"Hou","year":"2014","journal-title":"Chin. J. Cell Mol. Immunol."},{"key":"10.1016\/j.jep.2025.119645_bib18","first-page":"2627","article-title":"The effects of water wxtracts from Codonopsis pilosula on testicular morphology and the expression of Bax and VEGF in D-Galactose-induced aging mice","volume":"27","author":"Huang","year":"2016","journal-title":"Lishizhen Med. and Materia. Med. Res."},{"key":"10.1016\/j.jep.2025.119645_bib19","article-title":"Research on the anti-oxidant and anti-aging effects of Polygonatum kingianum saponins in Caenorhabditis elegans","volume":"10","author":"Huang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.119645_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.651860","article-title":"cDC1 dependent accumulation of memory T cells Is required for chronic autoimmune inflammation in murine testis","volume":"12","author":"Jing","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119645_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117220","article-title":"Multi-omics revealed the mechanisms of Codonopsis pilosula aqueous extract in improving UC through blocking abnormal activation of PI3K\/Akt signaling pathway","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119645_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.114002","article-title":"The crosstalk between M1 macrophage polarization and energy metabolism disorder contributes to polystyrene nanoplastics-triggered testicular inflammation","volume":"180","author":"Li","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119645_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154815","article-title":"TNF-alpha regulates alternative splicing of genes participating in pathways of crucial metabolic syndromes; a transcriptome wide study","volume":"125","author":"Louis","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2025.119645_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155586","article-title":"Glycyrrhizic acid alleviates concanavalin A-induced acute liver injury by regulating monocyte-derived macrophages","volume":"133","author":"Lu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119645_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.adg0934","article-title":"Aging fly cell atlas identifies exhaustive aging features at cellular resolution","volume":"380","author":"Lu","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.119645_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117863","article-title":"Extraction, purification, structural characteristics and biological properties of the polysaccharides from Codonopsis pilosula: a review","volume":"261","author":"Luan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2025.119645_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583135","article-title":"Pathomechanisms of autoimmune based testicular inflammation","volume":"11","author":"Lustig","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119645_bib28","article-title":"Immunoregulation and male reproductive function: impacts and mechanistic insights into inflammation","author":"Ma","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.jep.2025.119645_bib29","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s11154-022-09759-0","article-title":"Reproductive axis ageing and fertility in men","volume":"23","author":"Martins da Silva","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jep.2025.119645_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijmm.2020.4834","article-title":"Integration of lncRNA and mRNA profiles to reveal the protective effects of Codonopsis pilosula extract on the gastrointestinal tract of mice subjected to D-galactose-induced aging","volume":"47","author":"Meng","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2025.119645_bib31","first-page":"35","article-title":"Blocking an inflammatory protein slows the pace of ageing. Nature","volume":"632","author":"Miller","year":"2024"},{"key":"10.1016\/j.jep.2025.119645_bib55","series-title":"Chinese Pharmacopoeia","year":"2020"},{"key":"10.1016\/j.jep.2025.119645_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14712598.3.1.15","article-title":"CCL27\/PESKY: a novel paradigm for chemokine function","volume":"3","author":"Nibbs","year":"2003","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.jep.2025.119645_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133190","article-title":"Codonopsis pilosula polysaccharides (CPP) intervention alleviates sterigmatocystin (STC)-induced liver injury and gut microbiota dysbiosis","volume":"275","author":"Nie","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.119645_bib35","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/1472-6882-14-250","article-title":"Possible mechanism underlying the effect of Heshouwuyin, a tonifying kidney herb, on sperm quality in aging rats","volume":"14","author":"Niu","year":"2014","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2025.119645_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2022.05.006","article-title":"Causal effects of circulating cytokine concentrations on risk of Alzheimer's disease and cognitive function","volume":"104","author":"Pagoni","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2025.119645_bib37","doi-asserted-by":"crossref","DOI":"10.4161\/spmg.23870","article-title":"Dual role of immune cells in the testis: protective or pathogenic for germ cells?","volume":"3","author":"P\u00e9rez","year":"2013","journal-title":"Spermatogenesis"},{"key":"10.1016\/j.jep.2025.119645_bib38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ijbiomac.2018.12.025","article-title":"Study of the selenizing Codonopsis pilosula polysaccharides protects RAW264.7 cells from hydrogen peroxide-induced injury","volume":"125","author":"Qin","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.119645_bib39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2025.119645_bib40","first-page":"123","article-title":"Effect of rich selenium-banqiao-Codonopsis pilosula wine on testis of aging rats","volume":"29","author":"Tan","year":"2013","journal-title":"Zhongguo Ying Yong Sheng li xue za zhi= Zhongguo Yingyong Shenglixue Zazhi= Chinese J. Appl. Physiol."},{"key":"10.1016\/j.jep.2025.119645_bib41","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/eji.201847536","article-title":"C-type lectin receptors of the Dectin-1 cluster: physiological roles and involvement in disease","volume":"49","author":"Tone","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jep.2025.119645_bib42","first-page":"1332","article-title":"Integrated multi-omics approach reveals the interaction of brain-gut in D-galactose-induced aging model mice","volume":"39","author":"Wang","year":"2023","journal-title":"Chin. J. Biochem. Mol. Biol."},{"key":"10.1016\/j.jep.2025.119645_bib43","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/aja202488","article-title":"Research advances in inflammation and oxidative stress in varicocele-induced male infertility: a narrative review","volume":"27","author":"Wang","year":"2024","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jep.2025.119645_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118016","article-title":"Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism","volume":"327","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119645_bib45","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1080\/21691401.2019.1637882","article-title":"Transcriptome profiling of cervical cancer cells acquired resistance to cisplatin by deep sequencing","volume":"47","author":"Wang","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.jep.2025.119645_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124351","article-title":"Cucurbit[7]uril-based host-guest complexes for improving bioavailability and reducing side effects of piroxicam","volume":"660","author":"Wang","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jep.2025.119645_bib47","article-title":"Liuweidihuang pill alleviates inflammation of the testis via AMPK\/SIRT1\/NF-\u03baB pathway in aging rats","volume":"2020","author":"Wang","year":"2020","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2025.119645_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155075","article-title":"Levo-tetrahydropalmatine ameliorates neuropathic pain by inhibiting the activation of the Clec7a-MAPK\/NF-\u03baB-NLRP3 inflammasome axis","volume":"121","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119645_bib49","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.3390\/ijms24108819","article-title":"Macrophage-related testicular inflammation in individuals withidiopathic non-obstructive azoospermia: a single-cell analysis","volume":"24","author":"Xia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119645_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117106","article-title":"Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice","volume":"319","author":"Xie","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119645_bib52","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/liv.15160","article-title":"Roles for the mycobiome in liver disease","volume":"42","author":"Zeng","year":"2022","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2025.119645_bib53","first-page":"145","article-title":"Effects and mechanisms of Tibetan Codonopsis Saponins on testicular interstitial cells","volume":"17","author":"Zheng","year":"2011","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.119645_bib54","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.3390\/antiox12091781","article-title":"A pectic polysaccharide from Codonopsis pilosula alleviates inflammatory response and oxidative stress of aging mice via modulating intestinal microbiota-related gut-liver axis","volume":"12","author":"Zou","year":"2023","journal-title":"Antioxidants"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:57:30Z","timestamp":1762307850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125003290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":53,"alternative-id":["S0378874125003290"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119645","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Codonopsis pilosula water extract improves testicular inflammatory aging in D-galactose induced aging mice by modulating the CLEC7A\/inflammasome pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119645"}}