{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:41:34Z","timestamp":1792737694908,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119696","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T14:19:17Z","timestamp":1743257957000},"page":"119696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Exploring the mechanism of Sinisan in the treatment of ulcerative colitis with depression based on UPLC-Q-Orbitrap-MS combined with network pharmacology, molecular docking, and experimental validation"],"prefix":"10.1016","volume":"347","author":[{"given":"Meiling","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3116-2921","authenticated-orcid":false,"given":"Xiaopeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0472-8121","authenticated-orcid":false,"given":"Shanbo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119696_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.753279","article-title":"Luteolin modulates neural stem cells fate determination: in vitro study on human neural stem cells, and in vivo study on LPS-induced depression mice model","volume":"9","author":"Achour","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.jep.2025.119696_bib2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/ibd.21549","article-title":"Brain functional changes in patients with ulcerative colitis: a functional magnetic resonance imaging study on emotional processing","volume":"17","author":"Agostini","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/etm.2020.8710","article-title":"Changes in MMP-2, MMP-9, inflammation, blood coagulation and intestinal mucosal permeability in patients with active ulcerative colitis","volume":"20","author":"Bai","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2025.119696_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114278","article-title":"Systems pharmacological study based on UHPLC-Q-Orbitrap-HRMS, network pharmacology and experimental validation to explore the potential mechanisms of Danggui-Shaoyao-San against atherosclerosis","volume":"278","author":"Bi","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2025.119696_bib5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41575-022-00634-6","article-title":"Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment","volume":"19","author":"Bisgaard","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.jep.2025.119696_bib6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/sj.leu.2402824","article-title":"Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy","volume":"17","author":"Chang","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.jep.2025.119696_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/549691","article-title":"PPAR\u03b3 and the innate immune system mediate the resolution of inflammation","volume":"2015","author":"Croasdell","year":"2015","journal-title":"PPAR Res."},{"key":"10.1016\/j.jep.2025.119696_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154395","article-title":"Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats","volume":"106","author":"Deng","year":"2022","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.jep.2025.119696_bib9","first-page":"1179","article-title":"Research progress on anti-inflammatory effects and clinical application of sini powder","volume":"37","author":"Ding","year":"2022","journal-title":"Acta Chinese Medicine"},{"key":"10.1016\/j.jep.2025.119696_bib10","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.2147\/DDDT.S326029","article-title":"Investigation of the active ingredients and mechanism of hudi enteric-coated capsules in DSS-induced ulcerative colitis mice based on network pharmacology and experimental verification","volume":"15","author":"Ding","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"issue":"6","key":"10.1016\/j.jep.2025.119696_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065651","article-title":"Shared genes of PPARG and NOS2 in alzheimer's disease and ulcerative colitis drive macrophages and microglia polarization: evidence from bioinformatics analysis and following validation","volume":"24","author":"Dong","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119696_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121820","article-title":"Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-\u03baB and TGF-\u03b2\/EGFR signaling pathways","volume":"327","author":"El Mahdy","year":"2023","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.jep.2025.119696_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cells13020177","article-title":"Psychiatric comorbidities of inflammatory bowel disease: it is a matter of microglia's gut feeling","volume":"13","author":"Fakhfouri","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.119696_bib14","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2147\/NDT.S114560","article-title":"Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review","volume":"12","author":"Feng","year":"2016","journal-title":"Neuropsychiatric Dis. Treat."},{"issue":"9","key":"10.1016\/j.jep.2025.119696_bib15","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1136\/gutjnl-2018-317182","article-title":"Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression","volume":"68","author":"Frolkis","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jep.2025.119696_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bpg.2018.05.017","article-title":"Surgery in ulcerative colitis: when? How?","volume":"32\u201333","author":"Gallo","year":"2018","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"17","key":"10.1016\/j.jep.2025.119696_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179248","article-title":"The PPARg system in major depression: pathophysiologic and therapeutic implications","volume":"22","author":"Gold","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119696_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147661","article-title":"Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2","volume":"1772","author":"Guan","year":"2021","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.jep.2025.119696_bib19","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s12264-018-0288-5","article-title":"Cortical inflammation is increased in a DSS-induced colitis mouse model","volume":"34","author":"Han","year":"2018","journal-title":"Neurosci. Bull."},{"issue":"6","key":"10.1016\/j.jep.2025.119696_bib20","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/febs.15557","article-title":"Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor","volume":"288","author":"Hasegawa","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.jep.2025.119696_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113652","article-title":"Explore of the beneficial effects of Huang-Lian-Jie-Du Decoction on diabetic encephalopathy in db\/db mice by UPLC-Q-Orbitrap HRMS\/MS based untargeted metabolomics analysis","volume":"192","author":"He","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"7634","key":"10.1016\/j.jep.2025.119696_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/540S97a","article-title":"Inflammatory bowel disease","volume":"540","author":"Hodson","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jep.2025.119696_bib23","doi-asserted-by":"crossref","DOI":"10.1177\/00368504211054985","article-title":"Inflammatory cytokines TNF\u03b1, IL-1\u03b2, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades","volume":"104","author":"Ishijima","year":"2021","journal-title":"Sci. Prog."},{"key":"10.1016\/j.jep.2025.119696_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.643456","article-title":"Xiaoyao pills ameliorate depression-like behaviors and oxidative stress induced by olfactory bulbectomy in rats via the activation of the PIK3CA-AKT1-nfe2l2\/BDNF signaling pathway","volume":"12","author":"Ji","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119696_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130948","article-title":"UHPLC-Q-Orbitrap-based lipidomics reveals molecular mechanism of lipid changes during preservatives treatment of Hengshan goat meat sausages","volume":"369","author":"Jia","year":"2022","journal-title":"Food Chem."},{"issue":"6","key":"10.1016\/j.jep.2025.119696_bib26","first-page":"159","article-title":"Literature research on pharmacological actions and clinical applications of sini powder","volume":"19","author":"Jia","year":"2017","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"issue":"12","key":"10.1016\/j.jep.2025.119696_bib27","first-page":"29","article-title":"Research progress on sini powder and its single active ingredient with antidepressant effects","volume":"42","author":"Jin","year":"2024","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ajg.2017.423","article-title":"Depression is associated with more aggressive inflammatory bowel disease","volume":"113","author":"Kochar","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.119696_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.119008","article-title":"Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats","volume":"269","author":"Li","year":"2021","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib30","doi-asserted-by":"crossref","DOI":"10.1515\/med-2023-0785","article-title":"Luteolin alleviates ulcerative colitis in rats via regulating immune response, oxidative stress, and metabolic profiling","volume":"18","author":"Li","year":"2023","journal-title":"Open Med."},{"key":"10.1016\/j.jep.2025.119696_bib31","first-page":"1","article-title":"Key information research and visual analysis of research hotspots and frontier trends of classical prescription sini san based on bibliometrics","author":"Liang","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.119696_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114103","article-title":"Exercise more efficiently regulates the maturation of newborn neurons and synaptic plasticity than fluoxetine in a CUS-induced depression mouse model","volume":"354","author":"Liang","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2025.119696_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12950-018-0180-0","article-title":"Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model","volume":"15","author":"Lin","year":"2018","journal-title":"J. Inflamm."},{"issue":"27","key":"10.1016\/j.jep.2025.119696_bib34","article-title":"Common mechanism of pathogenesis in gastrointestinal diseases implied by consistent efficacy of single Chinese medicine formula: a PRISMA-compliant systematic review and meta-analysis","volume":"94","author":"Ling","year":"2015","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2025.119696_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112659","article-title":"Identifying potential active components of walnut leaf that action diabetes mellitus through integration of UHPLC-Q-Orbitrap HRMS and network pharmacology analysis","volume":"253","author":"Liu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119696_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105768","article-title":"Limonin ameliorates ulcerative colitis by regulating STAT3\/miR-214 signaling pathway","volume":"75","author":"Liu","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2025.119696_bib37","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1248\/bpb.31.1343","article-title":"Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis","volume":"31","author":"Luchini","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.119696_bib38","article-title":"Investigation of the mechanism of Bark of Ailanthus altissima in the treatment of ulcerative colitis based on network pharmacology and experimental verification","volume":"337","author":"Ma","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119696_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110247","article-title":"Paeoniflorin promotes intestinal stem cell-mediated epithelial regeneration and repair via PI3K-AKT-mTOR signalling in ulcerative colitis","volume":"119","author":"Ma","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.119696_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.2005.073817","article-title":"Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach","volume":"55","author":"Manichanh","year":"2006","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.jep.2025.119696_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127063","article-title":"Selective allosteric inhibition of MMP9 is efficacious in preclinical models of ulcerative colitis and colorectal cancer","volume":"10","author":"Marshall","year":"2015","journal-title":"PLoS One"},{"issue":"19","key":"10.1016\/j.jep.2025.119696_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911111","article-title":"The gut-immune-brain Axis: an important route for neuropsychiatric morbidity in inflammatory bowel disease","volume":"23","author":"Masanetz","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.119696_bib43","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00535-018-1439-1","article-title":"Evidence-based clinical practice guidelines for inflammatory bowel disease","volume":"53","author":"Matsuoka","year":"2018","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.119696_bib44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jpsychores.2016.06.001","article-title":"Depression and anxiety in patients with Inflammatory Bowel Disease: a systematic review","volume":"87","author":"Neuendorf","year":"2016","journal-title":"J. Psychosom. Res."},{"issue":"10114","key":"10.1016\/j.jep.2025.119696_bib45","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jep.2025.119696_bib46","first-page":"415","article-title":"Depression among patients presenting with gastrointestinal symptoms: prevalence and associated factors","volume":"30","author":"Saha","year":"2021","journal-title":"Mymensingh Med. J."},{"issue":"5","key":"10.1016\/j.jep.2025.119696_bib47","doi-asserted-by":"crossref","first-page":"795","DOI":"10.33549\/physiolres.933776","article-title":"Quercetin protects against stress-induced anxiety- and depression-like behavior and improves memory in male mice","volume":"67","author":"Samad","year":"2018","journal-title":"Physiol. Res."},{"issue":"5","key":"10.1016\/j.jep.2025.119696_bib48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/17460441.2019.1582638","article-title":"Liquid chromatography coupled to mass spectrometry for metabolite profiling in the field of drug discovery","volume":"14","author":"Saurina","year":"2019","journal-title":"Expet Opin. Drug Discov."},{"issue":"6","key":"10.1016\/j.jep.2025.119696_bib49","first-page":"1198","article-title":"Research progress of sini powder in treatment of depression","volume":"37","author":"Shao","year":"2022","journal-title":"Acta Chinese Medicine"},{"key":"10.1016\/j.jep.2025.119696_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107161","article-title":"Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-\u03baB signaling","volume":"90","author":"Song","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119696_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116659","article-title":"Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy involved in PI3K\/Akt\/mTOR pathway in mice","volume":"315","author":"Su","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"D1","key":"10.1016\/j.jep.2025.119696_bib52","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12974-019-1580-7","article-title":"Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain-gut axis","volume":"16","author":"Takahashi","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib54","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s10020-021-00414-z","article-title":"The effect and mechanism of Jiao-tai-wan in the treatment of diabetes mellitus with depression based on network pharmacology and experimental analysis","volume":"27","author":"Tang","year":"2021","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ptr.8027","article-title":"Quercetin ameliorates ulcerative colitis by activating aryl hydrocarbon receptor to improve intestinal barrier integrity","volume":"38","author":"Wang","year":"2024","journal-title":"Phytother Res."},{"issue":"10","key":"10.1016\/j.jep.2025.119696_bib56","article-title":"Interleukin-1\u03b2 induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"issue":"Pt B","key":"10.1016\/j.jep.2025.119696_bib57","article-title":"Luteolin ameliorates DSS-induced colitis in mice via suppressing macrophage activation and chemotaxis","volume":"124","author":"Xue","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2025.119696_bib58","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.chroma.2008.08.097","article-title":"Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry","volume":"1216","author":"Yang","year":"2009","journal-title":"J. Chromatogr. A"},{"issue":"11","key":"10.1016\/j.jep.2025.119696_bib59","first-page":"1252","article-title":"An exploration of YANG Ming-hui's experience in the application of Sini San","volume":"41","author":"Yang","year":"2022","journal-title":"Beijing Journal of Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.119696_bib60","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12906-020-02988-3","article-title":"Analysis of the pharmacological mechanism of Banxia Xiexin decoction in treating depression and ulcerative colitis based on a biological network module","volume":"20","author":"Yu","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.jep.2025.119696_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116658","article-title":"Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2\/Dap12 pathway","volume":"315","author":"Zheng","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.119696_bib62","first-page":"35","article-title":"Exploration on the mechanism of sini powder in the treatment of ulcerative colitis based on network pharmacology-molecular docking","volume":"53","author":"Zheng","year":"2022","journal-title":"Jiangxi Journal of Traditional Chinese Medicine"}],"updated-by":[{"DOI":"10.1016\/j.jep.2026.122030","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000}},{"DOI":"10.1016\/j.jep.2026.122030","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2027,1,30]],"date-time":"2027-01-30T00:00:00Z","timestamp":1801267200000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:04:04Z","timestamp":1779807844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125003800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":62,"alternative-id":["S0378874125003800"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119696","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the mechanism of Sinisan in the treatment of ulcerative colitis with depression based on UPLC-Q-Orbitrap-MS combined with network pharmacology, molecular docking, and experimental validation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119696"}}