{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:44:00Z","timestamp":1786992240754,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005147","name":"Yunnan Applied Basic Research Project","doi-asserted-by":"publisher","award":["2019FF002"],"award-info":[{"award-number":["2019FF002"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005147","name":"Yunnan Applied Basic Research Project","doi-asserted-by":"publisher","award":["\\u2212005"],"award-info":[{"award-number":["\\u2212005"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005147","name":"Yunnan Applied Basic Research Project","doi-asserted-by":"publisher","award":["202201AT070228"],"award-info":[{"award-number":["202201AT070228"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018576","name":"Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81960777"],"award-info":[{"award-number":["81960777"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jep.2025.119714","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T19:32:00Z","timestamp":1743363120000},"page":"119714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Unveiling the multifaceted benefits of Simiao Pill in ulcerative colitis: Integrative analysis of signaling pathways, gut microbiota, and lipid metabolism"],"prefix":"10.1016","volume":"346","author":[{"given":"XingJu","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QiuPing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CanJiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XingNa","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HengLi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiBiao","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XingLong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongPing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanPing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jep.2025.119714_bib76","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.3390\/nu14071414","article-title":"Lipid Metabolism in Inflammation and Immune Function","volume":"14","author":"Andersen","year":"2022","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jep.2025.119714_bib1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1517\/14656566.2014.925445","article-title":"Ulcerative colitis: current pharmacotherapy and future directions","volume":"15","author":"Bezzio","year":"2014","journal-title":"Expet Opin. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2025.119714_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/jpp\/rgae007","article-title":"Oligo\/polysaccharides from Cyathula officinalis and Achyranthes bidentata: a review of structures and bioactivities","volume":"76","author":"Chai","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib3","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.2147\/JIR.S418345","article-title":"Total flavonoids of rhizoma drynariae treat osteoarthritis by inhibiting arachidonic acid metabolites through AMPK\/NF\u03baB pathway","volume":"16","author":"Chen","year":"2023","journal-title":"J. Inflamm."},{"issue":"11","key":"10.1016\/j.jep.2025.119714_bib4","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1021\/acs.jafc.5b05841","article-title":"Anti-inflammatory and antinociceptive constituents of Atractylodes japonica koidzumi","volume":"64","author":"Chen","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.119714_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.121827","article-title":"Computational biomedical modeling and screening for prediction of molecular mechanisms of Simiao Pill against hyperuricemia","volume":"381","author":"Chen","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.jep.2025.119714_bib6","article-title":"Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal microbiota and the IL-6\/STAT3 signaling pathway","volume":"265","author":"Chen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113997","article-title":"Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3\/miR-214 signaling pathway","volume":"274","author":"Chen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.foodchem.2015.09.025","article-title":"Germinated brown rice and its bio-functional compounds","volume":"196","author":"Cho","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2025.119714_bib9","article-title":"Atractylenolide III ameliorates DSS-induced colitis by improving intestinal epithelial barrier via suppressing the NF-\u03baB-Mediated MLCK-pMLC signaling pathway","volume":"196","author":"Dai","year":"2024","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2025.119714_bib10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-065X.2012.01104.x","article-title":"I\u03baB kinase regulation of the TPL-2\/ERK MAPK pathway","volume":"246","author":"Gantke","year":"2012","journal-title":"Immunol. Rev."},{"issue":"Pt 1","key":"10.1016\/j.jep.2025.119714_bib11","article-title":"Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation","volume":"319","author":"Gao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-065137","article-title":"Glucocorticoid induced adrenal insufficiency","volume":"379","author":"Garrahy","year":"2022","journal-title":"Br. Med. J."},{"issue":"27","key":"10.1016\/j.jep.2025.119714_bib13","first-page":"3198","article-title":"From intestinal stem cells to inflammatory bowel diseases","volume":"17","author":"Gersemann","year":"2011","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jep.2025.119714_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ecco-jcc\/jjv219","article-title":"Clinical features and HLA association of 5-aminosalicylate (5-ASA)-induced nephrotoxicity in inflammatory bowel disease","volume":"10","author":"Heap","year":"2015","journal-title":"J. Crohns Colitis"},{"issue":"7","key":"10.1016\/j.jep.2025.119714_bib15","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3390\/nu11071613","article-title":"Gut microbiome: profound implications for diet and disease","volume":"11","author":"Hills","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.119714_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.intimp.2018.11.020","article-title":"Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells","volume":"66","author":"Hu","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.119714_bib17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00011-011-0325-6","article-title":"PI3K\/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis","volume":"60","author":"Huang","year":"2011","journal-title":"Inflamm. Res."},{"issue":"5","key":"10.1016\/j.jep.2025.119714_bib75","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/MOL.0000000000000334","article-title":"Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease","volume":"27","author":"Hui","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jep.2025.119714_bib18","unstructured":"Ji, F., 2019. Research on the correlation between the theory of meridians in Huangdi Neijing and ulcerative colitis. doi:10.27213\/d.cnki.glnzc.2019.000587."},{"issue":"11","key":"10.1016\/j.jep.2025.119714_bib19","first-page":"328","article-title":"Inflammatory bowel disease: the classic gastrointestinal autoimmune disease","volume":"44","author":"Kaistha","year":"2014","journal-title":"Curr. Prob. Pediatr. Ad."},{"issue":"4","key":"10.1016\/j.jep.2025.119714_bib20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/14712598.2019.1666101","article-title":"Modern use of 5-aminosalicylic acid compounds for ulcerative colitis","volume":"20","author":"Le Berre","year":"2020","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.jep.2025.119714_bib21","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.2147\/DDDT.S436359","article-title":"Exploration of berberine against ulcerative colitis via TLR4\/NF-\u03baB\/HIF-1\u03b1 pathway by bioinformatics and experimental validation","volume":"18","author":"Li","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"issue":"8","key":"10.1016\/j.jep.2025.119714_bib22","first-page":"2774","article-title":"Analysis of the differences in chemical components of fried Atractylodes macrocephala before and after processing based on UPLC-Q-TOF-MS method","volume":"45","author":"Li","year":"2023","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"7","key":"10.1016\/j.jep.2025.119714_bib23","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1021\/acs.jafc.3c08527","article-title":"Bifidobacterium breve protects the intestinal epithelium and mitigates inflammation in colitis via regulating the gut microbiota\u2013cholic acid pathway","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2025.119714_bib24","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00253-019-10307-1","article-title":"Berberine ameliorates colonic damage accompanied with the modulation of dysfunctional bacteria and functions in ulcerative colitis rats","volume":"104","author":"Liao","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"8","key":"10.1016\/j.jep.2025.119714_bib25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/10286020.2022.2142121","article-title":"Regulatory effect of isovitexin on MAPK\/NF-\u03baB signal in mice with acute ulcerative colitis","volume":"25","author":"Liu","year":"2022","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"10","key":"10.1016\/j.jep.2025.119714_bib26","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.bcp.2013.03.008","article-title":"A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome","volume":"85","author":"Liu","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jep.2018.08.033","article-title":"Rhubarb Peony Decoction ameliorates ulcerative colitis in mice by regulating gut microbiota to restoring Th17\/Treg balance","volume":"231","author":"Luo","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.119714_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01368-22","article-title":"Clostridium butyricum and its derived extracellular vesicles modulate gut homeostasis and ameliorate acute experimental colitis","volume":"10","author":"Ma","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"11","key":"10.1016\/j.jep.2025.119714_bib29","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.4065\/81.11.1462","article-title":"Smoking and inflammatory bowel disease: a meta-analysis","volume":"81","author":"Mahid","year":"2006","journal-title":"Mayo Clin. Proc."},{"issue":"7268","key":"10.1016\/j.jep.2025.119714_bib30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jep.2025.119714_bib31","first-page":"564","article-title":"Histologic evaluation of ulcerative colitis: a systematic review of disease activity indices","volume":"20","author":"Mosli","year":"2014","journal-title":"IBD"},{"key":"10.1016\/j.jep.2025.119714_bib32","doi-asserted-by":"crossref","first-page":"pages55","DOI":"10.1038\/s41577-024-01008-6","article-title":"Strategies for targeting cytokines in inflammatory bowel disease","volume":"24","author":"Neurath","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2025.119714_bib33","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/cdn\/nzac077.027","article-title":"Health benefits of Coix seed (Coix lacryma-jobi): a study review","volume":"6","author":"Nurkolis","year":"2022","journal-title":"Curr. Dev. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2025.119714_bib34","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1053\/j.gastro.2018.12.001","article-title":"Specific bacteria and metabolites associated with response to fecal microbiota transplantation in patients with ulcerative colitis","volume":"156","author":"Paramsothy","year":"2019","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jep.2025.119714_bib35","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1038\/s41467-020-18928-1","article-title":"Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization","volume":"11","author":"Pereira","year":"2020","journal-title":"Nat. Commun."},{"issue":"23","key":"10.1016\/j.jep.2025.119714_bib36","doi-asserted-by":"crossref","first-page":"7974","DOI":"10.1039\/C5AN01770J","article-title":"Electrochemical behavior of palmatine and its sensitive determination based on an electrochemically reduced L-methionine functionalized graphene oxide modified electrode","volume":"140","author":"Qiao","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.jep.2025.119714_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116906","article-title":"Modified Simiaowan prevents and treats gouty arthritis via the Nrf2\/NLRP3 inflammasome signaling pathway","volume":"318","author":"Qin","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.665376","article-title":"Atractylodin attenuates dextran sulfate sodium-induced colitis by alleviating gut microbiota dysbiosis and inhibiting inflammatory response through the MAPK pathway","volume":"12","author":"Qu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2025.119714_bib77","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.3390\/ijms11104149","article-title":"Lipid based therapy for ulcerative colitis-modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation","volume":"11","author":"Schneider","year":"2010","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jep.2025.119714_bib39","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"18","key":"10.1016\/j.jep.2025.119714_bib40","doi-asserted-by":"crossref","first-page":"8492","DOI":"10.1039\/D1FO01557E","article-title":"Rutin prevents inflammation-associated colon damage via inhibiting the p38\/MAPKAPK2 and PI3K\/Akt\/GSK3\u03b2\/NF-\u03baB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis","volume":"12","author":"Sharma","year":"2021","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.jep.2025.119714_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1055\/s-0029-1186197","article-title":"Luteolin inhibits lysophosphatidylcholine-induced apoptosis in endothelial cells by a calcium\/mitocondrion\/caspases-dependent pathway","volume":"76","author":"Song","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2025.119714_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117626","article-title":"Sophora flavescens-Angelica sinensis in the treatment of eczema by inhibiting TLR4\/MyD88\/NF-\u03baB pathway","volume":"322","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"D1","key":"10.1016\/j.jep.2025.119714_bib43","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2025.119714_bib44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jep.2025.119714_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5786053","article-title":"Integrating network pharmacology with molecular docking to unravel the active compounds and potential mechanism of Simiao pill treating rheumatoid arthritis","volume":"2020","author":"Tang","year":"2020","journal-title":"Evid. Based Complement Alternat Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119714_bib46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12929-021-00711-z","article-title":"Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency","volume":"28","author":"Tang","year":"2021","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.119714_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/jbcpp-2018-0036","article-title":"Immune response and inflammatory pathway of ulcerative colitis","volume":"30","author":"Tatiya-Aphiradee","year":"2018","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119714_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jmii.2024.09.006","article-title":"Alternations of the gut microbiota and the Firmicutes\/Bacteroidetes ratio after biologic treatment in inflammatory bowel disease","volume":"58","author":"Tsai","year":"2025","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"10080","key":"10.1016\/j.jep.2025.119714_bib49","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.jep.2025.119714_bib50","first-page":"164","article-title":"UPLC-Q-TOF-MS analysis of chemical components in rice bran oil before and after processing with Atractylodes macrocephala","volume":"28","author":"Wang","year":"2022","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.119714_bib51","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3997190","article-title":"Pharmacological activity of quercetin: an updated review","volume":"2022","author":"Wang","year":"2022","journal-title":"Evid. Based Complement Alternat Med. eCAM"},{"key":"10.1016\/j.jep.2025.119714_bib52","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.2147\/JIR.S500014","article-title":"Quzhou aurantii fructus flavonoids ameliorate inflammatory responses, intestinal barrier dysfunction in DSS-induced colitis by modulating PI3K\/AKT signaling pathway and gut microbiome","volume":"18","author":"Wang","year":"2025","journal-title":"J. Inflamm. Res."},{"issue":"14","key":"10.1016\/j.jep.2025.119714_bib53","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1021\/jf063623q","article-title":"Comparison of various extraction methods for policosanol from rice bran wax and establishment of chromatographic fingerprint of policosanol","volume":"55","author":"Wang","year":"2007","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jep.2025.119714_bib54","first-page":"481","article-title":"Epidemiological characteristics of ulcerative colitis and discussion on traditional Chinese medicine etiology and pathogenesis","volume":"17","author":"Wang","year":"2011","journal-title":"Journal of Basic Traditional Chinese Medicine"},{"issue":"12","key":"10.1016\/j.jep.2025.119714_bib55","doi-asserted-by":"crossref","first-page":"11138","DOI":"10.1021\/acsomega.2c07959","article-title":"Integrated multi-omics techniques and network pharmacology analysis to explore the material basis and mechanism of Simiao pill in the treatment of rheumatoid arthritis","volume":"8","author":"Wang","year":"2023","journal-title":"ACS Omega"},{"issue":"12","key":"10.1016\/j.jep.2025.119714_bib56","first-page":"3294","article-title":"Characterization and identification of alkaloids in phellodendri Chinensis cortex and Phellodendri Amurensis cortex based on UHPLC-IM-Q-TOF-MS","volume":"48","author":"Wen","year":"2023","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"3","key":"10.1016\/j.jep.2025.119714_bib57","first-page":"181","article-title":"Overview of the theory of meridians and its applications","volume":"55","author":"Wu","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"issue":"19","key":"10.1016\/j.jep.2025.119714_bib58","first-page":"5204","article-title":"Discussion on the main active ingredients and mechanisms of action of Sanmiao Pill in the treatment of rheumatoid arthritis","volume":"49","author":"Xia","year":"2024","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2025.119714_bib59","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1039\/C4AY01215A","article-title":"UPLC-Q-TOF-MS\/MS fingerprinting for rapid identification of the chemical constituents of Ermiao Wan","volume":"7","author":"Yan","year":"2015","journal-title":"Anal. Methods"},{"issue":"7","key":"10.1016\/j.jep.2025.119714_bib60","first-page":"2160","article-title":"Comparison of the chemical composition differences of various varieties of Achyranthes bidentata medicinal materials mased on UPLC-Q-TOF-MS\/MS technology combined with multivariate statistical analysis","volume":"55","author":"Yan","year":"2024","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.jep.2025.119714_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114123","article-title":"Simiao Wan attenuates monosodium urate crystal-induced arthritis in rats through contributing to macrophage M2 polarization","volume":"275","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300615","article-title":"Chemical profiling of Simiao pill and quantification of main effective constituents in it by ultra-high-performance liquid chromatography coupled with Q Exactive Orbitrap and triple quadrupole mass spectrometry","author":"Yang","year":"2024","journal-title":"J. Separ. Sci."},{"key":"10.1016\/j.jep.2025.119714_bib63","article-title":"Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-EP2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis","volume":"695","author":"Yu","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2025.119714_bib64","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.2147\/DDDT.S442154","article-title":"The role of AMPK signaling in ulcerative colitis","volume":"17","author":"Yuan","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"issue":"23","key":"10.1016\/j.jep.2025.119714_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000452","article-title":"Chlorogenic acid suppresses miR-155 and ameliorates ulcerative colitis through the NF-\u03baB\/NLRP3 inflammasome pathway","volume":"64","author":"Zeng","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.119714_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118492","article-title":"Simiao pills alleviates renal injury associated with hyperuricemia: a multi-omics analysis","volume":"333","author":"Zeng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib67","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2147\/JIR.S501745","article-title":"Coix seed oil alleviates DSS-induced ulcerative colitis via intestinal barrier repair and ferroptosis regulation","volume":"18","author":"Zeng","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2025.119714_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.576496","article-title":"Berberine suppresses colonic inflammation in dextran sulfate sodium-induced murine colitis through inhibition of cytosolic phospholipase A2 activity","volume":"11","author":"Zhai","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib71","unstructured":"Zhang, Z.G., 2023. Characteristics of traditional Chinese medicine syndrome distribution in ulcerative colitis and analysis of professor Wei Wei\u2019s medication patterns. doi:10.27658\/d.cnki.gzzyy.2023.000172."},{"issue":"8","key":"10.1016\/j.jep.2025.119714_bib69","first-page":"3854","article-title":"Analysis of the blood components before and after the preparation of rice washing water and Atractylodes using UPLC-Q-TOF-MS\/MS","volume":"35","author":"Zhang","year":"2020","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"5","key":"10.1016\/j.jep.2025.119714_bib70","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1021\/acs.jmedchem.3c00112","article-title":"Discovery, preliminary structure\u2013activity relationship, and evaluation of oleanane-type saponins from pulsatilla chinensis for the treatment of ulcerative colitis","volume":"66","author":"Zhang","year":"2023","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.jep.2025.119714_bib72","first-page":"321","article-title":"A UPLC-QTOF-MS\/MS method for the characterization of chemical constituents of Atractylodes lancea (Thunb.) DC","volume":"28","author":"Zhou","year":"2020","journal-title":"Atractylodes chinensis (DC.). Koidz. Pharmaceutical and Clinical Research"},{"key":"10.1016\/j.jep.2025.119714_bib73","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.intimp.2018.12.036","article-title":"Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats","volume":"68","author":"Zhu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119714_bib74","article-title":"Antioxidation and anti-inflammatory actions of the extract of Nitraria Tangutorum Bobr. fruits reduce the severity of ulcerative colitis in a dextran sulphate sodium-induced mice model","volume":"91","author":"Zou","year":"2022","journal-title":"J. Funct."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125003988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:57:02Z","timestamp":1762307822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125003988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":77,"alternative-id":["S0378874125003988"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119714","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the multifaceted benefits of Simiao Pill in ulcerative colitis: Integrative analysis of signaling pathways, gut microbiota, and lipid metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119714"}}