{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T06:21:29Z","timestamp":1788070889068,"version":"build-2784847793"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2023xkjT042"],"award-info":[{"award-number":["2023xkjT042"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072134"],"award-info":[{"award-number":["82072134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119729","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T17:56:54Z","timestamp":1744135014000},"page":"119729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Integrated metabolomics and network pharmacology reveal the mechanisms of Xuebijing in counteracting sepsis-induced myocardial dysfunction"],"prefix":"10.1016","volume":"347","author":[{"given":"Yan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingrui","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119729_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCRESAHA.122.322133","article-title":"EGFR\/IGF1R signaling modulates relaxation in hypertrophic cardiomyopathy","volume":"133","author":"Alg\u00fcl","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2025.119729_bib2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/art.40471","article-title":"Brief report: circulating cytokine profiles and antineutrophil cytoplasmic antibody specificity in patients with antineutrophil cytoplasmic antibody-associated vasculitis","volume":"70","author":"Berti","year":"2018","journal-title":"Arthritis. Rheumatol. Hoboken NJ."},{"key":"10.1016\/j.jep.2025.119729_bib3","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.18632\/aging.204740","article-title":"Xuebijing injection protects against sepsis-induced myocardial injury by regulating apoptosis and autophagy via mediation of PI3K\/AKT\/mTOR signaling pathway in rats","volume":"15","author":"Bi","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119729_bib4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3892\/ijmm.2016.2571","article-title":"Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-\u03b2-boswellic acid in combination on isoproterenol-induced myocardial injury in rats","volume":"37","author":"Chen","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2025.119729_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117072","article-title":"Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response","volume":"491","author":"Chen","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/aps.2015.103","article-title":"Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats","volume":"37","author":"Cheng","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2025.119729_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/CCM.0000000000006135","article-title":"Surviving sepsis campaign research priorities 2023","volume":"52","author":"De Backer","year":"2024","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jep.2025.119729_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175823","article-title":"Luteolin attenuates lupus nephritis by regulating macrophage oxidative stress via HIF-1\u03b1 pathway","volume":"953","author":"Ding","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116806","article-title":"Qingjie decoction attenuated e.coli-Induced diarrhea by regulating energy metabolism and alleviating inflammation based on network analysis and metabolomics","volume":"318","author":"Fan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1365639","article-title":"Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis","volume":"15","author":"Fu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.copbio.2014.08.006","article-title":"High-throughput discovery metabolomics","volume":"31","author":"Fuhrer","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.jep.2025.119729_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.immuni.2015.02.016","article-title":"HIF1\u03b1 allows monocytes to take a breather during sepsis","volume":"42","author":"Gilroy","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2025.119729_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41586-023-06299-8","article-title":"SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity","volume":"620","author":"Guo","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jep.2025.119729_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1004174","article-title":"Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: a Mendelian randomisation study","volume":"20","author":"Hamilton","year":"2023","journal-title":"PLoS Med."},{"key":"10.1016\/j.jep.2025.119729_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.873929","article-title":"Dihuang-yinzi alleviates cognition deficits via targeting energy-related metabolism in an alzheimer mouse model as demonstrated by integration of metabolomics and network pharmacology","volume":"14","author":"Han","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jep.2025.119729_bib16","article-title":"Curcumin simultaneously improves mitochondrial dynamics and myocardial cell bioenergy after sepsis via the SIRT1-DRP1\/PGC-1\u03b1 pathway","volume":"10","author":"Hou","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.119729_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110429","article-title":"Canagliflozin attenuates post-resuscitation myocardial dysfunction in diabetic rats by inhibiting autophagy through the PI3K\/Akt\/mTOR pathway","volume":"27","author":"Huang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jep.2025.119729_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117599","article-title":"Mechanism of shenfu injection in suppressing inflammation and preventing sepsis-induced apoptosis in murine cardiomyocytes based on network pharmacology and experimental validation","volume":"322","author":"Huang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jare.2022.04.010","article-title":"EGFR promotes the apoptosis of CD4+ T lymphocytes through TBK1\/Glut1 induced warburg effect in sepsis","volume":"44","author":"Huang","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2025.119729_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130151","article-title":"Telomerase inhibitors induce mitochondrial oxidation and DNA damage-dependent cell death rescued by Bcl-2\/Bcl-xL","volume":"264","author":"Jayaprasad","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.119729_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109163","article-title":"GC\/MS-based metabonomics approach reveals effects of xuebijing injection in CLP induced septic rats","volume":"117","author":"Jiang","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119729_bib22","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/s41467-021-21461-4","article-title":"Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-Induced inflammation","volume":"12","author":"Jones","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.119729_bib23","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/s12276-021-00649-0","article-title":"Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms","volume":"53","author":"Kang","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2025.119729_bib24","doi-asserted-by":"crossref","first-page":"8501","DOI":"10.18632\/aging.204990","article-title":"Xuebijing injection protects sepsis induced myocardial injury by mediating TLR4\/NF-\u03baB\/IKK\u03b1 and JAK2\/STAT3 signaling pathways","volume":"15","author":"Kang","year":"2023","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119729_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300704","article-title":"L-Glutamine substantially improves 5-Fluorouracil-Induced intestinal mucositis by modulating gut microbiota and maintaining the integrity of the gut barrier in mice","volume":"68","author":"Kuo","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.119729_bib26","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.3390\/ijms25094710","article-title":"Current perspectives of mitochondria in sepsis-induced cardiomyopathy","volume":"25","author":"Kuroshima","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119729_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.119008","article-title":"Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats","volume":"269","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2025.119729_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101771","article-title":"Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis","volume":"38","author":"Li","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.119729_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/JCI149711","article-title":"Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair","volume":"132","author":"Li","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.119729_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adn3285","article-title":"The de novo purine synthesis enzyme Adssl1 promotes cardiomyocyte proliferation and cardiac regeneration","volume":"17","author":"Li","year":"2024","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jep.2025.119729_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3892\/ijmm.2023.5319","article-title":"Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1\/p53\/SLC7A11 signaling pathway to alleviate sepsis-induced cardiomyopathy","volume":"52","author":"Lin","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2025.119729_bib32","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s00125-023-06073-5","article-title":"Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1\u03b1","volume":"67","author":"Liu","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2025.119729_bib33","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamainternmed.2023.0780","article-title":"Effect of an herbal-based injection on 28-Day mortality in patients with sepsis: the EXIT-SEP randomized clinical trial","volume":"183","author":"Liu","year":"2023","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.jep.2025.119729_bib34","first-page":"22","article-title":"Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent warburg effect","volume":"9","author":"Luo","year":"2022","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.jep.2025.119729_bib35","first-page":"30","article-title":"Pathophysiology of sepsis-induced myocardial dysfunction","volume":"3","author":"Lv","year":"2016","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.jep.2025.119729_bib36","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s10495-020-01615-3","article-title":"The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation","volume":"25","author":"Maimon","year":"2020","journal-title":"Apoptosis Int. J. Program. Cell Death"},{"key":"10.1016\/j.jep.2025.119729_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111902","article-title":"Canagliflozin, an SGLT-2 inhibitor, ameliorates acetic acid-induced colitis in rats through targeting glucose metabolism and inhibiting NOX2","volume":"141","author":"Morsy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119729_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ajh.2830480205","article-title":"Morphologic and ultrastructural evidence of interleukin-6 induced platelet activation","volume":"48","author":"Oleksowicz","year":"1995","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jep.2025.119729_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/cc13987","article-title":"Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function","volume":"18","author":"Orde","year":"2014","journal-title":"Crit. Care"},{"key":"10.1016\/j.jep.2025.119729_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202000777","article-title":"Anti-inflammatory effects of quercetin on high-glucose and pro-inflammatory cytokine challenged vascular endothelial cell metabolism","volume":"65","author":"Ozyel","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2025.119729_bib41","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1093\/eurheartj\/ehaa360","article-title":"Longevity genes, cardiac ageing, and the pathogenesis of cardiomyopathy: implications for understanding the effects of current and future treatments for heart failure","volume":"41","author":"Packer","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2025.119729_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13613-021-00893-7","article-title":"Energetic dysfunction in sepsis: a narrative review","volume":"11","author":"Preau","year":"2021","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.jep.2025.119729_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2025.119729_bib44","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.jep.2025.119729_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13613-024-01255-9","article-title":"Prevalence and prognosis of hyperdynamic left ventricular systolic function in septic patients: a systematic review and meta-analysis","volume":"14","author":"Sato","year":"2024","journal-title":"Ann. Intensive Care"},{"key":"10.1016\/j.jep.2025.119729_bib46","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s42003-025-07547-5","article-title":"Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding","volume":"8","author":"Shi","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jep.2025.119729_bib47","doi-asserted-by":"crossref","first-page":"e735","DOI":"10.1097\/CCM.0000000000003842","article-title":"XueBiJing injection versus placebo for critically ill patients with severe community-acquired pneumonia: a randomized controlled trial","volume":"47","author":"Song","year":"2019","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jep.2025.119729_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155175","article-title":"Chicoric acid ameliorates sepsis-induced cardiomyopathy via regulating macrophage metabolism reprogramming","volume":"123","author":"Sun","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119729_bib49","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/CCM.0b013e318174db05","article-title":"Actual incidence of global left ventricular hypokinesia in adult septic shock","volume":"36","author":"Vieillard-Baron","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jep.2025.119729_bib50","first-page":"500","article-title":"Real-world efficacy and safety of amivantamab for EGFR-mutant NSCLC","volume":"19","author":"Wang","year":"2024","journal-title":"J. Thorac. Oncol. Off. Publ. Int. Assoc. Study. Lung. Cancer."},{"key":"10.1016\/j.jep.2025.119729_bib51","article-title":"Paeoniflorin and hydroxysafflor yellow A in xuebijing injection attenuate sepsis-induced cardiac dysfunction and inhibit proinflammatory cytokine production","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104887","article-title":"Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle","volume":"159","author":"Xu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119729_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106759","article-title":"Xuebijing injection and its bioactive components alleviate nephrotic syndrome by inhibiting podocyte inflammatory injury","volume":"196","author":"Yuan","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.119729_bib54","first-page":"576","article-title":"Xuebijing alleviates LPS-Induced acute lung injury by downregulating pro-inflammatory cytokine production and inhibiting gasdermin-E-mediated pyroptosis of alveolar epithelial cells","volume":"21","author":"Zhang","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2025.119729_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109902","article-title":"EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-\u03baB\/MAPK-mediated inflammation and RIP3-dependent necroptosis","volume":"117","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119729_bib55","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s10020-024-00929-1","article-title":"Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1\/STAT3\/HIF-1\u03b1 signaling","volume":"30","author":"Zhang","year":"2024","journal-title":"Mol. Med. Camb. Mass"},{"key":"10.1016\/j.jep.2025.119729_bib57","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1021\/acs.jafc.8b00054","article-title":"Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.119729_bib58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12964-019-0332-8","article-title":"Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis","volume":"17","author":"Zhang","year":"2019","journal-title":"Cell Commun. Signal. CCS"},{"key":"10.1016\/j.jep.2025.119729_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.120710","article-title":"Integrated strategy for accurately screening biomarkers based on metabolomics coupled with network pharmacology","volume":"211","author":"Zhang","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.jep.2025.119729_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-022-05370-y","article-title":"EGFR tyrosine kinase activity and rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.119729_bib61","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-pharmtox-010611-134520","article-title":"Systems pharmacology: network analysis to identify multiscale mechanisms of drug action","volume":"52","author":"Zhao","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125004131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125004131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:03:24Z","timestamp":1779807804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125004131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":61,"alternative-id":["S0378874125004131"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119729","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated metabolomics and network pharmacology reveal the mechanisms of Xuebijing in counteracting sepsis-induced myocardial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119729"}}