{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:54:03Z","timestamp":1785556443065,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2022AH040074"],"award-info":[{"award-number":["2022AH040074"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2024AH051052"],"award-info":[{"award-number":["2024AH051052"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723049"],"award-info":[{"award-number":["2022M723049"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202672"],"award-info":[{"award-number":["82202672"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2108085QH319"],"award-info":[{"award-number":["2108085QH319"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017668","name":"Anhui Provincial Key Research and Development Plan","doi-asserted-by":"publisher","award":["2022e07020017"],"award-info":[{"award-number":["2022e07020017"]}],"id":[{"id":"10.13039\/501100017668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119816","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T16:11:27Z","timestamp":1744733487000},"page":"119816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Qing'e Pill rectifies bone homeostasis imbalance in diabetic osteoporosis via the AGE\/RAGE pathway: A network pharmacology analysis and multi-omics validation"],"prefix":"10.1016","volume":"348","author":[{"given":"Yingjie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanbo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-7745","authenticated-orcid":false,"given":"Xianzuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119816_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1178573","article-title":"Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy","volume":"10","author":"Bao","year":"2023","journal-title":"Front. Nutr."},{"issue":"C","key":"10.1016\/j.jep.2025.119816_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.mce.2015.12.005","article-title":"Deregulation of arginase induces bone complications in high-fat\/high-sucrose diet diabetic mouse model","volume":"422","author":"Bhatta","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib3","first-page":"308","article-title":"Clinical observation of Qing'e pills in the treatment ofpostmenopausal osteoporosis with syndrome of kidney deficiencyand blood stasis","volume":"33","author":"Bian","year":"2018","journal-title":"J. Chin. Tradit. Herb. Drugs."},{"issue":"7","key":"10.1016\/j.jep.2025.119816_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/dme.15031","article-title":"Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis","volume":"40","author":"Chen","year":"2023","journal-title":"Diabet. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s12967-024-05191-x","article-title":"Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jep.2025.119816_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40842-018-0062-7","article-title":"The challenges of diagnosing osteoporosis and the limitations of currently available tools","volume":"4","author":"Choksi","year":"2018","journal-title":"Clin. Diabet. Endocrinol."},{"issue":"2","key":"10.1016\/j.jep.2025.119816_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/endrev\/bnab028","article-title":"Secondary osteoporosis","volume":"43","author":"Ebeling","year":"2022","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.jep.2025.119816_bib8","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1007\/s00198-018-4650-2","article-title":"Diagnosis and management of bone fragility in diabetes: an emerging challenge","volume":"29","author":"Ferrari","year":"2018","journal-title":"Osteoporos. Int."},{"issue":"22","key":"10.1016\/j.jep.2025.119816_bib9","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1111\/jcmm.17928","article-title":"AR\/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2\/Keap1 pathway","volume":"27","author":"Fu","year":"2023","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2025.119816_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.902102","article-title":"Qing'e pill inhibits osteoblast ferroptosis via ATM serine\/threonine kinase (ATM) and the PI3K\/AKT pathway in primary osteoporosis","volume":"13","author":"Hao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119816_bib11","article-title":"Chemical stability of a Chinese herbal spirit using LC-MS-Based metabolomics and accelerated tests","volume":"13","author":"Hu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13020-021-00482-7","article-title":"Traditional application and modern pharmacological research of Eucommia ulmoides oliv","volume":"16","author":"Huang","year":"2021","journal-title":"Chin. Med."},{"issue":"17","key":"10.1016\/j.jep.2025.119816_bib13","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.3390\/nu14173519","article-title":"Effects of resveratrol, curcumin and Quercetin supplementation on bone Metabolism-A systematic review","volume":"14","author":"Inchingolo","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2025.119816_bib14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/nu16020220","article-title":"Network pharmacology and molecular modeling techniques in unraveling the underlying mechanism of citri reticulatae pericarpium aganist type 2 diabetic osteoporosis","volume":"16","author":"Li","year":"2024","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jep.2025.119816_bib15","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3390\/molecules23123321","article-title":"Evaluation of the absorption behavior of main component compounds of salt-fried herb ingredients in qing\u2019e pills by using Caco-2 cell model","volume":"23","author":"Lu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119816_bib16","article-title":"Investigating the molecular mechanism of quercetin protecting against podocyte injury to attenuate diabetic nephropathy through network pharmacology, MicroarrayData analysis, and molecular docking","volume":"16","author":"Ma","year":"2022","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"6","key":"10.1016\/j.jep.2025.119816_bib17","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41419-018-0718-3","article-title":"RAGE-Dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products","volume":"9","author":"Mao","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.119816_bib18","first-page":"S134","article-title":"Clinical guidance on management of osteoporosis in diabetic patients","volume":"29","author":"Neira","year":"2018","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11914-019-00499-w","article-title":"RAGE signaling in skeletal biology","volume":"17","author":"Plotkin","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"issue":"8","key":"10.1016\/j.jep.2025.119816_bib20","first-page":"1167","article-title":"Treatment of diabetic osteoporosis with Qing'e pill by regulation through Wnt1\/\u03b2-catenin signaling pathway","volume":"29","author":"Rao","year":"2023","journal-title":"Chin. J. Osteoporos."},{"key":"10.1016\/j.jep.2025.119816_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.571535","article-title":"A review of the pharmacological properties of psoralen","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2025.119816_bib22","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1016\/j.clnu.2021.03.005","article-title":"From the distinctive smell to therapeutic effects: garlic for cardiovascular, hepatic, gut, diabetes and chronic kidney disease","volume":"40","author":"Ribeiro","year":"2021","journal-title":"Clin. Nutr."},{"issue":"7","key":"10.1016\/j.jep.2025.119816_bib23","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.32604\/biocell.2023.028014","article-title":"Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility","volume":"47","author":"Rosenberg","year":"2023","journal-title":"Biocell"},{"issue":"3","key":"10.1016\/j.jep.2025.119816_bib24","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/cpt.1097","article-title":"Botanicals and hepatotoxicity","volume":"104","author":"Roytman","year":"2018","journal-title":"Clin. Pharmacol. Therapeut."},{"issue":"5","key":"10.1016\/j.jep.2025.119816_bib25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tem.2022.02.006","article-title":"Assessment and treatment of osteoporosis and fractures in type 2 diabetes","volume":"33","author":"Sheu","year":"2022","journal-title":"Trends Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tem.2022.11.003","article-title":"Contributors to impaired bone health in type 2 diabetes","volume":"34","author":"Sheu","year":"2023","journal-title":"Trends Endocrinol. Metabol."},{"issue":"4","key":"10.1016\/j.jep.2025.119816_bib27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11655-016-2604-0","article-title":"Positive effects of qing'e pill ( ) on trabecular microarchitecture and its mechanical properties in osteopenic ovariectomised mice","volume":"25","author":"Shuai","year":"2019","journal-title":"Chin. J. Integr. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.119816_bib28","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/ptr.7392","article-title":"Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF-\u03baB, TNF-\u03b1 and COX-2 proteins in rats","volume":"36","author":"Singh","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.119816_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib30","first-page":"314","article-title":"Research on the mechanism of kaempferol for treating senile osteoporosis by network pharmacology and molecular docking","volume":"17","author":"Tang","year":"2022","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2025.119816_bib31","series-title":"Protective Effect of Jiawei Qing'E Pills on Myocardial Tissue of Rats with Type 2 Diabetes Mellitus","first-page":"1382","author":"Wang","year":"2018"},{"key":"10.1016\/j.jep.2025.119816_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153247","article-title":"Timosaponin AIII attenuates inflammatory injury in AGEs-induced osteoblast and alloxan-induced diabetic osteoporosis zebrafish by modulating the RAGE\/MAPK signaling pathways","volume":"75","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119816_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1052592","article-title":"A narrative review of diabetic bone disease: characteristics, pathogenesis, and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jep.2025.119816_bib34","article-title":"Lycopene improves bone quality and regulates AGE\/RAGE\/NF-kB signaling pathway in high-fat diet-induced Obese mice","volume":"17","author":"Xia","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib35","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/13880209.2022.2056208","article-title":"Gut microbiota and metabonomics used to explore the mechanism of Qing'e pills in alleviating osteoporosis","volume":"60","author":"Xie","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.119816_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109278","article-title":"Astragalin mitigates inflammatory osteolysis by negatively modulating osteoclastogenesis via ROS and MAPK signaling pathway","volume":"112","author":"Xing","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119816_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114735","article-title":"Elucidating the estrogen-like effects and biocompatibility of the herbal components in the qing' E formula","volume":"283","author":"Xiong","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119816_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155342","article-title":"Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2\/GPX4 pathway","volume":"125","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib39","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1038\/s41598-021-83263-4","article-title":"Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014","volume":"11","author":"Xu","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2025.119816_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ptr.4959","article-title":"The role of traditional Chinese medicines in osteogenesis and angiogenesis","volume":"28","author":"Yang","year":"2014","journal-title":"Phytother Res."},{"issue":"Pt 4","key":"10.1016\/j.jep.2025.119816_bib41","article-title":"Alleviated diabetic osteoporosis and peripheral neuropathic pain by Rehmannia glutinosa libosch polysaccharide via increasing regulatory T cells","volume":"277","author":"Yue","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.jep.2025.119816_bib42","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1080\/10495398.2022.2088548","article-title":"Establishment of type 2 diabetes mellitus models using streptozotocin after 3 months high-fat diet in bama minipigs","volume":"34","author":"Zhao","year":"2023","journal-title":"Anim. Biotechnol."},{"issue":"2","key":"10.1016\/j.jep.2025.119816_bib43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1142\/S0192415X22500173","article-title":"Advances in anti-osteoporosis polysaccharides derived from medicinal herbs and other edible substances","volume":"50","author":"Zhao","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.119816_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115044","article-title":"The RAGE signaling in osteoporosis","volume":"165","author":"Zhou","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:00:33Z","timestamp":1762308033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125005008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":44,"alternative-id":["S0378874125005008"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119816","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Qing'e Pill rectifies bone homeostasis imbalance in diabetic osteoporosis via the AGE\/RAGE pathway: A network pharmacology analysis and multi-omics validation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119816","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119816"}}