{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:19:55Z","timestamp":1780589995211,"version":"3.54.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903938"],"award-info":[{"award-number":["81903938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141209"],"award-info":[{"award-number":["82141209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119842","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T19:10:43Z","timestamp":1745262643000},"page":"119842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Functional metabolomics combined with network pharmacology reveals the mechanism of alleviating rheumatoid arthritis with Yiyi Fuzi powder"],"prefix":"10.1016","volume":"348","author":[{"given":"Liping","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9377-8269","authenticated-orcid":false,"given":"Yubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119842_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114842","article-title":"An ethnoveterinary study of wild medicinal plants used by the Kyrgyz farmers","volume":"285","author":"Aldayarov","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2025.119842_bib2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/MOL.0000000000000550","article-title":"Metabolism: the road to inflammation and atherosclerosis","volume":"29","author":"Ali","year":"2018","journal-title":"Curr. Opin. Lipidol."},{"issue":"1","key":"10.1016\/j.jep.2025.119842_bib3","article-title":"Publisher correction: palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma","volume":"11","author":"Amine","year":"2021","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2025.119842_bib4","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","article-title":"Gasdermin D in pyroptosis","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.jep.2025.119842_bib5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.atherosclerosis.2007.01.004","article-title":"Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis","volume":"196","author":"Chung","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jep.2025.119842_bib6","series-title":"Pharmacopoeia of the People's Republic of China 2020","year":"2020"},{"issue":"9","key":"10.1016\/j.jep.2025.119842_bib7","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.cell.2024.03.008","article-title":"NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks","volume":"187","author":"David","year":"2024","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jep.2025.119842_bib8","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1007\/s12035-021-02434-6","article-title":"Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acid","volume":"58","author":"Flores-Le\u00f3n","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.jep.2025.119842_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41418-018-0212-6","article-title":"Pyroptosis versus necroptosis: similarities, differences, and crosstalk","volume":"26","author":"Frank","year":"2019","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.jep.2025.119842_bib10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/annrheumdis-2013-203755","article-title":"Free fatty acids: potential proinflammatory mediators in rheumatic diseases","volume":"74","author":"Frommer","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.jep.2025.119842_bib11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/ard.2004.031641","article-title":"Hypoxia inducible factor (HIF) in rheumatology: low O2! see what HIF can do","volume":"64","author":"Gaber","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2025.119842_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2020.07.002","article-title":"Immunometabolism and autoimmunity","volume":"67","author":"Galgani","year":"2020","journal-title":"Curr. Opin. Immunol."},{"issue":"10258","key":"10.1016\/j.jep.2025.119842_bib13","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jep.2025.119842_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11745-003-1067-z","article-title":"Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3","volume":"38","author":"Harbige","year":"2003","journal-title":"Lipids"},{"issue":"5","key":"10.1016\/j.jep.2025.119842_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/eurheartj\/ehx448","article-title":"Separate and combined associations of obesity and metabolic health with coronary heart disease: a Pan-European case-cohort analysis","volume":"39","author":"Lassale","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2025.119842_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1190607","article-title":"Lipid metabolism and rheumatoid arthritis","volume":"14","author":"Lei","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2025.119842_bib17","first-page":"82","article-title":"Laboratory diagnosis and correlation analysis on rheumatoid arthritis complicated with coronary heart disease","volume":"38","author":"Li","year":"2017","journal-title":"J. Kunming Med. Univ."},{"key":"10.1016\/j.jep.2025.119842_bib18","article-title":"A novel drug combination of mangiferin and cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4\/NF\u03baB\/NLRP3 activation-induced pyroptosis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119842_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101981","article-title":"Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: underlying mechanisms based on cell and molecular targets","volume":"89","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2025.119842_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116301","article-title":"Therapeutic effect of yiyi fuzi baijiang formula on TNBS-Induced ulcerative colitis via metabolism and Th17\/Treg cell balance","volume":"309","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119842_bib21","series-title":"Study on the Mechanism of Xingfeng Capsule on immuno-inflammation in RA Based on Pyroptosis Mediated by NLRP3\/GSDMD Pathway Anhui University of Chinese Medicine","author":"Lulin","year":"2023"},{"issue":"1","key":"10.1016\/j.jep.2025.119842_bib22","first-page":"263","article-title":"Dynamic variation patterns of aconitum alkaloids in daughter root of Aconitum carmichaelii (fuzi) in the decoction process based on the content changes of nine aconitum alkaloids by HPLC- MS- MS","volume":"15","author":"Luo","year":"2016","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.jep.2025.119842_bib23","article-title":"Research progress on chemical constituents, pharmacologicaeffects and clinical applications of yiyi fuzi baijiang powderand prediction analysis on potential Q-Marker","volume":"20","author":"MA Xing-yan","year":"2024","journal-title":"Chin. Arch. Trad. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2025.119842_bib24","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1\u03b2 in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2025.119842_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11926-021-01007-9","article-title":"Fatty acids and oxylipins in osteoarthritis and rheumatoid Arthritis-a complex field with significant potential for future treatments","volume":"23","author":"Mustonen","year":"2021","journal-title":"Curr. Rheumatol. Rep."},{"issue":"3","key":"10.1016\/j.jep.2025.119842_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2025.119842_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrrheum.2012.78","article-title":"Rheumatoid arthritis. How bad is obesity for RA?","volume":"8","author":"Onuora","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.jep.2025.119842_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5114\/reum.2018.75523","article-title":"Cartilage and bone damage in rheumatoid arthritis","volume":"56","author":"Ostrowska","year":"2018","journal-title":"Reumatologia"},{"issue":"3","key":"10.1016\/j.jep.2025.119842_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/art.27297","article-title":"The synovial lining micromass system: toward rheumatoid arthritis in a dish?","volume":"62","author":"Perlman","year":"2010","journal-title":"Arthritis Rheum."},{"issue":"11","key":"10.1016\/j.jep.2025.119842_bib30","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.celrep.2016.02.053","article-title":"Saturated fatty acids engage an IRE1\u03b1-Dependent pathway to activate the NLRP3 inflammasome in myeloid cells","volume":"14","author":"Robblee","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2025.119842_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2015.11.015","article-title":"Saturated fatty acids trigger TLR4-mediated inflammatory response","volume":"244","author":"Rocha","year":"2016","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.jep.2025.119842_bib32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.2337\/db16-0339","article-title":"The multifaceted roles of adipose tissue-therapeutic targets for diabetes and beyond: the 2015 banting lecture","volume":"65","author":"Scherer","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2025.119842_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000327785","article-title":"Importance of the omega-6\/omega-3 balance in health and disease: evolutionary aspects of diet","volume":"102","author":"Simopoulos","year":"2011","journal-title":"World Rev. Nutr. Diet."},{"issue":"5","key":"10.1016\/j.jep.2025.119842_bib34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1051\/rnd:2005046","article-title":"Docosahexaenoic acid affects cell signaling by altering lipid rafts","volume":"45","author":"Stillwell","year":"2005","journal-title":"Reprod. Nutr. Dev."},{"issue":"17","key":"10.1016\/j.jep.2025.119842_bib35","article-title":"Fish oil supplementation and arrhythmias","volume":"294","author":"Strauss","year":"2005","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jep.2025.119842_bib36","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1124\/jpet.123.002013","article-title":"Reversal of high fat diet-induced obesity, systemic inflammation, and astrogliosis by the NLRP3 inflammasome inhibitors NT-0249 and NT-0796","volume":"388","author":"Thornton","year":"2024","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"8","key":"10.1016\/j.jep.2025.119842_bib37","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.bbabio.2016.03.012","article-title":"Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis","volume":"1857","author":"Tretter","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2025.119842_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106985","article-title":"IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B\/S100A9-mediated pathway","volume":"88","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.119842_bib39","first-page":"321","article-title":"Mechanism of yiyi fuzi powder in homotherapy for rheumatoid arthritis and chronic heart failure based on network pharmacology and molecular docking","volume":"46","author":"Wang","year":"2023","journal-title":"Drug Eval Res"},{"issue":"4","key":"10.1016\/j.jep.2025.119842_bib40","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","article-title":"Metabolomics for investigating physiological and pathophysiological processes","volume":"99","author":"Wishart","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2025.119842_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102336","article-title":"Complement C1q synergizes with PTX3 in promoting NLRP3 inflammasome over-activation and pyroptosis in rheumatoid arthritis","volume":"106","author":"Wu","year":"2020","journal-title":"J. Autoimmun."},{"issue":"6","key":"10.1016\/j.jep.2025.119842_bib42","first-page":"790","article-title":"Research progress of traditional Chinese medicine for rheumatoid arthritis based on the principle of \u201ctreating the same disease differently\u201d","volume":"40","author":"Wu","year":"2023","journal-title":"Tianjin J. Trad. Chin. Med."},{"issue":"24","key":"10.1016\/j.jep.2025.119842_bib43","first-page":"8632","article-title":"Mechanism of NLRP3 mediated pyroptosis in rheumatoidarthritis and research progress in traditional Chinese medicine","volume":"55","author":"Wu","year":"2024","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"5","key":"10.1016\/j.jep.2025.119842_bib44","first-page":"821","article-title":"A preliminary study of associate professor he Qingyong's thoughts on the application of YiyiFuzi powder in the treatment of chest obstruction and heartache","volume":"25","author":"Yang","year":"2016","journal-title":"J. Emerg. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.119842_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.931690","article-title":"Role of NLRP3 inflammasome in rheumatoid arthritis","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.jep.2025.119842_bib46","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/art.38021","article-title":"The impact of inflammation on metabolomic profiles in patients with arthritis","volume":"65","author":"Young","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"13","key":"10.1016\/j.jep.2025.119842_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134714","article-title":"Inflammasome and mitophagy connection in health and disease","volume":"21","author":"Yuk","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119842_bib48","article-title":"Pharmacological effects and mechanisms of YiYiFuZi powder in chronic heart disease revealed by metabolomics and network pharmacology","volume":"10","author":"Yuming","year":"2023","journal-title":"Front. Mol. Biosci."},{"issue":"2","key":"10.1016\/j.jep.2025.119842_bib49","first-page":"321","article-title":"Mechanism of yiyi fuzi powder in homotherapy for rheumatoid arthritis and chronic heart failure based on network pharmacology and molecular docking","volume":"46","author":"Yuyu","year":"2023","journal-title":"Drug Evaluation Research"},{"key":"10.1016\/j.jep.2025.119842_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12986-020-0434-8","article-title":"Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis","volume":"17","author":"Zeng","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.jep.2025.119842_bib51","first-page":"379","article-title":"Study of the effect of the diester alkaloids,MonoesterAlkaloids and non-ester alkaloids in fuzi on AA rats","volume":"6","author":"Zhang","year":"2014","journal-title":"J.f Zhejiang Chin. Med. Univ."},{"issue":"1","key":"10.1016\/j.jep.2025.119842_bib52","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/13880209.2019.1687526","article-title":"Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund's adjuvant-induced rheumatoid arthritis model","volume":"57","author":"Zhang","year":"2019","journal-title":"Pharm. Biol."},{"issue":"7","key":"10.1016\/j.jep.2025.119842_bib53","first-page":"1802","article-title":"Study on the mechanism of yiyi fuzi powder in the treatment of rheumatoid arthritis based on metabolomics and network pharmacology","volume":"58","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.jep.2025.119842_bib54","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41556-024-01397-9","article-title":"A palmitoylation-depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"24","key":"10.1016\/j.jep.2025.119842_bib55","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1016\/j.molcel.2023.11.015","article-title":"ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation","volume":"83","author":"Zheng","year":"2023","journal-title":"Mol. Cell"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:54:57Z","timestamp":1762307697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125005264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":55,"alternative-id":["S0378874125005264"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119842","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional metabolomics combined with network pharmacology reveals the mechanism of alleviating rheumatoid arthritis with Yiyi Fuzi powder","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119842"}}