{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:30:44Z","timestamp":1768347044282,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192913"],"award-info":[{"award-number":["82192913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jep.2025.119849","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T13:54:43Z","timestamp":1745157283000},"page":"119849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Psoraleae Fructus affects the livers of normal and ulcerative colitis rats differently by altering bile acid metabolism"],"prefix":"10.1016","volume":"349","author":[{"given":"Xiaofeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-8922","authenticated-orcid":false,"given":"Xuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzhuo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingnan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-4405","authenticated-orcid":false,"given":"Aihua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119849_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115788","article-title":"Flavonoids: their putative neurologic roles, epigenetic changes, and gut microbiota alterations in parkinson's disease","volume":"168","author":"A\u00e7ar","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119849_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108689","article-title":"Vitamins and fatty acids against chemotherapy-induced intestinal mucositis","volume":"261","author":"Alcorta","year":"2024","journal-title":"Pharmacol. Ther."},{"issue":"27","key":"10.1016\/j.jep.2025.119849_bib3","doi-asserted-by":"crossref","first-page":"20148","DOI":"10.1016\/S0021-9258(20)80706-6","article-title":"Bile acid transport into hepatocyte smooth endoplasmic reticulum vesicles is mediated by microsomal epoxide hydrolase, a membrane protein exhibiting two distinct topological orientations","volume":"268","author":"Alves","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jep.2025.119849_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1939-165X.2005.tb00041.x","article-title":"Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies","volume":"34","author":"Boone","year":"2005","journal-title":"Vet. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.jep.2025.119849_bib5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"issue":"4","key":"10.1016\/j.jep.2025.119849_bib7","first-page":"449","article-title":"Characteristics of Psoralea corylifolia induced liver injury","volume":"20","author":"Chen","year":"2023","journal-title":"Chin J pharmacovigil"},{"issue":"23","key":"10.1016\/j.jep.2025.119849_bib8","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1111\/bph.14035","article-title":"p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice","volume":"174","author":"Chen","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119849_bib9","series-title":"Pharmacopoeia of the People's Republic of China","year":"2020"},{"issue":"Suppl. 1: s3\u2013105","key":"10.1016\/j.jep.2025.119849_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5604\/01.3001.0010.5493","article-title":"Bile acid physiology","volume":"16","author":"Ciaula","year":"2017","journal-title":"Ann. Hepatol.: official journal of the Mexican Association of Hepatology"},{"key":"10.1016\/j.jep.2025.119849_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00041433-199504000-00009","article-title":"Bile acid transporters","volume":"6","author":"Dawson","year":"1995","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jep.2025.119849_bib12","article-title":"Integrative proteomics-metabolomics strategy reveals the mechanism of hepatotoxicity induced by fructus psoraleae","volume":"221","author":"Duan","year":"2020","journal-title":"J. Proteonomics"},{"issue":"2","key":"10.1016\/j.jep.2025.119849_bib13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/ajcp\/73.2.196","article-title":"Within-day fluctuations in serum bile-acid concentrations among normal control subjects and patients with hepatic disease","volume":"73","author":"Engelking","year":"1980","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.jep.2025.119849_bib14","first-page":"1","article-title":"New insights in genetic cholestasis: from molecular mechanisms to clinical implications","author":"Eva","year":"2018","journal-title":"Canadian Journal of Gastroenterology & Hepatology"},{"key":"10.1016\/j.jep.2025.119849_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1280864","article-title":"The zhuyu pill relieves rat cholestasis by regulating the mRNA expression of lipid and bile metabolism associated genes","volume":"14","author":"Han","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.119849_bib16","first-page":"268","article-title":"Effect of ershen pill on inflammatory response and platelet in ulcerative colitis rats Hebei J tradi","volume":"44","author":"Han","year":"2022","journal-title":"Chin. Med."},{"issue":"13","key":"10.1016\/j.jep.2025.119849_bib17","first-page":"59","article-title":"Exploring mechanism of modified fuzi lizhongtang in intervening InflammatoryResponse of intestinal mucosa in rats with ulcerative colitis based on mTOR\/p-S6K1","volume":"26","author":"Hao","year":"2020","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.119849_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156035","article-title":"Sishen pills inhibit inflammatory dendritic cell differentiation via miR-505-3p mediated E-cadherin downregulation in ulcerative colitis","volume":"135","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119849_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105533","article-title":"Novel insights into bile acid detoxification via CYP, UGT and SULT enzymes","volume":"87","author":"Kastrinou Lampou","year":"2023","journal-title":"Toxicol. Vitro"},{"issue":"1","key":"10.1016\/j.jep.2025.119849_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28948-z","article-title":"GOATOOLS: a python library for gene ontology analyses","volume":"8","author":"Klopfenstein","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.119849_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2017.11.020","article-title":"Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice","volume":"283","author":"Li","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.jep.2025.119849_bib22","first-page":"16","article-title":"Effect of sishenwan on PI3K\/Akt\/mTOR signal pathway in colonic tissue of rats withUlcerative colitis model of spleen kidney yang deficiency","volume":"27","author":"Liu","year":"2021","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"12","key":"10.1016\/j.jep.2025.119849_bib23","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.119849_bib24","first-page":"987","article-title":"Research progress in the treatment of ulcerative colitis with sishen pills","volume":"36","author":"Ma","year":"2024","journal-title":"Clin J Tradit Chin Med"},{"issue":"14","key":"10.1016\/j.jep.2025.119849_bib25","first-page":"13","article-title":"Bile-acid-induced cell injury and protection","author":"Maria","year":"2009","journal-title":"World J. Gastroenterol."},{"issue":"23","key":"10.1016\/j.jep.2025.119849_bib26","doi-asserted-by":"crossref","first-page":"9589","DOI":"10.1158\/0008-5472.CAN-08-1791","article-title":"Nuclear bile acid receptor FXR protects against intestinal tumorigenesis","volume":"68","author":"Modica","year":"2008","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.jep.2025.119849_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"6","key":"10.1016\/j.jep.2025.119849_bib28","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1081\/CLT-200068863","article-title":"A case of acute cholestatic hepatitis associated with the seeds of Psoralea corylifolia (Boh-Gol-Zhee)","volume":"43","author":"Nam","year":"2008","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jep.2025.119849_bib29","article-title":"Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by PARP-1 and histone H1.2. association with sodium-dependent bile acid transport","volume":"10","author":"Peng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.119849_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463417","article-title":"Ultra-performance chromatography-electrospray tandem mass spectrometry analysis of bile acid profiles in the enterohepatic circulation following geniposide and acetaminophen-induced liver injury","volume":"1680","author":"Qin","year":"2022","journal-title":"J. Chromatogr. A"},{"issue":"5","key":"10.1016\/j.jep.2025.119849_bib31","first-page":"4","article-title":"Overview of the application of Psoralea corylifolia L. in ulcer diseases","volume":"17","author":"Rao","year":"2021","journal-title":"Asia-Pacific Tradit Med"},{"issue":"2","key":"10.1016\/j.jep.2025.119849_bib32","first-page":"431","article-title":"Bile formation,secretion,and excretion and the pathogenesis of cholestasis","volume":"35","author":"Shen","year":"2019","journal-title":"Chin. J. Clin. Hepatol."},{"issue":"16","key":"10.1016\/j.jep.2025.119849_bib33","first-page":"34","article-title":"Clinical effect of sishen pills and shenling baizhu powder combined with mesalazinefor ulcerative colitis and its effect on intestinal flora and intestinal barrier function","volume":"53","author":"Shen","year":"2021","journal-title":"New J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.119849_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117967","article-title":"Positive benefit-risk ratio of psoraleae fructus: comprehensive safety assessment and osteogenic effects in rats","volume":"326","author":"Shi","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119849_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/hep.29251","article-title":"Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice","volume":"66","author":"Slijepcevic","year":"2017","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jep.2025.119849_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000450983","article-title":"Bile acid uptake transporters as targets for therapy","volume":"35","author":"Slijepcevic","year":"2017","journal-title":"Dig. Dis."},{"key":"10.1016\/j.jep.2025.119849_bib37","article-title":"New insights in genetic cholestasis: from molecular mechanisms to clinical implications","volume":"2018","author":"Sticova","year":"2018","journal-title":"Chin. J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2025.119849_bib38","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/hep.22926","article-title":"Diferentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation","volume":"50","author":"Strazzabosco","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2025.119849_bib39","first-page":"92","article-title":"Study on the mechanism ofSishen Pills,Lizhong tang and mesalazinein the treatment of ulcerative colitis. West. J tradi","volume":"36","author":"Su","year":"2023","journal-title":"Chin. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.119849_bib40","first-page":"37","article-title":"Study on the extraction method of psoralen and isopsoralen FromPsoralen","volume":"49","author":"Sun","year":"2022","journal-title":"Liquor Mak."},{"key":"10.1016\/j.jep.2025.119849_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117917","article-title":"Angelicin: a leading culprit involved in fructus psoraleae liver injury via inhibition of VKORC1","volume":"328","author":"Tang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119849_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118837","article-title":"Screening and validation of biomarkers for cadmium-induced liver injury based on targeted bile acid metabolomics","volume":"300","author":"Tian","year":"2022","journal-title":"Environ. Pollut."},{"issue":"10","key":"10.1016\/j.jep.2025.119849_bib43","first-page":"107","article-title":"Preventive and therapeutic effect of banqiao codonopsis RadixPolysaccharide against ulcerative colitis in rats","volume":"22","author":"Tian","year":"2016","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"1","key":"10.1016\/j.jep.2025.119849_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2012.08.028","article-title":"Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of fructus psoraleae","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.119849_bib45","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/liv.14306","article-title":"Clinicopathological features of Bu Gu Zhi-induced liver injury, a long-term follow-up cohort study","volume":"40","author":"Wang","year":"2020","journal-title":"Liver Int. : official journal of the International Association for the Study of the Liver"},{"key":"10.1016\/j.jep.2025.119849_bib46","series-title":"Biomarkers and Mechanism Analysis for Polygoni Multiflori Radix Preparata-Induced Liver Injury by UHPLC-Q-TOF-MS-Based Metabolomics","author":"Wang","year":"2021"},{"issue":"4","key":"10.1016\/j.jep.2025.119849_bib47","first-page":"367","article-title":"Relationship of cholesterol ester hydrolase with ischemic cerebrovascular disease","volume":"16","author":"Wang","year":"2010","journal-title":"Prog. Anat. Sci."},{"key":"10.1016\/j.jep.2025.119849_bib48","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.biopha.2018.01.023","article-title":"Er shen wan extract reduces diarrhea and regulates AQP 4 and NHE 3 in a rat model of spleen-kidney yang deficiency-induced diarrhea","volume":"98","author":"Xiong","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"16","key":"10.1016\/j.jep.2025.119849_bib49","first-page":"4459","article-title":"Effect of 28-day administration of psoraleae fructus water extract onearly liver injury in rats","volume":"48","author":"Xu","year":"2023","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2025.119849_bib50","series-title":"Study on the Pharmacological Function Change in Treatment Ofulcerative Colitis and Related Processing Principles of Fructus Psoraleaecorylifoliae","author":"Xu","year":"2023"},{"key":"10.1016\/j.jep.2025.119849_bib51","article-title":"Interplay of breast cancer resistance protein (BCRP) and metabolizing enzymes","author":"Ye","year":"2015","journal-title":"Curr. Drug Metabol."},{"issue":"2","key":"10.1016\/j.jep.2025.119849_bib52","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/ptr.8087","article-title":"International clinical practice guideline on the use of traditional Chinese medicine for ulcerative colitis by board of specialty committee of digestive system disease of world Federation of Chinese medicine societies (2023)","volume":"38","author":"Zhang","year":"2024","journal-title":"Phytother Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T21:34:01Z","timestamp":1749677641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125005331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":51,"alternative-id":["S0378874125005331"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119849","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psoraleae Fructus affects the livers of normal and ulcerative colitis rats differently by altering bile acid metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119849"}}