{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T11:52:02Z","timestamp":1792324322276,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003927"],"award-info":[{"award-number":["82003927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119867","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:43:30Z","timestamp":1745390610000},"page":"119867","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Revealing the mechanism of Sanfu Patch dorsal application for alleviating OVA-induced asthma: an integrated approach combining TMT quantitative proteomics and molecular docking"],"prefix":"10.1016","volume":"348","author":[{"given":"Rui","family":"Dang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhejun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huida","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-4856","authenticated-orcid":false,"given":"Changhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2025.119867_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12040593","article-title":"Specific therapy for T2 asthma","volume":"12","author":"Bagnasco","year":"2022","journal-title":"J. Personalized Med."},{"issue":"10","key":"10.1016\/j.jep.2025.119867_bib2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/CS20210900","article-title":"Autophagy in asthma and chronic obstructive pulmonary disease","volume":"136","author":"Barnes","year":"2022","journal-title":"Clin. Sci."},{"key":"10.1016\/j.jep.2025.119867_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101333","article-title":"Immunologic mechanisms in asthma","volume":"46","author":"Boonpiyathad","year":"2019","journal-title":"Semin. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2025.119867_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1600-0625.2000.009003165.x","article-title":"The 500 dalton rule for the skin penetration of chemical compounds and drugs","volume":"9","author":"Bos","year":"2000","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jep.2025.119867_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114112","article-title":"The management of severe asthma in 2020","volume":"179","author":"C\u00f4t\u00e9","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.119867_bib6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaip.2019.11.020","article-title":"Diagnosis and management of T2-High asthma","volume":"8","author":"Coverstone","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"5","key":"10.1016\/j.jep.2025.119867_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2230.2000.00678.x","article-title":"Langerhans cell migration","volume":"25","author":"Cumberbatch","year":"2000","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.jep.2025.119867_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1113583","article-title":"Sinapis semen: a review on phytochemistry, pharmacology, toxicity, analytical methods and pharmacokinetics","volume":"14","author":"Dang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119867_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molimm.2020.03.009","article-title":"Blockade of CD40L inhibits immunogenic maturation of lung dendritic cells: implications for the role of lung iNKT cells in mouse models of asthma","volume":"121","author":"Deng","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jep.2025.119867_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2015.03.035","article-title":"Targeting and liposomal drug delivery to CD40L expressing T cells for treatment of autoimmune diseases","volume":"207","author":"Ding","year":"2015","journal-title":"J. Contr. Release"},{"issue":"11","key":"10.1016\/j.jep.2025.119867_bib11","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.3390\/cells11111840","article-title":"Lysosomal proteomics links disturbances in lipid homeostasis and sphingolipid metabolism to CLN5 disease","volume":"11","author":"Doccini","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jep.2025.119867_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121899","article-title":"Transdermal delivery of sinapine thiocyanate by gelatin microspheres and hyaluronic acid microneedles for allergic asthma in Guinea pigs","volume":"623","author":"Feng","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.jep.2025.119867_bib14","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.cell.2021.04.019","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib15","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00528-2020","article-title":"Treatment options in type-2 low asthma","volume":"57","author":"Hinks","year":"2021","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/tra.12925","article-title":"Mechanisms regulating the intracellular trafficking and release of CLN5 and CTSD","volume":"25","author":"Huber","year":"2024","journal-title":"Traffic"},{"key":"10.1016\/j.jep.2025.119867_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2020.107402","article-title":"A comprehensive application: molecular docking and network pharmacology for the prediction of bioactive constituents and elucidation of mechanisms of action in component-based Chinese medicine","volume":"90","author":"Jiao","year":"2021","journal-title":"Comput. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jep.2025.119867_bib18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/bjd.19808","article-title":"Inducible skin-associated lymphoid tissue (iSALT) in a patient with Schnitzler syndrome who manifested wheals on recurrent localized erythema","volume":"184","author":"Kamido","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.jep.2025.119867_bib19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4168\/aair.2019.11.2.222","article-title":"Multicenter adherence study of asthma medication for children in Korea","volume":"11","author":"Kim","year":"2019","journal-title":"Allergy Asthma Immunol. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40257-019-00480-4","article-title":"Twenty clinically pertinent factors\/observations for percutaneous absorption in humans","volume":"21","author":"Law","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"issue":"2","key":"10.1016\/j.jep.2025.119867_bib21","article-title":"Acupoint herbal patching for asthma: a systematic review and meta-analysis of randomized controlled trials","volume":"95","author":"Lee","year":"2016","journal-title":"Medicine (Baltim.)"},{"issue":"7330","key":"10.1016\/j.jep.2025.119867_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jep.2025.119867_bib23","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1124\/dmd.110.033936","article-title":"Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats","volume":"38","author":"Liu","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2025.119867_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.phymed.2018.09.170","article-title":"Protective effects and active ingredients of Salvia miltiorrhiza bunge extracts on airway responsiveness, inflammation and remodeling in mice with ovalbumin-induced allergic asthma","volume":"52","author":"Luo","year":"2019","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2025.119867_bib25","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1165\/rcmb.2018-0169OC","article-title":"Autophagy activation in asthma airways remodeling","volume":"60","author":"McAlinden","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.jep.2025.119867_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2500\/aap.2019.40.4253","article-title":"Classification of asthma","volume":"40","author":"Padem","year":"2019","journal-title":"Allergy Asthma Proc."},{"issue":"22","key":"10.1016\/j.jep.2025.119867_bib27","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa2203163","article-title":"Albuterol-budesonide fixed-dose combination rescue inhaler for asthma","volume":"386","author":"Papi","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.119867_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/15548627.2017.1389823","article-title":"Autophagy and inflammation in chronic respiratory disease","volume":"14","author":"Racanelli","year":"2018","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.jep.2025.119867_bib29","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/ncb3409","article-title":"Turn up the lysosome","volume":"18","author":"Saftig","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jep.2025.119867_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.863403","article-title":"Screening of bioactive fraction of Radix paeoniae Alba and enhancing anti-allergic asthma by stir-frying through regulating PI3K\/AKT signaling pathway","volume":"13","author":"Sang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.119867_bib31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.chest.2019.10.009","article-title":"Recent advances in severe asthma: from phenotypes to personalized medicine","volume":"157","author":"Schoettler","year":"2020","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.jep.2025.119867_bib32","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1021\/acs.analchem.8b05399","article-title":"Characterization and optimization of multiplexed quantitative analyses using high-field asymmetric-waveform ion mobility mass spectrometry","volume":"91","author":"Schweppe","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jep.2025.119867_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154177","article-title":"Identification of the active compounds and functional mechanisms of jinshui huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology","volume":"102","author":"Shao","year":"2022","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2025.119867_bib34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1142\/S0192415X16500154","article-title":"The chemical and biological properties of Euphorbia kansui","volume":"44","author":"Shen","year":"2016","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00281-020-00785-1","article-title":"Asthma epidemiology and risk factors","volume":"42","author":"Stern","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jep.2025.119867_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107709","article-title":"Molecular basis and therapeutic implications of CD40\/CD40L immune checkpoint","volume":"219","author":"Tang","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2025.119867_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.108947","article-title":"Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases","volume":"317","author":"Tew","year":"2020","journal-title":"Chem. Biol. Interact."},{"issue":"12","key":"10.1016\/j.jep.2025.119867_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126314","article-title":"Autophagy: a friend or foe in allergic asthma?","volume":"22","author":"Theofani","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119867_bib39","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-1-4939-9744-2_15","article-title":"Review of issues and solutions to data analysis reproducibility and data quality in clinical proteomics","volume":"2051","author":"Walzer","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.119867_bib40","article-title":"Acupoint herbal patching during sanfu days on reducing frequency of acute asthma attack in children: a systematic review and meta-analysis","volume":"99","author":"Wei","year":"2020","journal-title":"Medicine (Baltim.)"},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib41","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1186\/s13063-020-04604-8","article-title":"Sanfu herbal patch applied at acupoints in patients with bronchial asthma: study protocol for a randomized controlled trial","volume":"21","author":"Xie","year":"2020","journal-title":"Trials"},{"issue":"5","key":"10.1016\/j.jep.2025.119867_bib42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3892\/ol.2021.12648","article-title":"Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt\/mTOR signaling pathway","volume":"21","author":"Xing","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2025.119867_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155410","article-title":"Protopine ameliorates OVA-Induced asthma through modulatingTLR4\/MyD88\/NF-\u03baB pathway and NLRP3 inflammasome-mediated pyroptosis","volume":"126","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.jep.2025.119867_bib44","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1042\/BCJ20210171","article-title":"CLN5 and CLN3 function as a complex to regulate endolysosome function","volume":"478","author":"Yasa","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.jep.2025.119867_bib45","series-title":"Zhang Shi Yi Tong","author":"Zhang","year":"1990"},{"key":"10.1016\/j.jep.2025.119867_bib46","article-title":"Involvement of CD40-CD40L and ICOS-ICOSL in the development of chronic rhinosinusitis by targeting eosinophils","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119867_bib47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctim.2016.11.007","article-title":"Sanfu acupoint herbal patching for stable asthma: a systematic review and meta-analysis of randomised controlled trials","volume":"30","author":"Zhou","year":"2017","journal-title":"Compl. Ther. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.119867_bib48","article-title":"Effect of summer acupoint application treatment (SAAT) on gut microbiota in healthy Asian adults: a randomized controlled trial","volume":"102","author":"Zhou","year":"2023","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2025.119867_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154941","article-title":"TMT-Based quantitative proteomics revealed protective efficacy of icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS expression in OVA-Induced chronic asthma mice","volume":"118","author":"Zhou","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.119867_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40169-016-0084-7","article-title":"Randomized trial of acupoints herbal patching in sanfu days for asthma in clinical remission stage","volume":"5","author":"Zhu","year":"2016","journal-title":"Clin. Transl. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:10:59Z","timestamp":1748686259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125005513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":50,"alternative-id":["S0378874125005513"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119867","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revealing the mechanism of Sanfu Patch dorsal application for alleviating OVA-induced asthma: an integrated approach combining TMT quantitative proteomics and molecular docking","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119867","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119867"}}