{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:09Z","timestamp":1792001769453,"version":"4.4.0"},"reference-count":247,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305096"],"award-info":[{"award-number":["82305096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119870","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:51:51Z","timestamp":1745581911000},"page":"119870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Iridoid glycosides in kidney-tonifying Chinese medicinal herbs: Mechanisms and implications for Alzheimer's disease therapy"],"prefix":"10.1016","volume":"348","author":[{"given":"Yanjie","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minrui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5809-9475","authenticated-orcid":false,"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.119870_bib1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/cells13060485","article-title":"NF-\u03baB as an inducible regulator of inflammation in the central nervous system","volume":"13","author":"Anilkumar","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.119870_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110074","article-title":"Aucubin ameliorates liver fibrosis and hepatic stellate cells activation in diabetic mice via inhibiting ER stress-mediated IRE1\u03b1\/TXNIP\/NLRP3 inflammasome through NOX4\/ROS pathway","volume":"365","author":"Bao","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.119870_bib3","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.3390\/molecules27185901","article-title":"Sweroside ameliorated memory deficits in scopolamine-induced zebrafish (Danio rerio) model: involvement of cholinergic system and brain oxidative stress","volume":"27","author":"Brinza","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119870_bib4","doi-asserted-by":"crossref","DOI":"10.2174\/0118715273345712250119200430","article-title":"Sweroside modulates oxidative stress and neuroplasticity-related gene expression in scopolamine-treated zebrafish","volume":"24","author":"Brinza","year":"2025","journal-title":"CNSNDDT"},{"key":"10.1016\/j.jep.2025.119870_bib5","doi-asserted-by":"crossref","DOI":"10.14283\/jpad.2022.30","article-title":"Two randomized phase 3 studies of aducanumab in early alzheimer's disease","author":"Budd Haeberlein","year":"2022","journal-title":"J. Prev. Alz. Dis."},{"key":"10.1016\/j.jep.2025.119870_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2016.11.006","article-title":"Ginsenoside re reduces A\u03b2 production by activating PPAR\u03b3 to inhibit BACE1 in N2a\/APP695 cells","volume":"793","author":"Cao","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108911","article-title":"Emerging therapeutic potential of the iridoid molecule, asperuloside: a snapshot of its underlying molecular mechanisms","volume":"315","author":"Chan","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.119870_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejphar.2018.07.047","article-title":"Morroniside prevents H2O2 or A\u03b21\u201342-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation","volume":"834","author":"Chen","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib9","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1039\/D3FO01024D","article-title":"Asperuloside, the bioactive compound in the edible Eucommia ulmoides Male flower, delays muscle aging by daf-16 mediated improvement in mitochondrial dysfunction","volume":"14","author":"Chen","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119870_bib10","first-page":"1","article-title":"Geniposidic acid confers neuroprotective effects in a mouse model of alzheimer's disease through activation of a PI3K\/AKT\/GAP43 regulatory axis","author":"Chen","year":"2021","journal-title":"J. Prev. Alz. Dis."},{"key":"10.1016\/j.jep.2025.119870_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155262","article-title":"Catalpol attenuates osteoporosis in ovariectomized rats through promoting osteoclast apoptosis via the Sirt6-ER\u03b1-FasL axis","volume":"123","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s11064-018-2700-y","article-title":"Aucubin alleviates seizures activity in li-pilocarpine-induced epileptic mice: involvement of inhibition of neuroinflammation and regulation of neurotransmission","volume":"44","author":"Chen","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2025.119870_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijpharm.2013.08.017","article-title":"Influence of borneol and muscone on geniposide transport through MDCK and MDCK-MDR1 cells as blood\u2013brain barrier in vitro model","volume":"456","author":"Chen","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jep.2025.119870_bib14","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.3390\/molecules27238568","article-title":"Geniposidic acid from Eucommia ulmoides oliver staminate flower tea mitigates cellular oxidative stress via activating AKT\/NRF2 signaling","volume":"27","author":"Cheng","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119870_bib15","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.3390\/cells9091948","article-title":"Loganin attenuates high glucose-induced schwann cells pyroptosis by inhibiting ROS generation and NLRP3 inflammasome activation","volume":"9","author":"Cheng","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.119870_bib16","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3390\/antiox13121529","article-title":"Role of NRF2 in pathogenesis of alzheimer's disease","volume":"13","author":"Chu","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.119870_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000534623","article-title":"Iridoid glycoside cornuside alleviates the symptom of gestational diabetes mellitus by suppressing inflammation and regulating beta cell function","volume":"89","author":"Cui","year":"2024","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.jep.2025.119870_bib18","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/cbin.11060","article-title":"Loganin prevents BV-2 microglia cells from A\u03b2 1-42 -induced inflammation via regulating TLR4\/TRAF6\/NF-\u03baB axis: loganin prevents A\u03b2 1-42 -induced inflammation","volume":"42","author":"Cui","year":"2018","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.jep.2025.119870_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.apsb.2024.10.004","article-title":"Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications","volume":"15","author":"Dash","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2025.119870_bib20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0960327120960768","article-title":"Morroniside suppresses hydrogen peroxide-stimulated autophagy and apoptosis in rat ovarian granulosa cells through the PI3K\/AKT\/mTOR pathway","volume":"40","author":"Deng","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib21","first-page":"1","article-title":"UPLC-TOF-MS characterization and identification of bioactive iridoids in Cornus mas fruit","author":"Deng","year":"2013","journal-title":"J. Analyt. Methods Chem."},{"key":"10.1016\/j.jep.2025.119870_bib22","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2017.7864","article-title":"Cornin protects SH-SY5Y cells against oxygen and glucose deprivation-induced autophagy through the PI3K\/Akt\/mTOR pathway","author":"Ding","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.119870_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116227","article-title":"Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX\/PPAR\u03b1-mediated ferroptosis","volume":"307","author":"Dong","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib24","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s12640-022-00524-4","article-title":"Catalpol ameliorates neurotoxicity in N2a\/APP695swe cells and APP\/PS1 transgenic mice","volume":"40","author":"Du","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jep.2025.119870_bib25","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1007\/s11033-021-06715-0","article-title":"Catalpol synergistically potentiates the anti-tumour effects of regorafenib against hepatocellular carcinoma via dual inhibition of PI3K\/Akt\/mTOR\/NF-\u03baB and VEGF\/VEGFR2 signaling pathways","volume":"48","author":"El-Hanboshy","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2025.119870_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2022.11.058","article-title":"Monotropein attenuates doxorubicin-induced oxidative stress, inflammation, and arrhythmia via the AKT signal pathway","volume":"638","author":"Fang","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2025.119870_bib27","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.12659\/MSM.907569","article-title":"Efficacy, safety, and cost of therapy of the traditional Chinese medicine, catalpol, in patients following surgical resection for locally advanced Colon cancer","volume":"24","author":"Fei","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.jep.2025.119870_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202405781","article-title":"Intranasal delivery of pure nanodrug loaded liposomes for alzheimer's disease treatment by efficiently regulating microglial polarization","volume":"20","author":"Feng","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jep.2025.119870_bib29","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.18632\/aging.102985","article-title":"Microarray analysis of verbenalin-treated human amniotic epithelial cells reveals therapeutic potential for Alzheimer's disease","volume":"12","author":"Ferdousi","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119870_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41583-021-00533-w","article-title":"The probabilistic model of Alzheimer disease: the amyloid hypothesis revised","volume":"23","author":"Frisoni","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2025.119870_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.533809","article-title":"Morroniside inhibits H2O2-Induced podocyte apoptosis by down-regulating NOX4 expression controlled by autophagy in vitro","volume":"11","author":"Gao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/13880209.2014.916310","article-title":"Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms","volume":"53","author":"Gao","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.119870_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154715","article-title":"Aucubin enhances the antitumor activity of cisplatin through the inhibition of PD-L1 expression in hepatocellular carcinoma","volume":"112","author":"Gao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11418-019-01334-3","article-title":"Sweroside ameliorated carbon tetrachloride (CCl4)-induced liver fibrosis through FXR-miR-29a signaling pathway","volume":"74","author":"Gong","year":"2020","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2025.119870_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuropharm.2014.04.007","article-title":"Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors","volume":"84","author":"Gong","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2025.119870_bib37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/1568026623666221222142217","article-title":"Exploring the multitarget potential of iridoids: advances and applications","volume":"23","author":"Grover","year":"2023","journal-title":"CTMC"},{"key":"10.1016\/j.jep.2025.119870_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2015.08.019","article-title":"Combined therapy of di-Di-Huang-Yi-Zhi with Donepezil in patients with Parkinson's disease dementia","volume":"606","author":"Gu","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2025.119870_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00289","article-title":"Cistanches herba: a neuropharmacology review","volume":"7","author":"Gu","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102707","article-title":"Antioxidants in anti\u2010alzheimer\u2019s disease drug discovery","volume":"107","author":"Guo","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2025.119870_bib41","article-title":"The reduction of tau hyperphosphorylation by cornel iridoid glycosides is mediated by their influence on calpain activity","volume":"1\u20139","author":"Guo","year":"2022","journal-title":"Evide. Based Complement. Alterna. Med."},{"key":"10.1016\/j.jep.2025.119870_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116288","article-title":"Loganin improves chronic unpredictable mild stress-induced depressive-like behaviors and neurochemical dysfunction","volume":"308","author":"Guo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib43","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","article-title":"PINK1-PRKN mediated mitophagy: differences between in Vitro and In Vivo models","volume":"19","author":"Han","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2025.119870_bib44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.biopha.2017.08.007","article-title":"Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis","volume":"95","author":"Han","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18148-1","article-title":"Iridoid glycoside Aucubin protects against nonylphenol-induced testicular damage in Male rats via modulation of steroidogenic and apoptotic signaling","volume":"12","author":"Hassan","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2025.119870_bib46","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2025.119870_bib47","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1248\/bpb.28.1244","article-title":"Protective effects of Aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts","volume":"28","author":"Ho","year":"2005","journal-title":"Biol. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2025.119870_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112261","article-title":"Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-\u03baB activity and pyroptosis in chondrocytes","volume":"247","author":"Hu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1228679","article-title":"Recent progress of nanomedicine in the treatment of Alzheimer's disease","volume":"11","author":"Hu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2025.119870_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117345","article-title":"Catalpol rescues LPS-Induced cognitive impairment via inhibition of NF-\u039ab-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice","volume":"319","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155295","article-title":"Untargeted metabolomics reveals the regulatory effect of geniposidic acid on lipid accumulation in HepG2 cells and Caenorhabditis elegans and validation in hyperlipidemic hamsters","volume":"125","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib52","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jep.2017.11.010","article-title":"Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc","volume":"213","author":"Huang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib53","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3892\/mmr.2015.4496","article-title":"Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice","volume":"13","author":"Huang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2025.119870_bib54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13020-021-00482-7","article-title":"Traditional application and modern pharmacological research of Eucommia ulmoides oliv","volume":"16","author":"Huang","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.119870_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2023.107202","article-title":"Loganin reduces neuroinflammation and promotes functional recovery after spinal cord injury through inhibiting NF-\u03baB\/NLRP3 signalling","volume":"232","author":"Huang","year":"2023","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2025.119870_bib56","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jep.2025.119870_bib57","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/tox.23738","article-title":"Loganin attenuates neuroinflammation after ischemic stroke and fracture by regulating \u03b17nAChR \u2010mediated microglial polarization","volume":"38","author":"Huo","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib58","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.physbeh.2016.12.043","article-title":"Loganin enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments","volume":"171","author":"Hwang","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.jep.2025.119870_bib59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.phymed.2011.08.068","article-title":"Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells","volume":"19","author":"Jeong","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cbi.2015.05.022","article-title":"Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis","volume":"238","author":"Jeong","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.119870_bib246","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000235621","article-title":"Cornuside attenuates apoptosis and ameliorates mitochondrial energy metabolism in rat cortical neurons","volume":"84","author":"Jiang","year":"2009","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2025.119870_bib61","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2007.07.105","article-title":"Catalpol attenuates the neurotoxicity induced by \u03b2-amyloid1\u201342 in cortical neuron\u2013glia cultures","volume":"1188","author":"Jiang","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2025.119870_bib62","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1002\/ptr.7819","article-title":"Geniposidic acid attenuates DSS \u2010induced colitis through inhibiting inflammation and regulating gut microbiota","volume":"37","author":"Jiang","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.119870_bib63","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ptr.2978","article-title":"Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function: cornin and cerebral ischemia","volume":"24","author":"Jiang","year":"2010","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.119870_bib64","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.fct.2013.05.017","article-title":"Cornin induces angiogenesis through PI3K\u2013Akt\u2013eNOS\u2013VEGF signaling pathway","volume":"58","author":"Kang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib65","first-page":"2585","article-title":"Research advances in pharmacology of aucubin and aucubigenin","volume":"32","author":"Kang","year":"2007","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.119870_bib66","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1474-4422(10)70277-5","article-title":"Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease","volume":"10","author":"Kapogiannis","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jep.2025.119870_bib67","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1039\/C5FO00055F","article-title":"Neuroprotective effect of loganin against A\u03b2 25\u201335 -induced injury via the NF-\u03baB-dependent signaling pathway in PC12 cells","volume":"6","author":"Kim","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119870_bib68","article-title":"The effectiveness and safety of Jihwang-eumja (Dihuang Yizi) compared to Western medications in patients with Alzheimer's disease: a systematic review and meta-analysis","volume":"51","author":"Kim","year":"2023","journal-title":"Compl. Ther. Clin. Pract."},{"key":"10.1016\/j.jep.2025.119870_bib69","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4062\/biomolther.2019.130","article-title":"Catalpol and mannitol, two components of Rehmannia glutinosa , exhibit anticonvulsant effects probably via GABA A receptor regulation","volume":"28","author":"Kim","year":"2020","journal-title":"Biomole. Therapeu."},{"key":"10.1016\/j.jep.2025.119870_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110640","article-title":"Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis","volume":"382","author":"Kong","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.119870_bib71","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2009.06.062","article-title":"Loganin improves learning and memory impairments induced by scopolamine in mice","volume":"619","author":"Kwon","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib72","first-page":"1130","article-title":"Reinforcing Nrf2 signaling: help in the alzheimer's disease context","volume":"26","author":"La Torre","year":"2025","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.jep.2025.119870_bib73","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/aji.12423","article-title":"Regulatory effect of catalpol on Th1\/Th2 cells in mice with bone loss induced by Estrogen deficiency","volume":"74","author":"Lai","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jep.2025.119870_bib74","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jep.2025.119870_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12010-023-04500-2","article-title":"Asperulosidic acid restrains hepatocellular carcinoma development and enhances chemosensitivity through inactivating the MEKK1\/NF-\u03baB pathway","volume":"196","author":"Li","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jep.2025.119870_bib76","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12906-023-03967-0","article-title":"Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis","volume":"23","author":"Li","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2025.119870_bib77","article-title":"Catalpol rescues cognitive deficits by attenuating amyloid \u03b2 plaques and neuroinflammation","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib78","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/alz.12258","article-title":"Traditional Chinese medicine for dementia","volume":"17","author":"Li","year":"2021","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.jep.2025.119870_bib79","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/tox.23908","article-title":"Loganin alleviates myocardial ischemia\u2013reperfusion injury through GLP\u20101R\/NLRP3 \u2010mediated pyroptosis pathway","volume":"38","author":"Li","year":"2023","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib80","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.intimp.2016.04.026","article-title":"Loganin inhibits the inflammatory response in mouse 3T3L1 adipocytes and mouse model","volume":"36","author":"Li","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153577","article-title":"Neuroprotective effects of aucubin on hydrogen peroxide-induced toxicity in human neuroblastoma SH-SY5Y cells via the Nrf2\/HO-1 pathway","volume":"87","author":"Li","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib82","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13020-023-00748-2","article-title":"Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice","volume":"18","author":"Li","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.119870_bib83","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11481-024-10120-2","article-title":"Cornuside ameliorates cognitive impairments via RAGE\/TXNIP\/NF-\u03baB signaling in A\u03b21-42 induced Alzheimer's disease mice","volume":"19","author":"Lian","year":"2024","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib84","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuint.2009.07.004","article-title":"Catalpol protects primary cultured cortical neurons induced by A\u03b21\u201342 through a mitochondrial-dependent caspase pathway","volume":"55","author":"Liang","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2025.119870_bib85","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.3390\/molecules27248678","article-title":"Verbenalin reduces amyloid-beta peptide generation in cellular and animal models of alzheimer's disease","volume":"27","author":"Lim","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119870_bib86","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ptr.6043","article-title":"Catalpol provides a protective effect on fibrillary A\u03b2 1\u201342 \u2010induced barrier disruption in an in vitro model of the blood\u2013brain barrier","volume":"32","author":"Liu","year":"2018","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.119870_bib87","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2017.01.021","article-title":"Rehmanniae radix in osteoporosis: a review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology","volume":"198","author":"Liu","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib88","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.18632\/aging.203989","article-title":"Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1\/M2 polarization in an Alzheimer's disease mice model","volume":"14","author":"Liu","year":"2022","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119870_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116215","article-title":"Catalpol induces apoptosis in breast cancer in vitro and in vivo: involvement of mitochondria apoptosis pathway and post-translational modifications","volume":"454","author":"Liu","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib90","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2014.12.028","article-title":"Loganin attenuates diabetic nephropathy in C57BL\/6J mice with diabetes induced by streptozotocin and fed with diets containing high level of advanced glycation end products","volume":"123","author":"Liu","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2025.119870_bib91","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s10020-024-00818-7","article-title":"A study on the mechanism of Beclin-1 m6A modification mediated by catalpol in protection against neuronal injury and autophagy following cerebral ischemia","volume":"30","author":"Liu","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.jep.2025.119870_bib92","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/00498254.2018.1558309","article-title":"Effects of catalpol on the activity of human liver cytochrome P450 enzymes","volume":"49","author":"Liu","year":"2019","journal-title":"Xenobiotica"},{"key":"10.1016\/j.jep.2025.119870_bib93","article-title":"Regulating effect of Qifu Yin on intestinal microbiota in mice with memory impairment induced by scopolamine hydrobromide","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172954","article-title":"Morroniside enhances angiogenesis and improves cardiac function following acute myocardial infarction in rats","volume":"872","author":"Liu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.131800","article-title":"Aucubin protects against myocardial ischemia-reperfusion injury by regulating STAT3\/NF-\u03baB\/HMGB-1 pathway","volume":"400","author":"Liu","year":"2024","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2025.119870_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113422","article-title":"Aucubin administration suppresses STING signaling and mitigated high-fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice","volume":"169","author":"Liu","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib97","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.biopha.2018.04.156","article-title":"Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis","volume":"103","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib98","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/antiox14020121","article-title":"Inflammasomes in alzheimer's progression: Nrf2 as a preventive target","volume":"14","author":"L\u00f3pez-Hern\u00e1ndez","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.119870_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110838","article-title":"Monotropein inhibits colitis associated cancer through VDR\/JAK1\/STAT1 regulation of macrophage polarization","volume":"124","author":"Lu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154070","article-title":"Asperuloside inhibited epithelial-mesenchymal transition in colitis associated cancer via activation of vitamin D receptor","volume":"101","author":"Lu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib101","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuropharm.2014.09.019","article-title":"Multi-faced neuroprotective effects of geniposide depending on the RAGE-Mediated signaling in an alzheimer mouse model","volume":"89","author":"Lv","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jep.2025.119870_bib102","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s13577-015-0128-0","article-title":"Effect of morroniside on glomerular mesangial cells through AGE\u2013RAGE pathway","volume":"29","author":"Lv","year":"2016","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jep.2025.119870_bib103","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3389\/fphar.2018.01138","article-title":"Sweroside alleviated aconitine-induced cardiac toxicity in H9c2 cardiomyoblast cell line","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib104","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jep.2014.03.051","article-title":"Bioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathy","volume":"153","author":"Ma","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib105","first-page":"1","article-title":"Aucubin promotes osteogenic differentiation and facilitates bone formation through the lncRNA-H19 driven Wnt\/\u03b2-Catenin signaling regulatory axis","author":"Mai","year":"2024","journal-title":"Stem Cells Intern."},{"key":"10.1016\/j.jep.2025.119870_bib106","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41380-022-01631-6","article-title":"Mitophagy in Alzheimer's disease: molecular defects and therapeutic approaches","volume":"28","author":"Mary","year":"2023","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jep.2025.119870_bib107","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.1016\/j.sjbs.2015.10.006","article-title":"Effects of verbenalin on prostatitis mouse model","volume":"23","author":"Miao","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib108","first-page":"1019","article-title":"Guilingji capsule ( \u9f9f \u9f84 \u96c6 \u80f6 \u56ca ) for Alzheimer\u2019s disease: secondary analysis of a randomized non-inferiority controlled trial","volume":"43","author":"Ming","year":"2023","journal-title":"J. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2025.119870_bib109","volume":"vol. 39","author":"Mingyan","year":"2019"},{"key":"10.1016\/j.jep.2025.119870_bib110","article-title":"Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K\/Akt signaling pathway in INS-1 cell","volume":"22","author":"Mo","year":"2019","journal-title":"Iranian J. Basic Med. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib111","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1750-3639.2011.00531.x","article-title":"The neuroprotective effect of a specific P2X7 receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells: neuroprotective effect of a P2X7R antagonist","volume":"22","author":"Murphy","year":"2012","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jep.2025.119870_bib112","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.742065","article-title":"Microglia in neuroinflammation and neurodegeneration: from understanding to therapy","volume":"15","author":"Muzio","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jep.2025.119870_bib113","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209320","article-title":"Lecanemab questions","volume":"102","author":"Nadeau","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.jep.2025.119870_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101522","article-title":"Asperuloside improves obesity and type 2 diabetes through modulation of Gut microbiota and metabolic signaling","volume":"23","author":"Nakamura","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.jep.2025.119870_bib115","doi-asserted-by":"crossref","first-page":"23739","DOI":"10.18632\/aging.203646","article-title":"Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer's disease","volume":"13","author":"Nie","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119870_bib116","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/jmf.2017.4149","article-title":"Antioxidant effects of bioactive compounds isolated from pressurized steam-treated corni fructus and their protective effects against UVB-irradiated HS68 cells","volume":"21","author":"Park","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2025.119870_bib117","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3390\/antiox12051082","article-title":"Aucubin exerts neuroprotection against forebrain ischemia and reperfusion injury in gerbils through antioxidative and neurotrophic effects","volume":"12","author":"Park","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2025.119870_bib118","first-page":"3461","article-title":"Neuroprotective effects of aucubin against cerebral ischemia and ischemia injury through the inhibition of the TLR4\/NF-\u03baB inflammatory signaling pathway in gerbils","volume":"25","author":"Park","year":"2024","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.jep.2025.119870_bib119","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3390\/molecules27092926","article-title":"Effect of aucubin-containing eye drops on tear hyposecretion and lacrimal gland damage induced by urban particulate matter in rats","volume":"27","author":"Park","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.119870_bib120","article-title":"Alzheimer's disease: treatment strategies and their limitations","volume":"23","author":"Passeri","year":"2022","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.jep.2025.119870_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102665","article-title":"Quercetin-functionalized nanomaterials: innovative therapeutic avenues for Alzheimer's disease management","volume":"104","author":"Pei","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2025.119870_bib122","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11655-023-3695-z","article-title":"Asperuloside promotes apoptosis of cervical cancer cells through endoplasmic reticulum stress-mitochondrial pathway","volume":"30","author":"Qi","year":"2024","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2025.119870_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155224","article-title":"Morroniside improves the symptoms of post-stroke depression in mice through the BDNF signaling pathway mediated by MiR-409-3p","volume":"123","author":"Qian","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib124","doi-asserted-by":"crossref","DOI":"10.3892\/or.2020.7494","article-title":"Catalpol-mediated microRNA-34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer","author":"Qiao","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2025.119870_bib125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.intimp.2015.12.013","article-title":"Pretreatment with the compound asperuloside decreases acute lung injury via inhibiting MAPK and NF-\u03baB signaling in a murine model","volume":"31","author":"Qiu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib126","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12906-020-02951-2","article-title":"Uncovering the active compounds and effective mechanisms of the dried mature sarcocarp of Cornus officinalis Sieb. Et Zucc. For the treatment of Alzheimer's disease through a network pharmacology approach","volume":"20","author":"Qu","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2025.119870_bib127","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1007\/s12035-020-01945-y","article-title":"Mitochondrial dysfunction: a potential therapeutic target to treat alzheimer's disease","volume":"57","author":"Rai","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2025.119870_bib128","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1556\/2060.105.2018.1.8","article-title":"Impact of loganin on pro-inflammatory cytokines and depression- and anxiety-like behaviors in Male diabetic rats","volume":"105","author":"Rajabi","year":"2018","journal-title":"Acta Physiol. Hung."},{"key":"10.1016\/j.jep.2025.119870_bib129","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/diseases12080184","article-title":"Indole-3 carbinol and diindolylmethane mitigated \u03b2-Amyloid-Induced neurotoxicity and acetylcholinesterase enzyme activity: in silico, in vitro, and network pharmacology study","volume":"12","author":"Ramakrishna","year":"2024","journal-title":"Diseases"},{"key":"10.1016\/j.jep.2025.119870_bib130","first-page":"1659","article-title":"Rationale for a multi-factorial approach for the reversal of cognitive decline in alzheimer's disease and MCI: a review","volume":"24","author":"Rao","year":"2023","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.jep.2025.119870_bib131","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1177\/0271678X20951995","article-title":"Regulation of blood\u2013brain barrier integrity by microglia in health and disease: a therapeutic opportunity","volume":"40","author":"Ronaldson","year":"2020","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.jep.2025.119870_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109819","article-title":"Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78","volume":"125","author":"Rong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib133","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1007\/s12035-022-02873-9","article-title":"Cyanidin-3-O-Glucoside regulates the M1\/M2 polarization of microglia via PPAR\u03b3 and A\u03b242 phagocytosis through TREM2 in an alzheimer's disease model","volume":"59","author":"Sanjay","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2025.119870_bib134","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1523\/JNEUROSCI.3581-04.2004","article-title":"M 2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity","volume":"24","author":"Seeger","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2025.119870_bib135","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1415445","article-title":"Catalpol reduced LPS induced BV2 immunoreactivity through NF-\u03baB\/NLRP3 pathways: an in vitro and in silico study","volume":"15","author":"She","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175504","article-title":"Asperuloside alleviates lipid accumulation and inflammation in HFD-Induced NAFLD via AMPK signaling pathway and NLRP3 inflammasome","volume":"942","author":"Shen","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib137","article-title":"Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider","volume":"18","author":"Shen","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib138","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.3390\/nu14153179","article-title":"Cornuside is a potential agent against alzheimer's disease via orchestration of reactive astrocytes","volume":"14","author":"Shi","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.119870_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176002","article-title":"Aucubin inhibits hepatic stellate cell activation through stimulating Nrf2\/Smad7 axis","volume":"957","author":"Shi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109566","article-title":"Monotropein attenuates oxidative stress via Akt\/mTOR-mediated autophagy in osteoblast cells","volume":"121","author":"Shi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib141","first-page":"1037","article-title":"Effects of Aucubin on the healing of oral wounds","volume":"21","author":"Shim","year":"2007","journal-title":"in vivo"},{"key":"10.1016\/j.jep.2025.119870_bib142","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.fct.2012.12.013","article-title":"Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-Induced colitis via NF-\u03baB inactivation","volume":"53","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109625","article-title":"Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE\/RhoA\/ROCK signaling pathway","volume":"348","author":"Shu","year":"2021","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.119870_bib144","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2147\/DNND.S445130","article-title":"A comprehensive review and androgen deprivation therapy and its impact on alzheimer's disease risk in older men with prostate cancer","volume":"14","author":"Singh","year":"2024","journal-title":"DNND"},{"key":"10.1016\/j.jep.2025.119870_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115491","article-title":"LiuweiDihuang improved cognitive functions in SAMP8 mice by inhibiting COX-2 expression and subsequent neuroinflammation","volume":"296","author":"Song","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102404","article-title":"Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury","volume":"55","author":"Song","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.119870_bib147","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1080\/00207454.2018.1435535","article-title":"Effect of aucubin on neural precursor cell survival during neuronal differentiation","volume":"128","author":"Song","year":"2018","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.jep.2025.119870_bib148","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5607\/en.2018.27.2.112","article-title":"Aucubin promotes differentiation of neural precursor cells into GABAergic neurons","volume":"27","author":"Song","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.jep.2025.119870_bib149","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejmech.2018.11.049","article-title":"Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory","volume":"163","author":"Srivastava","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2025.119870_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1115387","article-title":"Radix rehmanniae praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR\/IRS-1\/AKT\/GSK-3\u03b2 signaling pathway and intestinal microbiota","volume":"14","author":"Su","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib151","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18228","article-title":"Geniposidic acid alleviates osteoarthritis progression through inhibiting inflammation and chondrocytes ferroptosis","volume":"28","author":"Sun","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2025.119870_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109492","article-title":"Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis","volume":"120","author":"Sun","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111274","article-title":"Inhibitory effects of catalpol on DNCB-Induced atopic dermatitis and IgE-mediated mast cells reaction","volume":"126","author":"Sun","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib154","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12866","article-title":"Morroniside attenuates high glucose\u2013induced BMSC dysfunction by regulating the Glo1\/AGE\/RAGE axis","volume":"53","author":"Sun","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jep.2025.119870_bib155","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0022-510X(00)00285-9","article-title":"Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains","volume":"175","author":"Sze","year":"2000","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib156","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3389\/fphar.2018.01162","article-title":"Antioxidant and oxidative stress: a mutual interplay in age-related diseases","volume":"9","author":"Tan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib157","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-2006-960062","article-title":"Iridoid glucosides from Penstemon nitidus","volume":"57","author":"Teborg","year":"1991","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2025.119870_bib158","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jep.2017.11.008","article-title":"Oral chronic toxicity study of geniposide in rats","volume":"213","author":"Tian","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib159","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lfs.2006.09.010","article-title":"Catalpol protects dopaminergic neurons from LPS-Induced neurotoxicity in mesencephalic neuron-glia cultures","volume":"80","author":"Tian","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2025.119870_bib160","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/chromsci\/bmu114","article-title":"Separation of catalpol from Rehmannia glutinosa libosch. By high-speed countercurrent chromatography","volume":"53","author":"Tong","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib161","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/DNND.S452009","article-title":"Review of pharmacotherapeutic targets in alzheimer's disease and its management using traditional medicinal plants","volume":"14","author":"Tripathi","year":"2024","journal-title":"DNND"},{"key":"10.1016\/j.jep.2025.119870_bib162","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bioorg.2018.12.017","article-title":"Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory","volume":"85","author":"Tripathi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2025.119870_bib163","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/ptr.6259","article-title":"The novel protective effects of loganin against 1\u2010methyl\u20104\u2010phenylpyridinium\u2010induced neurotoxicity: enhancement of neurotrophic signaling, activation of IGF\u20101R\/GLP\u20101R , and inhibition of RhoA\/ROCK pathway","volume":"33","author":"Tseng","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.119870_bib164","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.phrs.2016.05.023","article-title":"Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt\/mTOR in experimental models of spinal muscular atrophy","volume":"111","author":"Tseng","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119870_bib165","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.3390\/biom13101492","article-title":"The insulin-degrading enzyme from structure to allosteric modulation: new perspectives for drug design","volume":"13","author":"Tundo","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2025.119870_bib166","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2147\/DDDT.S210220","article-title":"Aucubin protects chondrocytes against IL-1\u03b2-Induced apoptosis in vitro and inhibits osteoarthritis in mice model","volume":"13","author":"Wang","year":"2019","journal-title":"DDDT"},{"key":"10.1016\/j.jep.2025.119870_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111312","article-title":"Attenuated memory impairment and neuroinflammation in Alzheimer's disease by aucubin via the inhibition of ERK-FOS axis","volume":"126","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103223","article-title":"Sweroside alleviates pressure overload-induced heart failure through targeting CaMK\u2161\u03b4 to inhibit ROS-Mediated NF-\u03baB\/NLRP3 in cardiomyocytes","volume":"74","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2025.119870_bib169","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fphar.2020.00236","article-title":"Total glycosides of Cistanche deserticola promote neurological function recovery by inducing neurovascular regeneration via Nrf-2\/Keap-1 pathway in MCAO\/R rats","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153300","article-title":"Catalpol protects vascular structure and promotes angiogenesis in cerebral ischemic rats by targeting HIF-1\u03b1\/VEGF","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116273","article-title":"Untargeted metabolomics revealed the mechanism of aucubin on glucocorticoid-induced osteoporosis in mice through modulating arachidonic acid metabolism","volume":"248","author":"Wang","year":"2024","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.119870_bib172","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s10753-021-01473-4","article-title":"Anti-inflammatory effects of sweroside on LPS-induced ALI in mice via activating SIRT1","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.119870_bib173","first-page":"688","article-title":"Catalpol regulates function of hypothalamic-pituitary-adrenocortical-axis in an Alzheimer's disease rat model","volume":"69","author":"Wang","year":"2014","journal-title":"Pharmazie"},{"key":"10.1016\/j.jep.2025.119870_bib174","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.biopha.2014.12.014","article-title":"Catalpol regulates cholinergic nerve system function through effect on choline acetyl-transferase not M receptor affinity","volume":"69","author":"Wang","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbrc.2017.10.054","article-title":"Catalpol suppresses osteosarcoma cell proliferation through blocking epithelial-mesenchymal transition (EMT) and inducing apoptosis","volume":"495","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2025.119870_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155077","article-title":"Cornuside improves murine autoimmune hepatitis through inhibition of inflammatory responses","volume":"120","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib177","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fnagi.2019.00316","article-title":"Catalpol exerts a neuroprotective effect in the MPTP mouse model of parkinson's disease","volume":"11","author":"Wang","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jep.2025.119870_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116208","article-title":"Clinical efficacy and safety of compound congrong Yizhi Capsules on Alzheimer's disease in mainland China: a systematic review with trial sequential analysis and GRADE assessment","volume":"309","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib179","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fnagi.2018.00066","article-title":"Catalpol inhibits Amyloid-\u03b2 generation through promoting \u03b1-Cleavage of APP in Swedish mutant APP overexpressed N2a cells","volume":"10","author":"Wang","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jep.2025.119870_bib247","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.neuroscience.2009.07.041","article-title":"Catalpol ameliorates beta amyloid\u2013induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors","volume":"163","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2025.119870_bib180","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/jcb.27535","article-title":"Catalpol inhibits TGF\u2010\u03b21\u2010induced epithelial\u2010mesenchymal transition in human non\u2013small\u2010cell lung cancer cells through the inactivation of Smad2\/3 and NF\u2010\u03baB signaling pathways","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.119870_bib181","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.biopha.2018.03.094","article-title":"Catalpol inhibits migration and induces apoptosis in gastric cancer cells and in athymic nude mice","volume":"103","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115252","article-title":"Cornuside ameliorates cognitive impairments in scopolamine induced AD mice: involvement of neurotransmitter and oxidative stress","volume":"293","author":"Wang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib183","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3892\/etm.2020.8725","article-title":"Loganin attenuates intestinal injury in severely burned rats by regulating the toll-like receptor 4\/NF-\u03baB signaling pathway","volume":"20","author":"Wen","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2025.119870_bib184","article-title":"Osthole\/Borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP\/PS1 transgenic mice","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib185","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1007\/s11064-022-03641-w","article-title":"Catalpol exerts antidepressant-like effects by enhancing anti-oxidation and neurotrophy and inhibiting neuroinflammation via activation of HO-1","volume":"47","author":"Wu","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2025.119870_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2023.131426","article-title":"Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2\/STAT3 signaling","volume":"395","author":"Xia","year":"2024","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2025.119870_bib187","doi-asserted-by":"crossref","first-page":"69303","DOI":"10.18632\/oncotarget.17951","article-title":"Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2025.119870_bib188","article-title":"Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2\/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model","volume":"27","author":"Xiang","year":"2024","journal-title":"Iranian J. Basic Med. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib189","doi-asserted-by":"crossref","DOI":"10.18632\/aging.103663","article-title":"Inflammatory factors and amyloid \u03b2-induced microglial polarization promote inflammatory crosstalk with astrocytes","author":"Xie","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119870_bib190","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2010.01.048","article-title":"Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum","volume":"167","author":"Xu","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.jep.2025.119870_bib191","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/bph.13720","article-title":"Morroniside, a secoiridoid glycoside from Cornus officinalis , attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors: morroniside produces antihypersensitivity","volume":"174","author":"Xu","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib192","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1002\/jcb.26010","article-title":"Neuroprotective effects of loganin on MPTP\u2010Induced parkinson's disease mice: neurochemistry, glial reaction and autophagy studies","volume":"118","author":"Xu","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.119870_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112183","article-title":"Cornuside alleviates psoriasis-like skin lesions in mice by relieving inflammatory effects","volume":"134","author":"Yan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib194","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.phrs.2017.12.026","article-title":"Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK\/NOX4\/PI3K\/AKT pathway","volume":"130","author":"Yan","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119870_bib195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-150728","article-title":"Morroniside-induced PP2A activation antagonizes Tau hyperphosphorylation in a cellular model of neurodegeneration","volume":"51","author":"Yang","year":"2016","journal-title":"JAD"},{"key":"10.1016\/j.jep.2025.119870_bib196","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1142\/S0192415X22500677","article-title":"Cornel iridoid glycoside and its effective component regulate ATPase Vps4A\/JNK to alleviate autophagy deficit with autophagosome accumulation","volume":"50","author":"Yang","year":"2022","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2025.119870_bib197","first-page":"2790","article-title":"Sweroside prevents non-alcoholic steatohepatitis by suppressing activation of the NLRP3 inflammasome","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.jep.2025.119870_bib198","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110768","article-title":"Verbenalin alleviates acute lung injury induced by sepsis and IgG immune complex through GPR18 receptor","volume":"109","author":"Yang","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jep.2025.119870_bib199","first-page":"1989","article-title":"Optimization of the HPLC fingerprint for Cornus officinalis","volume":"34","author":"Yang","year":"2014","journal-title":"Chin. J. Pharmaceu. Analy."},{"key":"10.1016\/j.jep.2025.119870_bib200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2017.09.016","article-title":"Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice","volume":"189","author":"Yang","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2025.119870_bib201","first-page":"909","article-title":"Geniposide attenuates postischemic long-term potentiation via GluN2A","volume":"34","author":"Yao","year":"2021","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2025.119870_bib202","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jcb.25749","article-title":"Unexpected neuroprotective effects of loganin on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced neurotoxicity and cell death in zebrafish: neuroprotection of loganin against MPTP toxicity","volume":"118","author":"Yao","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.119870_bib203","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainresbull.2008.12.010","article-title":"Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats","volume":"79","author":"Yao","year":"2009","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jep.2025.119870_bib204","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3390\/biom10101360","article-title":"Catalpol ameliorates insulin sensitivity and mitochondrial respiration in skeletal muscle of Type-2 diabetic mice through insulin signaling pathway and AMPK\/SIRT1\/PGC-1\u03b1\/PPAR-\u03b3 activation","volume":"10","author":"Yap","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2025.119870_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116296","article-title":"Geniposide effectively safeguards HT22 cells against A\u03b2-induced damage by activating mitophagy via the PINK1\/Parkin signaling pathway","volume":"226","author":"Ye","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib206","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1056460","article-title":"Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-\u03baB and regulating protein synthesis\/degradation","volume":"13","author":"Yi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib207","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.119870_bib208","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.phrs.2006.01.014","article-title":"Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1\/2 pathways independently","volume":"54","author":"Yu","year":"2006","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119870_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113447","article-title":"Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-\u03baB signaling","volume":"266","author":"Yu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib210","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1002\/ptr.7765","article-title":"Cornuside, by regulating the AGEs\u2010RAGE\u2010I\u03baB\u03b1\u2010ERK1\/2 signaling pathway, ameliorates cognitive impairment associated with brain aging","volume":"37","author":"Yu","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2025.119870_bib211","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106240","article-title":"Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3\/NF-\u043aB pathway","volume":"81","author":"Yuan","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib212","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70079","article-title":"Endothelial dysfunctions in blood\u2013brain barrier breakdown in alzheimer's disease: from mechanisms to potential therapies","volume":"30","author":"Yue","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jep.2025.119870_bib213","article-title":"Morroniside protects against cerebral ischemia\/reperfusion injury by inhibiting neuron apoptosis and MMP2\/9 expression","author":"Zeng","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2025.119870_bib214","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2019.104443","article-title":"A review of the pharmacology and toxicology of aucubin","volume":"140","author":"Zeng","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.119870_bib215","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00726-023-03262-9","article-title":"Sweroside: an iridoid glycoside of potential neuroprotective, antidiabetic, and antioxidant activities supported by molecular docking","volume":"55","author":"Zengin","year":"2023","journal-title":"Amino Acids"},{"key":"10.1016\/j.jep.2025.119870_bib216","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155703","article-title":"Morroniside delays the progression of non-alcoholic steatohepatitis by promoting AMPK-Mediated lipophagy","volume":"129","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib217","unstructured":"Zhang, J., Wang, H., n.d. Morroniside Protects Against Chronic Atrophic Gastritis in."},{"key":"10.1016\/j.jep.2025.119870_bib218","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jep.2017.10.028","article-title":"Morinda officinalis how. \u2013 a comprehensive review of traditional uses, phytochemistry and pharmacology","volume":"213","author":"Zhang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib219","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104319","article-title":"Long-term efficacy of Chinese medicine Bushen Capsule on cognition and brain activity in patients with amnestic mild cognitive impairment","volume":"146","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2025.119870_bib220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/10799893.2020.1837872","article-title":"Morroniside protects HT-22 cells against oxygen-glucose deprivation\/reperfusion through activating the Nrf2\/HO-1 signaling pathway","volume":"42","author":"Zhang","year":"2022","journal-title":"J. Recept. Signal Transduction"},{"key":"10.1016\/j.jep.2025.119870_bib221","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155362","article-title":"Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF\u20131\u03b1\/CXCR4 pathway","volume":"128","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2025.119870_bib222","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1631\/jzus.B2000771","article-title":"Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system","volume":"22","author":"Zhang","year":"2021","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.jep.2025.119870_bib223","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s10753-018-0906-4","article-title":"Protective effects of sweroside on IL-1\u03b2-Induced inflammation in rat articular chondrocytes through suppression of NF-\u03baB and mTORC1 signaling pathway","volume":"42","author":"Zhang","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2025.119870_bib224","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jep.2008.02.018","article-title":"Rehmannia glutinosa: review of botany, chemistry and pharmacology","volume":"117","author":"Zhang","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib225","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1016\/j.fct.2008.05.032","article-title":"d-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol","volume":"46","author":"Zhang","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib226","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fct.2013.04.006","article-title":"Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by d-galactose","volume":"58","author":"Zhang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2025.119870_bib227","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.24272\/j.issn.2095-8137.2023.294","article-title":"Targeting autophagy in Alzheimer's disease: animal models and mechanisms","volume":"44","author":"Zhang","year":"2023","journal-title":"Zool. Res."},{"key":"10.1016\/j.jep.2025.119870_bib228","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110408","article-title":"The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis","volume":"129","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.119870_bib229","first-page":"458","article-title":"Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis","volume":"20","author":"Zhang","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2025.119870_bib230","unstructured":"Zhang, Y., Wang, C., Lu, J., Jin, Y., Xu, C., Meng, Q., Liu, Q., Ma, X., Liu, K., Sun, H., n.d. Targeting of miR-96-5p by Catalpol Ameliorates Oxidative Stress and Hepatic Steatosis in LDLr-\/- Mice via p66shc\/cytochrome C Cascade."},{"key":"10.1016\/j.jep.2025.119870_bib231","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuint.2015.04.002","article-title":"Geniposide attenuates insulin-deficiency-induced acceleration of \u03b2-amyloidosis in an APP\/PS1 transgenic model of Alzheimer's disease","volume":"89","author":"Zhang","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2025.119870_bib232","doi-asserted-by":"crossref","first-page":"536","DOI":"10.18632\/aging.101759","article-title":"Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease","volume":"11","author":"Zhang","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.jep.2025.119870_bib233","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.fitote.2016.03.013","article-title":"Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice","volume":"110","author":"Zhang","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2025.119870_bib234","article-title":"Geniposide protects primary cortical neurons against oligomeric A\u03b21-42-Induced neurotoxicity through a mitochondrial pathway","volume":"11","author":"Zhao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.119870_bib235","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1260674","article-title":"Morroniside induces cardiomyocyte cell cycle activity and promotes cardiac repair after myocardial infarction in adult rats","volume":"14","author":"Zheng","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib236","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-025-01695-w","article-title":"Cornuside alleviates cognitive impairments induced by A\u03b21\u221242 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy","volume":"17","author":"Zhou","year":"2025","journal-title":"Alz. Res. Therapy"},{"key":"10.1016\/j.jep.2025.119870_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117569","article-title":"Neuroprotective effect of the traditional decoction tian-si-yin against Alzheimer's disease via suppression of neuroinflammation","volume":"321","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib238","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.14336\/AD.2018.0815-1","article-title":"Preclinical evidence and possible mechanisms of extracts or compounds from cistanches for alzheimer's disease","volume":"10","author":"Zhou","year":"2019","journal-title":"Aging Disease"},{"key":"10.1016\/j.jep.2025.119870_bib239","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116455","article-title":"Loganin alleviated cognitive impairment in 3\u00d7Tg-AD mice through promoting mitophagy mediated by optineurin","volume":"312","author":"Zhou","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172857","article-title":"Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4\/2 signaling pathway in APP\/PS1 mice","volume":"869","author":"Zhou","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2025.119870_bib241","doi-asserted-by":"crossref","first-page":"306","DOI":"10.21037\/atm.2019.06.25","article-title":"Catalpol May improve axonal growth via regulating miR-124 regulated PI3K\/AKT\/mTOR pathway in neurons after ischemia","volume":"7","author":"Zhu","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jep.2025.119870_bib242","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2147\/DDDT.S223322","article-title":"Catalpol enhances neurogenesis and inhibits apoptosis of new neurons via BDNF, but not the BDNF\/Trkb pathway","volume":"13","author":"Zhu","year":"2019","journal-title":"DDDT"},{"key":"10.1016\/j.jep.2025.119870_bib243","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110711","article-title":"Regulation of renal lipid deposition in diabetic nephropathy on morroniside via inhibition of NF-KB\/TNF-a\/SREBP1c signaling pathway","volume":"385","author":"Zhu","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2025.119870_bib244","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/WNR.0000000000001075","article-title":"Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice","volume":"29","author":"Zhu","year":"2018","journal-title":"Neuroreport"},{"key":"10.1016\/j.jep.2025.119870_bib245","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.2147\/JIR.S439981","article-title":"Aucubin alleviates intervertebral disc degeneration by repressing NF-\u03baB-NLRP3 inflammasome activation in endplate chondrocytes","volume":"16","author":"Zou","year":"2023","journal-title":"JIR"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:56:25Z","timestamp":1762307785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125005549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":247,"alternative-id":["S0378874125005549"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119870","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iridoid glycosides in kidney-tonifying Chinese medicinal herbs: Mechanisms and implications for Alzheimer's disease therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119870"}}