{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:46:33Z","timestamp":1792701993719,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515010720"],"award-info":[{"award-number":["2023A1515010720"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515140045"],"award-info":[{"award-number":["2023A1515140045"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jep.2025.119890","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T02:28:15Z","timestamp":1745634495000},"page":"119890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["p-Synephrine ameliorates non-alcoholic fatty liver disease by regulating liver-adipose axis via AMPK\/NF-kappa B pathway"],"prefix":"10.1016","volume":"348","author":[{"given":"Wei-Feng","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Kui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-2147","authenticated-orcid":false,"given":"Chun-Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1210\/jc.2012-3289","article-title":"Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men","volume":"98","author":"Alligier","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.jep.2025.119890_bib2","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1016\/j.fct.2008.04.037","article-title":"Concentrations of p-synephrine in fruits and leaves of citrus species (Rutaceae) and the acute toxicity testing of citrus aurantium extract and p-synephrine","volume":"46","author":"Arbo","year":"2008","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/nu16020248","article-title":"Citrus p-synephrine improves energy homeostasis by regulating amino acid metabolism in hfd-induced mice","volume":"16","author":"Bai","year":"2024","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2025.119890_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ph15040469","article-title":"Rutaecarpine promotes adipose thermogenesis and protects against hfd-induced obesity via ampk\/pgc-1alpha pathway","volume":"15","author":"Chen","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2025.119890_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.751938","article-title":"Therapeutic targeting of nonalcoholic fatty liver disease by downregulating srebp-1c expression via ampk-klf10 axis","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"3","key":"10.1016\/j.jep.2025.119890_bib6","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.26599\/FSHW.2022.9250134","article-title":"Limosilactobacillus mucosae fzjtz26m3 prevents nafld in mice through modulation of lipid metabolism and gut microbiota dysbiosis","volume":"13","author":"Dang","year":"2024","journal-title":"Food Sci. Human Wellness"},{"issue":"18","key":"10.1016\/j.jep.2025.119890_bib7","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.1039\/D1FO01429C","article-title":"Carotenoids obtained from an ionic liquid-mediated process displa anti-inflammatory response in the adipose tissue-liver axis","volume":"12","author":"de Souza","year":"2021","journal-title":"Food Funct."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.119890_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11010-019-03625-5","article-title":"Insulin-induced de novo lipid synthesis occurs mainly via mtor-dependent regulation of proteostasis of srebp-1c","volume":"463","author":"Dong","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.119890_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118415","article-title":"Artemisia argyi ethanol extract ameliorates nonalcoholic steatohepatitis-induced liver fibrosis by modulating gut microbiota and hepatic signaling","volume":"333","author":"Erdenebileg","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"13","key":"10.1016\/j.jep.2025.119890_bib10","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1039\/D2FO00081D","article-title":"Coffee peel extracts ameliorate non-alcoholic fatty liver disease via a fibroblast growth factor 21-adiponectin signaling pathway","volume":"13","author":"Fan","year":"2022","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.jep.2025.119890_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12933-024-02363-3","article-title":"Metscore: a molecular metric to evaluate the risk of metabolic syndrome based on serum nmr metabolomics","volume":"23","author":"Gil-Redondo","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.jep.2025.119890_bib12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3892\/ijmm.2016.2484","article-title":"Ampk and srebp-1c mediate the anti-adipogenic effect of beta-hydroxyisovalerylshikonin","volume":"37","author":"Ha","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.119890_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-020-00381-6","article-title":"Global epidemiology of nafld-related hcc: trends, predictions, risk factors and prevention","volume":"18","author":"Huang","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2025.119890_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116250","article-title":"Lactobacillus casei-fermented amomum xanthioides mitigates non-alcoholic fatty liver disease in a high-fat diet mice model","volume":"172","author":"Hwang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.jep.2025.119890_bib15","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1039\/D2FO00299J","article-title":"P-synephrine suppresses inflammatory responses in lipopolysaccharide-stimulated raw264.7 cells and alleviates systemic inflammatory response syndrome in mice","volume":"13","author":"Ishida","year":"2022","journal-title":"Food Funct."},{"issue":"36","key":"10.1016\/j.jep.2025.119890_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh0140","article-title":"Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet","volume":"9","author":"Iuso","year":"2023","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.jep.2025.119890_bib17","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1080\/10408398.2020.1746234","article-title":"In-vivo biotransformation of citrus functional components and their effects on health","volume":"61","author":"Karn","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2025.119890_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-024-01837-w","article-title":"Unraveling the role of mettl14 in metabolic dysfunction-associated fatty liver disease: insights and therapeutic implications","volume":"9","author":"Kim","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"19","key":"10.1016\/j.jep.2025.119890_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu14194019","article-title":"The safety and efficacy of citrus aurantium (bitter Orange) extracts and p-synephrine: a systematic review and meta-analysis","volume":"14","author":"Koncz","year":"2022","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jep.2025.119890_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biom11121764","article-title":"Combined anti-adipogenic effects of hispidulin and p-synephrine on 3t3-l1 adipocytes","volume":"11","author":"Lee","year":"2021","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.jep.2025.119890_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/nu14102164","article-title":"Phytochemical combination (p-synephrine, p-octopamine hydrochloride, and hispidulin) for improving obesity in Obese mice induced by high-fat diet","volume":"14","author":"Lee","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2025.119890_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153550","article-title":"Therapeutic effect of oxyberberine on Obese non-alcoholic fatty liver disease rats","volume":"85","author":"Li","year":"2021","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2025.119890_bib23","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.fshw.2022.03.025","article-title":"Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism- and inflammation-related gene expression","volume":"11","author":"Li","year":"2022","journal-title":"Food Sci. Human Wellness"},{"issue":"Pt 1","key":"10.1016\/j.jep.2025.119890_bib24","article-title":"Eriodictyol regulates white adipose tissue browning and hepatic lipid metabolism in high fat diet-induced obesity mice via activating ampk\/sirt1 pathway","volume":"337","author":"Lin","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.119890_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/nu15081813","article-title":"Casein hydrolysate alleviates adipose chronic inflammation in high fat-diet induced obese c57bl\/6j mice through mapk pathway","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1039\/D3FO03572G","article-title":"Hepatoprotective efficacy and interventional mechanism of the panaxadiol saponin component in high-fat diet-induced nafld mice","volume":"15","author":"Mi","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2025.119890_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154661","article-title":"Diosgenin attenuates non-alcoholic fatty liver disease in type 2 diabetes through regulating sirt6-related fatty acid uptake","volume":"111","author":"Nie","year":"2023","journal-title":"Phytomedicine"},{"issue":"16","key":"10.1016\/j.jep.2025.119890_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165731","article-title":"Metabolic and molecular mechanisms of macrophage polarisation and adipose tissue insulin resistance","volume":"21","author":"Orliaguet","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.jep.2025.119890_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11133649","article-title":"The role of insulin resistance in fueling nafld pathogenesis: from molecular mechanisms to clinical implications","volume":"11","author":"Palma","year":"2022","journal-title":"J. Clin. Med."},{"issue":"13","key":"10.1016\/j.jep.2025.119890_bib30","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1158\/0008-5472.CAN-08-0511","article-title":"Berberine modifies cysteine 179 of ikappabalpha kinase, suppresses nuclear factor-kappab-regulated antiapoptotic gene products, and potentiates apoptosis","volume":"68","author":"Pandey","year":"2008","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jep.2025.119890_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166850","article-title":"Lipodystrophic gene agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in ldlr(-\/-) mice","volume":"1870","author":"Peng","year":"2024","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.jep.2025.119890_bib32","article-title":"Chronic inflammation-a link between nonalcoholic fatty liver disease (nafld) and dysfunctional adipose tissue","volume":"58","author":"Petrescu","year":"2022","journal-title":"Med. Lith."},{"key":"10.1016\/j.jep.2025.119890_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118657","article-title":"Exploring the effect and mechanism of Hippophae rhamnoides L. Triterpenoid acids on improving nafld based on network pharmacology and experimental validation in vivo and in vitro","volume":"335","author":"Ren","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.119890_bib34","article-title":"Nf-kappab signaling and inflammation-drug repurposing to treat inflammatory disorders?","volume":"11","author":"Roberti","year":"2022","journal-title":"Biology-Basel"},{"issue":"1","key":"10.1016\/j.jep.2025.119890_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.jep.2025.119890_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/nu13010233","article-title":"Effects of p-synephrine during exercise: a brief narrative review","volume":"13","author":"Ruiz-Moreno","year":"2021","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.jep.2025.119890_bib37","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1007\/s12011-021-03027-z","article-title":"Oral subacute exposure to cadmium loael dose induces insulin resistance and impairment of the hormonal and metabolic liver-adipose axis in wistar rats","volume":"200","author":"Sarmiento-Ortega","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1091581811435708","article-title":"Toxicological effects of a mixture used in weight loss products: p-synephrine associated with ephedrine, salicin, and caffeine","volume":"31","author":"Schmitt","year":"2012","journal-title":"Int. J. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2025.119890_bib39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.molmet.2017.05.002","article-title":"Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows Down development of a type 2 diabetes-like state","volume":"6","author":"Schommers","year":"2017","journal-title":"Mol. Metabol."},{"issue":"30","key":"10.1016\/j.jep.2025.119890_bib40","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1021\/acs.jafc.7b02244","article-title":"Various antioxidant effects were attributed to different components in the dried blossoms of citrus aurantium L. Var. Amara engl","volume":"65","author":"Shen","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2025.119890_bib41","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jff.2018.05.057","article-title":"Water soluble fraction from ethanolic extract of clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice","volume":"47","author":"Shen","year":"2018","journal-title":"J. Funct.Foods"},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/toxsci\/kfaa042","article-title":"Obesity as a source of endogenous compounds associated with chronic disease: a review","volume":"175","author":"Smith","year":"2020","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2025.119890_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101383","article-title":"Regulation and metabolic significance of de novo lipogenesis in adipose tissues","volume":"10","author":"Song","year":"2018","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.jep.2025.119890_bib44","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.numecd.2014.04.017","article-title":"Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity","volume":"24","author":"Spoto","year":"2014","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"issue":"10","key":"10.1016\/j.jep.2025.119890_bib45","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/ptr.5879","article-title":"Safety, efficacy, and mechanistic studies regarding citrus aurantium (bitter Orange) extract and p-synephrine","volume":"31","author":"Stohs","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jep.2025.119890_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejphar.2018.08.011","article-title":"Induction of beige adipocytes by naturally occurring beta3-adrenoceptor agonist p-synephrine","volume":"836","author":"Takagi","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib47","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/hep.31518","article-title":"Multiple parallel hits hypothesis in nonalcoholic fatty liver disease: revisited after a decade","volume":"73","author":"Tilg","year":"2021","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jep.2025.119890_bib48","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.numecd.2013.12.014","article-title":"Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the predimed study","volume":"24","author":"Tresserra-Rimbau","year":"2014","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"issue":"11","key":"10.1016\/j.jep.2025.119890_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10111694","article-title":"Anti-nafld effect of djulis hull and its major compound, rutin, in mice with high-fat diet (hfd)-induced obesity","volume":"10","author":"Tung","year":"2021","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.jep.2025.119890_bib50","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00125-018-4568-4","article-title":"Prediction of clamp-derived insulin sensitivity from the oral glucose insulin sensitivity index","volume":"61","author":"Tura","year":"2018","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.jep.2025.119890_bib51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2006.04.002","article-title":"Complementary action of the pgc-1 coactivators in mitochondrial biogenesis and brown fat differentiation","volume":"3","author":"Uldry","year":"2006","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.jep.2025.119890_bib52","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1177\/106002809302701019","article-title":"Pharmacy practice and education in the People'S Republic of China","volume":"27","author":"Wang","year":"1993","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.jep.2025.119890_bib53","article-title":"Functional foods and dietary supplements in the management of non-alcoholic fatty liver disease: a systematic review and meta-analysis","volume":"10","author":"Wang","year":"2023","journal-title":"Front. Nutr."},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib54","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/acs.jafc.3c06442","article-title":"Chemical composition and antibacterial and antiulcerative colitis activities of essential oil from pruni semen","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.jep.2025.119890_bib55","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/acs.jafc.3c06442","article-title":"Chemical composition and antibacterial and antiulcerative colitis activities of essential oil from pruni semen","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2025.119890_bib56","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1039\/D2FO03003A","article-title":"P-synephrine ameliorates alloxan-induced diabetes mellitus through inhibiting oxidative stress and inflammation via suppressing the nf-kappa b and mapk pathways","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct."},{"issue":"36","key":"10.1016\/j.jep.2025.119890_bib57","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1039\/D0CC00513D","article-title":"Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (nafld)","volume":"56","author":"Wang","year":"2020","journal-title":"Chem. Commun."},{"issue":"6","key":"10.1016\/j.jep.2025.119890_bib58","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00011-014-0715-7","article-title":"P-synephrine suppresses lipopolysaccharide-induced acute lung injury by inhibition of the nf-kappab signaling pathway","volume":"63","author":"Wu","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2025.119890_bib59","article-title":"Aconiti lateralis radix praeparata total alkaloids exert anti-ra effects by regulating nf-kappab and jak\/stat signaling pathways and promoting apoptosis","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.119890_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154633","article-title":"Improvement of obesity by liupao tea is through the irs-1\/pi3k\/akt\/glut4 signaling pathway according to network pharmacology and experimental verification","volume":"110","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.119890_bib61","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s11658-022-00381-1","article-title":"5-methoxyflavone-induced ampk\u03b1 activation inhibits nf-\u03bab and p38 mapk signaling to attenuate influenza a virus-mediated inflammation and lung injury in vitro and in vivo","volume":"27","author":"Yang","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"6","key":"10.1016\/j.jep.2025.119890_bib62","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11655-017-2810-4","article-title":"Liver-adipose tissue crosstalk: a key player in the pathogenesis of glucolipid metabolic disease","volume":"23","author":"Ye","year":"2017","journal-title":"Chin. J. Integr. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.119890_bib63","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.fshw.2022.03.031","article-title":"Polygonatum sibiricum polysaccharides protect against obesity and non - alcoholic fatty liver disease in rats fed a high - fat diet","volume":"11","author":"Zeng","year":"2022","journal-title":"Food Sci. Human Wellness"},{"issue":"20","key":"10.1016\/j.jep.2025.119890_bib64","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1021\/acs.jafc.3c00952","article-title":"Dietary isoquercetin reduces hepatic cholesterol and triglyceride in nafld mice by modulating bile acid metabolism via intestinal fxr-fgf15 signaling","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jep.2025.119890_bib65","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cmet.2023.03.014","article-title":"Metformin triggers a kidney gdf15-dependent area postrema axis to regulate food intake and body weight","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.119890_bib66","article-title":"Lipidomics reveals the lipid-lowering and hepatoprotective effects of celosia semen on high-fat diet-induced nafld mice","volume":"337","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125005744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:56:48Z","timestamp":1762307808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125005744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":66,"alternative-id":["S0378874125005744"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119890","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p-Synephrine ameliorates non-alcoholic fatty liver disease by regulating liver-adipose axis via AMPK\/NF-kappa B pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"119890"}}