{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:07:23Z","timestamp":1793736443612,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274455"],"award-info":[{"award-number":["82274455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104805"],"award-info":[{"award-number":["82104805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018559","name":"Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program","doi-asserted-by":"publisher","award":["RC200370"],"award-info":[{"award-number":["RC200370"]}],"id":[{"id":"10.13039\/501100018559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of The Peoples Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["2024-JYTCB-045"],"award-info":[{"award-number":["2024-JYTCB-045"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["JYTMS20231828"],"award-info":[{"award-number":["JYTMS20231828"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023-MSLH-147"],"award-info":[{"award-number":["2023-MSLH-147"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jep.2025.119967","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T01:41:10Z","timestamp":1746927670000},"page":"119967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2\/NF-\u03baB axis"],"prefix":"10.1016","volume":"351","author":[{"given":"Zhuo","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanlin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2025.119967_bib1","doi-asserted-by":"crossref","first-page":"7434","DOI":"10.1038\/s41598-024-57300-x","article-title":"Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-\u03b1, NF-\u03baB, and bax","volume":"14","author":"Abd-Eldayem","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2025.119967_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12902-019-0350-y","article-title":"The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism","volume":"19","author":"Al-Khaldi","year":"2019","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.jep.2025.119967_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110797","article-title":"Modulating SIRT1, Nrf2, and NF-\u03baB signaling pathways by bergenin ameliorates the cadmium-induced nephrotoxicity in rats","volume":"387","author":"Alanazi","year":"2024","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib4","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1210\/endo-118-5-1977","article-title":"The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB\/W rat","volume":"118","author":"Allen","year":"1986","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.jep.2025.119967_bib5","article-title":"SIRT1\/Nrf2\/NF-\u03baB signaling mediates anti-inflammatory and anti-apoptotic activities of oleanolic acid in a mouse model of acute hepatorenal damage","volume":"59","author":"Alqrad","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.jep.2025.119967_bib6","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3389\/fimmu.2019.01511","article-title":"Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1\/Nrf2 pathway","volume":"10","author":"Arioz","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.119967_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1353029","article-title":"Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1\/Nrf2\/NF-\u03baB\/TNF-\u03b1 signaling pathways","volume":"15","author":"Botros","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/rej.2022.0023","article-title":"Berberine ameliorates lipopolysaccharide-induced cognitive impairment through SIRT1\/NRF2\/NF-\u03baB signaling pathway in C57BL\/6J mice","volume":"25","author":"Chen","year":"2022","journal-title":"Rejuvenation Res."},{"issue":"19","key":"10.1016\/j.jep.2025.119967_bib9","first-page":"5288","article-title":"effect of buzhong yiqi decoction on treg cells in rats with autoimmune thyroiditis through TGF-\u03b2\/Smad signaling pathway","volume":"49","author":"Chu","year":"2024","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.119967_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.172392","article-title":"SIRT1 alleviates Cd nephrotoxicity through NF-\u03baB\/p65 deacetylation-mediated pyroptosis in rat renal tubular epithelial cells","volume":"929","author":"Dong","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jep.2025.119967_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118237","article-title":"Bu zhong Yiqi Decoction ameliorates mild cognitive impairment by improving mitochondrial oxidative stress damage via the SIRT3\/MnSOD\/OGG1 pathway","volume":"331","author":"Dong","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5603\/ep.100701","article-title":"Autoimmune thyroiditis: an update on treatment possibilities","volume":"75","author":"Dyrka","year":"2024","journal-title":"Endokrynol. Pol."},{"issue":"1","key":"10.1016\/j.jep.2025.119967_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2023.2205051","article-title":"Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1\/Nrf2\/HO-1 pathway","volume":"45","author":"Guo","year":"2023","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.jep.2025.119967_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2020.07.031","article-title":"NF\u03baB promotes oxidative stress-induced necrosis and ischemia\/reperfusion injury by inhibiting Nrf2-ARE pathway","volume":"159","author":"Guo","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.jep.2025.119967_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083806","article-title":"Oxidative stress-induced Sirtuin1 downregulation correlates to HIF-1\u03b1, GLUT-1, and VEGF-A upregulation in Th1 autoimmune hashimoto's thyroiditis","volume":"22","author":"Hepp","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.119967_bib39","doi-asserted-by":"crossref","first-page":"1020709","DOI":"10.3389\/fpubh.2022.1020709","article-title":"Global prevalence and epidemiological trends of Hashimoto\u2019s thyroiditis in adults: A systematic review and meta-analysis","volume":"10","author":"Hu","year":"2022","journal-title":"Front. Public Health"},{"issue":"7","key":"10.1016\/j.jep.2025.119967_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13070868","article-title":"Traditional Chinese medicine for hashimoto's thyroiditis: focus on selenium and antioxidant phytochemicals","volume":"13","author":"Huang","year":"2024","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.jep.2025.119967_bib42","first-page":"1114","article-title":"Research progress of spleen-strengthening and Qi-invigorating herbal medicine in treatment of immune imbalance of autoimmune thyroiditis","volume":"13","author":"Jin","year":"2018","journal-title":"China Medicine"},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib16","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1007\/s12035-016-9893-3","article-title":"Inosine, an endogenous purine nucleoside, suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis: a role for A2A adenosine receptor","volume":"54","author":"Junqueira","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.jep.2025.119967_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/10799893.2021.1905665","article-title":"SIRT1\/NF\u03baB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH)","volume":"42","author":"Komeili-Movahhed","year":"2022","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib18","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/thy.2016.0432","article-title":"Glycyrrhizin, a direct HMGB1 antagonist, ameliorates inflammatory infiltration in a model of autoimmune thyroiditis via inhibition of TLR2-HMGB1 signaling","volume":"27","author":"Li","year":"2017","journal-title":"Thyroid"},{"key":"10.1016\/j.jep.2025.119967_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.taap.2017.12.019","article-title":"Astragaloside IV protects blood-brain barrier integrity from LPS-Induced disruption via activating Nrf2 antioxidant signaling pathway in mice","volume":"340","author":"Li","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.119967_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03baB in oxidative stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr Opin Toxicol"},{"issue":"1","key":"10.1016\/j.jep.2025.119967_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13020-021-00541-z","article-title":"Honokiol alleviates LPS-Induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo","volume":"16","author":"Liu","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.119967_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110494","article-title":"MIF promotes Th17 cell differentiation in hashimoto's thyroiditis by binding HVEM and activating NF-\u03baB signaling pathway","volume":"121","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.119967_bib23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2174\/1386207326666230417120421","article-title":"Based on mRNA sequencing techniques to explore the molecular mechanism of buzhong yiqi decoction for autoimmune thyroiditis","volume":"27","author":"Liu","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"issue":"3","key":"10.1016\/j.jep.2025.119967_bib25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.5114\/aoms.2016.59871","article-title":"Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation","volume":"14","author":"Qiao","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.jep.2025.119967_bib26","first-page":"1","article-title":"The whole blood DNA methylation patterns of extrinsic apoptotic signaling pathway related genes in autoimmune thyroiditis among areas with different iodine levels","author":"Qu","year":"2022","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/08916934.2015.1134506","article-title":"Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease","volume":"49","author":"Sarumaru","year":"2016","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jep.2025.119967_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113170","article-title":"Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function","volume":"231","author":"Shan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2025.119967_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.779177","article-title":"SIRT1: a potential therapeutic target in autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2025.119967_bib30","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.chom.2022.03.028","article-title":"Thymidine starvation promotes c-di-AMP-dependent inflammation during pathogenic bacterial infection","volume":"30","author":"Tang","year":"2022","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.jep.2025.119967_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060918","article-title":"Molecular mechanisms in autoimmune thyroid disease","volume":"12","author":"Vargas-Uricoechea","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.119967_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fendo.2018.00629","article-title":"IL-34 expression is reduced in hashimoto's thyroiditis and associated with thyrocyte apoptosis","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.jep.2025.119967_bib40","first-page":"1424","article-title":"Short-term and long-term effects of modified Buzhong Yiqi decoction on autoantibody levels in Hashimoto\u2019s thyroiditis","volume":"34","author":"Wei","year":"2023","journal-title":"J. Li-shizhen Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.119967_bib33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/kjm2.12310","article-title":"Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-\u03baB pathways via targeting SIRT1","volume":"37","author":"Wu","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.jep.2025.119967_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8798069","article-title":"Calycosin-7-O-\u03b2-D-glucoside attenuates OGD\/R-Induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1\/FOXO1\/PGC-1\u03b1 pathway in HT22 cells","volume":"2019","author":"Yan","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.jep.2025.119967_bib35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.taap.2018.10.024","article-title":"Astragaloside IV regulates differentiation and induces apoptosis of activated CD4(+) T cells in the pathogenesis of experimental autoimmune encephalomyelitis","volume":"362","author":"Yang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.119967_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153211","article-title":"Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-\u03baB inflammatory response via upregulating Sirt1","volume":"69","author":"Yang","year":"2020","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2025.119967_bib37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.14744\/SEMB.2023.95826","article-title":"Higher levels of plasma Fetuin-A, Nrf2, and cytokeratin 18 in patients with hashimoto's disease","volume":"57","author":"Yetim","year":"2023","journal-title":"Sisli Etfal Hastan Tip Bul"},{"issue":"5","key":"10.1016\/j.jep.2025.119967_bib38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.15586\/aei.v52i5.1147","article-title":"Buzhong Yiqi decoction attenuates acquired myasthenia by regulating the JAK2\/STAT3\/AKT signaling pathway, inhibiting inflammation, and improving mitochondrial function","volume":"52","author":"Zeng","year":"2024","journal-title":"Allergol. Immunopathol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412500652X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412500652X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:24:42Z","timestamp":1769689482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412500652X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"alternative-id":["S037887412500652X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.119967","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2\/NF-\u03baB axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.119967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"119967"}}