{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:07:56Z","timestamp":1782835676427,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jep.2025.120039","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T19:17:56Z","timestamp":1748546276000},"page":"120039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Efficacy and safety of Shou Hui Tong Bian capsules in the treatment of functional constipation in middle-aged and elderly patients: A multicenter, randomized, controlled trial"],"prefix":"10.1016","volume":"351","author":[{"given":"Chunhui","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jufang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjiang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2025.120039_bib1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1089\/acu.2013.1007","article-title":"Traditional Chinese medicine as a basis for treating psychiatric disorders: a review of theory with illustrative cases","volume":"25","author":"Aung","year":"2013","journal-title":"Med. Acupunct."},{"key":"10.1016\/j.jep.2025.120039_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113627","article-title":"Shouhui Tongbian capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis","volume":"154","author":"Bai","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2025.120039_bib3","first-page":"298","article-title":"Clinical observation of Shouhui Tongbian capsules in treatment of senile functional fonstipation (deficiency syndrome)","volume":"36","author":"Chen","year":"2021","journal-title":"Drugs Clin."},{"issue":"2","key":"10.1016\/j.jep.2025.120039_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/M16-2977","article-title":"CONSORT extension for Chinese herbal medicine formulas 2017: recommendations, explanation, and elaboration","volume":"167","author":"Cheng","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jep.2025.120039_bib5","series-title":"Pharmacopoeia of the People's Republic of China 2015","year":"2015"},{"issue":"6","key":"10.1016\/j.jep.2025.120039_bib6","first-page":"1257","article-title":"Rome IV-Functional GI disorders: disorders of gut-brain interaction","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology (New York, N. Y., 1943)"},{"issue":"2","key":"10.1016\/j.jep.2025.120039_bib7","first-page":"239","article-title":"Shouhui Tongbian capsule in treatment of constipation: treatment and mechanism development","volume":"16","author":"Gong","year":"2023","journal-title":"Chin. Herb. Med."},{"issue":"12","key":"10.1016\/j.jep.2025.120039_bib8","first-page":"1123","article-title":"Yunchang capsule in treatment of functional constipation: a randomizeddouble-blinded controlled,multicenter trial","volume":"7","author":"Guo","year":"2009","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.jep.2025.120039_bib9","article-title":"Efficacy and safety of Shouhui Tongbian capsules in the treatment of constipation: a systematic review and meta-analysis","volume":"108","author":"Guo","year":"2023","journal-title":"Phytomedicine (Stuttg.)"},{"issue":"3","key":"10.1016\/j.jep.2025.120039_bib10","first-page":"236","article-title":"Constipation: evaluation and management. Mo","volume":"115","author":"Jani","year":"2018","journal-title":"M\u00e9d. Sur"},{"issue":"4","key":"10.1016\/j.jep.2025.120039_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.5056\/jnm20210","article-title":"Medical management of constipation in elderly patients: systematic review","volume":"27","author":"Kang","year":"2021","journal-title":"J. Neurogastroenterol. Motil."},{"issue":"9","key":"10.1016\/j.jep.2025.120039_bib12","first-page":"2268","article-title":"Effects of Shouhui Tongbian capsule on intestine pushing rate and colonic mucus secretion in rats with slow transit constipation","volume":"13","author":"Li","year":"2018","journal-title":"World Chin. Med."},{"key":"10.1016\/j.jep.2025.120039_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115575","article-title":"Chinese patent medicine shouhui tongbian capsule attenuated loperamide-induced constipation through modulating the gut microbiota in rat","volume":"298","author":"Lin","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2025.120039_bib15","first-page":"122","article-title":"Effect of Shouhui Tongbian capsule on serum MTL and SP levels in elderly patients with functional constipation","volume":"4","author":"Liu","year":"2020","journal-title":"Mod. Med. Health Res. Electron. J."},{"issue":"3","key":"10.1016\/j.jep.2025.120039_bib16","article-title":"Understanding traditional Chinese medicine therapeutics: an overview of the basics and clinical applications","volume":"9","author":"Matos","year":"2021","journal-title":"Health Care"},{"issue":"1","key":"10.1016\/j.jep.2025.120039_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpg.2010.12.010","article-title":"Epidemiology of constipation in children and adults: a systematic review","volume":"25","author":"Mugie","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120039_bib18","series-title":"Diagnostic and Therapeutic Criteria for Traditional Chinese Medicine","year":"1994"},{"issue":"5","key":"10.1016\/j.jep.2025.120039_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrgastro.2016.53","article-title":"Diagnosis and management of chronic constipation in adults","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2025.120039_bib20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12906-016-1518-x","article-title":"Quantifying traditional Chinese medicine patterns using modern test theory: an example of functional constipation","volume":"17","author":"Shen","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2025.120039_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114495","article-title":"Shouhui Tongbian capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: with no obvious toxicity","volume":"161","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"18","key":"10.1016\/j.jep.2025.120039_bib13","first-page":"71","article-title":"Effect of Shouhui Tongbian capsules and bifidobacterium triple viable Bacteria Capsules in treatment of senile functional constipation differentiated as deficiency of qi and yin syndrome","volume":"25","author":"Tan","year":"2021","journal-title":"J. Clin. Med. Pract."},{"key":"10.1016\/j.jep.2025.120039_bib22","article-title":"Complementary and alternative therapies for chronic constipation","volume":"2015","author":"Wang","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.jep.2025.120039_bib24","first-page":"13","article-title":"Effect of traditional Chinese medicine external therapy for functional constipation: a meta-analysis","volume":"15","author":"Yan","year":"2023","journal-title":"Am. J. Transl. Res."},{"issue":"3","key":"10.1016\/j.jep.2025.120039_bib25","first-page":"526","article-title":"Molecular mechanism study of Shouhui Tongbian capsules on promotingenergy metabolism of gastrointestinal stromal cells","volume":"46","author":"Zhang","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2025.120039_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115846","article-title":"Synergistic and attenuated effects and molecular biological mechanisms of Shouhui Tongbian capsule in the treatment of slow transit constipation based on UPLC-MS\/MS, network pharmacology and animal experimental validation","volume":"239","author":"Zhang","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2025.120039_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2024.124331","article-title":"Integration of UPLC-MS\/MS-based metabolomics and desorption electrospray ionization-mass spectrometry imaging reveals that Shouhui Tongbian capsule alleviates slow transit constipation by regulating bile acid metabolism","volume":"1247","author":"Zhang","year":"2024","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"issue":"3","key":"10.1016\/j.jep.2025.120039_bib28","first-page":"520","article-title":"Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice","volume":"46","author":"Zheng","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"issue":"7","key":"10.1016\/j.jep.2025.120039_bib29","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.cgh.2018.04.005","article-title":"Efficacy of MaZiRenWan, a Chinese herbal medicine, in patients with functional constipation in a randomized controlled trial","volume":"17","author":"Zhong","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"S2","key":"10.1016\/j.jep.2025.120039_bib30","first-page":"149","article-title":"Observation on the curative effect of Shouhui Tongbian capsule in the treatment of senile functional constipation","volume":"22","author":"Zhou","year":"2019","journal-title":"Chin. Gen. Pract."},{"issue":"18","key":"10.1016\/j.jep.2025.120039_bib31","first-page":"3448","article-title":"Effect of Shouhui Tongbian capsule combined with mosapride on serum SP, MTL, NO levels and quality of life in patients with functional constipation","volume":"21","author":"Zhou","year":"2021","journal-title":"Prog. Mod. Biomed."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125007263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125007263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:16:05Z","timestamp":1769688965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125007263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":30,"alternative-id":["S0378874125007263"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120039","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of Shou Hui Tong Bian capsules in the treatment of functional constipation in middle-aged and elderly patients: A multicenter, randomized, controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"120039"}}