{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:33:10Z","timestamp":1793035990962,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jep.2025.120042","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T02:43:10Z","timestamp":1749782590000},"page":"120042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis"],"prefix":"10.1016","volume":"351","author":[{"given":"Yishu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuokai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120042_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2025.120042_bib2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13880209.2021.1877734","article-title":"Kaempferol suppresses acetaminophen-induced liver damage by upregulation\/activation of SIRT1","volume":"59","author":"BinMowyna","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.120042_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/annrheumdis-2011-200557","article-title":"Autophagy activation by rapamycin reduces severity of experimental osteoarthritis","volume":"71","author":"Caram\u00e9s","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2025.120042_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2025.120042_bib5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41419-021-03508-y","article-title":"SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation","volume":"12","author":"Deng","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2025.120042_bib6","first-page":"376","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthritis. Lancet"},{"key":"10.1016\/j.jep.2025.120042_bib7","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/1759-7714.13925","article-title":"Quercetin induces pro-apoptotic autophagy via SIRT1\/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro","volume":"12","author":"Guo","year":"2021","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.jep.2025.120042_bib8","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/ijms22041742","article-title":"Overview of MMP-13 as a promising target for the treatment of osteoarthritis","volume":"22","author":"Hu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120042_bib9","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/FJC.0000000000000376","article-title":"Protective effects of isorhamnetin on cardiomyocytes against Anoxia\/reoxygenation-Induced injury is mediated by SIRT1","volume":"67","author":"Huang","year":"2016","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.jep.2025.120042_bib10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/03008207.2016.1240790","article-title":"Autophagy in osteoarthritis","volume":"58","author":"Jeon","year":"2017","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.jep.2025.120042_bib11","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/term.3090","article-title":"Saikosaponin D: a potential therapeutic drug for osteoarthritis","volume":"14","author":"Jiang","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.jep.2025.120042_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114515","article-title":"Quercetin activates the Sestrin2\/AMPK\/SIRT1 axis to improve amyotrophic lateral sclerosis","volume":"161","author":"Jin","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120042_bib13","article-title":"SIRT1 promotes host protective immunity against Toxoplasma gondii by controlling the FoxO-Autophagy axis via the AMPK and PI3K\/AKT signalling pathways","volume":"23","author":"Lee","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120042_bib14","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s12276-023-01012-1","article-title":"SIRT1 ubiquitination is regulated by opposing activities of APC\/C-Cdh1 and AROS during stress-induced premature senescence","volume":"55","author":"Lee","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2025.120042_bib15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2025.120042_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.jep.2025.120042_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2025.120042_bib19","article-title":"17\u03b2-Estradiol induces mitophagy upregulation to protect chondrocytes via the SIRT1-Mediated AMPK\/mTOR signaling pathway","volume":"11","author":"Mei","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2025.120042_bib20","doi-asserted-by":"crossref","first-page":"20560","DOI":"10.3390\/ijms160920560","article-title":"Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis","volume":"16","author":"Musumeci","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2025.120042_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Nogales","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.120042_bib22","first-page":"681","article-title":"[precise application of beichaihu and nanchaihu in classical formulas]","volume":"48","author":"She","year":"2023","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2025.120042_bib23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0254-6272(18)30912-9","article-title":"Efficacy and safety of Shaoyang Xibi decoction in patients with knee osteoarthritis: a multi-center, single-blind, randomized controlled trial","volume":"38","author":"Si","year":"2018","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.120042_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.952560","article-title":"The effects of metformin in the treatment of osteoarthritis: current perspectives","volume":"13","author":"Song","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120042_bib25","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.pop.2013.08.003","article-title":"Diagnosis and treatment of osteoarthritis","volume":"40","author":"Taruc-Uy","year":"2013","journal-title":"Prim Care"},{"key":"10.1016\/j.jep.2025.120042_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116129","article-title":"A comprehensive review on traditional and modern research of the genus bupleurum (Bupleurum L., Apiaceae) in recent 10 years","volume":"306","author":"Teng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120042_bib27","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-023-06621-4","article-title":"Apoptotic stress causes mtDNA release during senescence and drives the SASP","volume":"622","author":"Victorelli","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jep.2025.120042_bib28","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.7150\/ijms.53024","article-title":"Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells by promoting autophagy via inhibiting mTOR phosphorylation","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jep.2025.120042_bib29","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.7150\/ijbs.46627","article-title":"The role of autophagy and mitophagy in bone metabolic disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2025.120042_bib30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/jcb.22126","article-title":"Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation","volume":"107","author":"Wong","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2025.120042_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117560","article-title":"An alkaloid from Menispermum dauricum, dauricine mediates Ca2+ influx and inhibits NF-\u03baB pathway to protect chondrocytes from IL-1\u03b2-induced inflammation and catabolism","volume":"321","author":"Xia","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120042_bib32","article-title":"Radix bupleuri: a review of traditional uses, botany, phytochemistry, pharmacology, and toxicology","author":"Yang","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2025.120042_bib33","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120042_bib34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/13880209.2016.1262433","article-title":"A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications","volume":"55","author":"Yuan","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2025.120042_bib35","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.joca.2015.06.014","article-title":"SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis","volume":"23","author":"Zhang","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.jep.2025.120042_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpha.2023.09.001","article-title":"The potential of herbal drugs to treat heart failure: the roles of Sirt1\/AMPK","volume":"14","author":"Zhang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jep.2025.120042_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116306","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125007299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125007299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:13:20Z","timestamp":1769688800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125007299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":36,"alternative-id":["S0378874125007299"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120042","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120042"}}