{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:05:39Z","timestamp":1792008339019,"version":"4.4.0"},"reference-count":284,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460925"],"award-info":[{"award-number":["82460925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["24YFFA067"],"award-info":[{"award-number":["24YFFA067"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017702","name":"Innovation and Entrepreneurship Talent Project of Lanzhou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009620","name":"Gansu Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011529","name":"Support Program for Longyuan Youth and Fundamental Research Funds for the Universities of Gansu Province","doi-asserted-by":"publisher","award":["2024QNGR53"],"award-info":[{"award-number":["2024QNGR53"]}],"id":[{"id":"10.13039\/501100011529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jep.2025.120128","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:49:29Z","timestamp":1749656969000},"page":"120128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Research progress on the regulation of interstitial cell of Cajal autophagy and apoptosis crosstalk by traditional Chinese medicine in gastrointestinal motility disorders"],"prefix":"10.1016","volume":"351","author":[{"given":"Lumei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaxicao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1312-2513","authenticated-orcid":false,"given":"Zhigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol. Cell Biol."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib2","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.7314\/APJCP.2013.14.12.7537","article-title":"Terpinen-4-ol induces autophagic and apoptotic cell death in human leukemic HL-60 cells","volume":"14","author":"Banjerdpongchai","year":"2013","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"10.1016\/j.jep.2025.120128_bib3","series-title":"From the Changes of Colonic ICC and AQP3 in Rats with Slow Transit Constipation to Explore the Mechanism of Wenyang Yiqi Prescription in Improving Constipation","author":"Ben-Sheng","year":"2019"},{"issue":"15","key":"10.1016\/j.jep.2025.120128_bib4","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/s41388-020-1212-9","article-title":"The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production","volume":"39","author":"Bessou","year":"2020","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib5","first-page":"528","article-title":"Baicalin inhibits inflammation and apoptosis of interstitial cells of cajal by targeting the NF-\u03baB-mediated AMPK\/Erk\/Akt pathway in an ulcerative colitis rat model","volume":"42","author":"Bi","year":"2021","journal-title":"Neuroendocrinol. Lett."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/bbb\/zbab189","article-title":"20(S)-Ginsenoside Rh2-induced apoptosis and protective autophagy in cervical cancer cells by inhibiting AMPK\/mTOR pathway","volume":"86","author":"Bian","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.33549\/physiolres.933947","article-title":"Coupling activation of pro-apoptotic caspases with autophagy in the Meckel\u2032s cartilage","volume":"68","author":"B\u00edlikov\u00e1","year":"2019","journal-title":"Physiol. Res."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094374","article-title":"Inhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic death","volume":"9","author":"Bosnjak","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040678","article-title":"PINK1 protects against staurosporine-induced apoptosis by interacting with Beclin1 and impairing its pro-apoptotic cleavage","volume":"11","author":"Brunelli","year":"2022","journal-title":"Cells"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2025.120128_bib10","first-page":"S103","article-title":"Disorders of interstitial cells of cajal","volume":"45","author":"Burns","year":"2007","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241202","article-title":"Efficacy of banxia xiexin decoction for chronic atrophic gastritis: a systematic review and meta-analysis","volume":"15","author":"Cao","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib12","article-title":"Apoptosis-50 years after its discovery","volume":"11","author":"Capela","year":"2023","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib13","first-page":"1721","article-title":"Effects of banxia xiexin decoction on therapeutic efficacy andintestinal flora in elderly patients with diabetic gastroparesis","volume":"30","author":"Chang","year":"2024","journal-title":"Geriatrics & Health Care"},{"issue":"9","key":"10.1016\/j.jep.2025.120128_bib14","first-page":"1102","article-title":"The effect of total glucosides of Paeonia lactiflora on apoptosis of interstitial cells of cajal and serum inflammatory factors in rats with intestinal ischemia-reperfusion","volume":"28","author":"Che","year":"2024","journal-title":"Chin. J. Lab. Diagnosis"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib15","first-page":"1190","article-title":"Forty-two cases of functional dyspepsia in children treated with hovenia jianpi xiaopi granules in combination with conventional Western medicine","volume":"30","author":"Chen","year":"2023","journal-title":"Chinese Journal of Traditional Medical Science and Technology"},{"key":"10.1016\/j.jep.2025.120128_bib16","unstructured":"Chen, L., Gu, T., Huang, X., Qu, X., Effect of xiangsha liujunzi decoction combined with xiaochaihu decoction on serum inflammatory factors and gastrointestinal hormone levels in patients with acute gastritis(syndrome of liver depression and spleen deficiency). Journal of Liaoning University of Traditional Chinese Medicine, 1-10."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083904","article-title":"Electroacupuncture at ST36 ameliorates gastric emptying and rescues networks of interstitial cells of cajal in the stomach of diabetic rats","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib18","first-page":"741","article-title":"Studies on interstitial cells of cajal of melanosis coli caused by rhubarb","volume":"24","author":"Chen","year":"2016","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine Digestion"},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib20","first-page":"26","article-title":"A clinical study of \u201cWen Yang Yi Qi Ke Li\" and Western MedicineTreatment to 38 cases of diabetic gastroparesis","volume":"50","author":"Chen","year":"2018","journal-title":"Jiangsu Journal of Traditional Chinese Medicine"},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib22","first-page":"468","article-title":"The mechanism of tongxie yaofang in the treatment of diarrheal irritable bowel syndrome by inducing autophagy through PI3K-AKT pathway","volume":"16","author":"Chen","year":"2021","journal-title":"World Journal of Integrated Traditional and Western Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11655-021-3297-6","article-title":"Protective effect of tangshen formula ( ) on interstitial cells of cajal in Colon of diabetic rats","volume":"28","author":"Chen","year":"2022","journal-title":"Chin. J. Integr. Med."},{"issue":"Pt 6","key":"10.1016\/j.jep.2025.120128_bib24","article-title":"Effect of in vitro digestion and fermentation of kiwifruit pomace polysaccharides on structural characteristics and human gut microbiota","volume":"253","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2025.120128_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112393","article-title":"Tangshen formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism","volume":"188","author":"Chen","year":"2024","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jep.2025.120128_bib28","article-title":"Zengye decoction regulated the expression of aquaporin in Colon tissue of rats with constipation through miR-10a-5p targeting Drd2\/AC\/cAMP axis","volume":"18876","author":"Chen","year":"2025","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.jep.2025.120128_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.917739","article-title":"A Fenton-like cation can improve arsenic trioxide treatment of sclerodermatous chronic graft-versus-host disease in mice","volume":"13","author":"Ch\u00eane","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2025.120128_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1149869","article-title":"Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine HOCl-induced model of systemic sclerosis","volume":"14","author":"Ch\u00eane","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3892\/ol.2020.11979","article-title":"Outcomes of resection for hepatocellular carcinoma with macroscopic bile duct tumour thrombus: a propensity score matched study","volume":"20","author":"Chi","year":"2020","journal-title":"Oncol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.jep.2025.120128_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1582-4934.2008.00403.x","article-title":"Receptor tyrosine and MAP kinase are involved in effects of H(2)O(2) on interstitial cells of cajal in murine intestine","volume":"14","author":"Choi","year":"2010","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib33","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/jcmm.17087","article-title":"Hyperpolarization-activated cyclic nucleotide-gated channels working as pacemaker channels in colonic interstitial cells of cajal","volume":"26","author":"Choi","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2025.120128_bib34","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.toxrep.2016.10.009","article-title":"Silica nanoparticles induce endoplasmic reticulum stress response and activate mitogen activated kinase (MAPK) signalling","volume":"3","author":"Christen","year":"2016","journal-title":"Toxicol. Rep."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib36","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1080\/15548627.2023.2229656","article-title":"The autophagic protein FYCO1 controls TNFRSF10\/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)","volume":"19","author":"Coppola","year":"2023","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib37","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"issue":"29","key":"10.1016\/j.jep.2025.120128_bib38","first-page":"89","article-title":"Clinical study on removing blood stasis and promoting bowel movements decoction in improvement of intestinal motility of patients with slow transit constipation","volume":"10","author":"Dai","year":"2024","journal-title":"Smart Healthcare"},{"issue":"26","key":"10.1016\/j.jep.2025.120128_bib39","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.3748\/wjg.v23.i26.4724","article-title":"Jianpi qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of cajal","volume":"23","author":"Dai","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120128_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1588786","article-title":"Zengye decoction attenuated severe acute pancreatitis complicated with acute kidney injury by modulating the gut microbiome and serum amino acid metabolome","volume":"2022","author":"Dai","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib41","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00192-015-2632-x","article-title":"Changes in hyperpolarization-activated cyclic nucleotide-gated channel expression and activity in bladder interstitial cells of cajal from rats with detrusor overactivity","volume":"26","author":"Deng","year":"2015","journal-title":"Int Urogynecol J"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib42","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1142\/S0192415X17500392","article-title":"Acupuncture ameliorates postoperative ileus via IL-6-miR-19a-KIT axis to protect interstitial cells of cajal","volume":"45","author":"Deng","year":"2017","journal-title":"Am. J. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/0964528419829755","article-title":"Acupuncture protects the interstitial cells of cajal by regulating miR-222 in a rat model of post-operative ileus","volume":"37","author":"Deng","year":"2019","journal-title":"Acupunct. Med."},{"issue":"48","key":"10.1016\/j.jep.2025.120128_bib45","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","article-title":"JNK signaling in apoptosis","volume":"27","author":"Dhanasekaran","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2025.120128_bib46","series-title":"The Function and Mechanism of Zisheng Decoction on Slow Transit Constipation","author":"Ding","year":"2023"},{"key":"10.1016\/j.jep.2025.120128_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154700","article-title":"Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K\/AKT\/mTOR pathway in diabetic kidney disease","volume":"112","author":"Dong","year":"2023","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib48","first-page":"31","article-title":"Treatment of diabetes with diarrhoea by zisheng tang: 21 cases","author":"Du","year":"1993","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12102972","article-title":"Therapeutic potential of PI3K\/AKT\/mTOR pathway in gastrointestinal stromal tumors: Rationale and progress","volume":"12","author":"Duan","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib50","article-title":"Tumor necrosis factor alpha derived from classically activated \"M1\" macrophages reduces interstitial cell of cajal numbers","volume":"29","author":"Eisenman","year":"2017","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2025.120128_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2022.104814","article-title":"Phloretin enhances autophagy by impairing AKT activation and inducing JNK-Beclin-1 pathway activation","volume":"127","author":"Fan","year":"2022","journal-title":"Exp. Mol. Pathol."},{"issue":"23","key":"10.1016\/j.jep.2025.120128_bib52","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1021\/acs.jcim.3c00954","article-title":"Molecular insights into the MLCK activation by CaM","volume":"63","author":"Fang","year":"2023","journal-title":"J. Chem. Inf. Model."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib53","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1158\/1055-9965.EPI-21-0361","article-title":"Reproducibility, temporal variability, and concordance of serum and fecal bile acids and short chain fatty acids in a population-based study","volume":"30","author":"Farhat","year":"2021","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"11","key":"10.1016\/j.jep.2025.120128_bib54","first-page":"817","article-title":"Observation on the effect of integrating Chinese and Western medicine in constipation due to opioids in elderly patients","volume":"55","author":"Feng","year":"2020","journal-title":"Zhejiang Journal of Traditional Chinese Medicine"},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jep.2025.120128_bib56","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuropharm.2016.08.024","article-title":"Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease","volume":"111","author":"Filpa","year":"2016","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/15548627.2021.1909406","article-title":"How autophagy controls the intestinal epithelial barrier","volume":"18","author":"Foerster","year":"2022","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124540","article-title":"Understanding the biology of human interstitial cells of cajal in gastrointestinal motility","volume":"21","author":"Foong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib59","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s00383-023-05467-1","article-title":"Interstitial cells of cajal: clinical relevance in pediatric gastrointestinal motility disorders","volume":"39","author":"Friedmacher","year":"2023","journal-title":"Pediatr. Surg. Int."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib60","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4240\/wjgs.v12.i5.226","article-title":"Effect of cholesterol on in vitro cultured interstitial Cajal-like cells isolated from Guinea pig gallbladders","volume":"12","author":"Fu","year":"2020","journal-title":"World J. Gastrointest. Surg."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib62","first-page":"40","article-title":"Clinical study on modified xiangsha liujunzi decoction for reflux esophagitis with syndrome of middle-energizer deficiency and Qi counterflow","volume":"57","author":"Gan","year":"2025","journal-title":"New Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1315402","article-title":"Moringa oleifera leaf alleviates functional constipation via regulating the gut microbiota and the enteric nervous system in mice","volume":"14","author":"Gao","year":"2023","journal-title":"Front. Microbiol."},{"issue":"23","key":"10.1016\/j.jep.2025.120128_bib64","first-page":"112","article-title":"Clinical effect observation of modified cyperus and amomum with six noble ingredients decoction combined with acupoint moxibustion for gastrointestinal neuropathy of diabetes","volume":"10","author":"Ge","year":"2024","journal-title":"Smart Healthcare"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib65","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1365-2982.2010.01590.x","article-title":"Changes in interstitial cells of cajal with age in the human stomach and Colon","volume":"23","author":"Gomez-Pinilla","year":"2011","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2025.120128_bib66","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.dib.2016.02.085","article-title":"mRNA and protein dataset of autophagy markers (LC3 and p62) in several cell lines","volume":"7","author":"G\u00f3mez-S\u00e1nchez","year":"2016","journal-title":"Data Brief"},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib67","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1111\/jgh.15994","article-title":"METTL3 contributes to slow transit constipation by regulating miR-30b-5p\/PIK3R2\/Akt\/mTOR signaling Cascade through DGCR8","volume":"37","author":"Gong","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib68","first-page":"239","article-title":"Shouhui tongbian capsule in treatment of constipation: treatment and mechanism development","volume":"16","author":"Gong","year":"2024","journal-title":"Chin Herb Med"},{"key":"10.1016\/j.jep.2025.120128_bib69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pharmthera.2017.02.019","article-title":"Modulation of the TRPV4 ion channel as a therapeutic target for disease","volume":"177","author":"Grace","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2025.120128_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.655048","article-title":"From cell death to regeneration: rebuilding after injury","volume":"9","author":"Guerin","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib71","first-page":"270","article-title":"Effects of shuwei decoction on the expressions of Beclin-1, mTOR, Cx43 protein and mRNA in gastrointestinal smooth muscle of rats with functional dyspepsia due to liver depression and spleen deficiency","volume":"40","author":"Guo","year":"2018","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2025.120128_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113489","article-title":"Diverse role of gut microbiota on reduction of ascites and intestinal injury in malignant ascites effusion rats treated with Euphorbia kansui stir-fried with vinegar","volume":"267","author":"Guo","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120128_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154541","article-title":"Efficacy and safety of shouhui tongbian capsules in the treatment of constipation: a systematic review and meta-analysis","volume":"108","author":"Guo","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib74","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12964-025-02104-3","article-title":"p53-regulated SESN1 and SESN2 regulate cell proliferation and cell death through control of STAT3","volume":"23","author":"Haidurov","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"24","key":"10.1016\/j.jep.2025.120128_bib75","first-page":"2357","article-title":"Effect of citrus flavonoids tablets combined with endovascular interventional therapy on deep venous thrombosis of lower extremities and its influence on ultrasonic elastography parameters of patients","volume":"45","author":"Han","year":"2024","journal-title":"Journal of Qiqihar Medical University"},{"issue":"26","key":"10.1016\/j.jep.2025.120128_bib76","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.2174\/138161210793176464","article-title":"The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; A systematic review","volume":"16","author":"Hasani-Ranjbar","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib77","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jcmgh.2020.07.011","article-title":"Wnt-induced, TRP53-mediated cell cycle arrest of precursors underlies interstitial cell of cajal depletion during aging","volume":"11","author":"Hayashi","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib78","first-page":"45","article-title":"Meta-analysis of clinical efficacy of baizhu qiwu granules combined with acupuncture in treatment of slow transit constipation","volume":"47","author":"He","year":"2013","journal-title":"Journal of Shanxi University of Chinese Medicine"},{"issue":"20","key":"10.1016\/j.jep.2025.120128_bib79","first-page":"6575","article-title":"The function of hyperpolarization-activated cyclic nucleotide-gated channel in diabetic cystopathy","volume":"22","author":"He","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib80","first-page":"2928","article-title":"Study on the effect of electricity on the expression of autophagy-related proteins in interstitial cell of cajal of Colon in rats with slow-transit constipation","volume":"23","author":"He","year":"2021","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib81","first-page":"411","article-title":"[research progress of mechanisms of acupuncture in treating slow transit constipation]","volume":"48","author":"He","year":"2023","journal-title":"Zhen Ci Yan Jiu"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2025.120128_bib82","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.genm.2009.03.004","article-title":"Do fluctuations in ovarian hormones affect gastrointestinal symptoms in women with irritable bowel syndrome?","volume":"6","author":"Heitkemper","year":"2009","journal-title":"Gend. Med."},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.120128_bib83","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1113\/jphysiol.2004.075168","article-title":"Heteromeric KCNE2\/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells","volume":"561","author":"Heitzmann","year":"2004","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib84","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41589-020-00726-x","article-title":"VCP\/p97 regulates Beclin-1-dependent autophagy initiation","volume":"17","author":"Hill","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib85","first-page":"1849","article-title":"The clinical efficacy of jianpi yishen zengye decoction combined with conventional treatment in elderly patients with chronic functional constipation","volume":"45","author":"Su","year":"2023","journal-title":"Chinese Patent Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib86","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib87","first-page":"639","article-title":"Effects of electroacupuncture on autophagy signaling pathway of gastric antrum interstitial cells of cajal in diabetic gastroparesis rats","volume":"39","author":"hua","year":"2023","journal-title":"Chin. J. Pathophysiol."},{"key":"10.1016\/j.jep.2025.120128_bib88","article-title":"Emodin repairs interstitial cells of cajal damaged by cholelithiasis in the gallbladder","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib89","first-page":"391","article-title":"[role of platelet-derived growth factor receptor \u03b1 positive cells in purinergic inhibitory nerve-smooth muscle transmission]","volume":"72","author":"Huang","year":"2020","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.jep.2025.120128_bib91","article-title":"Molecular mechanism of the effect of zhizhu pill on gastroesophageal reflux disease based on network pharmacology and molecular docking","volume":"2022","author":"Huang","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib93","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/15548627.2022.2064624","article-title":"Acetylation of SCFD1 regulates SNARE complex formation and autophagosome-lysosome fusion","volume":"19","author":"Huang","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2025.120128_bib95","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ymeth.2024.02.004","article-title":"Design, in silico evaluation, and in vitro verification of new bivalent smac mimetics with pro-apoptotic activity","volume":"224","author":"Huang","year":"2024","journal-title":"Methods"},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib97","first-page":"1238","article-title":"Yiqi wenyang tongfu method in treatment of multiple organ DysfunctionSyndrome complicated with gastrointestinal dysfunction","volume":"36","author":"Huang Feibo","year":"2018","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib98","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50707","article-title":"Correction: proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation","volume":"8","author":"Hung","year":"2019","journal-title":"eLife"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib99","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/19768354.2020.1746398","article-title":"Hesperidin depolarizes the pacemaker potentials through 5-HT(4) receptor in murine small intestinal interstitial cells of cajal","volume":"24","author":"Hwang","year":"2020","journal-title":"Anim. Cell Syst."},{"key":"10.1016\/j.jep.2025.120128_bib100","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022110","article-title":"Banxia xiexin decoction in the treatment of chronic atrophic gastritis: a protocol for systematic review and meta-analysis","volume":"99","author":"Ji","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib101","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.945624","article-title":"Hesperidin promotes gastric motility in rats with functional dyspepsia by regulating Drp1-mediated ICC mitophagy","volume":"13","author":"Jia","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120128_bib102","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.molimm.2024.09.013","article-title":"Pharmacodynamic and pharmacokinetic study of shaoyao gancao decoction for repairing intestinal barrier damage in ulcerative colitis","volume":"175","author":"Jia","year":"2024","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib103","doi-asserted-by":"crossref","first-page":"G203","DOI":"10.1152\/ajpgi.00144.2019","article-title":"Role of estrogen and stress on the brain-gut axis","volume":"317","author":"Jiang","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"13","key":"10.1016\/j.jep.2025.120128_bib104","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1021\/acs.jafc.1c00140","article-title":"The crosstalk between autophagy and apoptosis is necessary for myogenic differentiation","volume":"69","author":"Jiang","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.120128_bib106","article-title":"Structure characterization of polysaccharides from Cistanche deserticola and their neuroprotective effects against oxidative stress in slow transit constipation mice","volume":"260","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib107","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1758-5996-5-12","article-title":"Curcumin improves expression of SCF\/c-kit through attenuating oxidative stress and NF-\u03baB activation in gastric tissues of diabetic gastroparesis rats","volume":"5","author":"Jin","year":"2013","journal-title":"Diabetol. Metab. Syndr."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib108","first-page":"5","article-title":"Study on the mechanism of baizhu qiwu granules on regulating PI3K\/AKT\/m TOR pathway and inhibiting cajal interstitial cell apoptosis in the treatment of slow transit constipation","volume":"25","author":"jing","year":"2023","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib109","first-page":"21","article-title":"Effects of chaihu shugan powder on the apoptosis of gastrointestinal ICCs in rats with gastrointestinal dysfunction","volume":"33","author":"ju","year":"2020","journal-title":"Western Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1540\/jsmr.59.1","article-title":"Interstitial cells of cajal in gastrointestinal inflammatory diseases","volume":"59","author":"Kaji","year":"2023","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.jep.2025.120128_bib111","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.phrs.2016.07.030","article-title":"Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of cajal during inflammation","volume":"111","author":"Kaji","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"17","key":"10.1016\/j.jep.2025.120128_bib112","article-title":"Banxia xiexin tang for gastro-oesophageal reflux disease: a protocol for a systematic review of controlled trials","volume":"97","author":"Kang","year":"2018","journal-title":"MEDICINE -BALTIMORE-"},{"key":"10.1016\/j.jep.2025.120128_bib113","series-title":"Clinical Observation on the Therapeutic Effect of QishiShengjiang Guiyuan Granule on Gastroesophageal Reflux Diseasebased on the Real World","author":"Ke","year":"2023"},{"issue":"20","key":"10.1016\/j.jep.2025.120128_bib114","first-page":"1563","article-title":"Meta-analysis of the effectiveness of painful diarrhoea essential formula plus combined with acupuncture in the treatment of irritable bowel syndrome","volume":"24","author":"Ke","year":"2024","journal-title":"Health Protection and Promotion"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.imr.2017.02.001","article-title":"Naringenin inhibits pacemaking activity in interstitial cells of cajal from murine small intestine","volume":"6","author":"Kim","year":"2017","journal-title":"Integr Med Res"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib116","doi-asserted-by":"crossref","first-page":"470","DOI":"10.14348\/molcells.2019.0028","article-title":"The mechanism of action of ghrelin and motilin in the pacemaker potentials of interstitial cells of cajal from the murine small intestine","volume":"42","author":"Kim","year":"2019","journal-title":"Mol. Cells"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib117","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bcp.2014.01.027","article-title":"Role of Bcl-xL\/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death","volume":"88","author":"Kim","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"22","key":"10.1016\/j.jep.2025.120128_bib118","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260790","article-title":"Expanding roles of BCL-2 proteins in apoptosis execution and beyond","volume":"136","author":"King","year":"2023","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib119","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1152\/ajpregu.00339.2018","article-title":"Combined effects of cholecystokinin-8 and gastric distension on food intake in humans","volume":"317","author":"Kissileff","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jep.2025.120128_bib120","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/ncomms2626","article-title":"Interstitial cells of cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity","volume":"4","author":"Klein","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2025.120128_bib121","series-title":"Experimental Study on Xiao Fu Tong Jie Fang in Promoting Repair of Enteric Nervous System Network Structure in Slow Transit Constipation Rats","author":"Kong","year":"2019"},{"key":"10.1016\/j.jep.2025.120128_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.826916","article-title":"Digital therapeutics care utilizing genetic and gut microbiome signals for the management of functional gastrointestinal disorders: results from a preliminary retrospective study","volume":"13","author":"Kumbhare","year":"2022","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.jep.2025.120128_bib123","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.tcb.2018.06.007","article-title":"Rab GTPase function in endosome and lysosome biogenesis","volume":"28","author":"Langemeyer","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jep.2025.120128_bib124","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jep.2015.05.025","article-title":"The traditional herbal medicine, ge-gen-tang, inhibits pacemaker potentials by nitric oxide\/cGMP dependent ATP-Sensitive K(+) channels in cultured interstitial cells of cajal from mouse small intestine","volume":"170","author":"Lee","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.jep.2025.120128_bib125","first-page":"38","article-title":"Clinical observation on 126 cases of functional dyspepsia treated with painful diarrhoea essentials formula plus flavour","volume":"3","author":"Lei","year":"2011","journal-title":"Clinical Journal of Chinese Medicine"},{"issue":"7330","key":"10.1016\/j.jep.2025.120128_bib126","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib127","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease Cascade","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib128","first-page":"210","article-title":"[Effect of Zhizhu Pill on Gastric Smooth Muscle Contractile Response and Protein Expression of Growth Hormone Secretagogue Receptor in Functional Dyspepsia Rats]","volume":"36","author":"Li","year":"2016","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.jep.2025.120128_bib129","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.gene.2018.11.099","article-title":"Knockdown MTMR14 promotes cell apoptosis and inhibits migration in liver cancer cells","volume":"691","author":"Li","year":"2019","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib130","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12331","article-title":"Atractylenolide-1 alleviates gastroparesis in diabetic rats by activating the stem cell factor\/c-kit signaling pathway","volume":"24","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib131","article-title":"Effectiveness of acupuncture for the recovery of gastrointestinal function of patients with gastric cancer in the postoperative period: a protocol for systematic review and meta-analysis","volume":"100","author":"Li","year":"2021","journal-title":"Medicine (Baltim.)"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib132","first-page":"7","article-title":"Meta-analysis of painful diarrhoea essentials formula in the treatment of ulcerative colitis","volume":"31","author":"Li","year":"2022","journal-title":"J. Emerg. Tradit. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib133","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1080\/21655979.2022.2054501","article-title":"Long non-coding RNA MEG3 promotes tumor necrosis factor-alpha induced oxidative stress and apoptosis in interstitial cells of cajal via targeting the microRNA-21\/I-kappa-B-kinase beta axis","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib134","doi-asserted-by":"crossref","DOI":"10.3390\/nu14122413","article-title":"Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer cells by activating the NGFR-AMPK-mTOR pathway","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/13880209.2023.2166966","article-title":"Chaihu shugan powder promotes gastric motility in rats with functional dyspepsia by regulating Drp-1-mediated ICC mitophagy","volume":"61","author":"Li","year":"2023","journal-title":"Pharm. Biol."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib138","first-page":"272","article-title":"Effect of shou-hui tongbian capsules on intestinal function in mice withpostoperative ileus","volume":"36","author":"Li","year":"2024","journal-title":"Chin. J. Microecol."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib140","first-page":"150","article-title":"Bioinformatics and animal experiments reveal mechanism of shouhui tongbian capsules in treating constipation","volume":"31","author":"Liang","year":"2025","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib141","first-page":"150","article-title":"Bioinformatics and animal experiments reveal mechanism of ShouhuiTongbian capsules in treating constipation","volume":"31","author":"Liang Yong","year":"2025","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib142","first-page":"1669","article-title":"Clinical effect of xiangsha liujunzi tang combined with warm acupuncture in the treatment of chronic atrophic gastritis with spleen and stomach deficiency and cold syndrome","volume":"37","author":"Liao","year":"2024","journal-title":"The Journal of Medical Theory and Practice"},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib143","article-title":"The interventional effects of qishishengjiangguiyuan granules on rats with gastroesophageal reflux disease (GERD) and the possible mechanisms","volume":"51","author":"Li","year":"2024","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib144","first-page":"608","article-title":"Research progress of interstitial cells of cajal in gastrointestinal motility disorders","volume":"30","author":"Liu","year":"2022","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine on Digestion"},{"key":"10.1016\/j.jep.2025.120128_bib145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/B978-0-12-394274-6.00003-0","article-title":"Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance","volume":"117","author":"Liu","year":"2013","journal-title":"Adv. Cancer Res."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib146","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.apsb.2020.12.003","article-title":"The Ca(2+)-activated chloride channel ANO1\/TMEM16A: an emerging therapeutic target for epithelium-originated diseases?","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib147","first-page":"1048","article-title":"Research progress on the molecular mechanism of electroacupuncture at \"zusanli\" (ST36) for regulating gastrointestinal dysfunction","volume":"48","author":"Liu","year":"2023","journal-title":"Zhen Ci Yan Jiu"},{"issue":"18","key":"10.1016\/j.jep.2025.120128_bib148","first-page":"4977","article-title":"[molecular mechanism of xiangsha liujunzi decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology]","volume":"49","author":"Liu","year":"2024","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"19","key":"10.1016\/j.jep.2025.120128_bib150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194940","article-title":"The regulatory role of MicroRNAs in breast cancer","volume":"20","author":"Loh","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib151","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.3390\/cimb45040232","article-title":"Interstitial cells of cajal and enteric nervous system in gastrointestinal and neurological pathology, relation to oxidative stress","volume":"45","author":"L\u00f3pez-Pingarr\u00f3n","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib152","first-page":"529","article-title":"Study on mechanism of the regulation of mitochondrial autophagy by hewei liqi decoction on gastrointestinal motility disorders in functional dyspepsia based on PINK1\/Parkin pathway","volume":"44","author":"Lu","year":"2023","journal-title":"Journal of Air Force Medical University"},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib153","first-page":"408","article-title":"Mechanism of shengxue tongbian granules in treating slow transit constipation based on network pharmacology and experimental validation","volume":"44","author":"Luo","year":"2024","journal-title":"Journal of Hunan University of Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib35","doi-asserted-by":"crossref","first-page":"3177201","DOI":"10.1155\/2022\/3177201","article-title":"A Prospective Study of Using Chaihu Shugan Powder Combined with Zu San Li Acupoint Stimulation to Improve the Prognosis of Liver Stagnation and Qi Stagnation Syndrome in Acute Pancreatitis","volume":"2022","author":"Lu","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2025.120128_bib154","unstructured":"Lv, M., Duan, Y., Jin, J., Shao, W., Wu, Q., Tian, Y., Bai, M., Cheng, Y., Mechanism of xiangsha liujunzi decoction in improving autophagy in interstitial cells of cajal of rats with functional dyspepsia by regulation of IRE1\/ASK1\/JNK pathway. China J. Chin. Mater. Med., 1\u20139."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib155","first-page":"341","article-title":"Clinical efficacy of traditional Chinese medicine and Western medicine combined on pelvic achalasia constipation","volume":"42","author":"Ma","year":"2017","journal-title":"J. Guangxi Med. Univ."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib156","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/sj.emboj.7601689","article-title":"Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1","volume":"26","author":"Maiuri","year":"2007","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib157","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1053\/j.gastro.2020.10.066","article-title":"The microbiota-gut-brain axis: from motility to mood","volume":"160","author":"Margolis","year":"2021","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib158","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.cmet.2017.09.020","article-title":"System-wide benefits of intermeal fasting by autophagy","volume":"26","author":"Martinez-Lopez","year":"2017","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib159","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00428-009-0739-5","article-title":"Apoptosis of interstitial cells of cajal, smooth muscle cells, and enteric neurons induced by intestinal ischemia and reperfusion injury in adult Guinea pigs","volume":"454","author":"Mei","year":"2009","journal-title":"Virchows Arch."},{"key":"10.1016\/j.jep.2025.120128_bib160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4020-6554-5_4","article-title":"Apoptotic pathways in tumor progression and therapy","volume":"615","author":"Melet","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib161","first-page":"1056","article-title":"Study of huayu tongbian decoction's effects on cajal cells and protein expression in constipated rats","volume":"33","author":"Meng","year":"2022","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib162","first-page":"130","article-title":"Hedysari radix polysaccharide regulates apoptosis of smooth muscle cells in gastric antrum of rat model of diabetic gastroparesis via IGF-1\/PI3K\/Akt signaling pathway","volume":"30","author":"Miao","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"9","key":"10.1016\/j.jep.2025.120128_bib163","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034165","article-title":"Use of bioelectronics in the gastrointestinal tract","volume":"9","author":"Miller","year":"2019","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib164","first-page":"1376","article-title":"Clinical observation on the jianpi xiaopi decoction combined with acupoint application in the treatment of gastroesophageal reflux cough","volume":"40","author":"Mingping","year":"2023","journal-title":"Journal of Guangzhou University of Traditional Chinese Medicine"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib165","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/MED.0000000000000707","article-title":"Gastrointestinal hormones and regulation of gastric emptying","volume":"29","author":"Mori","year":"2022","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib166","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/pro.3519","article-title":"The molecular details of cytokine signaling via the JAK\/STAT pathway","volume":"27","author":"Morris","year":"2018","journal-title":"Protein Sci."},{"issue":"11","key":"10.1016\/j.jep.2025.120128_bib167","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011254","article-title":"MAP kinase pathways","volume":"4","author":"Morrison","year":"2012","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib168","first-page":"89","article-title":"Sex difference in irritable bowel syndrome: do gonadal hormones play a role?","volume":"17","author":"Mulak","year":"2010","journal-title":"Gastroenterol. Pol."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib169","doi-asserted-by":"crossref","DOI":"10.3390\/cells11101712","article-title":"Colonic fluid and electrolyte transport 2022: an update","volume":"11","author":"Negussie","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120128_bib170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-16-2830-6_1","article-title":"The classification and basic processes of autophagy","volume":"1208","author":"Nie","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"25","key":"10.1016\/j.jep.2025.120128_bib171","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1038\/sj.onc.1202581","article-title":"Caspases: the proteases of the apoptotic pathway","volume":"17","author":"Nu\u00f1ez","year":"1998","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib172","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/cmdc.200800246","article-title":"Peptides and peptide mimics as modulators of apoptotic pathways","volume":"4","author":"Orz\u00e1ez","year":"2009","journal-title":"ChemMedChem"},{"issue":"16","key":"10.1016\/j.jep.2025.120128_bib173","first-page":"1407","article-title":"Effect of electroacupuncture \u201cZusanli (ST36)\u201d on autophagy of gastric antrum cajal interstitial cells in functional dyspepsia model rats","volume":"60","author":"Pan","year":"2019","journal-title":"J. Tradit. Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib174","first-page":"486","article-title":"[electroacupuncture at \"Zusanli\"(ST36) promotes gastrointestinal motility possibly by suppres-sing excessive autophagy via AMPK\/ULK1 signaling in rats with functional dyspepsia]","volume":"44","author":"Pan","year":"2019","journal-title":"Zhen Ci Yan Jiu"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib175","doi-asserted-by":"crossref","first-page":"C606","DOI":"10.1152\/ajpcell.00045.2015","article-title":"Setting the pace for GI motility: ryanodine receptors and IP3 receptors within interstitial cells of cajal. Focus on \"Intracellular Ca2+ release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal\"","volume":"308","author":"Pappas","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib176","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00039.2011","article-title":"Structure and function of TMEM16 proteins (anoctamins)","volume":"94","author":"Pedemonte","year":"2014","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib177","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.abb.2011.03.009","article-title":"Regulation of gastrointestinal motility by Ca2+\/calmodulin-stimulated protein kinase II","volume":"510","author":"Perrino","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2025.120128_bib178","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijbiomac.2022.02.005","article-title":"Beclin1-mediated interplay between autophagy and apoptosis: new understanding","volume":"204","author":"Prerna","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib179","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11655-010-0539-4","article-title":"Morphological changes in network of enteric nerve-interstitial cells of Cajal-smooth muscle cells in rats with multiple organ dysfunction syndrome and therapeutic effects of dachengqi decoction (\u5927\u627f\u6c14\u6c64)","volume":"16","author":"Qi","year":"2010","journal-title":"Chin. J. Integr. Med."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib180","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jep.2013.01.029","article-title":"Chaihu-shugan-san, an oriental herbal preparation, for the treatment of chronic gastritis: a meta-analysis of randomized controlled trials","volume":"146","author":"Qin","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120128_bib181","series-title":"Network Pharmacology and Molecular Docking Study of Zhishi-Baizhu Herb Pair in the Treatment of Gastric Cancer","author":"Qu","year":"2021"},{"issue":"21","key":"10.1016\/j.jep.2025.120128_bib182","doi-asserted-by":"crossref","first-page":"eadg8156","DOI":"10.1126\/sciadv.adg8156","article-title":"Mitophagy restricts BAX\/BAK-independent, Parkin-mediated apoptosis","volume":"9","author":"Quarato","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jep.2025.120128_bib183","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.821344","article-title":"JAK\/STAT signaling: molecular targets, therapeutic opportunities, and limitations of targeted inhibitions in solid malignancies","volume":"13","author":"Rah","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib184","first-page":"893","article-title":"[Post-stroke constipation treated with acupuncture therapy of regulating qi circulation of fu-organ]","volume":"33","author":"Ren","year":"2013","journal-title":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib185","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20187065","article-title":"TNF-\u03b1 inhibits SCF, ghrelin, and substance P expressions through the NF-\u03baB pathway activation in interstitial cells of cajal","volume":"51","author":"Ren","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib186","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00383-007-2022-7","article-title":"Interstitial cells of cajal in the normal gut and in intestinal motility disorders of childhood","volume":"23","author":"Rolle","year":"2007","journal-title":"Pediatr. Surg. Int."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib187","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molcel.2011.10.014","article-title":"The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis","volume":"44","author":"Rubinstein","year":"2011","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib188","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/dna.2013.2089","article-title":"Simulated microgravity contributes to autophagy induction by regulating AMP-Activated protein kinase","volume":"33","author":"Ryu","year":"2014","journal-title":"DNA Cell Biol."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib189","first-page":"176","article-title":"c-FLIP, a master anti-apoptotic regulator","volume":"34","author":"Safa","year":"2012","journal-title":"Exp. Oncol."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib190","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1365-2982.1999.00164.x","article-title":"Development and plasticity of interstitial cells of cajal","volume":"11","author":"Sanders","year":"1999","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib191","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1152\/physiol.00006.2016","article-title":"Regulation of gastrointestinal smooth muscle function by interstitial cells","volume":"31","author":"Sanders","year":"2016","journal-title":"Physiology"},{"key":"10.1016\/j.jep.2025.120128_bib192","article-title":"Interstitial cells of cajal - pacemakers of the gastrointestinal tract","author":"Sanders","year":"2023","journal-title":"J Physiol."},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2024.102410","article-title":"Modified zhizhu pill improves the loperamide-induced slow transit constipation via gut microbiota and neurotransmitters in microbiota-gut-brain axis","volume":"48","author":"Shen","year":"2024","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib194","first-page":"122","article-title":"80 cases of paediatric anorexia nervosa treated with zisheng decoction","author":"Shi","year":"1991","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib195","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.3892\/mmr.2016.5689","article-title":"Regulation of the pacemaker activities in cultured interstitial cells of cajal by citrus unshiu peel extracts","volume":"14","author":"Shim","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib196","first-page":"34","article-title":"Observation of the clinical efficacy of modified shaoyao gancao tang combined with ear acupoint embedding for elderly functional constipation patients with intestinal dryness and fluid deficiency","volume":"45","author":"Shuqi Zhao","year":"2024","journal-title":"Shanghai Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib197","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-021-05078-y","article-title":"Efficacy of modified banxia xiexin decoction in the management of Wei-Pi syndrome (postprandial distress syndrome): study protocol for a randomized, waitlist-controlled trial","volume":"22","author":"Sin","year":"2021","journal-title":"Trials"},{"issue":"18","key":"10.1016\/j.jep.2025.120128_bib198","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1113\/jphysiol.2014.277152","article-title":"Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of cajal","volume":"592","author":"Singh","year":"2014","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib199","doi-asserted-by":"crossref","first-page":"947","DOI":"10.14309\/ajg.0000000000001767","article-title":"The role of food in the treatment of bowel disorders: focus on irritable bowel syndrome and functional constipation","volume":"117","author":"Singh","year":"2022","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib200","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.clinthera.2017.01.005","article-title":"Factors affecting gastrointestinal absorption of levothyroxine: a review","volume":"39","author":"Skelin","year":"2017","journal-title":"Clin. Ther."},{"issue":"9","key":"10.1016\/j.jep.2025.120128_bib201","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091479","article-title":"Crosstalk of autophagy and apoptosis","volume":"11","author":"Sorice","year":"2022","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.jep.2025.120128_bib202","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41575-023-00794-z","article-title":"Irritable bowel syndrome and mental health comorbidity - approach to multidisciplinary management","volume":"20","author":"Staudacher","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib203","doi-asserted-by":"crossref","first-page":"170","DOI":"10.21037\/atm-23-6","article-title":"Laxative effect of wenyang yiqi decoction on loperamide-induced astriction model mice","volume":"11","author":"Su","year":"2023","journal-title":"Ann. Transl. Med."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib204","doi-asserted-by":"crossref","first-page":"G283","DOI":"10.1152\/ajpgi.00223.2020","article-title":"Intestinal dysmotility after bowel resection in rats is associated with decreased ghrelin and vimentin expression and loss of intestinal cells of cajal","volume":"320","author":"Sukhotnik","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib205","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082125","article-title":"Calcium signaling regulates autophagy and apoptosis","volume":"10","author":"Sukumaran","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120128_bib206","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2023.102997","article-title":"Acupuncture as an adjunctive therapy for gastric ulcer: a modified Delphi consensus study","volume":"79","author":"Sun","year":"2023","journal-title":"Compl. Ther. Med."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib207","first-page":"2134","article-title":"Clinical study on the effect of rhubarb on inflammatory factors in patients with acute pancreatitis","volume":"32","author":"Sun","year":"2023","journal-title":"J. Emerg. Tradit. Chin. Med."},{"issue":"9","key":"10.1016\/j.jep.2025.120128_bib208","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1113\/JP275478","article-title":"The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach","volume":"596","author":"Sung","year":"2018","journal-title":"J. Physiol."},{"issue":"19","key":"10.1016\/j.jep.2025.120128_bib209","doi-asserted-by":"crossref","DOI":"10.1172\/JCI171955","article-title":"Mechanosensing piezo channels in gastrointestinal disorders","volume":"133","author":"Swain","year":"2023","journal-title":"J. Clin. Investig."},{"issue":"20","key":"10.1016\/j.jep.2025.120128_bib210","doi-asserted-by":"crossref","first-page":"28821","DOI":"10.18632\/oncotarget.8936","article-title":"Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids","volume":"7","author":"Swiader","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib211","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ueg2.12097","article-title":"The gastrointestinal tract in hunger and satiety signalling","volume":"9","author":"Tack","year":"2021","journal-title":"United European Gastroenterol J"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib212","first-page":"1532","article-title":"Establishment of autophagy model of rat gastric interstitial cells of cajal induced by glutamic acid","volume":"34","author":"Tan","year":"2018","journal-title":"Chin. J. Pathophysiol."},{"key":"10.1016\/j.jep.2025.120128_bib213","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7318616","article-title":"Effect of chaihu shugan powder-contained serum on glutamate-induced autophagy of interstitial cells of cajal in the rat gastric antrum","volume":"2019","author":"Tan","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib214","first-page":"34","article-title":"Effect of cajal interstitial cell apoptosis induced by high cholesterol on cholesterol gallstone disease","volume":"3","author":"Tan","year":"2020","journal-title":"Bachu Medical Journal"},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib215","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1080\/15548627.2021.1995150","article-title":"LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization","volume":"18","author":"Tanaka","year":"2022","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib216","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1002\/jcp.26272","article-title":"MicroRNA-497 accelerates apoptosis while inhibiting proliferation, migration, and invasion through negative regulation of the MAPK\/ERK signaling pathway via RAF-1","volume":"233","author":"Tao","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"19","key":"10.1016\/j.jep.2025.120128_bib217","first-page":"120","article-title":"Efficacy of zhizhuwan decoction and its ingredient-contained serums on proliferation and apoptosis of rat Colon interstitial cells of cajal","volume":"26","author":"Teng","year":"2020","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120128_bib218","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2022.110261","article-title":"Effect of iodinated radiographic contrast media on radioimmunoassay for measuring thyroid hormones","volume":"185","author":"Thumvijit","year":"2022","journal-title":"Appl. Radiat. Isot."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib219","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082029","article-title":"Physcion induces potential anticancer effects in cervical cancer cells","volume":"10","author":"Trybus","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib220","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.immuni.2020.04.010","article-title":"Caspase-8-Dependent inflammatory responses are controlled by its adaptor, FADD, and necroptosis","volume":"52","author":"Tummers","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2025.120128_bib221","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.exer.2015.11.003","article-title":"Involvement of the extrinsic and intrinsic pathways in ultraviolet B-induced apoptosis of corneal epithelial cells","volume":"145","author":"Ubels","year":"2016","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib222","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1128\/JVI.01726-09","article-title":"Caspase 9 is essential for Herpes simplex virus type 2-induced apoptosis in T cells","volume":"84","author":"Vanden Oever","year":"2010","journal-title":"J. Virol."},{"issue":"Pt 3","key":"10.1016\/j.jep.2025.120128_bib223","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1113\/jphysiol.2007.140608","article-title":"Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice","volume":"584","author":"Vanneste","year":"2007","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib224","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2694","article-title":"Signal integration by JNK and p38 MAPK pathways in cancer development","volume":"9","author":"Wagner","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib225","first-page":"1393","article-title":"Mechanism of saikosaponin D mediating autophagy in ICCs by regulating CaMKK\u03b2\/AMPK signaling pathway","volume":"26","author":"Wan","year":"2024","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib242","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2174\/0115748928265981231204044653","article-title":"Tyrosine kinase inhibitor lenvatinib causes cardiotoxicity by inducing endoplasmic reticulum stress and apoptosis through activating ATF6, IRE1\u03b1 and PERK signaling pathways","volume":"20","author":"Wang","year":"2025","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.jep.2025.120128_bib226","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114473","article-title":"Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK\/mTOR\/ULK1 pathway","volume":"161","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib227","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3892\/ijo.2014.2259","article-title":"The IL-6\/JAK\/STAT3 pathway: potential therapeutic strategies in treating colorectal cancer","volume":"44","author":"Wang","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jep.2025.120128_bib228","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3389\/fphar.2018.00841","article-title":"System pharmacology-based strategy to decode the synergistic mechanism of zhi-Zhu wan for functional dyspepsia","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib229","first-page":"7","article-title":"Regulative effect of rhubarb dispensing granule on autophagy and gastrointestinal motility of cajal interstitial cells in rats with chronic transit constipation","volume":"43","author":"Wang","year":"2021","journal-title":"Int. J. Translat. Community Med."},{"key":"10.1016\/j.jep.2025.120128_bib230","article-title":"Gastric electrical pacing reduces apoptosis of interstitial cells of cajal via antioxidative stress effect attributing to phenotypic polarization of M2 macrophages in diabetic rats","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2025.120128_bib231","article-title":"Electroacupuncture regularizes gastric contraction and reduces apoptosis of interstitial cells of cajal in diabetic rats","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib232","first-page":"579","article-title":"Effect of miR-129-3p on autophagy of interstitial cells of cajal in slow transit constipation through SCF C-kit signaling pathway","volume":"69","author":"Wang","year":"2022","journal-title":"Acta Biochim. Pol."},{"issue":"22","key":"10.1016\/j.jep.2025.120128_bib235","first-page":"3180","article-title":"Effect of jianpi xiaopi prescription combined with massage on gastrointestinal motility and autophagy of interstitial cells of cajal in anorexia","volume":"18","author":"Wang","year":"2023","journal-title":"World Chinese Medicine"},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib239","first-page":"2407","article-title":"Clinical observation of modified xiao chengqi decoction as an adjuvant treatment for mild acute pancreatitis","volume":"40","author":"Wang","year":"2024","journal-title":"Journal of Practical Traditional Chinese Medicine"},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib240","first-page":"43","article-title":"Efficacy and safety of shouhui tongbian capsule in the treatment of abdominal distension in type 2 diabetes patients after oral acarbose","volume":"19","author":"Wang","year":"2024","journal-title":"China Journal of Pharmaceutical Economics"},{"key":"10.1016\/j.jep.2025.120128_bib241","article-title":"Efficacy and safety of xiangsha liujunzi decoction for functional dyspepsia: a systematic review and meta-analysis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120128_bib243","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117695","article-title":"Chaihu shugan powder inhibits interstitial cells of cajal mitophagy through USP30 in the treatment of functional dyspepsia","volume":"323","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"000","key":"10.1016\/j.jep.2025.120128_bib244","first-page":"11","article-title":"Effect of chaihu-shugan-san on functional dyspepsia and gut microbiota: a randomized, double-blind, placebo-controlled trial","volume":"322","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120128_bib245","article-title":"Electroacupuncture relieves suppression of autophagy in interstitial cells of cajal of diabetic gastroparesis rats","volume":"2020","author":"Wei","year":"2020","journal-title":"Chin. J. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib246","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1007\/s12035-024-03958-3","article-title":"Total flavonoids of aurantii fructus immaturus regulate miR-5100 to improve constipation by targeting Fzd2 to alleviate calcium balance and autophagy in interstitial cells of cajal","volume":"61","author":"Wen","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib247","first-page":"2478","article-title":"Study on the mechanism of P2X7-ICC autophagy balance in visceral hypersensitivity of diarrhea-predominant irritable bowel syndrome rats treated with electroacupuncture","volume":"35","author":"Weng","year":"2024","journal-title":"Lishizhen Medicine and Materia Medica"},{"issue":"7692","key":"10.1016\/j.jep.2025.120128_bib248","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature25486","article-title":"Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis","volume":"554","author":"Wong","year":"2018","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.jep.2025.120128_bib249","first-page":"4882","article-title":"Clinical therapy of zisheng decoction recipe for chronic atrophic gastritis with intestinal metaplasia","volume":"42","author":"Wu","year":"2017","journal-title":"China J. Chin. Mater. Med."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib250","first-page":"6691","article-title":"Occurrence of substance P and neurokinin receptors during the early phase of spinal fusion","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib251","doi-asserted-by":"crossref","DOI":"10.3892\/or.2022.8423","article-title":"The role of interaction between autophagy and apoptosis in tumorigenesis","volume":"48","author":"Xi","year":"2022","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib252","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/med.21772","article-title":"The regulatory factors and pathological roles of autophagy-related protein 4 in diverse diseases: recent research advances","volume":"41","author":"Xia","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jep.2025.120128_bib253","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109556","article-title":"Hexokinase inhibitor 2-deoxyglucose coordinates citrullination of vimentin and apoptosis of fibroblast-like synoviocytes by inhibiting HK2\/mTORC1-induced autophagy","volume":"114","author":"Xian","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib254","first-page":"306","article-title":"Forty cases of diabetic gastroparesis treated with jianpixiaopi soup","volume":"36","author":"Xiao","year":"2015","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2025.120128_bib255","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/584179","article-title":"Electroacupuncture regulates apoptosis\/proliferation of intramuscular interstitial cells of cajal and restores colonic motility in diabetic constipation rats","volume":"2013","author":"Xu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib256","first-page":"6","article-title":"Clinical effect of shengxue tongbian granules in treatment of gastrointestinal function injury with blood deficiency and intestinal dryness caused by sepsis","volume":"38","author":"Xu","year":"2022","journal-title":"Hunan Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib257","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6236904","article-title":"Aqueous extracts of herba cistanche promoted intestinal motility in loperamide-induced constipation rats by ameliorating the interstitial cells of cajal","volume":"2017","author":"Yan","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2025.120128_bib258","volume":"vol. 5","author":"Yan","year":"2020"},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib259","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.21037\/apm-20-280","article-title":"Metabolomics study on the therapeutic effect of the Chinese herb pair fructus aurantii immaturus and rhizoma atractylodis macrocephalae in constipated rats based on UPLC-Q\/TOF-MS analysis","volume":"9","author":"Yan","year":"2020","journal-title":"Ann. Palliat. Med."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib260","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.joim.2020.04.005","article-title":"Suppressive effect of aurantii fructus immaturus and atractylodis macrocephalae rhizoma on glutamic acid-induced autophagy of interstitial cells of cajal","volume":"18","author":"Yan","year":"2020","journal-title":"J Integr Med"},{"key":"10.1016\/j.jep.2025.120128_bib261","article-title":"Modified chaihu shugan powder for functional dyspepsia: meta-analysis for randomized controlled trial","volume":"2013","author":"Yang","year":"2013","journal-title":"Evidence-Based Complementray and Alternative Medicine"},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib262","first-page":"49","article-title":"Role of interstitial cells of cajal apoptosis in the pathogenesis of hirschsprung's disease and its cognate diseases","volume":"15","author":"Yang","year":"2016","journal-title":"Journal of Clinical Pediatric Surgery"},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib263","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170776","article-title":"Impaired insulin\/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of cajal","volume":"37","author":"Yang","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2025.120128_bib264","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.biopha.2018.04.072","article-title":"Inhibition of PI3K\/Akt\/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells","volume":"103","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2025.120128_bib265","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106842","article-title":"Efficacy and safety of total glucosides of paeony in the treatment of 5 types of inflammatory arthritis: a systematic review and meta-analysis","volume":"195","author":"Yang","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib266","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13020-024-01015-8","article-title":"Integrated serum pharmacochemistry, 16S rDNA sequencing, and metabolomics to reveal the material basis and mechanism of shouhui tongbian capsule against diphenoxylate-induced slow transit constipation in rats","volume":"19","author":"Yang","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2025.120128_bib267","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.913420","article-title":"Based on network pharmacology and gut microbiota analysis to investigate the mechanism of the laxative effect of pterostilbene on loperamide-induced slow transit constipation in mice","volume":"13","author":"Yao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib268","first-page":"679","article-title":"Randomized controlled trial of tongxie yaofang combined with turtle-shell-partitioned moxibustion and Meridian massage in the treatment of irritable bowel syndrome with diarrhea","volume":"28","author":"Yao","year":"2024","journal-title":"Frontiers in Pharmaceutical Sciences"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib269","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0254-6272(14)60067-4","article-title":"Effect of banxiaxiexin tang on treatment of functional dyspepsia: a meta-analysis of randomized controlled trials","volume":"34","author":"Yongkang","year":"2014","journal-title":"J. Tradit. Chin. Med."},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib270","first-page":"524","article-title":"Influence of acupuncture and moxibustion on gastrointestinal function and adverse events in gastric cancer patients after surgery and chemotherapy: a meta-analysis","volume":"32","author":"Yu","year":"2024","journal-title":"Support. Care Cancer"},{"issue":"3","key":"10.1016\/j.jep.2025.120128_bib271","first-page":"90","article-title":"Clinical value of increasing and decreasing of zishen decoction in the treatment of patients with chronic atrophic gastritis combined with HP infection","volume":"28","author":"Yuan","year":"2021","journal-title":"Journal of Rare and Uncommon Diseases"},{"key":"10.1016\/j.jep.2025.120128_bib272","article-title":"Efficacy and safety of modified banxia xiexin decoction (pinellia decoction for draining the heart) for gastroesophageal reflux disease in adults: a systematic review and meta-analysis","volume":"2017","author":"Yunkai","year":"2017","journal-title":"Evidence-Based Complementray and Alternative Medicine"},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib273","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2174\/0113862073262404231004053116","article-title":"Effects of saikosaponin D on apoptosis, autophagy, and morphological structure of intestinal cells of cajal with functional dyspepsia","volume":"27","author":"Zeng","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib274","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41420-022-01015-3","article-title":"Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway","volume":"8","author":"Zhan","year":"2022","journal-title":"Cell Death Discov."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib275","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.freeradbiomed.2011.02.031","article-title":"Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis","volume":"50","author":"Zhang","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib276","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/cbin.10604","article-title":"Autophagy regulates the apoptosis of bone marrow-derived mesenchymal stem cells under hypoxic condition via AMP-Activated protein kinase\/mammalian target of rapamycin pathway","volume":"40","author":"Zhang","year":"2016","journal-title":"Cell Biol. Int."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib277","first-page":"1527","article-title":"Systematic evaluation and meta-analysis of tongxieyaofang and Western medicine treatment for ulcerative colitis","volume":"28","author":"Zhang","year":"2017","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib280","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/bab.1635","article-title":"Investigation of autophagy and differentiation of myenteric interstitial cells of cajal in the pathogenesis of gastric motility disorders in rats with functional dyspepsia","volume":"65","author":"Zhang","year":"2018","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"10","key":"10.1016\/j.jep.2025.120128_bib281","first-page":"69","article-title":"Clinical efficacy of jianpi qingchang decoction in treating patients with spleen deficiency damp-heat hormone-dependent ulcerative colitis","volume":"25","author":"Zhang","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120128_bib282","article-title":"Observation on the efficacy of shouhui tongbian capsule in the treatment of functional constipation and study on its regulatory effect on intestinal flora","volume":"2021","author":"Zhang","year":"2021","journal-title":"J. Healthc. Eng."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib285","first-page":"1060","article-title":"The effect of electroacupuncture on autophagy of interstitial cells of cajal in the antrum of diabetic gastroparesis rats based on the PI3K\/Akt\/mTOR signaling pathway","volume":"47","author":"Zhang","year":"2022","journal-title":"Acupunct. Res."},{"issue":"12","key":"10.1016\/j.jep.2025.120128_bib286","first-page":"1060","article-title":"[electroacupuncture promotes gastrointestinal motility by activating autophagy of cajal interstitial cells via downregulating PI3K\/Akt\/mTOR signaling pathway in stomach of diabetic gastro-paresis rats]","volume":"47","author":"Zhang","year":"2022","journal-title":"Zhen Ci Yan Jiu"},{"key":"10.1016\/j.jep.2025.120128_bib287","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154180","article-title":"Wei-tong-xin ameliorates functional dyspepsia via inactivating TLR4\/MyD88 by regulating gut microbial structure and metabolites","volume":"102","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"issue":"Pt A","key":"10.1016\/j.jep.2025.120128_bib288","article-title":"Comparative study on alleviating effect of kiwi berry (Actinidia arguta) polysaccharide and polyphenol extracts on constipated mice","volume":"162","author":"Zhang","year":"2022","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2025.120128_bib289","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154374","article-title":"Xiangsha liujunzi decoction improves gastrointestinal motility in functional dyspepsia with spleen deficiency syndrome by restoring mitochondrial quality control homeostasis","volume":"105","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib290","first-page":"55","article-title":"Rats with gastric electrical dysrhythmia were established in Male SD rats by using a single-day diet and a double fasting method (drinking diluted hydrochloric acid water during the period) for 4 weeks","volume":"29","author":"Zhang","year":"2023","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2025.120128_bib293","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116253","article-title":"Wei-tong-xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2\/HO-1 pathway","volume":"308","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib294","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/CM9.0000000000002691","article-title":"Meta-analysis of clinical efficacy of baizhu qiwu granules combined with acupuncture in treatment of slow transit constipation","volume":"25","author":"Zhang","year":"2024","journal-title":"Journal of Shanxi University of Chinese Medicine"},{"issue":"13","key":"10.1016\/j.jep.2025.120128_bib296","first-page":"279","article-title":"Mechanism and research progress of banxia xiexintang inTreating ulcerative colitis based on shanghanlun","volume":"30","author":"Zhang","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"Pt 2","key":"10.1016\/j.jep.2025.120128_bib297","article-title":"Multi-platform analysis revealed the substance basis and mechanism of wei-tong-xin in ameliorating ENS dysfunction for dyspepsia treatment","volume":"337","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2025.120128_bib298","first-page":"5492","article-title":"Changes of amount and ultrastructure of interstitial cells of cajal in rats with severe acute pancreatitis and their importance","volume":"8","author":"Zhao","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib299","first-page":"1518","article-title":"The effect of electroacupuncture on autophagy of interstitial cells of cajal in the antrum of diabetic gastroparesis rats","volume":"32","author":"Zhao","year":"2021","journal-title":"Lishizhen Medicine and Materia Medica"},{"issue":"6","key":"10.1016\/j.jep.2025.120128_bib302","first-page":"892","article-title":"Effect of electroacupuncture at \"zusanli\" and other points on autophagy and apoptosis of interstitial cells of cajal in gastric antrum of diabetic gastroparesis rats","volume":"28","author":"Zhao","year":"2022","journal-title":"Journal of Basic Chinese Medicine"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib303","first-page":"66","article-title":"Effect of faeces bombycis extract on cajal interstitial cells in diabetic gastroparesis rats based on PI3K\/Akt\/mTOR signaling pathway","volume":"30","author":"zhen","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"2","key":"10.1016\/j.jep.2025.120128_bib304","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s12664-020-01143-7","article-title":"miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of cajal isolated from slow transit constipation rats by targeting c-kit","volume":"40","author":"Zheng","year":"2021","journal-title":"Indian J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.jep.2025.120128_bib308","first-page":"12","article-title":"Discussion on the mechanism of treating functional constipation with XiaofuTongjie Fang","volume":"33","author":"Zhou","year":"2013","journal-title":"Modern Chinese Medicine"},{"issue":"9","key":"10.1016\/j.jep.2025.120128_bib309","first-page":"56","article-title":"Clinical study of 40 cases of gastric dyskinesia treated with moxapride in combination with acupoint application of jianpixiaopi cream","volume":"49","author":"Zhou","year":"2017","journal-title":"Jiangsu Journal of Traditional Chinese Medicine"},{"issue":"49","key":"10.1016\/j.jep.2025.120128_bib310","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000023458","article-title":"Effects of chaihu-shugan-san for reflux esophagitis: a protocol for systematic review and meta-analysis","volume":"99","author":"Zhou","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2025.120128_bib311","article-title":"Effects of xiao chengqi formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120128_bib312","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155203","article-title":"Nobiletin, an active component of wenyang yiqi formula, alleviates constipation associated depression through targeting MAPT to inhibit the MAPK signaling pathway","volume":"126","author":"Zhou","year":"2024","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.jep.2025.120128_bib313","first-page":"101","article-title":"Effect of shengji yuhong cream combined with citrus flavonoid tablets on anal Function,Wound healing,and wound tissue in postoperative patients with mixed hemorrhoids","volume":"34","author":"Zhouyu","year":"2025","journal-title":"China Pharmaceuticals"},{"issue":"8","key":"10.1016\/j.jep.2025.120128_bib314","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160398","article-title":"Total glucosides of paeony promote intestinal motility in slow transit constipation rats through amelioration of interstitial cells of cajal","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120128_bib315","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.2147\/JIR.S326416","article-title":"The effect of shaoyao gancao decoction on sphincter of oddi dysfunction in hypercholesterolemic rabbits via protecting the enteric nervous system-interstitial cells of cajal-smooth muscle cells network","volume":"14","author":"Zhu","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"10.1016\/j.jep.2025.120128_bib317","doi-asserted-by":"crossref","first-page":"8187","DOI":"10.1038\/s41467-023-43889-6","article-title":"GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis","volume":"14","author":"Zhu","year":"2023","journal-title":"Nat. Commun."}],"updated-by":[{"DOI":"10.1016\/j.jep.2026.121719","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000}},{"DOI":"10.1016\/j.jep.2026.121719","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125008153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125008153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:10:41Z","timestamp":1786021841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125008153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":284,"alternative-id":["S0378874125008153"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120128","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research progress on the regulation of interstitial cell of Cajal autophagy and apoptosis crosstalk by traditional Chinese medicine in gastrointestinal motility disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120128"}}