{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:40:55Z","timestamp":1789432855858,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","award":["88887.910272\/2023-00"],"award-info":[{"award-number":["88887.910272\/2023-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"Foundation for Support and Development of Education Science and Technology of Mato Grosso do Sul State","doi-asserted-by":"publisher","award":["83\/013.186\/2023"],"award-info":[{"award-number":["83\/013.186\/2023"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305742\/2022-1"],"award-info":[{"award-number":["305742\/2022-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jep.2025.120140","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T19:16:11Z","timestamp":1749582971000},"page":"120140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ethnopharmacological investigations on the cardiometabolic protective effects of Caiman yacare fat oil in hypertensive and dyslipidemic rats"],"prefix":"10.1016","volume":"351","author":[{"given":"Luciane Barbosa","family":"Pessoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Polizzeli","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Aparecida Macedo","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane Barbosa","family":"Pessoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9133-6249","authenticated-orcid":false,"given":"Luana Ale Bertoncello","family":"Pael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyne Garcia Tafarelo","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza Fidelis","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Viana","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-5628","authenticated-orcid":false,"given":"Danielle Ayr Tavares","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio Utrera","family":"Martines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-6219","authenticated-orcid":false,"given":"Jesus Rafael Rodriguez","family":"Amado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricio","family":"Rios-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francislaine Aparecida dos Reis","family":"L\u00edvero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"670352","key":"10.1016\/j.jep.2025.120140_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/670352","article-title":"Wild animals used as food medicine in Brazil","volume":"2013","author":"Alves","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2025.120140_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.wndm.2020.100195","article-title":"Healing potential of Caiman yacare (daudin, 1802) visceral fat oil","volume":"31","author":"Azevedo","year":"2020","journal-title":"Wound Med."},{"key":"10.1016\/j.jep.2025.120140_bib3","first-page":"970","volume":"vol. 132","author":"Baaten","year":"2023"},{"issue":"6","key":"10.1016\/j.jep.2025.120140_bib5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1161\/CIRCGENETICS.114.000533","article-title":"Hypertensive renal injury is associated with gene variation affecting immune signaling","volume":"7","author":"Braun","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"2","key":"10.1016\/j.jep.2025.120140_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1067-1927.2004.012216.x","article-title":"Influence of topical administration of n\u20103 and n\u20106 essential and n\u20109 nonessential fatty acids on the healing of cutaneous wounds","volume":"12","author":"Cardoso","year":"2004","journal-title":"Wound Repair Regen."},{"issue":"1","key":"10.1016\/j.jep.2025.120140_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2217\/fca-2023-0030","article-title":"Inflammation, atherosclerosis and hypertension: the impact of depression and stress on their complex relationship","volume":"20","author":"Coronelli","year":"2024","journal-title":"Future Cardiol."},{"issue":"6","key":"10.1016\/j.jep.2025.120140_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jelectrocard.2009.06.016","article-title":"The electrocardiogram in left ventricular hypertrophy: past and future","volume":"42","author":"Estes","year":"2009","journal-title":"J. Electrocardiol."},{"issue":"2","key":"10.1016\/j.jep.2025.120140_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High blood pressure and cardiovascular disease","volume":"75","author":"Fuchs","year":"2020","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.jep.2025.120140_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11745-997-0050-z","article-title":"Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol\u2010fed rats","volume":"32","author":"Fukushima","year":"1997","journal-title":"Lipids"},{"issue":"3","key":"10.1016\/j.jep.2025.120140_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.jep.2025.120140_bib12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jep.2009.01.021","article-title":"Natriuretic and diuretic effects of Tropaeolum majus (tropaeolaceae) in rats","volume":"122","author":"Gasparotto","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2025.120140_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejphar.2016.08.006","article-title":"Nitric oxide and kir 6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of rats","volume":"788","author":"Gasparotto Junior","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120140_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2010.12.026","article-title":"Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme","volume":"134","author":"Gasparotto Junior","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2025.120140_bib15","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.3390\/ijms19123703","article-title":"Fish, fish oils and cardioprotection: promise or fish tale?","volume":"19","author":"Goel","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jep.2025.120140_bib16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3390\/biom9110664","article-title":"Development of a predictive model to induce atherogenesis and hepato-renal impairment in female rats","volume":"9","author":"Guarnier","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2025.120140_bib17","first-page":"25","article-title":"LDL cholesterol and atherosclerosis: the evidence","volume":"33","author":"Guijarro","year":"2021","journal-title":"Cl\u00edn. Invest. Arterioscler."},{"issue":"12","key":"10.1016\/j.jep.2025.120140_bib18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11883-016-0632-z","article-title":"The different facets of dyslipidemia and hypertension in atherosclerosis","volume":"18","author":"Hurtubise","year":"2016","journal-title":"Curr. Atheroscler. Rep."},{"issue":"3","key":"10.1016\/j.jep.2025.120140_bib19","doi-asserted-by":"crossref","first-page":"H768","DOI":"10.1152\/ajpheart.00690.2015","article-title":"Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not Male) rats","volume":"311","author":"Ip","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.jep.2025.120140_bib20","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/antiox11050856","article-title":"Nitrotyrosine, nitrated lipoproteins, and cardiovascular dys-function in patients with type 2 diabetes: what do we know and what remains to be explained?","volume":"11","author":"Jakubiak","year":"2022","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jep.2025.120140_bib21","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0003-2697(92)90122-N","article-title":"Ferrous ion oxidation in the presence of xylenol Orange for detection of lipid hydroperoxide in low density lipoprotein","volume":"202","author":"Jiang","year":"1992","journal-title":"Anal. Biochem."},{"issue":"7","key":"10.1016\/j.jep.2025.120140_bib22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00392-020-01709-7","article-title":"NAFLD and cardiovascular diseases: a clinical review","volume":"110","author":"Kasper","year":"2021","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.jep.2025.120140_bib23","doi-asserted-by":"crossref","first-page":"5245308","DOI":"10.1155\/2020\/5245308","article-title":"Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis","volume":"2020","author":"Khatana","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"10.1016\/j.jep.2025.120140_bib24","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","article-title":"Atherosclerosis","volume":"123","author":"Kobiyama","year":"2018","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.jep.2025.120140_bib25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/ATVBAHA.115.305380","volume":"35","author":"Lu","year":"2015","journal-title":"Atherosclerosis. Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.jep.2025.120140_bib26","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/ATVBAHA.119.313286","article-title":"Emerging mechanisms of cardiovascular protection for the Omega-3 fatty acid eicosapentaenoic acid","volume":"40","author":"Mason","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.jep.2025.120140_bib35","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765202120190949","article-title":"Carcass and commercial cuts yields of caiman (Caiman crocodilus yacare) farmed in a ranching system in the Brazilian Pantanal","volume":"93","author":"Medeiros","year":"2021","journal-title":"An Acad Bras Cienc"},{"issue":"8","key":"10.1016\/j.jep.2025.120140_bib27","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/bph.14167","article-title":"Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system","volume":"176","author":"Mitchell","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2025.120140_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"2","key":"10.1016\/j.jep.2025.120140_bib29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.ATV.20.2.317","article-title":"Warfarin-induced artery calcification is accelerated by growth and vitamin D","volume":"20","author":"Price","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"26","key":"10.1016\/j.jep.2025.120140_bib30","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1080\/10408398.2022.2056867","article-title":"Blood levels of omega-6 fatty acids and coronary heart disease: a systematic review and metaanalysis of observational epidemiology","volume":"63","author":"Ren","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"3","key":"10.1016\/j.jep.2025.120140_bib31","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000000510","article-title":"Dietary fats and cardiovascular disease: a presidential advisory from the American heart association","volume":"136","author":"Sacks","year":"2017","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jep.2025.120140_bib32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/07315724.2002.10719248","article-title":"Omega-3 fatty acids in inflammation and autoimmune diseases","volume":"21","author":"Simopoulos","year":"2002","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.jep.2025.120140_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in bio-logical samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2025.120140_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biopha.2015.12.024","article-title":"The influence of common free radicals and antioxidants on development of Alzheimer's disease","volume":"78","author":"Wojtunik-Kulesza","year":"2016","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125008281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874125008281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:26:18Z","timestamp":1769689578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874125008281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"alternative-id":["S0378874125008281"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120140","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethnopharmacological investigations on the cardiometabolic protective effects of Caiman yacare fat oil in hypertensive and dyslipidemic rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120140"}}