{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:05:41Z","timestamp":1791461141596,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2019MS08198"],"award-info":[{"award-number":["2019MS08198"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2023MS08066"],"award-info":[{"award-number":["2023MS08066"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2014MS0813"],"award-info":[{"award-number":["2014MS0813"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460567"],"award-info":[{"award-number":["81460567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160709"],"award-info":[{"award-number":["82160709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jep.2025.120142","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T19:24:50Z","timestamp":1749669890000},"page":"120142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sea buckthorn regulates PXR\/CAR\/NF-\u03baB signaling and restores CYP2C metabolic function in BCG-induced hepatitis"],"prefix":"10.1016","volume":"351","author":[{"given":"Peipei","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2189-5478","authenticated-orcid":false,"given":"Yongzhi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2025.120142_bib1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/hep.20387","article-title":"Interleukin 1beta inhibits CAR-Induced expression of hepatic genes involved in drug and bilirubin clearance","volume":"40","author":"Assenat","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2025.120142_bib2","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1172\/JCI13210","article-title":"Arachidonic acid as a bioactive molecule","volume":"107","author":"Brash","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2025.120142_bib3","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/d41586-022-00811-2","article-title":"Hepatitis B","volume":"603","author":"Brody","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jep.2025.120142_bib4","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.3748\/wjg.v20.i26.8681","article-title":"Expression of P450 and nuclear receptors in normal and end-stage Chinese livers","volume":"20","author":"Chen","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120142_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2174\/138920009789375397","article-title":"The transcriptional regulation of the human CYP2C genes","volume":"10","author":"Chen","year":"2009","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.jep.2025.120142_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109170","article-title":"Why is sea buckthorn (Hippophae rhamnoides L.) so exceptional? A review","volume":"133","author":"Ciesarov\u00e1","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2025.120142_bib7","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3390\/cells9112395","article-title":"Regulation of CAR and PXR expression in health and disease","volume":"9","author":"Daujat-Chavanieu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jep.2025.120142_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.prostaglandins.2017.08.004","article-title":"Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis","volume":"131","author":"Deng","year":"2017","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.jep.2025.120142_bib9","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11655-021-3346-1","article-title":"Seabuckthorn berries extract attenuates pulmonary vascular hyperpermeability in lipopolysaccharide-induced acute lung injury in mice","volume":"28","author":"Du","year":"2022","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2025.120142_bib10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.tips.2012.07.003","article-title":"Targeting xenobiotic receptors PXR and CAR for metabolic diseases","volume":"33","author":"Gao","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2025.120142_bib11","doi-asserted-by":"crossref","first-page":"14784","DOI":"10.1096\/fj.201901872R","article-title":"Expression of Cyp2c\/Cyp2j subfamily members and oxylipin levels during LPS-Induced inflammation and resolution in mice","volume":"33","author":"Graves","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2025.120142_bib12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2004.07.031","article-title":"Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins","volume":"41","author":"Guler","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2025.120142_bib13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.taap.2015.03.022","article-title":"Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice","volume":"286","author":"Harris","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2025.120142_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/abbi.2000.1772","article-title":"Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site","volume":"377","author":"Iber","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2025.120142_bib15","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.2741\/3893","article-title":"Nuclear receptors CAR and PXR; therapeutic targets for cholestatic liver disease","volume":"16","author":"Kakizaki","year":"2011","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.jep.2025.120142_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/BOR.0b013e3283588dbb","article-title":"The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis","volume":"24","author":"Lenna","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2025.120142_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fphar.2018.00614","article-title":"BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-\u03baB and activating PKA\/CREB","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2025.120142_bib18","article-title":"Involvement of NF-\u03baB in the reversal of CYP3A down-regulation induced by sea buckthorn in BCG-Induced rats","volume":"15","author":"Liu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2025.120142_bib19","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s11095-008-9788-8","article-title":"Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways","volume":"26","author":"Li","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jep.2025.120142_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/db22-0636","article-title":"VEGF-A: a novel mechanistic link between CYP2C-derived EETs and Nox4 in diabetic kidney disease","volume":"72","author":"Njeim","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2025.120142_bib21","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","article-title":"Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids","volume":"285","author":"Node","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jep.2025.120142_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3892\/br.2022.1573","article-title":"The anti-hepatitis B virus activity of sea buckthorn is attributed to quercetin, kaempferol and isorhamnetin","volume":"17","author":"Parvez","year":"2022","journal-title":"Biomed. Rep."},{"issue":"24","key":"10.1016\/j.jep.2025.120142_bib23","first-page":"4493","article-title":"In search of authenticity biomarkers in food supplements containing sea buckthorn: a metabolomics approach","volume":"12","author":"Raclariu-Manolic\u0103","year":"2023","journal-title":"Foods (Basel, Switzerland)"},{"key":"10.1016\/j.jep.2025.120142_bib24","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.3390\/molecules27072224","article-title":"Metabolomic profiling reveals protective effects and mechanisms of sea buckthorn sterol against carbon tetrachloride-induced acute liver injury in rats","volume":"27","author":"Sheng","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120142_bib25","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.3390\/molecules27123873","article-title":"CYP450 epoxygenase metabolites, epoxyeicosatrienoic acids, as novel anti-inflammatory mediators","volume":"27","author":"Shi","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2025.120142_bib26","doi-asserted-by":"crossref","first-page":"12462","DOI":"10.3748\/wjg.v20.i35.12462","article-title":"Potential mechanisms of hepatitis B virus induced liver injury","volume":"20","author":"Suhail","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2025.120142_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1124\/dmd.110.035287","article-title":"Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism","volume":"39","author":"Theken","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2025.120142_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.steroids.2006.12.006","article-title":"CAR and PXR: the xenobiotic-sensing receptors","volume":"72","author":"Timsit","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.jep.2025.120142_bib29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-020-00443-w","article-title":"Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2025.120142_bib30","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1080\/10408398.2021.1905605","article-title":"Bioactive compounds, health benefits and functional food products of sea buckthorn: a review","volume":"62","author":"Wang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2025.120142_bib31","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1042\/BST0341119","article-title":"The impact of pregnane X receptor activation on liver fibrosis","volume":"34","author":"Wright","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jep.2025.120142_bib32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S2095-4964(14)60039-X","article-title":"Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities","volume":"12","author":"Zhao","year":"2014","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.jep.2025.120142_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22641","article-title":"New insights into the downregulation of cytochrome P450 2E1 via nuclear factor \u03baB-dependent pathways in immune-mediated liver injury","volume":"9","author":"Zou","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2025.120142_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44590-w","article-title":"Hippophae rhamnoides reverses decreased CYP2D6 expression in rats with BCG-induced liver injury","volume":"13","author":"Zou","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412500830X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412500830X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:45:37Z","timestamp":1777571137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412500830X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"alternative-id":["S037887412500830X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2025.120142","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sea buckthorn regulates PXR\/CAR\/NF-\u03baB signaling and restores CYP2C metabolic function in BCG-induced hepatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2025.120142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"120142"}}